{"id":"https://openalex.org/W1815264987","doi":"https://doi.org/10.1111/bcp.12546","title":"Characterization of the inflammatory response to inhaled lipopolysaccharide in mild to moderate chronic obstructive pulmonary disease","display_name":"Characterization of the inflammatory response to inhaled lipopolysaccharide in mild to moderate chronic obstructive pulmonary disease","publication_year":2014,"publication_date":"2014-11-07","ids":{"openalex":"https://openalex.org/W1815264987","doi":"https://doi.org/10.1111/bcp.12546","mag":"1815264987","pmid":"https://pubmed.ncbi.nlm.nih.gov/25377849","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4415713"},"language":"en","primary_location":{"id":"doi:10.1111/bcp.12546","doi":"https://doi.org/10.1111/bcp.12546","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bcp.12546","pdf_url":"https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.12546","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.12546","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Vandana Gupta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210151016","display_name":"Medicines Evaluation Unit","ror":"https://ror.org/05e497m36","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210151016"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Vandana Gupta","raw_affiliation_strings":["Medicines Evaluation Unit University Hospital of South Manchester Foundation Trust University of Manchester Southmoor Rd Manchester UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicines Evaluation Unit University Hospital of South Manchester Foundation Trust University of Manchester Southmoor Rd Manchester UK","institution_ids":["https://openalex.org/I28407311","https://openalex.org/I4210151016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069493161","display_name":"Antonia Banyard","orcid":"https://orcid.org/0000-0002-2430-8013","observed_orcids":["https://orcid.org/0000-0002-2430-8013"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210151016","display_name":"Medicines Evaluation Unit","ror":"https://ror.org/05e497m36","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210151016"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Antonia Banyard","raw_affiliation_strings":["Medicines Evaluation Unit University Hospital of South Manchester Foundation Trust University of Manchester Southmoor Rd Manchester UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicines Evaluation Unit University Hospital of South Manchester Foundation Trust University of Manchester Southmoor Rd Manchester UK","institution_ids":["https://openalex.org/I28407311","https://openalex.org/I4210151016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091205021","display_name":"Aoibheann F. Mullan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210151016","display_name":"Medicines Evaluation Unit","ror":"https://ror.org/05e497m36","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210151016"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Aoibheann Mullan","raw_affiliation_strings":["Medicines Evaluation Unit University Hospital of South Manchester Foundation Trust University of Manchester Southmoor Rd Manchester UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicines Evaluation Unit University Hospital of South Manchester Foundation Trust University of Manchester Southmoor Rd Manchester UK","institution_ids":["https://openalex.org/I28407311","https://openalex.org/I4210151016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032756802","display_name":"Srividya Sriskantharajah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Srividya Sriskantharajah","raw_affiliation_strings":["Refractory Respiratory Inflammation Discovery Performance Unit, GlaxoSmithKline, Stevenage, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Refractory Respiratory Inflammation Discovery Performance Unit, GlaxoSmithKline, Stevenage, UK","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090083154","display_name":"Thomas W. Southworth","orcid":"https://orcid.org/0000-0002-8127-565X","observed_orcids":["https://orcid.org/0000-0002-8127-565X"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210151016","display_name":"Medicines Evaluation Unit","ror":"https://ror.org/05e497m36","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210151016"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas Southworth","raw_affiliation_strings":["Medicines Evaluation Unit University Hospital of South Manchester Foundation Trust University of Manchester Southmoor Rd Manchester UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicines Evaluation Unit University Hospital of South Manchester Foundation Trust University of Manchester Southmoor Rd Manchester UK","institution_ids":["https://openalex.org/I28407311","https://openalex.org/I4210151016"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068917661","display_name":"Dave Singh","orcid":"https://orcid.org/0000-0001-8918-7075","observed_orcids":["https://orcid.org/0000-0001-8918-7075"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210151016","display_name":"Medicines