{"id":"https://openalex.org/W181706016","doi":null,"title":"Origine ontog\u00e9n\u00e9tique et \u00e9volutive de l'hypophyse : \u00e9tude cellulaire et mol\u00e9culaire du d\u00e9veloppement du complexe neural de l'ascidie Ciona intestinalis","display_name":"Origine ontog\u00e9n\u00e9tique et \u00e9volutive de l'hypophyse : \u00e9tude cellulaire et mol\u00e9culaire du d\u00e9veloppement du complexe neural de l'ascidie Ciona intestinalis","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W181706016","mag":"181706016"},"language":"fr","primary_location":{"id":"pmh:oai:HAL:tel-02833428v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/tel-02833428v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sciences du Vivant [q-bio]. Universit\u00e9 Paris Sud - Paris 11, 2004. Fran\u00e7ais. ⟨NNT : ⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080705309","display_name":"Lionel Christiaen","orcid":"https://orcid.org/0000-0001-5930-5667","observed_orcids":["https://orcid.org/0000-0001-5930-5667"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lionel Christiaen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5930-5667","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5080705309"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"81 p.","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12142","display_name":"Marine Invertebrate Physiology and Ecology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1911","display_name":"Paleontology"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pituitary-development","display_name":"pituitary development","score":0.8560000061988831},{"id":"https://openalex.org/keywords/ontogeny","display_name":"ontogeny","score":0.781000018119812},{"id":"https://openalex.org/keywords/evolution","display_name":"evolution","score":0.6690000295639038},{"id":"https://openalex.org/keywords/ciona-intestinalis","display_name":"Ciona intestinalis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/ascidians","display_name":"ascidians","score":0.8349999785423279},{"id":"https://openalex.org/keywords/neural-complex","display_name":"neural complex","score":0.7480000257492065},{"id":"https://openalex.org/keywords/cell-lineage","display_name":"cell lineage","score":0.5170000195503235},{"id":"https://openalex.org/keywords/molecular-mechanisms","display_name":"molecular mechanisms","score":0.515999972820282},{"id":"https://openalex.org/keywords/neuroendocrine-development","display_name":"neuroendocrine development","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.59815514087677},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49685123562812805},{"id":"https://openalex.org/C2779528156","wikidata":"https://www.wikidata.org/wiki/Q2567701","display_name":"Ciona intestinalis","level":3,"score":0.41908693313598633},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11349821090698242},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07745462656021118}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:HAL:tel-02833428v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/tel-02833428v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sciences du Vivant [q-bio]. Universit\u00e9 Paris Sud - Paris 11, 2004. Fran\u00e7ais. ⟨NNT : ⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:181706016","doi":null,"is_oa":false,"landing_page_url":"https://hal.inrae.fr/tel-02833428","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"HAL (Le Centre pour la Communication Scientifique Directe)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6995599327","https://openalex.org/W2008678420","https://openalex.org/W7061919364","https://openalex.org/W898010822","https://openalex.org/W2104368417","https://openalex.org/W2058456218","https://openalex.org/W7066128973","https://openalex.org/W7143691139","https://openalex.org/W4291078361","https://openalex.org/W2065515897"],"abstract_inverted_index":{"J'ai":[0],"initie":[1],"une":[2,55,110,201],"etude":[3],"comparee":[4],"du":[5,18,21,30,39,181],"developpement":[6,19,38],"hypophysaire":[7,32],"chez":[8,24,61,79,211],"les":[9,62,63,66,150,172,212],"Chordes,":[10],"par":[11,126,166],"l'analyse":[12,127],"des":[13,86,92,112,118,142,167],"aspects":[14],"cellulaires":[15],"et":[16,58,65,88,101,107,139,152,160,206],"moleculaires":[17],"precoce":[20,187],"complexe":[22,90],"neural":[23,91],"l'ascidie,":[25],"Ciona":[26],"intestinalis.":[27],"La":[28],"specification":[29],"champ":[31],"presomptif":[33],"est":[34,76,164],"intimement":[35],"liee":[36],"au":[37],"stomodaeum":[40,162],"(ectoderme":[41],"oral),":[42],"dont":[43,171],"derive":[44],"la":[45,51,136,189],"placode":[46,190],"adenohypophysaire.":[47],"Les":[48],"genes":[49],"de":[50,74,115,121,128,144,156,185,203],"famille":[52],"pitx":[53,75,145],"presentent":[54],"expression":[56],"pan-stomodaeale":[57,73],"pan-hypophysaire":[59],"conservee":[60,78],"Vertebres":[64,87],"Cephalochordes.":[67],"Mes":[68,132],"resultats":[69],"montrent":[70,134],"que":[71,84,135,196],"l'expression":[72],"aussi":[77],"l'ascidie.":[80],"Ces":[81],"observations":[82,133],"suggerent":[83],"l'hypophyse":[85],"le":[89,153,161,197],"ascidies":[93,151],"se":[94],"developpent":[95],"a":[96,123],"partir":[97],"d'un":[98],"primordium":[99],"ancestral":[100],"conserve.":[102],"L'analyse":[103,179],"d'autres":[104],"marqueurs":[105],"hypophysaires":[106],"hypothalamiques":[108],"suggere":[109,195],"diversification":[111],"etapes":[113],"successives":[114],"l'organogenese.":[116],"L'etude":[117],"mecanismes":[119],"d'activation":[120],"Ci-pitx":[122,157],"ete":[124],"entreprise":[125],"son":[129],"systeme":[130],"cis-regulateur.":[131],"structure":[137],"genomique":[138],"l'usage":[140],"transcriptionnel":[141],"exons":[143],"sont":[146,177],"majoritairement":[147],"conserves":[148],"entre":[149],"Vertebres.":[154],"L'expression":[155],"dans":[158,188],"l'ANB":[159],"larvaire":[163],"controlee":[165],"modules":[168],"cis-regulateurs":[169],"distincts":[170],"patrons":[173],"spatio-temporels":[174],"d'activite":[175],"transcriptionnelle":[176],"complementaires.":[178],"detaillee":[180],"module":[182],"D1,":[183],"responsable":[184],"l'activation":[186],"stomodaeale":[191],"(i.":[192],"E.":[193],"L'ANB),":[194],"code":[198],"cis-regulateur":[199],"integrant":[200],"combinaison":[202],"signaux":[204],"acivateurs":[205],"represseurs":[207],"puisse":[208],"etre":[209],"conserve":[210],"chordes.":[213]},"counts_by_year":[],"updated_date":"2026-10-25T09:29:13.331239","created_date":"2016-06-24T00:00:00"}