{"id":"https://openalex.org/W1820140377","doi":"https://doi.org/10.1128/cmr.1.1.109-123.1988","title":"Beta-lactamase inhibitors from laboratory to clinic","display_name":"Beta-lactamase inhibitors from laboratory to clinic","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W1820140377","doi":"https://doi.org/10.1128/cmr.1.1.109-123.1988","mag":"1820140377","pmid":"https://pubmed.ncbi.nlm.nih.gov/3060240","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/358033"},"language":"en","primary_location":{"id":"doi:10.1128/cmr.1.1.109-123.1988","doi":"https://doi.org/10.1128/cmr.1.1.109-123.1988","is_oa":false,"landing_page_url":"https://doi.org/10.1128/cmr.1.1.109-123.1988","pdf_url":null,"source":{"id":"https://openalex.org/S112662651","display_name":"Clinical Microbiology Reviews","issn_l":"0893-8512","issn":["0893-8512","1070-6305","1098-6618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Microbiology Reviews","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC358033","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022556893","display_name":"Karen Bush","orcid":"https://orcid.org/0000-0002-7843-2474","observed_orcids":["https://orcid.org/0000-0002-7843-2474"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"K Bush","raw_affiliation_strings":["Squibb Institute for Medical Research, Princeton, New Jersey 08540"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Squibb Institute for Medical Research, Princeton, New Jersey 08540","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5022556893"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.642,"has_fulltext":false,"cited_by_count":216,"citation_normalized_percentile":{"value":0.93403005,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"1","issue":"1","first_page":"109","last_page":"123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13489","display_name":"Synthesis of \u03b2-Lactam Compounds","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-lactamase-inhibitors","display_name":"beta-lactamase inhibitors","score":0.996999979019165},{"id":"https://openalex.org/keywords/beta-lactamase","display_name":"beta-lactamase","score":0.7789999842643738},{"id":"https://openalex.org/keywords/clavulanic-acid","display_name":"clavulanic acid","score":0.9470000267028809},{"id":"https://openalex.org/keywords/sulbactam","display_name":"sulbactam","score":1.0},{"id":"https://openalex.org/keywords/amoxicillin-clavulanic-acid","display_name":"amoxicillin-clavulanic acid","score":0.8370000123977661},{"id":"https://openalex.org/keywords/ampicillin-sulbactam","display_name":"ampicillin-sulbactam","score":0.9700000286102295},{"id":"https://openalex.org/keywords/sultamicillin","display_name":"sultamicillin","score":0.8069999814033508},{"id":"https://openalex.org/keywords/tem-beta-lactamase","display_name":"TEM beta-lactamase","score":0.652999997138977},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.4099999964237213},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C2778478555","wikidata":"https://www.wikidata.org/wiki/Q423393","display_name":"Sulbactam","level":5,"score":0.910027027130127},{"id":"https://openalex.org/C2779454058","wikidata":"https://www.wikidata.org/wiki/Q415709","display_name":"Clavulanic acid","level":4,"score":0.824431300163269},{"id":"https://openalex.org/C2910641391","wikidata":"https://www.wikidata.org/wiki/Q310286","display_name":"Beta-Lactamase Inhibitors","level":3,"score":0.7566054463386536},{"id":"https://openalex.org/C2776021129","wikidata":"https://www.wikidata.org/wiki/Q244150","display_name":"Ampicillin","level":3,"score":0.6914181709289551},{"id":"https://openalex.org/C2781288988","wikidata":"https://www.wikidata.org/wiki/Q311379","display_name":"Beta-lactamase","level":4,"score":0.6103659272193909},{"id":"https://openalex.org/C64778159","wikidata":"https://www.wikidata.org/wiki/Q271021","display_name":"Cephalosporin","level":3,"score":0.5855129361152649},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5763829350471497},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5451464056968689},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.5360790491104