{"id":"https://openalex.org/W1821827104","doi":null,"title":"Dynamics of the glomerular filtration barrier - Physiological and pathophysiological aspects","display_name":"Dynamics of the glomerular filtration barrier - Physiological and pathophysiological aspects","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W1821827104","mag":"1821827104"},"language":"en","primary_location":{"id":"pmh:oai:lup.lub.lu.se:f2212751-84a0-452e-93ed-467b89debbc2","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/1967872","pdf_url":"https://lup.lub.lu.se/record/1967872","source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lup.lub.lu.se/record/1967872","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012356774","display_name":"Josefin Axelsson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Josefin Axelsson","raw_affiliation_strings":["Nephrology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5012356774"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glomerular-filtration-barrier","display_name":"glomerular filtration barrier","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glomerular-permeability","display_name":"glomerular permeability","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sieving-coefficient","display_name":"sieving coefficient","score":0.9309999942779541},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.44999998807907104},{"id":"https://openalex.org/keywords/ficoll","display_name":"Ficoll","score":0.8069999814033508},{"id":"https://openalex.org/keywords/microalbuminuria","display_name":"microalbuminuria","score":0.8920000195503235},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.9649999737739563},{"id":"https://openalex.org/keywords/lipopolysaccharide-induced-sepsis","display_name":"lipopolysaccharide-induced sepsis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/anaphylaxis","display_name":"anaphylaxis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/laparotomy","display_name":"laparotomy","score":0.8920000195503235},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/rho-kinase","display_name":"Rho kinase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/atrial-natriuretic-peptide","display_name":"atrial natriuretic peptide","score":0.8610000014305115},{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C5362183","wikidata":"https://www.wikidata.org/wiki/Q410200","display_name":"Ficoll","level":4,"score":0.9162352085113525},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6771334409713745},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.631259560585022},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.530517041683197},{"id":"https://openalex.org/C104471311","wikidata":"https://www.wikidata.org/wiki/Q16670987","display_name":"Oncotic pressure","level":3,"score":0.4777783155441284},{"id":"https://openalex.org/C2781203188","wikidata":"https://www.wikidata.org/wiki/Q1676817","display_name":"Microalbuminuria","level":3,"score":0.4548618495464325},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.4456367492675781},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37793073058128357},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37399527430534363},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.34639251232147217},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23460900783538818},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18827399611473083},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.13065078854560852},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1293480098247528},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:lup.lub.lu.se:f2212751-84a0-452e-93ed-467b89debbc2","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/1967872","pdf_url":"https://lup.lub.lu.se/record/1967872","source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1821827104","doi":null,"is_oa":false,"landing_page_url":"https://portal.research.lu.se/portal/files/4150724/1967879.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:lup.lub.lu.se:f2212751-84a0-452e-93ed-467b89debbc2","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/1967872","pdf_url":"https://lup.lub.lu.se/record/1967872","source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8999025819","display_name":null,"funder_award_id":"08285","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321806","display_name":"Lunds Universitet","ror":"https://ror.org/012a77v79"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320335189","display_name":"Medicinska Fakulteten, Lunds Universitet","ror":"https://ror.org/012a77v79"},{"id":"https://openalex.org/F4320335552","display_name":"Medicinska fakulteten, Ume\u00e5 Universitet","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1821827104.pdf","grobid_xml":"https://content.openalex.org/works/W1821827104.