{"id":"https://openalex.org/W1818200260","doi":null,"title":"Evaluation of the potential anti-inflammatory of Ocimum americanum L. essential oil in different experimental models of acute inflammation","display_name":"Evaluation of the potential anti-inflammatory of Ocimum americanum L. essential oil in different experimental models of acute inflammation","publication_year":2014,"publication_date":"2014-05-16","ids":{"openalex":"https://openalex.org/W1818200260","mag":"1818200260"},"language":"en","primary_location":{"id":"mag:1818200260","doi":null,"is_oa":false,"landing_page_url":"http://ijarnp.org/index.php/ijarnp/article/view/238","pdf_url":null,"source":{"id":"https://openalex.org/S2764815085","display_name":"International journal of applied research in natural products","issn_l":"1940-6223","issn":["1940-6223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International journal of applied research in natural products","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077537232","display_name":"Alcil\u00e9ia Nunes Yamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Alcil\u00e9ia Nunes Yamada","raw_affiliation_strings":["State University of Maring\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of Maring\u00e1","institution_ids":["https://openalex.org/I123443094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029813098","display_name":"Renata Grespan","orcid":"https://orcid.org/0000-0003-3644-7632","observed_orcids":["https://orcid.org/0000-0003-3644-7632"]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Renata Grespan","raw_affiliation_strings":["State University of Maring\u00e1"],"raw_orcid":"https://orcid.org/0000-0003-3644-7632","affiliations":[{"raw_affiliation_string":"State University of Maring\u00e1","institution_ids":["https://openalex.org/I123443094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038879434","display_name":"Abel Felipe Freitag","orcid":"https://orcid.org/0000-0002-0398-9550","observed_orcids":["https://orcid.org/0000-0002-0398-9550"]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Abel Felipe Freitag","raw_affiliation_strings":["State University of Maring\u00e1"],"raw_orcid":"https://orcid.org/0000-0002-0398-9550","affiliations":[{"raw_affiliation_string":"State University of Maring\u00e1","institution_ids":["https://openalex.org/I123443094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113853040","display_name":"M\u00e1rcio Jos\u00e9 Dami\u00e3o","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M\u00e1rcio Jos\u00e9 Dami\u00e3o","raw_affiliation_strings":["State University of Maring\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of Maring\u00e1","institution_ids":["https://openalex.org/I123443094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010644478","display_name":"Raquel Kummer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Raquel Kummer","raw_affiliation_strings":["State University of Maring\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of Maring\u00e1","institution_ids":["https://openalex.org/I123443094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021084145","display_name":"Rafael Lucena","orcid":"https://orcid.org/0000-0002-4625-2460","observed_orcids":["https://orcid.org/0000-0002-4625-2460"]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafael Lucena","raw_affiliation_strings":["State University of Maring\u00e1"],"raw_orcid":"https://orcid.org/0000-0002-4625-2460","affiliations":[{"raw_affiliation_string":"State University of Maring\u00e1","institution_ids":["https://openalex.org/I123443094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103064127","display_name":"Ciomar Aparecida Bersani\u2010Amado","orcid":"https://orcid.org/0000-0002-0247-2090","observed_orcids":["https://orcid.org/0000-0002-0247-2090"]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ciomar Aparecida Bersani\u2010Amado","raw_affiliation_strings":["State University of Maring\u00e1"],"raw_orcid":"https://orcid.org/0000-0002-0247-2090","affiliations":[{"raw_affiliation_string":"State University of Maring\u00e1","institution_ids":["https://openalex.org/I123443094"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029726638","display_name":"Roberto Kenji Nakamura Cuman","orcid":"https://orcid.org/0000-0002-4906-887X","observed_orcids":["https://orcid.org/0000-0002-4906-887X"]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Roberto