{"id":"https://openalex.org/W182248641","doi":null,"title":"The challenge of cholestatic pruritus.","display_name":"The challenge of cholestatic pruritus.","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W182248641","mag":"182248641","pmid":"https://pubmed.ncbi.nlm.nih.gov/23402082"},"language":"en","primary_location":{"id":"pmid:23402082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23402082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta gastro-enterologica Belgica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054582630","display_name":"A. Ruth Bolier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A R Bolier","raw_affiliation_strings":["Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089126790","display_name":"Suraj Peri","orcid":"https://orcid.org/0000-0002-1909-8218","observed_orcids":["https://orcid.org/0000-0002-1909-8218"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Peri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044314042","display_name":"Ronald P.J. Oude Elferink","orcid":"https://orcid.org/0000-0002-1779-0833","observed_orcids":["https://orcid.org/0000-0002-1779-0833"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R P J Oude Elferink","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018461629","display_name":"Ulrich H. Beuers","orcid":"https://orcid.org/0000-0001-5114-7799","observed_orcids":["https://orcid.org/0000-0001-5114-7799"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Beuers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1792,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.57116236,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"75","issue":"4","first_page":"399","last_page":"404"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.1216999962925911,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholestatic-pruritus","display_name":"cholestatic pruritus","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cholestasis","display_name":"cholestasis","score":0.847000002861023},{"id":"https://openalex.org/keywords/autotaxin","display_name":"autotaxin","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cholestyramine","display_name":"cholestyramine","score":0.7950000166893005},{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.996999979019165},{"id":"https://openalex.org/keywords/naltrexone","display_name":"naltrexone","score":0.9580000042915344},{"id":"https://openalex.org/keywords/sertraline","display_name":"sertraline","score":1.0},{"id":"https://openalex.org/keywords/pxr-agonists","display_name":"PXR agonists","score":0.6660000085830688},{"id":"https://openalex.org/keywords/antipruritic-treatment","display_name":"antipruritic therapy","score":0.8659999966621399},{"id":"https://openalex.org/keywords/uvb-phototherapy","display_name":"UVB phototherapy","score":0.9300000071525574},{"id":"https://openalex.org/keywords/extracorporeal-albumin-dialysis","display_name":"extracorporeal albumin dialysis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/nasobiliary-drainage","display_name":"nasobiliary drainage","score":0.9919999837875366},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/pruritus-pathophysiology","display_name":"pruritus pathophysiology","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7621797323226929},{"id":"https://openalex.org/C2778593092","wikidata":"https://www.wikidata.org/wiki/Q1075923","display_name":"Cholestasis","level":2,"score":0.6323169469833374},{"id":"https://openalex.org/C2778697171","wikidata":"https://www.wikidata.org/wiki/Q418006","display_name":"Cholestyramine","level":3,"score":0.5536103844642639},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41376838088035583},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3189111351966858},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099189","descriptor_name":"Lysophospholipase D","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000837","descriptor_name":"Anion Exchange Resins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000982","descriptor_name":"Antipruritics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002779","descriptor_name":"Cholestasis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D002779","descriptor_name":"Cholestasis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002792","descriptor_name":"Cholestyramine Resin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003956","descriptor_name":"Dialysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009292","descriptor_name":"Narcotic Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010789","descriptor_name":"Phototherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011537","descriptor_name":"Pruritus","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011537","descriptor_name":"Pruritus","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011537","descriptor_name":"Pruritus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011537","descriptor_name":"Pruritus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:23402082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23402082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta gastro-enterologica Belgica","raw_type":"Journal Article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/bda9e8f6-8d7c-4f05-8ff1-f45279b1a3d5","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/the-challenge-of-cholestatic-pruritus(bda9e8f6-8d7c-4f05-8ff1-f45279b1a3d5).