{"id":"https://openalex.org/W181957012","doi":null,"title":"Oncolytic adenovirus vectors for nitroreductase suicide gene therapy of prostate cancer","display_name":"Oncolytic adenovirus vectors for nitroreductase suicide gene therapy of prostate cancer","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W181957012","mag":"181957012"},"language":"en","primary_location":{"id":"pmh:oai:etheses.bham.ac.uk:957","doi":null,"is_oa":false,"landing_page_url":"http://etheses.bham.ac.uk/957/1/Herod_10PhD.pdf","pdf_url":"http://etheses.bham.ac.uk/957/1/Herod_10PhD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://etheses.bham.ac.uk/957/1/Herod_10PhD.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019882289","display_name":"Morgan R. Herod","orcid":"https://orcid.org/0000-0002-8626-6787","observed_orcids":["https://orcid.org/0000-0002-8626-6787"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Morgan R. Herod","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8626-6787","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019882289"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitroreductase","display_name":"nitroreductase","score":0.9330000281333923},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8149999976158142},{"id":"https://openalex.org/keywords/suicide-gene-therapy","display_name":"suicide gene therapy","score":0.8529999852180481},{"id":"https://openalex.org/keywords/enzyme-prodrug-therapy","display_name":"enzyme prodrug therapy","score":0.9200000166893005},{"id":"https://openalex.org/keywords/tumor-selectivity","display_name":"tumor selectivity","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.9475750923156738},{"id":"https://openalex.org/C2777283488","wikidata":"https://www.wikidata.org/wiki/Q7095181","display_name":"Oncolytic adenovirus","level":4,"score":0.8775638341903687},{"id":"https://openalex.org/C2781326480","wikidata":"https://www.wikidata.org/wiki/Q7041501","display_name":"Nitroreductase","level":3,"score":0.8600074052810669},{"id":"https://openalex.org/C49744831","wikidata":"https://www.wikidata.org/wiki/Q600121","display_name":"Virotherapy","level":4,"score":0.7287490367889404},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.6903338432312012},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5575888752937317},{"id":"https://openalex.org/C34981463","wikidata":"https://www.wikidata.org/wiki/Q3311663","display_name":"Suicide gene","level":4,"score":0.55257648229599},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.5195425152778625},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5126611590385437},{"id":"https://openalex.org/C2776954459","wikidata":"https://www.wikidata.org/wiki/Q193447","display_name":"Adenoviridae","level":4,"score":0.4908648133277893},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.49085646867752075},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46429333090782166},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4250684082508087},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3903367221355438},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.3664918839931488},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3477320075035095},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.313909649848938},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.133748859167099},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.1303403377532959},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10438567399978638}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:etheses.bham.ac.uk:957","doi":null,"is_oa":false,"landing_page_url":"http://etheses.bham.ac.uk/957/1/Herod_10PhD.pdf","pdf_url":"http://etheses.bham.ac.uk/957/1/Herod_10PhD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:uilis.unsyiah.ac.id:39632","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/39632","pdf_url":"http://etheses.bham.ac.uk/957/1/Herod_10PhD.pdf","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:hdl:10068/973917","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/973917","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:181957012","doi":null,"is_oa":false,"landing_page_url":"http://etheses.bham.ac.uk/957/1/Herod_10PhD.