{"id":"https://openalex.org/W1820337809","doi":"https://doi.org/10.1039/c5ra15026d","title":"Enzyme-sensitive magnetic core\u2013shell nanocomposites for triggered drug release","display_name":"Enzyme-sensitive magnetic core\u2013shell nanocomposites for triggered drug release","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W1820337809","doi":"https://doi.org/10.1039/c5ra15026d","mag":"1820337809"},"language":"en","primary_location":{"id":"doi:10.1039/c5ra15026d","doi":"https://doi.org/10.1039/c5ra15026d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c5ra15026d","pdf_url":null,"source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101462251","display_name":"Chunyu Yang","orcid":"https://orcid.org/0000-0002-2285-917X","observed_orcids":["https://orcid.org/0000-0002-2285-917X"]},"institutions":[{"id":"https://openalex.org/I134052481","display_name":"Harbin Normal University","ror":"https://ror.org/0270y6950","country_code":"CN","type":"education","lineage":["https://openalex.org/I134052481"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunyu Yang","raw_affiliation_strings":["College of Chemistry and Chemical Engineering","Harbin 150025","Harbin Normal University","P. R. China","College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering","institution_ids":[]},{"raw_affiliation_string":"Harbin 150025","institution_ids":[]},{"raw_affiliation_string":"Harbin Normal University","institution_ids":["https://openalex.org/I134052481"]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, P.R. China","institution_ids":["https://openalex.org/I134052481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055651047","display_name":"Wei Guo","orcid":"https://orcid.org/0000-0001-5445-7872","observed_orcids":["https://orcid.org/0000-0001-5445-7872"]},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Guo","raw_affiliation_strings":["Harbin 150080","Harbin Institute of Technology","Key Laboratory of Microsystems and Microstructures Manufacturing","Ministry of Education","P. R. China","Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Harbin Institute of Technology, Harbin, 150080, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harbin 150080","institution_ids":[]},{"raw_affiliation_string":"Harbin Institute of Technology","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"Key Laboratory of Microsystems and Microstructures Manufacturing","institution_ids":[]},{"raw_affiliation_string":"Ministry of Education","institution_ids":[]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Harbin Institute of Technology, Harbin, 150080, P. R. China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100716102","display_name":"Na An","orcid":"https://orcid.org/0000-0002-5323-6805","observed_orcids":["https://orcid.org/0000-0002-5323-6805"]},"institutions":[{"id":"https://openalex.org/I134052481","display_name":"Harbin Normal University","ror":"https://ror.org/0270y6950","country_code":"CN","type":"education","lineage":["https://openalex.org/I134052481"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na An","raw_affiliation_strings":["College of Chemistry and Chemical Engineering","Harbin 150025","Harbin Normal University","P. R. China","College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering","institution_ids":[]},{"raw_affiliation_string":"Harbin 150025","institution_ids":[]},{"raw_affiliation_string":"Harbin Normal University","institution_ids":["https://openalex.org/I134052481"]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, P.R. China","institution_ids":["https://openalex.org/I134052481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038238812","display_name":"Liru Cui","orcid":"https://orcid.org/0009-0004-3284-9030","observed_orcids":["https://orcid.org/0009-0004-3284-9030"]},"institutions":[{"id":"https://openalex.org/I134052481","display_name":"Harbin Normal University","ror":"https://ror.org/0270y6950","country_code":"CN","type":"education","lineage":["https://openalex.org/I134052481"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liru Cui","raw_affiliation_strings":["College of Chemistry and Chemical Engineering","Harbin 150025","Harbin Normal University","P. R. China","College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering","institution_ids":[]},{"raw_affiliation_string":"Harbin 150025","institution_ids":[]},{"raw_affiliation_string":"Harbin Normal University","institution_ids":["https://openalex.org/I134052481"]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, P.R. China","institution_ids":["https://openalex.org/I134052481"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ting Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134052481","display_name":"Harbin Normal