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta gastro-enterologica Belgica, 75(4), 399 - 404. Universa Press","raw_type":"info:eu-repo/semantics/other"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/b0c22a2f-5797-43fa-8d23-416bc43a928c","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/b0c22a2f-5797-43fa-8d23-416bc43a928c","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bolier, A R, Peri, S, Oude Elferink, R P J & Beuers, U 2012, 'The challenge of cholestatic pruritus', Acta gastro-enterologica Belgica, vol. 75, no. 4, pp. 399-404.","raw_type":"info:eu-repo/semantics/review"},{"id":"mag:182248641","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23402082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W1672613","https://openalex.org/W44055024","https://openalex.org/W56488575","https://openalex.org/W61662957","https://openalex.org/W107290262","https://openalex.org/W1219313770","https://openalex.org/W1510939576","https://openalex.org/W1533854455","https://openalex.org/W1557387797","https://openalex.org/W1568521174","https://openalex.org/W1581789522","https://openalex.org/W1776760292","https://openalex.org/W1946522611","https://openalex.org/W1964934445","https://openalex.org/W1966722313","https://openalex.org/W1970449031","https://openalex.org/W1972145571","https://openalex.org/W1976270005","https://openalex.org/W1988523760","https://openalex.org/W1988604484","https://openalex.org/W1989472614","https://openalex.org/W1990133259","https://openalex.org/W1993563841","https://openalex.org/W1993816135","https://openalex.org/W1994142514","https://openalex.org/W1995374814","https://openalex.org/W1996236128","https://openalex.org/W2000729096","https://openalex.org/W2001389021","https://openalex.org/W2003707006","https://openalex.org/W2004301965","https://openalex.org/W2005343899","https://openalex.org/W2005678638","https://openalex.org/W2006248456","https://openalex.org/W2008911434","https://openalex.org/W2010189325","https://openalex.org/W2010822245","https://openalex.org/W2012543042","https://openalex.org/W2013022794","https://openalex.org/W2018936464","https://openalex.org/W2019796203","https://openalex.org/W2024799765","https://openalex.org/W2028536961","https://openalex.org/W2038340761","https://openalex.org/W2043915680","https://openalex.org/W2047844288","https://openalex.org/W2051358292","https://openalex.org/W2051441289","https://openalex.org/W2053773594","https://openalex.org/W2054162552","https://openalex.org/W2055077741","https://openalex.org/W2065612717","https://openalex.org/W2069428597","https://openalex.org/W2071346815","https://openalex.org/W2075054530","https://openalex.org/W2076734646","https://openalex.org/W2079146831","https://openalex.org/W2080224946","https://openalex.org/W2080561720","https://openalex.org/W2081286968","https://openalex.org/W2082648984","https://openalex.org/W2087004322","https://openalex.org/W2087322919","https://openalex.org/W2088699936","https://openalex.org/W2088794972","https://openalex.org/W2090292912","https://openalex.org/W2094285893","https://openalex.org/W2094436994","https://openalex.org/W2096194006","https://openalex.org/W2103125502","https://openalex.org/W2103809565","https://openalex.org/W2105176852","https://openalex.org/W2106604860","https://openalex.org/W2108087274","https://openalex.org/W2120452779","https://openalex.org/W2120577168","https://openalex.org/W2123163420","https://openalex.org/W2128598867","https://openalex.org/W2134613519","https://openalex.org/W2137528178","https://openalex.org/W2147975541","https://openalex.org/W2151134041","https://openalex.org/W2154447673","https://openalex.org/W2156518406","https://openalex.org/W2159556063","https://openalex.org/W2169053291","https://openalex.org/W2169871921","https://openalex.org/W2313206844","https://openalex.org/W2377678051","https://openalex.org/W2410897707","https://openalex.org/W2411711754","https://openalex.org/W2414725265","https://openalex.org/W2786456523","https://openalex.org/W3022109954","https://openalex.org/W3152200344"],"related_works":["https://openalex.org/W1968369999","https://openalex.org/W2411711754","https://openalex.org/W2065612717","https://openalex.org/W3141060216","https://openalex.org/W2440567745","https://openalex.org/W3017176778","https://openalex.org/W2795838406","https://openalex.org/W2079146831","https://openalex.org/W2168820428","https://openalex.org/W4307771971"],"abstract_inverted_index":{"Pruritus":[0],"can":[1],"be":[2,45],"the":[3,52,56,61,81,120],"dominant":[4],"symptom":[5],"of":[6,39,127],"cholestatic":[7,87,131],"liver":[8,113],"disease":[9],"but":[10,30],"is":[11,19],"difficult":[12],"to":[13,44,75,92],"treat":[14,76],"since":[15],"unraveling":[16],"its":[17,31],"pathophysiology":[18],"a":[20],"great":[21],"challenge.":[22],"Serum":[23],"autotaxin":[24,94],"activity":[25],"correlates":[26],"with":[27,119],"pruritus":[28,132],"intensity,":[29],"causal":[32],"relationship,":[33],"expression":[34],"pattern":[35],"and":[36,60,108,124],"exact":[37],"mode":[38],"action":[40],"during":[41],"cholestasis":[42],"remain":[43],"established.":[46],"The":[47],"anion":[48],"exchange":[49],"resin":[50],"cholestyramine,":[51],"PXR":[53],"agonist":[54],"rifampicin,":[55],"opioid":[57],"antagonist":[58],"naltrexone":[59],"serotonine":[62],"reuptake":[63],"inhibitor":[64],"sertraline":[65],"are":[66,133],"recommended":[67],"by":[68],"evidence-based":[69],"guidelines":[70],"as":[71],"stepwise":[72],"therapeutic":[73],"approaches":[74,99],"itch":[77],"in":[78,86,96,109,130],"cholestasis.":[79],"Rifampicin,":[80],"most":[82],"effective":[83],"antipruritic":[84],"agent":[85],"itch,":[88],"has":[89],"been":[90],"shown":[91],"reduce":[93],"transcription":[95],"vitro.":[97],"Experimental":[98],"include":[100],"UVB":[101],"phototherapy,":[102],"extracorporeal":[103],"albumin":[104],"dialysis,":[105],"nasobiliary":[106],"drainage":[107],"desperate":[110],"cases":[111],"even":[112],"transplantation.":[114],"Relevant":[115],"clinical":[116],"observations":[117],"along":[118],"different":[121],"metabolic,":[122],"neurologic":[123],"endocrine":[125],"targets":[126],"available":[128],"therapies":[129],"reviewed":[134],"here.":[135]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}