{"id":"https://openalex.org/W1822977601","doi":"https://doi.org/10.1002/0471140864.ps1806s23","title":"Disulfide Bond Formation in Peptides","display_name":"Disulfide Bond Formation in Peptides","publication_year":2001,"publication_date":"2001-03-01","ids":{"openalex":"https://openalex.org/W1822977601","doi":"https://doi.org/10.1002/0471140864.ps1806s23","mag":"1822977601","pmid":"https://pubmed.ncbi.nlm.nih.gov/18429142"},"language":"en","primary_location":{"id":"doi:10.1002/0471140864.ps1806s23","doi":"https://doi.org/10.1002/0471140864.ps1806s23","is_oa":false,"landing_page_url":"https://doi.org/10.1002/0471140864.ps1806s23","pdf_url":null,"source":{"id":"https://openalex.org/S2764865717","display_name":"Current Protocols in Protein Science","issn_l":"1934-3655","issn":["1934-3655","1934-3663"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Protocols in Protein Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100443792","display_name":"Lin Chen","orcid":"https://orcid.org/0000-0003-1444-3446","observed_orcids":["https://orcid.org/0000-0003-1444-3446"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin Chen","raw_affiliation_strings":["AxCell Biosciences Corporation Newtown Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AxCell Biosciences Corporation Newtown Pennsylvania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048605956","display_name":"Ioana Annis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388891856","display_name":"Union Carbide (United States)","ror":"https://ror.org/04hj96d73","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133143","https://openalex.org/I4388891856"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ioana Annis","raw_affiliation_strings":["Union Carbide Corporation Bound Brook New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Union Carbide Corporation Bound Brook New Jersey","institution_ids":["https://openalex.org/I4388891856"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019782256","display_name":"George B\u00e1r\u00e1ny","orcid":"https://orcid.org/0000-0002-6373-2706","observed_orcids":["https://orcid.org/0000-0002-6373-2706"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Barany","raw_affiliation_strings":["University of Minnesota Minneapolis Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota Minneapolis Minnesota","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5050,"currency":"USD","value_usd":5050},"apc_paid":null,"fwci":0.2577,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.47974728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"23","issue":"1","first_page":"18.6.1","last_page":"18.6.19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12189","display_name":"Sulfur-Based Synthesis Techniques","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disulfide-bond-formation","display_name":"disulfide bond formation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.9169999957084656},{"id":"https://openalex.org/keywords/peptide-synthesis","display_name":"peptide synthesis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/intramolecular-disulfide-bond","display_name":"intramolecular disulfide bond","score":0.9100000262260437},{"id":"https://openalex.org/keywords/intermolecular-disulfide-bonds","display_name":"intermolecular disulfide bonds","score":0.996999979019165},{"id":"https://openalex.org/keywords/peptide-folding","display_name":"peptide folding","score":0.8460000157356262},{"id":"https://openalex.org/keywords/peptide-stability","display_name":"peptide stability","score":0.5180000066757202},{"id":"https://openalex.org/keywords/biological-activity-enhancement","display_name":"biological activity enhancement","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C27256138","wikidata":"https://www.wikidata.org/wiki/Q1230226","display_name":"Disulfide bond","level":2,"score":0.8783220052719116},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.7109645009040833},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.6612601280212402},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6129453778266907},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6000601649284363},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.5720998048782349},{"id":"https://openalex.org/C166950319","wikidata":"https://www.wikidata.org/wiki/Q245031","display_name":"Intermolecular force","level":3,"score":0.46839451789855957},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.39385324716567993},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3009941577911377},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26337915658950806},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.18307089805603027},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13168346881866455},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005292","descriptor_name":"Ferricyanides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/0471140864.ps1806s23","doi":"https://doi.org/10.1002/0471140864.ps1806s23","is_oa":false,"landing_page_url":"https://doi.org/10.1002/0471140864.ps1806s23","pdf_url":null,"source":{"id":"https://openalex.org/S2764865717","display_name":"Current