University","ror":"https://ror.org/0270y6950","country_code":"CN","type":"education","lineage":["https://openalex.org/I134052481"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Zhang","raw_affiliation_strings":["College of Chemistry and Chemical Engineering","Harbin 150025","Harbin Normal University","P. R. China","College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering","institution_ids":[]},{"raw_affiliation_string":"Harbin 150025","institution_ids":[]},{"raw_affiliation_string":"Harbin Normal University","institution_ids":["https://openalex.org/I134052481"]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, P.R. China","institution_ids":["https://openalex.org/I134052481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065997105","display_name":"Ruihan Tong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134052481","display_name":"Harbin Normal University","ror":"https://ror.org/0270y6950","country_code":"CN","type":"education","lineage":["https://openalex.org/I134052481"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruihan Tong","raw_affiliation_strings":["College of Chemistry and Chemical Engineering","Harbin 150025","Harbin Normal University","P. R. China","College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering","institution_ids":[]},{"raw_affiliation_string":"Harbin 150025","institution_ids":[]},{"raw_affiliation_string":"Harbin Normal University","institution_ids":["https://openalex.org/I134052481"]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, P.R. China","institution_ids":["https://openalex.org/I134052481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100384514","display_name":"Yuhua Chen","orcid":"https://orcid.org/0000-0002-2187-5469","observed_orcids":["https://orcid.org/0000-0002-2187-5469","https://orcid.org/0009-0007-1235-3451"]},"institutions":[{"id":"https://openalex.org/I134052481","display_name":"Harbin Normal University","ror":"https://ror.org/0270y6950","country_code":"CN","type":"education","lineage":["https://openalex.org/I134052481"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhua Chen","raw_affiliation_strings":["College of Chemistry and Chemical Engineering","Harbin 150025","Harbin Normal University","P. R. China","College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering","institution_ids":[]},{"raw_affiliation_string":"Harbin 150025","institution_ids":[]},{"raw_affiliation_string":"Harbin Normal University","institution_ids":["https://openalex.org/I134052481"]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, P.R. China","institution_ids":["https://openalex.org/I134052481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055351772","display_name":"Huiming Lin","orcid":"https://orcid.org/0000-0003-3902-6286","observed_orcids":["https://orcid.org/0000-0003-3902-6286"]},"institutions":[{"id":"https://openalex.org/I134052481","display_name":"Harbin Normal University","ror":"https://ror.org/0270y6950","country_code":"CN","type":"education","lineage":["https://openalex.org/I134052481"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huiming Lin","raw_affiliation_strings":["College of Chemistry and Chemical Engineering","Harbin 150025","Harbin Normal University","P. R. China","College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering","institution_ids":[]},{"raw_affiliation_string":"Harbin 150025","institution_ids":[]},{"raw_affiliation_string":"Harbin Normal University","institution_ids":["https://openalex.org/I134052481"]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, P.R. China","institution_ids":["https://openalex.org/I134052481"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112235613","display_name":"Fengyu Qu","orcid":"https://orcid.org/0000-0002-6426-5812","observed_orcids":["https://orcid.org/0000-0002-6426-5812"]},"institutions":[{"id":"https://openalex.org/I134052481","display_name":"Harbin Normal University","ror":"https://ror.org/0270y6950","country_code":"CN","type":"education","lineage":["https://openalex.org/I134052481"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fengyu Qu","raw_affiliation_strings":["College of Chemistry and Chemical Engineering","Harbin 150025","Harbin Normal University","P. R. China","College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering","institution_ids":[]},{"raw_affiliation_string":"Harbin 150025","institution_ids":[]},{"raw_affiliation_string":"Harbin Normal University","institution_ids":["https://openalex.org/I134052481"]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, P.R. China","institution_ids":["https://openalex.org/I134052481"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055351772","https://openalex.org/A5112235613"],"corresponding_institution_ids":["https://openalex.org/I134052481"],"apc_list":{"value":850,"currency":"GBP","value_usd":1042},"apc_paid":null,"fwci":0.6294,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.56456859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5","issue":"98","first_page":"80728","last_page":"80738"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fe3o4-sio2-nanoparticles","display_name":"Fe3O4@SiO2 