{"id":"https://openalex.org/W1821230285","doi":"https://doi.org/10.6004/jnccn.2013.0054","title":"A Patient With Anaplastic Lymphoma Kinase\u2013Positive Non\u2013Small Cell Lung Cancer With Development of Leptomeningeal Carcinomatosis While on Targeted Treatment With Crizotinib","display_name":"A Patient With Anaplastic Lymphoma Kinase\u2013Positive Non\u2013Small Cell Lung Cancer With Development of Leptomeningeal Carcinomatosis While on Targeted Treatment With Crizotinib","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W1821230285","doi":"https://doi.org/10.6004/jnccn.2013.0054","mag":"1821230285","pmid":"https://pubmed.ncbi.nlm.nih.gov/23584342","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6329611"},"language":"en","primary_location":{"id":"doi:10.6004/jnccn.2013.0054","doi":"https://doi.org/10.6004/jnccn.2013.0054","is_oa":false,"landing_page_url":"https://doi.org/10.6004/jnccn.2013.0054","pdf_url":null,"source":{"id":"https://openalex.org/S935620192","display_name":"Journal of the National Comprehensive Cancer Network","issn_l":"1540-1405","issn":["1540-1405","1540-1413"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4324004213","host_organization_name":"National Comprehensive Cancer","host_organization_lineage":["https://openalex.org/P4324004213"],"host_organization_lineage_names":["National Comprehensive Cancer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Comprehensive Cancer Network","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6329611","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082506495","display_name":"Jonathan Wesley Riess","orcid":"https://orcid.org/0000-0001-7370-7304","observed_orcids":["https://orcid.org/0000-0001-7370-7304"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan W. Riess","raw_affiliation_strings":["Department of Medicine, Division of Oncology, Division of Neuro-Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California 94305, USA. riessjo@stanford.edu","Department of Medicine, Division of Oncology, Division of Neuro-Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Oncology, Division of Neuro-Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California 94305, USA. riessjo@stanford.edu","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Medicine, Division of Oncology, Division of Neuro-Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025685342","display_name":"Seema Nagpal","orcid":"https://orcid.org/0000-0002-0289-2319","observed_orcids":["https://orcid.org/0000-0002-0289-2319"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seema Nagpal","raw_affiliation_strings":["Department of Neurology, Division of Neuro-Oncology. Stanford Cancer Institute. Stanford University School of Medicine. Stanford, CA","From the aDepartment of Medicine, Division of Oncology, and bDepartment of Neurology, Division of Neuro-Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Division of Neuro-Oncology. Stanford Cancer Institute. Stanford University School of Medicine. Stanford, CA","institution_ids":["https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"raw_affiliation_string":"From the aDepartment of Medicine, Division of Oncology, and bDepartment of Neurology, Division of Neuro-Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034377849","display_name":"Joel W. Neal","orcid":"https://orcid.org/0000-0003-3119-9334","observed_orcids":["https://orcid.org/0000-0003-3119-9334"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel W. Neal","raw_affiliation_strings":["Department of Medicine, Division of Oncology. Stanford Cancer Institute. Stanford University School of Medicine. Stanford, CA","From the aDepartment of Medicine, Division of Oncology, and bDepartment of Neurology, Division of Neuro-Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Oncology. Stanford Cancer Institute. Stanford University School of Medicine. Stanford, CA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"raw_affiliation_string":"From the aDepartment of Medicine, Division of Oncology, and bDepartment of Neurology, Division of Neuro-Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035640724","display_name":"Heather A. Wakelee","orcid":"https://orcid.org/0000-0003-1136-980X","observed_orcids":["https://orcid.org/0000-0003-1136-980X"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather A. Wakelee","raw_affiliation_strings":["Department of Medicine, Division of Oncology. Stanford Cancer Institute. Stanford University School of Medicine. Stanford, CA","From the aDepartment of Medicine, Division of Oncology, and bDepartment of Neurology, Division of Neuro-Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Oncology. Stanford Cancer Institute. Stanford University School of Medicine. Stanford, CA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"raw_affiliation_string":"From the aDepartment of Medicine, Division of Oncology, and bDepartment of Neurology, Division of Neuro-Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4373,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.88510316,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"11","issue":"4","first_page":"389","last_page":"394"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.7803000211715698,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.7803000211715698,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.21199999749660492,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptomeningeal-metastasis","display_name":"leptomeningeal metastasis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.906000018119812},{"id":"https://openalex.org/keywords/anaplastic-lymphoma-kinase","display_name":"anaplastic lymphoma kinase","score":0.9800000190734863},{"id":"https://openalex.org/keywords/alk-positive-non-small-cell-lung-cancer","display_name":"ALK-positive non-small cell lung cancer","score":0.7829999923706055},{"id":"https://openalex.org/keywords/crizotinib","display_name":"crizotinib","score":1.0},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9150000214576721},{"id":"https://openalex.org/keywords/central-nervous-system-progression","display_name":"central nervous system progression","score":0.7059999704360962},{"id":"https://openalex.org/keywords/intracranial-pressure","display_name":"intracranial