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uilis.unsyiah.ac.id:39632","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/39632","pdf_url":"http://etheses.bham.ac.uk/957/1/Herod_10PhD.pdf","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W181957012.pdf","grobid_xml":"https://content.openalex.org/works/W181957012.grobid-xml"},"referenced_works_count":407,"referenced_works":["https://openalex.org/W64861853","https://openalex.org/W95751165","https://openalex.org/W107911935","https://openalex.org/W109375810","https://openalex.org/W155422586","https://openalex.org/W191108608","https://openalex.org/W297134298","https://openalex.org/W342448828","https://openalex.org/W904109129","https://openalex.org/W1484339355","https://openalex.org/W1486052360","https://openalex.org/W1489452981","https://openalex.org/W1489777963","https://openalex.org/W1491631791","https://openalex.org/W1498027707","https://openalex.org/W1507619429","https://openalex.org/W1512188643","https://openalex.org/W1512409450","https://openalex.org/W1530317014","https://openalex.org/W1537365266","https://openalex.org/W1542924271","https://openalex.org/W1546670423","https://openalex.org/W1554330891","https://openalex.org/W1556094015","https://openalex.org/W1556164773","https://openalex.org/W1560526335","https://openalex.org/W1565518567","https://openalex.org/W1567384233","https://openalex.org/W1578747168","https://openalex.org/W1587582539","https://openalex.org/W1603052159","https://openalex.org/W1626412747","https://openalex.org/W1651086125","https://openalex.org/W1661332635","https://openalex.org/W1734478427","https://openalex.org/W1752093409","https://openalex.org/W1767854628","https://openalex.org/W1783890974","https://openalex.org/W1790843347","https://openalex.org/W1816486083","https://openalex.org/W1820101210","https://openalex.org/W1831834373","https://openalex.org/W1843173018","https://openalex.org/W1846023877","https://openalex.org/W1879151472","https://openalex.org/W1899128416","https://openalex.org/W1899760105","https://openalex.org/W1903745386","https://openalex.org/W1913924834","https://openalex.org/W1916905989","https://openalex.org/W1924062135","https://openalex.org/W1934772501","https://openalex.org/W1943398466","https://openalex.org/W1946657588","https://openalex.org/W1950851607","https://openalex.org/W1951335634","https://openalex.org/W1956017529","https://openalex.org/W1963555577","https://openalex.org/W1964290387","https://openalex.org/W1964706227","https://openalex.org/W1965194293","https://openalex.org/W1965295123","https://openalex.org/W1965372133","https://openalex.org/W1966675362","https://openalex.org/W1967077112","https://openalex.org/W1968222023","https://openalex.org/W1968383985","https://openalex.org/W1968812729","https://openalex.org/W1969188509","https://openalex.org/W1969708945","https://openalex.org/W1970203934","https://openalex.org/W1973158635","https://openalex.org/W1973190526","https://openalex.org/W1973533589","https://openalex.org/W1973905531","https://openalex.org/W1975273266","https://openalex.org/W1976327299","https://openalex.org/W1978306626","https://openalex.org/W1978834861","https://openalex.org/W1978847370","https://openalex.org/W1978861644","https://openalex.org/W1978870802","https://openalex.org/W1980486105","https://openalex.org/W1981327173","https://openalex.org/W1982225512","https://openalex.org/W1982651102","https://openalex.org/W1983200566","https://openalex.org/W1983319967","https://openalex.org/W1983999278","