{"id":"https://openalex.org/W1821038029","doi":null,"title":"Fixed combination therapies in COPD--effect on quality of life.","display_name":"Fixed combination therapies in COPD--effect on quality of life.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1821038029","mag":"1821038029","pmid":"https://pubmed.ncbi.nlm.nih.gov/18268928","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2699960"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2043659","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2699960","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2699960","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037289471","display_name":"Beatrix Groneberg\u2010Kloft","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Beatrix Groneberg-Kloft","raw_affiliation_strings":["Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070824120","display_name":"Axel Fischer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Axel Fischer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059857876","display_name":"Tobias Welte","orcid":"https://orcid.org/0000-0002-9947-7356","observed_orcids":["https://orcid.org/0000-0002-9947-7356"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tobias Welte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2698,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.66258803,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"2","issue":"4","first_page":"551","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fixed-dose-combination","display_name":"fixed-dose combination","score":0.746999979019165},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9100000262260437},{"id":"https://openalex.org/keywords/salmeterol-fluticasone","display_name":"salmeterol/fluticasone","score":0.906000018119812},{"id":"https://openalex.org/keywords/inhaled-corticosteroids","display_name":"inhaled corticosteroids","score":0.9620000123977661},{"id":"https://openalex.org/keywords/bronchodilators","display_name":"bronchodilators","score":0.9210000038146973},{"id":"https://openalex.org/keywords/monotherapy-comparison","display_name":"monotherapy comparison","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9582332372665405},{"id":"https://openalex.org/C2776719499","wikidata":"https://www.wikidata.org/wiki/Q424333","display_name":"Salmeterol","level":3,"score":0.9403486251831055},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.8492143750190735},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.7038296461105347},{"id":"https://openalex.org/C2781212218","wikidata":"https://www.wikidata.org/wiki/Q1002165","display_name":"Fluticasone","level":3,"score":0.703019917011261},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.6861636638641357},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.5674362182617188},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5003314018249512},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.462698757648468},{"id":"https://openalex.org/C2779028295","wikidata":"https://www.wikidata.org/wiki/Q8564098","display_name":"Fluticasone propionate","level":3,"score":0.4518798887729645},{"id":"https://openalex.org/C29374701","wikidata":"https://www.wikidata.org/wiki/Q1931388","display_name":"Cause of death","level":3,"score":0.4388566017150879},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3744671940803528},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3653927743434906},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3431417942047119},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.20133650302886963},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005858","descriptor_name":"Germany","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2043659","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2699960","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:18268928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18268928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of chronic obstructive pulmonary disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2699960","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2699960/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Chron Obstruct Pulmon Dis","raw_type":"Text"},{"id":"mag:1821038029","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18268928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2043659","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2699960","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W58518567","https://openalex.org/W1759279638","https://openalex.org/W1892949664","https://openalex.org/W1999226863","https://openalex.org/W2006193143","https://openalex.org/W2019823288","https://openalex.org/W2023600125","https://openalex.org/W2045616259","https://openalex.org/W2071805440","https://openalex.org/W2083436606","https://openalex.org/W2084702877","https://openalex.org/W2087220821","https://openalex.org/W2108361166","https://openalex.org/W2112334970","https://openalex.org/W2114847734","https://openalex.org/W2120629366","https://openalex.org/W2124546101","https://openalex.org/W2133964622","https://openalex.org/W2136593482","https://openalex.org/W2139347600","https://openalex.org/W2141086527","https://openalex.org/W2142724633","https://openalex.org/W2144713838","https://openalex.org/W2145152803","https://openalex.org/W2159803589","https://openalex.org/W2166432084","https://openalex.org/W2170298115","https://openalex.org/W2467220637","https://openalex.org/W2739938455","https://openalex.org/W2891681370"],"related_works":["https://openalex.org/W2726836368","https://openalex.org/W2232672854","https://openalex.org/W2491340489","https://openalex.org/W646890645","https://openalex.org/W49015223","https://openalex.org/W2388152036","https://openalex.org/W2000644780","https://openalex.org/W2130181973","https://openalex.org/W4225729951","https://openalex.org/W2922447076"],"abstract_inverted_index":{"Chronic":[0,72],"obstructive":[1],"pulmonary":[2],"disease":[3],"(COPD)":[4],"represents":[5],"a":[6,145],"major":[7],"global":[8,21],"cause":[9,22],"of":[10,23,34,58,90,113,151],"disability":[11],"and":[12,25,77,85],"death.":[13],"COPD":[14,80],"is":[15],"currently":[16],"the":[17,52,55,61,66,71,78,118,149],"fourth":[18],"most":[19],"common":[20],"death":[24],"also":[26],"exerts":[27],"an":[28],"enormous":[29],"toll":[30],"on":[31,54],"patients":[32,56],"quality":[33,57,89],"life.":[35,59],"The":[36],"present":[37],"database":[38],"analysis":[39],"aimed":[40],"to":[41,123,137,144],"identify":[42],"clinical":[43],"trials":[44,141],"using":[45],"fixed":[46],"combination":[47,95,114,119,133,152],"therapies":[48,96,115,134],"that":[49],"have":[50],"assessed":[51],"impact":[53],"Within":[60],"different":[62],"studies,":[63],"questionnaires":[64],"including":[65],"George's":[67],"Respiratory":[68,73],"Questionnaire":[69,75,81],"(SGRQ)":[70],"Disease":[74],"(CRDQ)":[76],"Clinical":[79],"(CCQ)":[82],"were":[83,92,102,108,128,135],"used":[84],"differing":[86],"results":[87],"in":[88,111],"life":[91],"obtained":[93],"when":[94,117,132],"such":[97],"as":[98],"fluticasone/salmeterol":[99,101],"or":[100],"compared":[103,122,136],"with":[104],"monotherapies.":[105,139],"While":[106],"there":[107,127],"some":[109],"differences":[110,131],"favor":[112],"reported":[116],"therapy":[120],"was":[121],"inhaled":[124],"steroid":[125],"monotherapy":[126],"no":[129],"consistent":[130],"bronchodilator":[138],"Future":[140],"will":[142],"lead":[143],"proof-of-principle":[146],"stage":[147],"concerning":[148],"use":[150],"therapies.":[153]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