pressure","score":0.8569999933242798}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.928324818611145},{"id":"https://openalex.org/C117643217","wikidata":"https://www.wikidata.org/wiki/Q17824987","display_name":"Anaplastic lymphoma kinase","level":4,"score":0.8980015516281128},{"id":"https://openalex.org/C2779422266","wikidata":"https://www.wikidata.org/wiki/Q5186964","display_name":"Crizotinib","level":4,"score":0.8834172487258911},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6303387880325317},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5528426766395569},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.552388072013855},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5455952286720276},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.5306980013847351},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46084854006767273},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.43722596764564514},{"id":"https://openalex.org/C2778347629","wikidata":"https://www.wikidata.org/wiki/Q4652380","display_name":"ALK inhibitor","level":5,"score":0.42753303050994873},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4125719964504242},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35718557238578796},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2776232967","wikidata":"https://www.wikidata.org/wiki/Q6743514","display_name":"Malignant pleural effusion","level":3,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077547","descriptor_name":"Crizotinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077548","descriptor_name":"Anaplastic Lymphoma Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D055756","descriptor_name":"Meningeal Carcinomatosis","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.6004/jnccn.2013.0054","doi":"https://doi.org/10.6004/jnccn.2013.0054","is_oa":false,"landing_page_url":"https://doi.org/10.6004/jnccn.2013.0054","pdf_url":null,"source":{"id":"https://openalex.org/S935620192","display_name":"Journal of the National Comprehensive Cancer Network","issn_l":"1540-1405","issn":["1540-1405","1540-1413"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4324004213","host_organization_name":"National Comprehensive Cancer","host_organization_lineage":["https://openalex.org/P4324004213"],"host_organization_lineage_names":["National Comprehensive Cancer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Comprehensive Cancer Network","raw_type":"journal-article"},{"id":"pmid:23584342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23584342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Comprehensive Cancer Network : JNCCN","raw_type":"Case Reports"},{"id":"pmh:oai:europepmc.org:5304225","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6329611","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6329611","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6329611","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Natl Compr Canc Netw","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5304225","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6329611","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G7141018098","display_name":"Stanford Center for Clinical and Translational Education and Research (SCCTER)KL2","funder_award_id":"KL2RR025743","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1984841223","https://openalex.org/W2013865180","https://openalex.org/W2019539885","https://openalex.org/W2060254075","https://openalex.org/W2081095165","https://openalex.org/W2090615329","https://openalex.org/W2099725888","https://openalex.org/W2111662961","https://openalex.org/W2128688922","https://openalex.org/W2132157071","https://openalex.org/W2136963436","https://openalex.org/W2144660856","https://openalex.org/W2145835533","https://openalex.org/W2147038864","https://openalex.org/W2149112407","https://openalex.org/W2154581953","https://openalex.org/W2158638287","https://openalex.org/W2159711942","https://openalex.org/W2166084034","https://openalex.org/W2171136529","https://openalex.org/W2287372748","https://openalex.org/W2520220492","https://openalex.org/W2602210469","https://openalex.org/W2748693890","https://openalex.org/W2788612690","https://openalex.org/W2998884390"],"related_works":["https://openalex.org/W2069277433","https://openalex.org/W2036099482","https://openalex.org/W4402236968","https://openalex.org/W4250610324","https://openalex.org/W4400646950","https://openalex.org/W3198999730","https://openalex.org/W2949987709","https://openalex.org/W2903335149","https://openalex.org/W2901607343","https://openalex.org/W2213763714"],"abstract_inverted_index":{"Leptomeningeal":[0],"carcinomatosis":[1],"(LM)":[2],"is":[3,21,50,92],"an":[4],"infrequent":[5],"yet":[6,82],"morbid":[7],"and":[8,28,41,67,98,141],"often":[9,23,83],"fatal":[10],"complication":[11],"of":[12,19,31,101,107,115,133],"non-small":[13],"cell":[14],"lung":[15],"cancer":[16],"(NSCLC).":[17],"Management":[18],"LM":[20,102,123],"multimodal,":[22],"involving":[24],"systemic":[25,76],"chemotherapy,":[26],"radiotherapy,":[27],"a":[29,116],"variety":[30],"symptom":[32],"management":[33,100,114],"maneuvers":[34],"to":[35,75],"address":[36],"elevated":[37],"intracranial":[38],"pressure,":[39],"pain,":[40],"mood":[42],"changes":[43],"that":[44,53],"can":[45],"accompany":[46],"the":[47,86,95,113,131],"disease.":[48],"It":[49],"increasingly":[51],"recognized":[52],"tumors":[54],"with":[55,78,118,128],"actionable":[56],"mutations":[57,66],"in":[58,85,103,139],"NSCLC,":[59],"including":[60],"epidermal":[61],"growth":[62],"factor":[63],"receptor":[64],"(EGFR)":[65],"anaplastic":[68],"lymphoma":[69],"kinase":[70,80],"(ALK)":[71],"translocations,":[72],"respond":[73],"well":[74],"therapy":[77],"tyrosine":[79],"inhibitors":[81],"progress":[84],"central":[87],"nervous":[88],"system.":[89],"More":[90],"information":[91],"needed":[93],"regarding":[94],"natural":[96],"history":[97],"optimal":[99],"specific":[104],"molecular":[105],"subtypes":[106],"NSCLC.":[108],"This":[109],"case":[110],"report":[111],"summarizes":[112],"patient":[117],"ALK-positive":[119],"NSCLC":[120],"who":[121],"developed":[122],"while":[124],"on":[125],"targeted":[126],"treatment":[127],"crizotinib":[129],"within":[130],"context":[132],"current":[134],"NCCN":[135],"Clinical":[136],"Practice":[137],"Guidelines":[138],"Oncology":[140],"recently":[142],"published":[143],"studies.":[144]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