https://openalex.org/W1984579053","https://openalex.org/W1985842299","https://openalex.org/W1986509391","https://openalex.org/W1986518773","https://openalex.org/W1987132350","https://openalex.org/W1987434164","https://openalex.org/W1988079343","https://openalex.org/W1989158987","https://openalex.org/W1990167868","https://openalex.org/W1990287298","https://openalex.org/W1991711092","https://openalex.org/W1993771588","https://openalex.org/W1993863823","https://openalex.org/W1995304123","https://openalex.org/W1997563347","https://openalex.org/W1999064296","https://openalex.org/W1999863856","https://openalex.org/W2001476460","https://openalex.org/W2001758369","https://openalex.org/W2002382263","https://openalex.org/W2002688702","https://openalex.org/W2002743595","https://openalex.org/W2002760980","https://openalex.org/W2003113791","https://openalex.org/W2004109991","https://openalex.org/W2005490545","https://openalex.org/W2005603741","https://openalex.org/W2006388599","https://openalex.org/W2007821283","https://openalex.org/W2007854533","https://openalex.org/W2009087603","https://openalex.org/W2009359714","https://openalex.org/W2009722064","https://openalex.org/W2010708749","https://openalex.org/W2011206688","https://openalex.org/W2011824328","https://openalex.org/W2011855430","https://openalex.org/W2012658992","https://openalex.org/W2012714016","https://openalex.org/W2013002972","https://openalex.org/W2013241294","https://openalex.org/W2013445442","https://openalex.org/W2013619396","https://openalex.org/W2014780970","https://openalex.org/W2015967163","https://openalex.org/W2016235220","https://openalex.org/W2017021215","https://openalex.org/W2017726973","https://openalex.org/W2018611026","https://openalex.org/W2019034425","https://openalex.org/W2019296882","https://openalex.org/W2019414781","https://openalex.org/W2019995569","https://openalex.org/W2020222773","https://openalex.org/W2021236605","https://openalex.org/W2021423477","https://openalex.org/W2021703992","https://openalex.org/W2022855258","https://openalex.org/W2024339218","https://openalex.org/W2024989815","https://openalex.org/W2027339548","https://openalex.org/W2028302056","https://openalex.org/W2029484094","https://openalex.org/W2029777838","https://openalex.org/W2029784758","https://openalex.org/W2030117043","https://openalex.org/W2030375968","https://openalex.org/W2030617886","https://openalex.org/W2032925373","https://openalex.org/W2032928525","https://openalex.org/W2033386718","https://openalex.org/W2033642093","https://openalex.org/W2033752192","https://openalex.org/W2034684223","https://openalex.org/W2034902271","https://openalex.org/W2035151180","https://openalex.org/W2037561205","https://openalex.org/W2039084800","https://openalex.org/W2039169884","https://openalex.org/W2039224704","https://openalex.org/W2039599894","https://openalex.org/W2040576446","https://openalex.org/W2040976531","https://openalex.org/W2041303526","https://openalex.org/W2041515545","https://openalex.org/W2042351268","https://openalex.org/W2043400006","https://openalex.org/W2044296969","https://openalex.org/W2044594872","https://openalex.org/W2044927416","https://openalex.org/W2045028970","https://openalex.org/W2045415534","https://openalex.org/W2045596296","https://openalex.org/W2046881557","https://openalex.org/W2046894905","https://openalex.org/W2047151196","https://openalex.org/W2047474797","https://openalex.org/W2047942455","https://openalex.org/W2049060720","https://openalex.org/W2050547666","https://openalex.org/W2052148578","https://openalex.org/W2052860581","https://openalex.org/W2053837657","https://openalex.org/W2053888572","https://openalex.org/W2054408541","https://openalex.org/W2054767441","https://openalex.org/W2054840039","https://openalex.org/W2056602419","https://openalex.org/W2057044825","https://openalex.org/W2057058623