126},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45779284834861755},{"id":"https://openalex.org/C2779708577","wikidata":"https://www.wikidata.org/wiki/Q201928","display_name":"Amoxicillin","level":3,"score":0.33449581265449524},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3255787491798401},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27572354674339294},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.26750028133392334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23531889915466309},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2193223237991333},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.06115815043449402},{"id":"https://openalex.org/C2779631663","wikidata":"https://www.wikidata.org/wiki/Q425152","display_name":"Imipenem","level":4,"score":0.053847938776016235},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002969","descriptor_name":"Clavulanic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002969","descriptor_name":"Clavulanic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013407","descriptor_name":"Sulbactam","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013407","descriptor_name":"Sulbactam","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019818","descriptor_name":"Clavulanic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065093","descriptor_name":"beta-Lactamase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1128/cmr.1.1.109-123.1988","doi":"https://doi.org/10.1128/cmr.1.1.109-123.1988","is_oa":false,"landing_page_url":"https://doi.org/10.1128/cmr.1.1.109-123.1988","pdf_url":null,"source":{"id":"https://openalex.org/S112662651","display_name":"Clinical Microbiology Reviews","issn_l":"0893-8512","issn":["0893-8512","1070-6305","1098-6618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Microbiology Reviews","raw_type":"journal-article"},{"id":"doi:10.1128/cmr.1.1.109","doi":"https://doi.org/10.1128/cmr.1.1.109","is_oa":false,"landing_page_url":"https://doi.org/10.1128/cmr.1.1.109","pdf_url":null,"source":{"id":"https://openalex.org/S112662651","display_name":"Clinical Microbiology Reviews","issn_l":"0893-8512","issn":["0893-8512","1070-6305","1098-6618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Microbiology Reviews","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:25930","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC358033","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:3060240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3060240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical microbiology reviews","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:358033","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC358033/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Microbiol Rev","raw_type":"Text"},{"id":"mag:2186184169","doi":null,"is_oa":false,"landing_page_url":"https://cmr.asm.org/content/1/1/109.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:25930","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC358033","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":145,"referenced_works":["https://openalex.org/W59579273","https://openalex.org/W97716245","https://openalex.org/W153457620","https://openalex.org/W1499482268","https://openalex.org/W1555343774","https://openalex.org/W1840929356","https://openalex.org/W1852544270","https://openalex.org/W1859534571","https://openalex.org/W1914611966","https://openalex.org/W1920211381","https://openalex.org/W1920920596","https://openalex.org/W1965975518","https://openalex.org/W1966009777","https://openalex.org/W1966297632","https://openalex.org/W1969813629","https://openalex.org/W1969907232","https://openalex.org/W1972020615","https://openalex.org/W1974728819","https://openalex.org/W1979081804","https://openalex.org/W1980460948","https://openalex.org/W1980616168","https://openalex.org/W1980781255","https://openalex.org/W1981243904","https://openalex.org/W1982128803","https://openalex.org/W1982456798","https://openalex.org/W1985324896","https://openalex.org/W1986441889","https://openalex.org/W1987634568","https://openalex.org/W1989275701","https://openalex.org/W1989