Evaluation Unit","ror":"https://ror.org/05e497m36","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210151016"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dave Singh","raw_affiliation_strings":["Medicines Evaluation Unit University Hospital of South Manchester Foundation Trust University of Manchester Southmoor Rd Manchester UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicines Evaluation Unit University Hospital of South Manchester Foundation Trust University of Manchester Southmoor Rd Manchester UK","institution_ids":["https://openalex.org/I28407311","https://openalex.org/I4210151016"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I28407311","https://openalex.org/I4210151016"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":1.6017,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.83289228,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"79","issue":"5","first_page":"767","last_page":"776"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9440000057220459},{"id":"https://openalex.org/keywords/bacterial-exacerbations","display_name":"bacterial exacerbations","score":0.6809999942779541},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.906000018119812},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8610000014305115},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9599999785423279},{"id":"https://openalex.org/keywords/clara-cell-secretory-protein","display_name":"Clara cell secretory protein","score":0.859000027179718},{"id":"https://openalex.org/keywords/sputum-neutrophilia","display_name":"sputum neutrophilia","score":0.8309999704360962},{"id":"https://openalex.org/keywords/induced-sputum","display_name":"induced sputum","score":0.7070000171661377},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.8560000061988831},{"id":"https://openalex.org/keywords/macrophage-inflammatory-protein-1beta","display_name":"macrophage inflammatory protein-1\u03b2","score":0.9490000009536743},{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.8960000276565552},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.8309999704360962},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.7139999866485596},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8224608302116394},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7380889058113098},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.7030805945396423},{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.6803870797157288},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.6561013460159302},{"id":"https://openalex.org/C2776317360","wikidata":"https://www.wikidata.org/wiki/Q14905648","display_name":"Neutrophil elastase","level":3,"score":0.6138796210289001},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5612242221832275},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5467128753662109},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5017368793487549},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.47368717193603516},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.4469878375530243},{"id":"https://openalex.org/C2776822972","wikidata":"https://www.wikidata.org/wiki/Q14907577","display_name":"Lipopolysaccharide binding protein","level":4,"score":0.42937329411506653},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39171379804611206},{"id":"https://openalex.org/C57194454","wikidata":"https://www.wikidata.org/wiki/Q424211","display_name":"Acute-phase protein","level":3,"score":0.2671215236186981},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15429359674453735},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.09259393811225891},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07317134737968445},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013183","descriptor_name":"Sputum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013183","descriptor_name":"Sputum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019570","descriptor_name":"Inhalation Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1111/bcp.12546","doi":"https://doi.org/10.1111/bcp.12546","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bcp.12546","pdf_url":"https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.12546","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3818872","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4415713","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4415713","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4415713","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"},{"id":"pmid:25377849","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25377849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/8663b15e-e586-44ab-9465-eb61d8d2958f","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/8663b15e-e586-44ab-9465-eb61d8d2958f","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gupta, V, Banyard, A, Mullan, A, Sriskantharajah, S, Southworth, T & Singh, D 2015, 'Characterization of the inflammatory response to inhaled lipopolysaccharide in mild to moderate chronic obstructive pulmonary disease.', British Journal of Clinical Pharmacology, vol. 79, no. 5. https://doi.org/10.1111/bcp.12546","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1111/bcp.12546","doi":"https://doi.org/10.1111/bcp.12546","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bcp.12546","pdf_url":"https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.12546","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1815264987.pdf","grobid_xml":"https://content.openalex.org/works/W1815264987.