{"id":"https://openalex.org/W1821155865","doi":null,"title":"Role of the Capsid Helix 4-5 Loop in Equine Infectious Anemia Virus Infection","display_name":"Role of the Capsid Helix 4-5 Loop in Equine Infectious Anemia Virus Infection","publication_year":2013,"publication_date":"2013-03-18","ids":{"openalex":"https://openalex.org/W1821155865","mag":"1821155865"},"language":"en","primary_location":{"id":"pmh:oai:dash.harvard.edu:1/10436283","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:10436283","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:10436283","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:10436283","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060714151","display_name":"Brooke Bollman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Brooke Bollman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5060714151"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/equine-infectious-anemia-virus","display_name":"equine infectious anemia virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/capsid-protein","display_name":"capsid protein","score":0.781000018119812},{"id":"https://openalex.org/keywords/viral-uncoating","display_name":"viral uncoating","score":0.8420000076293945},{"id":"https://openalex.org/keywords/nuclear-import","display_name":"nuclear import","score":0.7039999961853027},{"id":"https://openalex.org/keywords/preintegration-complex","display_name":"preintegration complex","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cyclophilin-a","display_name":"cyclophilin A","score":0.8949999809265137},{"id":"https://openalex.org/keywords/lentivirus-infection","display_name":"lentiviral infection","score":0.753000020980835},{"id":"https://openalex.org/keywords/hiv-1-comparison","display_name":"HIV-1 comparison","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C2781053568","wikidata":"https://www.wikidata.org/wiki/Q19000458","display_name":"Equine infectious anemia","level":3,"score":0.9401847124099731},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7718071937561035},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.7285125851631165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4670008420944214},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4592227339744568}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dash.harvard.edu:1/10436283","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:10436283","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:10436283","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},{"id":"mag:1821155865","doi":null,"is_oa":false,"landing_page_url":"http://dash.harvard.edu/bitstream/handle/1/10436283/Bollman_gsas.harvard_0084L_10674.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dash.harvard.edu:1/10436283","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:10436283","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:10436283","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1821155865.pdf","grobid_xml":"https://content.openalex.org/works/W1821155865.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W99086265","https://openalex.org/W1550872944","https://openalex.org/W1587940136","https://openalex.org/W1652037864","https://openalex.org/W1720727101","https://openalex.org/W1770932653","https://openalex.org/W1816747902","https://openalex.org/W1966733909","https://openalex.org/W1973779048","https://openalex.org/W1987128366","https://openalex.org/W1991398215","https://openalex.org/W1993021726","https://openalex.org/W1995958102","https://openalex.org/W2009320893","https://openalex.org/W2020498024","https://openalex.org/W2020597127","https://openalex.org/W2022593443","https://openalex.org/W2022895621","https://openalex.org/W2023247488","https://openalex.org/W2034606779","https://openalex.org/W2037074791","https://openalex.org/W2040706842","https://openalex.org/W2048682843","https://openalex.org/W2051916846","https://openalex.org/W2061714407","https://openalex.org/W2062639699","https://openalex.org/W2066053818","https://openalex.org/W2067109667","https://openalex.org/W2067653786","https://openalex.org/W2071622591","https://openalex.org/W2071827167","https://openalex.org/W2073266364","https://openalex.org/W2076811542","https://openalex.org/W2076965602","https://openalex.org/W2078738195","https://openalex.org/W2079247377","https://openalex.org/W2090592602","https://openalex.org/W2091340735","https://openalex.org/W2094692623","https://openalex.org/W2100892474","https://openalex.org/W2109123523","https://openalex.org/W2111673257","https://openalex.org/W2118944608","https://openalex.org/W2119875571