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1484503896","https://openalex.org/W1902747848","https://openalex.org/W1971337562","https://openalex.org/W1972567438","https://openalex.org/W1976396591","https://openalex.org/W2000468365","https://openalex.org/W2018964430","https://openalex.org/W2020140879","https://openalex.org/W2022828038","https://openalex.org/W2053416546","https://openalex.org/W2054200884","https://openalex.org/W2069640515","https://openalex.org/W2103998815","https://openalex.org/W2114241638","https://openalex.org/W2120372571","https://openalex.org/W2123665694","https://openalex.org/W2138055894","https://openalex.org/W2139466045","https://openalex.org/W2142943438","https://openalex.org/W2145805708","https://openalex.org/W2156712517","https://openalex.org/W2158485980","https://openalex.org/W2170135173","https://openalex.org/W2196954536","https://openalex.org/W2269567008","https://openalex.org/W2272679087","https://openalex.org/W2281691222"],"related_works":["https://openalex.org/W1794132254","https://openalex.org/W1852533363","https://openalex.org/W2138055894","https://openalex.org/W2317788034","https://openalex.org/W1992621774","https://openalex.org/W2410547659","https://openalex.org/W2742766467","https://openalex.org/W2139466045","https://openalex.org/W1972268125","https://openalex.org/W1978268623"],"abstract_inverted_index":{"The":[0,247],"dynamic":[1,338],"properties":[2,34],"of":[3,10,16,21,29,35,50,60,84,141,267,282,335,349],"the":[4,14,17,27,33,36,88,93,139,145,265,332,347,350],"glomerular":[5,38,121,203,241,288,339],"filtration":[6,39,56,340],"barrier":[7,40,341],"(GFB)":[8],"are":[9],"fundamental":[11],"importance":[12],"for":[13,100,108,124,128,158,162,226,290,322],"understanding":[15],"physiology":[18],"and":[19,23,46,64,72,106,126,160,237,298,363],"pathophysiology":[20],"microalbuminuria":[22],"proteinuric":[24],"diseases.":[25],"In":[26,147,171,189,275,329],"studies":[28],"this":[30,330],"doctoral":[31],"thesis":[32,331],"rat":[37],"were":[41],"investigated":[42],"under":[43],"resting":[44,91],"conditions":[45,92],"following":[47],"a":[48,175,211,260,310,314,336],"number":[49,140],"challenges":[51],"using":[52,74],"highly":[53],"sensitive":[54],"gel":[55],"chromatography":[57],"(HPSEC)":[58],"detection":[59],"FITC-Ficoll":[61],"in":[62,87,120,132,138,144,156,202,224,287],"serum":[63],"urine.":[65,89],"This":[66],"permeability":[67,122,177,204,242,248,289],"model":[68],"is":[69,342],"extremely":[70,81],"sensitive,":[71],"by":[73,259],"HPSEC,":[75],"it":[76],"was":[77,103,110,174,184,209,243,256,309,356],"possible":[78],"to":[79,112,210,245,327,358,361],"measure":[80],"low":[82,280],"concentrations":[83],"Ficoll":[85,101,129,163,227,291,323],"molecules":[86],"Under":[90],"sieving":[94],"coefficient":[95],"(\u03b8;":[96],"filtrate-to-plasma":[97],"concentration":[98],"ratio)":[99],"70\u00c5":[102],"approximately":[104],"0.00001,":[105],"\u03b8":[107,123,127,157,161,225,321],"albumin":[109,125,159],"found":[111,357],"be":[113,273,359],"low,":[114],"0.0003":[115],"(or":[116],"less).":[117],"During":[118,301,344],"increases":[119,155],"50-80\u00c5":[130,228,324],"increased":[131],"parallel,":[133],"conceivably":[134],"reflecting":[135],"an":[136,200,222,285],"increase":[137,201,223,249,286],"large":[142,212],"pores":[143],"GFB.":[146],"study":[148,190,276],"I,":[149],"lipopolysaccharide":[150],"(LPS)":[151],"induced":[152,199,221,284],"sepsis":[153],"produced":[154],"50-80\u00c5,":[164,292],"at":[165,234,253,296],"120":[166],"min":[167,182,240,255],"after":[168,180,205,215,229,238,251,316,319],"LPS":[169],"injection.":[170],"anaphylaxis":[172],"there":[173,308],"rapid":[176,362],"response":[178],"already":[179],"5":[181,206,235,297],"which":[183,208,320],"reversed":[185],"within":[186],"40":[187],"min.":[188,217,300],"II,":[191],"laparotomy,":[192],"with":[193,313],"or":[194,279],"without":[195],"muscle":[196],"crush":[197],"trauma,":[198],"min,":[207,231,236,318],"extent":[213],"sustained":[214],"60":[216,239],"Hyperglycemia":[218],"(study":[219],"III)":[220],"20":[230,254],"but":[232],"not":[233],"back":[244],"normal.":[246],"seen":[250],"hyperglycemia":[252],"totally":[257],"abolished":[258],"Rho-kinase":[261],"inhibitor,":[262],"indicating":[263],"that":[264],"cytoskeleton":[266],"endothelial":[268],"cells":[269],"and/or":[270],"podocytes":[271],"may":[272],"involved.":[274],"IV,":[277],"high":[278],"doses":[281],"ANP":[283,302],"reaching":[293],"its":[294,354],"maximum":[295],"15":[299],"infusion":[303],"(cf.":[304],"congestive":[305],"heart":[306],"failure)":[307],"bimodal":[311],"response,":[312],"dip":[315],"30":[317],"again":[325],"tended":[326],"increase.":[328],"novel":[333],"concept":[334],"rapidly":[337],"introduced.":[343],"different":[345],"challenges,":[346],"size-selectivity":[348],"GFB,":[351],"rather":[352],"than":[353],"charge-selectivity,":[355],"subject":[360],"reversible":[364],"alterations.":[365]},"counts_by_year":[],"updated_date":"2026-09-01T08:31:24.195828","created_date":"2016-06-24T00:00:00"}