Kenji Nakamura Cuman","raw_affiliation_strings":["State University of Maring\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of Maring\u00e1","institution_ids":["https://openalex.org/I123443094"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I123443094"],"apc_list":null,"apc_paid":null,"fwci":0.7967,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.78005599,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"7","issue":"3","first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.8012999892234802,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.8012999892234802,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.09480000287294388,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.06419999897480011,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ocimum-americanum","display_name":"Ocimum americanum","score":0.9990000128746033},{"id":"https://openalex.org/keywords/essential-oils","display_name":"essential oils","score":0.8830000162124634},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/acute-inflammation","display_name":"acute inflammation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/carrageenan-induced-pleurisy","display_name":"carrageenan-induced pleurisy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/leukocyte-rolling","display_name":"leukocyte rolling","score":0.6499999761581421},{"id":"https://openalex.org/keywords/leukocyte-adhesion","display_name":"leukocyte adhesion","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ear-edema","display_name":"ear edema","score":0.9160000085830688},{"id":"https://openalex.org/keywords/croton-oil","display_name":"croton oil","score":0.9380000233650208},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/topical-application","display_name":"topical application","score":0.843999981880188},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C2778978224","wikidata":"https://www.wikidata.org/wiki/Q55998","display_name":"Pleurisy","level":3,"score":0.7893896102905273},{"id":"https://openalex.org/C2781227287","wikidata":"https://www.wikidata.org/wiki/Q421991","display_name":"Carrageenan","level":2,"score":0.695304274559021},{"id":"https://openalex.org/C2778942509","wikidata":"https://www.wikidata.org/wiki/Q456053","display_name":"Croton oil","level":3,"score":0.6804718971252441},{"id":"https://openalex.org/C2778573061","wikidata":"https://www.wikidata.org/wiki/Q1139400","display_name":"Exudate","level":2,"score":0.639313280582428},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.6188164353370667},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6128770709037781},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.587357759475708},{"id":"https://openalex.org/C2778261524","wikidata":"https://www.wikidata.org/wiki/Q519802","display_name":"Croton","level":2,"score":0.5708449482917786},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.5536575317382812},{"id":"https://openalex.org/C2859252","wikidata":"https://www.wikidata.org/wiki/Q1543928","display_name":"Intravital microscopy","level":3,"score":0.509292721748352},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49225011467933655},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4113766551017761},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33868756890296936},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25979870557785034},{"id":"https://openalex.org/C2779634585","wikidata":"https://www.wikidata.org/wiki/Q1334541","display_name":"Pleural effusion","level":2,"score":0.1789463460445404},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1777188777923584},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.13933253288269043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12622559070587158},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.12482845783233643},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1818200260","doi":null,"is_oa":false,"landing_page_url":"http://ijarnp.org/index.php/ijarnp/article/view/238","pdf_url":null,"source":{"id":"https://openalex.org/S2764815085","display_name":"International journal of applied research in natural products","issn_l":"1940-6223","issn":["1940-6223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International journal of applied research in