nanoparticles","score":0.8960000276565552},{"id":"https://openalex.org/keywords/triggered-drug-release","display_name":"triggered drug release","score":0.8830000162124634},{"id":"https://openalex.org/keywords/magnetic-nanoparticles","display_name":"magnetic nanoparticles","score":0.5580000281333923},{"id":"https://openalex.org/keywords/drug-encapsulation","display_name":"drug encapsulation","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.7431120872497559},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6438175439834595},{"id":"https://openalex.org/C92880739","wikidata":"https://www.wikidata.org/wiki/Q2639556","display_name":"Nanocomposite","level":2,"score":0.5962761044502258},{"id":"https://openalex.org/C2781052500","wikidata":"https://www.wikidata.org/wiki/Q2230313","display_name":"Shell (structure)","level":2,"score":0.5390498042106628},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49950695037841797},{"id":"https://openalex.org/C2164484","wikidata":"https://www.wikidata.org/wiki/Q5170150","display_name":"Core (optical fiber)","level":2,"score":0.49395376443862915},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.464702308177948},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.4211598038673401},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.40961766242980957},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.32807475328445435},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2116386890411377},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.13110694289207458},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.10772213339805603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05315789580345154},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1039/c5ra15026d","doi":"https://doi.org/10.1039/c5ra15026d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c5ra15026d","pdf_url":null,"source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1963508789","https://openalex.org/W1970034438","https://openalex.org/W1975139160","https://openalex.org/W1985921318","https://openalex.org/W1993502969","https://openalex.org/W1996315170","https://openalex.org/W1996648985","https://openalex.org/W1998629772","https://openalex.org/W2002063000","https://openalex.org/W2003229108","https://openalex.org/W2008125921","https://openalex.org/W2008904362","https://openalex.org/W2011698473","https://openalex.org/W2012727362","https://openalex.org/W2015821654","https://openalex.org/W2017479359","https://openalex.org/W2020538451","https://openalex.org/W2023015700","https://openalex.org/W2040173160","https://openalex.org/W2048735112","https://openalex.org/W2055204109","https://openalex.org/W2055776993","https://openalex.org/W2059416726","https://openalex.org/W2064215841","https://openalex.org/W2072198924","https://openalex.org/W2073732456","https://openalex.org/W2076189832","https://openalex.org/W2083334819","https://openalex.org/W2083785791","https://openalex.org/W2089753996","https://openalex.org/W2098723382","https://openalex.org/W2118969052","https://openalex.org/W2127466034","https://openalex.org/W2136843236","https://openalex.org/W2142771852","https://openalex.org/W2142894827","https://openalex.org/W2146536848","https://openalex.org/W2153712665","https://openalex.org/W2158155063","https://openalex.org/W2168696947","https://openalex.org/W2203908584","https://openalex.org/W2312683158","https://openalex.org/W2314296344","https://openalex.org/W2315687649","https://openalex.org/W2323299954","https://openalex.org/W2324415512","https://openalex.org/W2325546121","https://openalex.org/W2328511663","https://openalex.org/W2332693523","https://openalex.org/W2334145555","https://openalex.org/W2335474726"],"related_works":["https://openalex.org/W1390199","https://openalex.org/W1564355075","https://openalex.org/W1976256973","https://openalex.org/W2909055450","https://openalex.org/W4391418884","https://openalex.org/W2281135663","https://openalex.org/W2041445520","https://openalex.org/W1965214515","https://openalex.org/W7011299429","https://openalex.org/W7132183272"],"abstract_inverted_index":{"Sodium":[0],"hyaluronic":[1],"acid":[2],"cross-linked":[3],"gel":[4],"was":[5],"employed":[6],"to":[7,18],"coat":[8],"outside":[9],"of":[10],"Fe":[11],"3":[12],"O":[13],"4":[14],"@mSiO":[15],"2":[16],"nanopaticles":[17],"prevent":[19],"drug":[20],"pervasion":[21],"by":[22],"a":[23],"novel":[24],"approach.":[25]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}