","https://openalex.org/W2057134010","https://openalex.org/W2058795593","https://openalex.org/W2059666706","https://openalex.org/W2059711954","https://openalex.org/W2060643446","https://openalex.org/W2061021155","https://openalex.org/W2061295749","https://openalex.org/W2061448062","https://openalex.org/W2061909665","https://openalex.org/W2062746221","https://openalex.org/W2063008647","https://openalex.org/W2063717118","https://openalex.org/W2063802293","https://openalex.org/W2064785549","https://openalex.org/W2065424348","https://openalex.org/W2065656557","https://openalex.org/W2066324183","https://openalex.org/W2066859499","https://openalex.org/W2067671227","https://openalex.org/W2067740988","https://openalex.org/W2068890039","https://openalex.org/W2070596285","https://openalex.org/W2071137639","https://openalex.org/W2071698515","https://openalex.org/W2072581924","https://openalex.org/W2073134590","https://openalex.org/W2074273997","https://openalex.org/W2076133729","https://openalex.org/W2077462718","https://openalex.org/W2077850392","https://openalex.org/W2078081724","https://openalex.org/W2079263000","https://openalex.org/W2079523736","https://openalex.org/W2079832429","https://openalex.org/W2080706214","https://openalex.org/W2081879614","https://openalex.org/W2082470115","https://openalex.org/W2082823773","https://openalex.org/W2082927803","https://openalex.org/W2084017165","https://openalex.org/W2084550104","https://openalex.org/W2085834739","https://openalex.org/W2085926379","https://openalex.org/W2086409978","https://openalex.org/W2086474743","https://openalex.org/W2087244642","https://openalex.org/W2087287669","https://openalex.org/W2087510109","https://openalex.org/W2087773557","https://openalex.org/W2088311855","https://openalex.org/W2090375463","https://openalex.org/W2090640195","https://openalex.org/W2091304395","https://openalex.org/W2092712702","https://openalex.org/W2093023074","https://openalex.org/W2093424805","https://openalex.org/W2093519391","https://openalex.org/W2093979243","https://openalex.org/W2094288454","https://openalex.org/W2094404959","https://openalex.org/W2094807913","https://openalex.org/W2098374956","https://openalex.org/W2101889062","https://openalex.org/W2102032120","https://openalex.org/W2102236923","https://openalex.org/W2102743010","https://openalex.org/W2102838769","https://openalex.org/W2102843335","https://openalex.org/W2103673388","https://openalex.org/W2103879666","https://openalex.org/W2105375220","https://openalex.org/W2105449052","https://openalex.org/W2106100179","https://openalex.org/W2106254834","https://openalex.org/W2106448082","https://openalex.org/W2106989835","https://openalex.org/W2107587383","https://openalex.org/W2107962824","https://openalex.org/W2108500672","https://openalex.org/W2108645139","https://openalex.org/W2108763786","https://openalex.org/W2109890939","https://openalex.org/W2110592777","https://openalex.org/W2111364560","https://openalex.org/W2111389460","https://openalex.org/W2111496511","https://openalex.org/W2111754083","https://openalex.org/W2111950267","https://openalex.org/W2112226781","https://openalex.org/W2113822184","https://openalex.org/W2113903634","https://openalex.org/W2114216165","https://openalex.org/W2114233076","https://openalex.org/W2115048507","https://openalex.org/W2115314035","https://openalex.org/W2115499978","https://openalex.org/W2116071714","https://openalex.org/W2116074878","https://openalex.org/W2116167672","https://openalex.org/W2116899012","https://openalex.org/W2117403816","https://openalex.org/W2117572685","https://openalex.org/W2118511790","https://openalex.org/W2119280607","https://openalex.org/W2120292596","https://openalex.org/W2120432918","https://openalex.org/W2120867214","https://openalex.org/W2120994472","https://openalex.org/W2121037023","https://openalex.org/W2121183277