natural products","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W29183733","https://openalex.org/W1504829674","https://openalex.org/W1976387104","https://openalex.org/W1976973210","https://openalex.org/W1990165855","https://openalex.org/W1996059978","https://openalex.org/W2004745837","https://openalex.org/W2007558668","https://openalex.org/W2020358486","https://openalex.org/W2031700913","https://openalex.org/W2042464457","https://openalex.org/W2055903916","https://openalex.org/W2080480446","https://openalex.org/W2082379050","https://openalex.org/W2090105816","https://openalex.org/W2119600746","https://openalex.org/W2130574764","https://openalex.org/W2141746526","https://openalex.org/W2162341513","https://openalex.org/W2319737480","https://openalex.org/W2322917061","https://openalex.org/W2598786995","https://openalex.org/W2618616772"],"related_works":["https://openalex.org/W2119600746","https://openalex.org/W2481135089","https://openalex.org/W7064368860","https://openalex.org/W47160368","https://openalex.org/W2189625021","https://openalex.org/W7214907710","https://openalex.org/W2025687626","https://openalex.org/W96806047","https://openalex.org/W2906921924","https://openalex.org/W7098073085"],"abstract_inverted_index":{"Summary.":[0],"Anti-inflammatory":[2],"effects":[3],"of":[4,26,30,56,74,140,152,204,206,216,227,230,252,264,269,273,287],"O":[6],"cimum":[8],"americanum":[9,302],"L.":[11],"essential":[12,258,275,306],"oil":[13,44,259,276],"(OEO)":[14],"were":[15,107],"investigated":[16],"using":[17],"carrageenan-induced":[18,22,79],"pleurisy":[19,80],"in":[20,34,48,77,144,162,191,198,224,260],"rats,":[21],"rolling":[23,161],"and":[24,45,59,95,98,104,125,127,155,165,177],"adhesion":[25,170],"leucocytes":[27],"by":[28,42,87,173],"technique":[29,139],"intravital":[31,141],"microscopy":[32,142],"situ":[37,145],",":[38,146],"ear":[39,84],"edema":[40,85,112,308],"induced":[41,86],"croton":[43,88],"myeloperoxidase":[46,116],"determination":[47],"mice.":[49],"The":[50,214,267],"OEO":[51,90,99,121,147,189],"administered":[52],"orally":[53,148],"at":[54,122,150],"doses":[55,123,151],"100,":[57,153],"200":[58,94,154],"400":[60,96,156],"mg/kg":[61,157],"significantly":[62],"inhibited":[63,172],"the":[64,72,78,111,138,159,186,199,202,225,249,253,270,279],"exudate":[65],"pleural":[66],"volume":[67],"(p<0.05),":[68],"without":[69],"interfere":[70],"with":[71,188],"number":[73],"migrated":[75],"cells":[76],"model.":[81],"While":[82],"evaluating":[83],"oil,":[89],"oral":[91,118],"treatment":[92,119,203,226],"(100,":[93],"mg/kg)":[97,176],"topical":[100,128],"application":[101,129],"(1.0,":[102],"2.0":[103,131],"4.0":[105],"mg/ear)":[106],"able":[108],"to":[109,247,285],"reduce":[110],"formation":[113],"(p<0.05).":[114,136],"In":[115,137],"determination,":[117],"\u00a0with":[120],"100":[124],"200mg/kg":[126],"1.0,":[130],"mg/ear":[132],"showed":[133],"significant":[134],"inhibition":[135],"treated":[149],"reduced":[158],"leukocyte":[160,169,304],"35,":[163],"37":[164],"51%,":[166],"respectively,":[167],"whereas,":[168],"was":[171],"68%":[174],"(100":[175],"43%":[178],"(200":[179],"mg/kg).":[180],"Thus,":[181],"our":[182],"results":[183],"suggest":[184],"that":[185],"screening":[187,268],"realized":[190],"this":[192,245,274],"new":[193,288],"study":[194,246],"can":[195],"be":[196,283],"useful":[197,284],"future":[200],"for":[201,278],"disease":[205],"origin":[207],"inflammatory.":[208],"Industrial":[211],"relevance":[212],".":[213],"leaves":[215],"Ocimum":[218,255,301],"americanun":[219,256],"are":[221],"traditionally":[222],"used":[223],"various":[228],"types":[229],"inflammatory":[231],"diseases.":[232],"However,":[233],"there":[234],"is":[235],"no":[236],"scientific":[237],"data":[238],"available":[239],"given":[240],"supporting.":[241],"Hence,":[242],"we":[243],"conducted":[244],"evaluate":[248],"anti-nflammatory":[250],"potential":[251],"different":[261],"experimental":[262],"models":[263],"acute":[265],"inflammation.":[266],"biological":[271],"activity":[272],"responsible":[277],"anti-inflammatory":[280],"property":[281],"may":[282],"development":[286],"drug":[289],"anti-inflammatory,":[290],"on":[291],"a":[292],"commercial":[293],"scale.":[294],"Keywords.":[298],";":[303],"migration;":[305],"oil;":[307]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}