288773","https://openalex.org/W1989423690","https://openalex.org/W1991380683","https://openalex.org/W1997261237","https://openalex.org/W2000168862","https://openalex.org/W2000916274","https://openalex.org/W2000982495","https://openalex.org/W2002161076","https://openalex.org/W2005162112","https://openalex.org/W2006134287","https://openalex.org/W2006476566","https://openalex.org/W2006607144","https://openalex.org/W2006626721","https://openalex.org/W2007092195","https://openalex.org/W2008888914","https://openalex.org/W2010522914","https://openalex.org/W2010745002","https://openalex.org/W2012124631","https://openalex.org/W2013119669","https://openalex.org/W2014183316","https://openalex.org/W2016063991","https://openalex.org/W2016208589","https://openalex.org/W2017191752","https://openalex.org/W2017929600","https://openalex.org/W2022533418","https://openalex.org/W2022610263","https://openalex.org/W2025762875","https://openalex.org/W2027121619","https://openalex.org/W2027793850","https://openalex.org/W2027951876","https://openalex.org/W2028107996","https://openalex.org/W2029153362","https://openalex.org/W2030655700","https://openalex.org/W2034107164","https://openalex.org/W2034904485","https://openalex.org/W2035377743","https://openalex.org/W2035935797","https://openalex.org/W2036155156","https://openalex.org/W2036454332","https://openalex.org/W2037223904","https://openalex.org/W2037815406","https://openalex.org/W2039666374","https://openalex.org/W2040519218","https://openalex.org/W2042326970","https://openalex.org/W2043142038","https://openalex.org/W2054099484","https://openalex.org/W2054564097","https://openalex.org/W2057336796","https://openalex.org/W2057495661","https://openalex.org/W2059481642","https://openalex.org/W2061100086","https://openalex.org/W2062191527","https://openalex.org/W2062856928","https://openalex.org/W2063399195","https://openalex.org/W2064912338","https://openalex.org/W2067418977","https://openalex.org/W2067461802","https://openalex.org/W2069228091","https://openalex.org/W2071422693","https://openalex.org/W2073818833","https://openalex.org/W2075240502","https://openalex.org/W2077895584","https://openalex.org/W2078836517","https://openalex.org/W2079989516","https://openalex.org/W2081096611","https://openalex.org/W2083767908","https://openalex.org/W2087011890","https://openalex.org/W2088021352","https://openalex.org/W2090536074","https://openalex.org/W2091950027","https://openalex.org/W2094995138","https://openalex.org/W2099608737","https://openalex.org/W2100327038","https://openalex.org/W2104382548","https://openalex.org/W2104896462","https://openalex.org/W2107215468","https://openalex.org/W2107351432","https://openalex.org/W2113718059","https://openalex.org/W2114795538","https://openalex.org/W2115916971","https://openalex.org/W2116223860","https://openalex.org/W2118238971","https://openalex.org/W2120720680","https://openalex.org/W2126879779","https://openalex.org/W2128636184","https://openalex.org/W2132208010","https://openalex.org/W2134750226","https://openalex.org/W2143874510","https://openalex.org/W2150063182","https://openalex.org/W2150346178","https://openalex.org/W2150360397","https://openalex.org/W2151476311","https://openalex.org/W2152777302","https://openalex.org/W2153896094","https://openalex.org/W2154946929","https://openalex.org/W2161675098","https://openalex.org/W2162469709","https://openalex.org/W2184764384","https://openalex.org/W2187322887","https://openalex.org/W2228764555","https://openalex.org/W2312481240","https://openalex.org/W2315090912","https://openalex.org/W2318695343","https://openalex.org/W2333586636","https://openalex.org/W2345759752","https://openalex.org/W2408148854","https://openalex.org/W2408444969","https://openalex.org/W2409529974","https://openalex.org/W2410322250","https://openalex.org/W2414238912","https://openalex.org/W2416381840","https://openalex.org/W2472421816","https://openalex.org/W2585339519","https://openalex.org/W2942901958","https://openalex.org/W3021045797","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2073436850","https://openalex.org/W1895007034","https://openalex.org/W2053129457","https://openalex.org/W2951766792","https://openalex.org/W2063779640","https://openalex.org/W230951250","https://openalex.org/W1783470754","https://openalex.org/W4250170301","https://openalex.org/W2413117401","https://openalex.org/W1981050914"],"abstract_inverted_index":{"beta-Lactamases":[0],"constitute":[1],"the":[2,13,65,98,115,131,135,153,165,173,195,204,219,298],"major":[3],"defense":[4],"mechanism":[5,61],"of":[6,16,67,110,137,144,152,218,300,310],"pathogenic":[7],"bacteria":[8],"against":[9,130],"beta-lactam":[10,14,100,175],"antibiotics.":[11],"When":[12],"ring":[15],"this":[17,59],"antibiotic":[18,80,248],"class":[19],"is":[20,24],"hydrolyzed,":[21],"antimicrobial":[22],"activity":[23,126],"destroyed.":[25],"Although":[26,119,288],"beta-lactamases":[27],"have":[28,250,272,285],"been":[29,63,158,180,191,210,234,251,273,286,295],"identified":[30],"with":[31,39,78,85,162,170,282,291,314,322],"clinical":[32,53],"failures":[33],"for":[34,212,215,236,275],"over":[35],"40":[36],"years,":[37],"enzymes":[38,117],"various":[40],"abilities":[41],"to":[42,57,96,183,254,303],"hydrolyze":[43],"specific":[44],"penicillins":[45,89],"or":[46,90,106,202],"cephalosporins":[47],"are":[48,140,227],"appearing":[49],"more":[50,123],"frequently":[51,160],"in":[52,164,172,194],"isolates.":[54],"One":[55],"approach":[56],"counteracting":[58],"resistance":[60,301],"has":[62,157,179,190,209,232,294],"through":[64],"development":[66,302],"beta-lactamase":[68,292],"inactivators.":[69],"beta-Lactamase":[70],"inhibitors":[71,93,146],"include":[72],"clavulanic":[73,120,315],"acid":[74,121,156],"and":[75,87,169,244,260,266,277],"sulbactam,":[76,128],"molecules":[77,112],"minimal":[79],"activity.":[81],"However,":[82],"when":[83],"combined":[84,161],"safe":[86],"efficacious":[88],"cephalosporins,":[91],"these":[92,111,145,213,283],"can":[94,312],"serve":[95],"protect":[97,184],"familiar":[99],"antibiotics":[101],"from":[102,186,325],"hydrolysis":[103],"by":[104],"penicillinases":[105],"broad-spectrum":[107,133],"beta-lactamases.":[108],"Both":[109],"eventually":[113],"inactivate":[114],"target":[116],"permanently.":[118],"exhibits":[122],"potent":[124],"inhibitory":[125,138],"than":[127],"especially":[129,321],"TEM-type":[132],"beta-lactamases,":[134],"spectrum":[136],"activities":[139],"very":[141],"similar.":[142],"Neither":[143],"acts":[147],"as":[148,200,203],"a":[149,326],"good":[150],"inhibitor":[151],"cephalosporinases.":[154],"Clavulanic":[155],"most":[159,216,279],"amoxicillin":[163],"orally":[166,196],"active":[167],"Augmentin":[168,276],"ticarcillin":[171],"parenteral":[174],"combination":[176,206,289],"Timentin.":[177],"Sulbactam":[178,189],"used":[181,192,252,296],"primarily":[182],"ampicillin":[185],"enzymatic":[187],"hydrolysis.":[188],"either":[193],"absorbed":[197],"prodrug":[198],"form":[199],"sultamicillin":[201],"injectable":[205],"ampicillin-sulbactam.":[207],"Synergy":[208,231],"demonstrated":[211],"combinations":[214,249],"members":[217],"Enterobacteriaceae,":[220],"although":[221],"those":[222],"organisms":[223],"that":[224],"produce":[225],"cephalosporinases":[226,311],"not":[228],"well":[229],"inhibited.":[230],"also":[233],"observed":[235],"Neisseria":[237],"gonorrhoeae,":[238],"Haemophilus":[239],"influenzae,":[240],"penicillinase-producing":[241],"Staphylococcus":[242],"aureus,":[243],"anaerobic":[245],"organisms.":[246],"These":[247],"clinically":[253],"treat":[255],"urinary":[256],"tract":[257],"infections,":[258,262,265],"bone":[259],"soft-tissue":[261],"gonorrhea,":[263],"respiratory":[264],"otitis":[267],"media.":[268],"Gastrointestinal":[269],"side":[270,280],"effects":[271,281],"reported":[274],"sultamicillin;":[278],"agents":[284,305],"mild.":[287],"therapy":[290],"inactivators":[293],"successfully,":[297],"problem":[299],"two":[304],"must":[306],"be":[307],"considered.":[308],"Induction":[309],"occur":[313],"acid.":[316],"Permeability":[317],"mutants":[318],"could":[319],"arise,":[320],"added":[323],"pressure":[324],"second":[327],"beta-lactam.(ABSTRACT":[328],"TRUNCATED":[329],"AT":[330],"250":[331],"WORDS)":[332]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}