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W157721590","https://openalex.org/W1520167189","https://openalex.org/W1580622436","https://openalex.org/W1900975454","https://openalex.org/W1989906516","https://openalex.org/W1990674750","https://openalex.org/W1993511722","https://openalex.org/W1995744610","https://openalex.org/W2008561141","https://openalex.org/W2011097744","https://openalex.org/W2018086360","https://openalex.org/W2029753427","https://openalex.org/W2032632523","https://openalex.org/W2037542404","https://openalex.org/W2042495092","https://openalex.org/W2043450272","https://openalex.org/W2044433987","https://openalex.org/W2055415548","https://openalex.org/W2055906007","https://openalex.org/W2074100262","https://openalex.org/W2084388859","https://openalex.org/W2093714042","https://openalex.org/W2097547390","https://openalex.org/W2099004448","https://openalex.org/W2099627512","https://openalex.org/W2107442953","https://openalex.org/W2108168568","https://openalex.org/W2109143421","https://openalex.org/W2110947112","https://openalex.org/W2112989452","https://openalex.org/W2115822599","https://openalex.org/W2118961129","https://openalex.org/W2121231290","https://openalex.org/W2123547619","https://openalex.org/W2125252801","https://openalex.org/W2125756467","https://openalex.org/W2130052573","https://openalex.org/W2130055391","https://openalex.org/W2141193850","https://openalex.org/W2141202162","https://openalex.org/W2141831091","https://openalex.org/W2149077179","https://openalex.org/W2154513385","https://openalex.org/W2158549296","https://openalex.org/W2159816032","https://openalex.org/W2160418158","https://openalex.org/W2160443208","https://openalex.org/W2163139709","https://openalex.org/W2166532440","https://openalex.org/W2166731705","https://openalex.org/W2169780324","https://openalex.org/W2171649568"],"related_works":["https://openalex.org/W1520167189","https://openalex.org/W1916864011","https://openalex.org/W1576362548","https://openalex.org/W2313785846","https://openalex.org/W4312726243","https://openalex.org/W2808199070","https://openalex.org/W2384102768","https://openalex.org/W2357073110","https://openalex.org/W2136718097","https://openalex.org/W2905780709"],"abstract_inverted_index":{"AIMS:":[0],"Lipopolysaccharide":[1],"(LPS)":[2],"inhalation":[3,13],"causes":[4,204],"increased":[5,162,180,193,205],"airway":[6,206],"and":[7,34,67,72,81,95,103,118,158,164,178,187,207],"systemic":[8,35,122,208],"inflammation.":[9,209],"We":[10,28,37],"investigated":[11,40],"LPS":[12,126,199],"in":[14,32,44,86,150,172,200],"patients":[15,50,202],"with":[16,182],"chronic":[17],"obstructive":[18],"pulmonary":[19],"disease":[20],"(COPD)":[21],"as":[22],"a":[23,147,213],"model":[24,214],"of":[25],"bacterial":[26],"exacerbations.":[27,218],"studied":[29],"safety,":[30],"changes":[31],"sputum":[33,155,173],"biomarkers.":[36],"have":[38],"also":[39],"interleukin":[41],"(IL)-17":[42],"concentrations":[43],"this":[45],"model.":[46],"METHODS:":[47],"Twelve":[48],"COPD":[49,201,217],"inhaled":[51],"5":[52,127],"\u03bcg":[53,128],"LPS.":[54],"Safety":[55],"was":[56,62,89,129,136,146,169],"monitored":[57],"over":[58],"24":[59,68,96,165],"h.":[60,196],"Sputum":[61],"induced":[63],"at":[64,91,116,139,194],"baseline,":[65,92],"6":[66,163],"h":[69,97,120,141,166],"for":[70,98,121,215],"cells":[71,112],"IL-8,":[73],"IL-17,":[74],"neutrophil":[75,159],"elastase,":[76],"monocyte":[77],"chemoattractant":[78],"protein-1":[79],"(MCP-1)":[80],"macrophage":[82],"inflammatory":[83],"protein-1\u03b2":[84],"(MIP-1\u03b2)":[85],"supernatants.":[87],"Serum":[88],"collected":[90],"4,":[93],"8":[94],"IL-6,":[99,176],"C-reactive":[100],"protein":[101,106],"(CRP)":[102],"Clara":[104],"cell":[105,156,189],"(CC-16)":[107],"concentrations.":[108],"Peripheral":[109],"blood":[110],"mononuclear":[111],"(PBMCs)":[113],"were":[114],"isolated":[115],"baseline":[117],"4":[119,195],"IL-17":[123,191],"analysis.":[124],"RESULTS:":[125],"well":[130],"tolerated.":[131],"The":[132],"greatest":[133],"FEV1":[134],"change":[135,171],"11.7%":[137],"(mean)":[138],"1":[140],"(95%":[142],"CI":[143],"5.1-18.2%).":[144],"There":[145,168],"large":[148],"range":[149],"maximal":[151],"fall":[152],"(2.5-37.7%).":[153],"Total":[154],"count":[157,160],"significantly":[161,192],"post-LPS.":[167],"no":[170],"supernatant":[174],"mediators.":[175],"CRP":[177],"CC-16":[179],"post-inhalation,":[181],"different":[183],"temporal":[184],"patterns.":[185],"CD4+":[186],"CD8+":[188],"associated":[190],"CONCLUSIONS:":[197],"Inhaled":[198],"safely":[203],"This":[210],"may":[211],"be":[212],"studying":[216]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}