","https://openalex.org/W2121220886","https://openalex.org/W2122632939","https://openalex.org/W2123330579","https://openalex.org/W2124375652","https://openalex.org/W2125373492","https://openalex.org/W2125391335","https://openalex.org/W2125491349","https://openalex.org/W2125809738","https://openalex.org/W2126648733","https://openalex.org/W2127835664","https://openalex.org/W2128054910","https://openalex.org/W2130109620","https://openalex.org/W2130567937","https://openalex.org/W2130699680","https://openalex.org/W2131007957","https://openalex.org/W2131233598","https://openalex.org/W2131720300","https://openalex.org/W2133193301","https://openalex.org/W2133822846","https://openalex.org/W2134908844","https://openalex.org/W2135206918","https://openalex.org/W2135658143","https://openalex.org/W2137330819","https://openalex.org/W2137440275","https://openalex.org/W2137716536","https://openalex.org/W2137867170","https://openalex.org/W2137961581","https://openalex.org/W2138110425","https://openalex.org/W2138505075","https://openalex.org/W2138863592","https://openalex.org/W2139405922","https://openalex.org/W2142271065","https://openalex.org/W2142807370","https://openalex.org/W2143408261","https://openalex.org/W2143666652","https://openalex.org/W2143865856","https://openalex.org/W2144624167","https://openalex.org/W2144634347","https://openalex.org/W2144933756","https://openalex.org/W2145626748","https://openalex.org/W2145678829","https://openalex.org/W2146066955","https://openalex.org/W2146415292","https://openalex.org/W2146509482","https://openalex.org/W2147948281","https://openalex.org/W2148872113","https://openalex.org/W2150364154","https://openalex.org/W2150816534","https://openalex.org/W2151047671","https://openalex.org/W2152134349","https://openalex.org/W2152776641","https://openalex.org/W2152871735","https://openalex.org/W2153138904","https://openalex.org/W2153155292","https://openalex.org/W2153231414","https://openalex.org/W2153389806","https://openalex.org/W2154055662","https://openalex.org/W2156119419","https://openalex.org/W2156383817","https://openalex.org/W2158744232","https://openalex.org/W2160062943","https://openalex.org/W2160652539","https://openalex.org/W2161541723","https://openalex.org/W2162044353","https://openalex.org/W2162734004","https://openalex.org/W2163010298","https://openalex.org/W2163133175","https://openalex.org/W2164440528","https://openalex.org/W2164510915","https://openalex.org/W2165016134","https://openalex.org/W2165197545","https://openalex.org/W2166167705","https://openalex.org/W2166329605","https://openalex.org/W2167039974","https://openalex.org/W2168443065","https://openalex.org/W2168971544","https://openalex.org/W2169743800","https://openalex.org/W2169864486","https://openalex.org/W2170197058","https://openalex.org/W2170543799","https://openalex.org/W2171304774","https://openalex.org/W2171427593","https://openalex.org/W2242902452","https://openalex.org/W2313228602","https://openalex.org/W2320568382","https://openalex.org/W2323120659","https://openalex.org/W2323800150","https://openalex.org/W2325631985","https://openalex.org/W2328476123","https://openalex.org/W2334093679","https://openalex.org/W2408842178","https://openalex.org/W2410556282","https://openalex.org/W2417944730","https://openalex.org/W2443673815","https://openalex.org/W2467196038","https://openalex.org/W3022598401","https://openalex.org/W3142152021","https://openalex.org/W3196006275"],"related_works":["https://openalex.org/W2001522142","https://openalex.org/W2793492180","https://openalex.org/W2076822140","https://openalex.org/W2106100179","https://openalex.org/W4253387802","https://openalex.org/W2385871042","https://openalex.org/W3208681393","https://openalex.org/W2241486613","https://openalex.org/W2037561205","https://openalex.org/W1562241969"],"abstract_inverted_index":{"Prostate":[0],"cancer":[1,7],"is":[2],"the":[3,9,27,74,79,100,105,125,137,143,169,172,185,199,225,250,260,275,293,296,333,359,369,378,392],"most":[4,276],"common":[5],"male":[6],"in":[8,155,233,344],"UK":[10],"and":[11,19,35,45,68,77,86,142,162,195,241,280,288,317,353,356,373,388],"USA,":[12],"with":[13,136,189,208,358,377],"a":[14,20,130],"1/13":[15],"chance":[16],"of":[17,24,57,71,92,132,158,171,178,201,235,265,295,346],"diagnosis":[18],"1/30":[21],"lifetime":[22],"risk":[23],"death":[25],"from":[26,42,99],"disease.":[28],"Current":[29],"treatment":[30],"options":[31],"include":[32],"radiotherapy,":[33],"surgery":[34],"hormone":[36],"therapy,":[37],"however":[38,112],"1/3":[39],"patients":[40],"escape":[41],"all":[43],"therapies":[44,47],"novel":[46],"are":[48,321],"urgently":[49],"required":[50],"for":[51,82,168,191,292,332],"this":[52,156,179,202,382],"patient":[53],"group.":[54],"The":[55,90,152,176,267,299,336],"University":[56],"Birmingham":[58],"gene":[59,88],"therapy":[60],"group":[61],"constructed":[62,305],"two":[63,94,154,322],"oncolytic":[64,84,133,166,193],"adenovirus":[65,134],"vectors,":[66,95,159],"CRAd-NTR":[67],"vNR6,":[69,96,258],"both":[70,222],"which":[72,327],"contained":[73],"E1B-55K":[75,253,393],"deletion":[76,141],"expressed":[78],"transgene":[80,174,227,237],"nitroreductase":[81,98,190,320,338],"combined":[83,192,375,389],"virotherapy":[85,194],"enzyme/prodrug":[87,196],"therapy.":[89,197],"latter":[91],"these":[93,245],"expressing":[97,224,339,364],"pIX":[101],"virus":[102,110,255,347],"promoter":[103,145],"demonstrated":[104,281],"greatest":[106,374],"cytotoxicity":[107,283,357,376,390],"at":[108,124],"low":[109],"concentrations":[111],"also":[113],"showed":[114,368,384],"some":[115],"lytic":[116],"activity":[117,331],"to":[118,183,220,249,257,284,306],"non-transformed":[119,285],"human":[120,286],"fibroblasts.":[121],"Our":[122],"collaborators":[123],"Institut":[126],"Catal\u00e0":[127],"d'Oncologia":[128],"designed":[129],"panel":[131],"vectors":[135,188,223,230,246,270,279,303,341],"E1A":[138,144,242,352],"CR2":[139],"\uf04424":[140],"replaced":[146],"by":[147],"an":[148,252],"insulated":[149],"E2F-1":[150],"promoter.":[151],"latest":[153],"series":[157],"termed":[160],"ICOVIR-5":[161,210],"ICOVIR-7,":[163],"provide":[164],"potential":[165],"backbones":[167],"introduction":[170,294],"therapeutic":[173,297],"nitroreductase.":[175,315],"aim":[177],"thesis":[180],"was":[181,216],"therefore":[182,217,290],"\u2018arm\u2019":[184],"ICOVIR":[186],"based":[187,213,269,302],"At":[198],"beginning":[200],"study":[203],"no":[204,282],"reports":[205],"were":[206,231,247,271,289,304,342],"published":[207],"either":[209,308],"or":[211,312],"ICOVIR-7":[212,268,301,340],"vectors.":[214],"It":[215],"first":[218],"decided":[219],"construct":[221],"marker":[226],"eGFP.":[228],"These":[229],"characterised":[232,324,343],"terms":[234,345],"cytotoxicity,":[236,349],"expression,":[238],"DNA":[239],"replication":[240],"expression.":[243],"Furthermore,":[244,381],"compared":[248],"vNR3,":[251],"deleted":[254,394],"similar":[256],"but":[259],"eGFP":[261],"ORF":[262],"replacing":[263],"that":[264],"pIX.":[266],"identified":[272],"as":[273],"being":[274],"tumour":[277,350,371,386],"selective":[278],"fibroblasts,":[287],"chosen":[291],"transgenes.":[298],"new":[300,337],"express":[307],"wildtype,":[309],"double":[310,365],"mutant":[311,314,319,325,366],"triple":[313,318],"Double":[316],"previously":[323],"nitroreductases,":[326],"show":[328],"enhanced":[329],"catalytic":[330],"prodrug":[334,360,379],"CB1954.":[335,361,380],"mediated":[348],"selectivity,":[351],"NTR":[354],"expression":[355],"One":[362],"vector,":[363],"nitroreductase,":[367],"highest":[370],"selectivity":[372,387],"vector":[383,395],"greater":[385],"than":[391],"vNR6.":[396]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}