Protocols in Protein Science","issn_l":"1934-3655","issn":["1934-3655","1934-3663"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Protocols in Protein Science","raw_type":"journal-article"},{"id":"pmid:18429142","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18429142","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current protocols in protein science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W614117726","https://openalex.org/W621448943","https://openalex.org/W631397590","https://openalex.org/W1513861898","https://openalex.org/W1528422305","https://openalex.org/W1563586280","https://openalex.org/W1577742213","https://openalex.org/W1917622076","https://openalex.org/W1952295494","https://openalex.org/W1965101542","https://openalex.org/W1966113325","https://openalex.org/W1969187585","https://openalex.org/W1970870394","https://openalex.org/W1974930933","https://openalex.org/W1975707236","https://openalex.org/W1975972704","https://openalex.org/W1976118295","https://openalex.org/W1984774970","https://openalex.org/W1987502076","https://openalex.org/W1989439356","https://openalex.org/W1992424014","https://openalex.org/W1995227176","https://openalex.org/W2000999653","https://openalex.org/W2002411650","https://openalex.org/W2003117311","https://openalex.org/W2007640756","https://openalex.org/W2011823820","https://openalex.org/W2013510499","https://openalex.org/W2016488773","https://openalex.org/W2024674593","https://openalex.org/W2026151231","https://openalex.org/W2027333557","https://openalex.org/W2027739998","https://openalex.org/W2030355410","https://openalex.org/W2030753212","https://openalex.org/W2031839103","https://openalex.org/W2032036090","https://openalex.org/W2032819946","https://openalex.org/W2036243377","https://openalex.org/W2037133292","https://openalex.org/W2037387279","https://openalex.org/W2039632352","https://openalex.org/W2042804489","https://openalex.org/W2043349645","https://openalex.org/W2044154766","https://openalex.org/W2048258234","https://openalex.org/W2055106628","https://openalex.org/W2060542507","https://openalex.org/W2066036146","https://openalex.org/W2066686002","https://openalex.org/W2066874205","https://openalex.org/W2070606660","https://openalex.org/W2073551056","https://openalex.org/W2074153666","https://openalex.org/W2076242147","https://openalex.org/W2080668690","https://openalex.org/W2084168484","https://openalex.org/W2084924708","https://openalex.org/W2086676721","https://openalex.org/W2090338919","https://openalex.org/W2091473494","https://openalex.org/W2094243088","https://openalex.org/W2103260368","https://openalex.org/W2116811805","https://openalex.org/W2157770635","https://openalex.org/W2259871909","https://openalex.org/W2316896482","https://openalex.org/W2317326608","https://openalex.org/W2407990031","https://openalex.org/W2951201975","https://openalex.org/W2952810714","https://openalex.org/W3021626239","https://openalex.org/W3044617864","https://openalex.org/W4237142329"],"related_works":["https://openalex.org/W2160582849","https://openalex.org/W74544524","https://openalex.org/W1550896597","https://openalex.org/W2171609","https://openalex.org/W4242043299","https://openalex.org/W259117946","https://openalex.org/W2363447748","https://openalex.org/W2950670411","https://openalex.org/W2477137269","https://openalex.org/W4241481553"],"abstract_inverted_index":{"The":[0],"formation":[1],"of":[2,31,42,66,81],"disulfide":[3,20,43,77],"bridges":[4,44,78],"is":[5,15],"often":[6,51],"a":[7,60],"crucial":[8],"final":[9],"stage":[10],"in":[11,25,79],"peptide":[12,34],"synthesis.":[13],"There":[14],"compelling":[16],"evidence":[17],"that":[18,68],"the":[19,26,39],"pattern":[21],"can":[22,69],"be":[23,70],"critical":[24],"folding":[27],"and":[28,35,55],"structural":[29],"stabilization":[30],"many":[32],"natural":[33,46],"protein":[36],"sequences,":[37],"while":[38],"artificial":[40],"introduction":[41],"into":[45],"or":[47,75],"designed":[48],"peptides":[49],"may":[50],"improve":[52],"biological":[53],"activities/specificities":[54],"stabilities.":[56],"This":[57],"unit":[58],"provides":[59],"highly":[61],"selective,":[62],"albeit":[63],"state-of-the-art,":[64],"menu":[65],"procedures":[67],"performed":[71],"to":[72],"establish":[73],"intramolecular":[74],"intermolecular":[76],"targets":[80],"varying":[82],"complexities.":[83]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}