","https://openalex.org/W2121753315","https://openalex.org/W2124397413","https://openalex.org/W2125371109","https://openalex.org/W2126098576","https://openalex.org/W2127416395","https://openalex.org/W2129951322","https://openalex.org/W2135767314","https://openalex.org/W2136137668","https://openalex.org/W2140613358","https://openalex.org/W2141419914","https://openalex.org/W2143701668","https://openalex.org/W2144904664","https://openalex.org/W2145928000","https://openalex.org/W2146734555","https://openalex.org/W2148690437","https://openalex.org/W2150469985","https://openalex.org/W2150860726","https://openalex.org/W2156696460","https://openalex.org/W2156829363","https://openalex.org/W2161323000","https://openalex.org/W2163047779","https://openalex.org/W2165311084","https://openalex.org/W2166420278","https://openalex.org/W2167464144","https://openalex.org/W2316512281","https://openalex.org/W2406008754"],"related_works":["https://openalex.org/W2055267952","https://openalex.org/W2143015604","https://openalex.org/W2102510059","https://openalex.org/W2037267150","https://openalex.org/W4210348353","https://openalex.org/W2999273731","https://openalex.org/W4291020250","https://openalex.org/W1964061454","https://openalex.org/W3213961293","https://openalex.org/W3142233576"],"abstract_inverted_index":{"The":[0,69,111,183,225],"lentiviral":[1],"capsid":[2,54,85,93,105,237],"core,":[3],"which":[4,31,205],"encapsulates":[5],"the":[6,13,18,23,25,44,47,52,59,65,84,100,146,165,200,222,234,267,270,285,288,308,311],"viral":[7,19,147,247],"RNA":[8],"genome,":[9],"is":[10,56,123],"delivered":[11],"into":[12],"target":[14],"cell":[15],"cytoplasm":[16],"during":[17],"entry":[20],"process.":[21],"In":[22,50,87,293],"cytoplasm,":[24],"conical":[26],"core":[27],"undergoes":[28],"morphological":[29],"changes,":[30],"are":[32],"termed":[33],"uncoating.":[34,127],"Proper":[35],"uncoating":[36,189],"has":[37],"been":[38],"shown":[39],"to":[40,79,195,233,252,259,283,313],"be":[41,257],"critical":[42,57,124,137,251],"for":[43,58,125,138,276,287],"infectivity":[45,140,206,289],"of":[46,61,64,104,154,164,199,221,227,236,241,269,296,301,310],"lentivirus":[48,70],"HIV-1.":[49],"addition,":[51,294],"HIV-1":[53,90,121,253,305,319],"protein":[55],"process":[60],"nuclear":[62,197,242,273,302],"import":[63,198,243,254,274,303],"preintegration":[66],"complex":[67],"(PIC).":[68],"equine":[71],"infectious":[72],"anemia":[73],"virus":[74],"(EIAV)":[75],"shares":[76],"many":[77],"similarities":[78,82],"HIV-1,":[80],"including":[81],"in":[83,99,120,145,159,168,181,204,272,291,298,315,320],"protein.":[86],"particular,":[88],"both":[89],"and":[91,109,122,244,248],"EIAV":[92,139,173,218,297],"contain":[94],"a":[95,152,178,239],"proline-rich":[96],"loop":[97,119,134,161],"region":[98],"amino":[101,155],"terminal":[102],"domain":[103],"between":[106],"helices":[107],"4":[108],"5.":[110],"host":[112],"cellular":[113,249],"factor":[114],"cyclophilin":[115],"A":[116],"binds":[117],"this":[118,131,160,228],"proper":[126],"We":[128,150],"hypothesized":[129],"that":[130,246],"helix":[132],"4-5":[133],"was":[135,207],"also":[136,256],"at":[141,219],"some":[142,277],"early":[143],"step":[144],"infection":[148],"cycle.":[149],"created":[151],"panel":[153],"acid":[156],"substitution":[157],"mutations":[158,166,176,185,203],"region.":[162],"Some":[163,175],"resulted":[167],"severely":[169],"deleterious":[170,184],"effects":[171],"on":[172,265],"infectivity.":[174,182],"caused":[177],"slight":[179],"increase":[180,290],"did":[186,210],"not":[187,211],"affect":[188],"or":[190],"reverse":[191],"transcription":[192],"but":[193],"appeared":[194],"block":[196],"PIC.":[201],"Those":[202],"slightly":[208],"increased":[209],"exhibit":[212],"significantly":[213],"different":[214],"phenotypes":[215],"from":[216],"wild-type":[217],"any":[220],"stages":[223],"examined.":[224],"results":[226],"study":[229],"lend":[230],"further":[231],"support":[232],"role":[235],"as":[238,279,281],"determinant":[240],"suggest":[245],"factors":[250],"may":[255],"applicable":[258],"EIAV.":[260],"Future":[261],"research":[262],"should":[263],"focus":[264],"identifying":[266],"causes":[268],"defects":[271],"observed":[275],"mutants,":[278],"well":[280],"attempt":[282],"identify":[284],"reason":[286],"others.":[292],"inclusion":[295],"future":[299],"studies":[300],"involving":[304],"can":[306],"broaden":[307],"scope":[309],"data":[312],"lentiviruses":[314],"general":[316],"rather":[317],"than":[318],"particular.":[321]},"counts_by_year":[],"updated_date":"2026-09-01T08:31:24.195828","created_date":"2016-06-24T00:00:00"}
