{"id":"https://openalex.org/W1813899649","doi":"https://doi.org/10.1042/bj1770813","title":"Selective inactivation of lactate dehydrogenase of rat tissues by sodium deoxycholate","display_name":"Selective inactivation of lactate dehydrogenase of rat tissues by sodium deoxycholate","publication_year":1979,"publication_date":"1979-03-01","ids":{"openalex":"https://openalex.org/W1813899649","doi":"https://doi.org/10.1042/bj1770813","mag":"1813899649","pmid":"https://pubmed.ncbi.nlm.nih.gov/444206","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1186445"},"language":"en","primary_location":{"id":"doi:10.1042/bj1770813","doi":"https://doi.org/10.1042/bj1770813","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1770813","pdf_url":"https://portlandpress.com/biochemj/article-pdf/177/3/813/571405/bj1770813.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/177/3/813/571405/bj1770813.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"T Lehnert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T Lehnert","raw_affiliation_strings":["Institute ofPathochemistry and General Neurochemistry , University ofHeidelberg , D-6900 Heidelberg , German Federal Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute ofPathochemistry and General Neurochemistry , University ofHeidelberg , D-6900 Heidelberg , German Federal Republic","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113634459","display_name":"Hans H. Berlet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H H Berlet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.731,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.6165682,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"177","issue":"3","first_page":"813","last_page":"818"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.365200012922287,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.365200012922287,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.2581000030040741,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.10540000349283218,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sodium-deoxycholate","display_name":"sodium deoxycholate","score":0.9800000190734863},{"id":"https://openalex.org/keywords/enzyme-inactivation","display_name":"enzyme inactivation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/lactate-dehydrogenase-isoenzymes","display_name":"lactate dehydrogenase isoenzymes","score":0.871999979019165},{"id":"https://openalex.org/keywords/subunit-a","display_name":"subunit a","score":0.8240000009536743},{"id":"https://openalex.org/keywords/b-subunit","display_name":"B subunit","score":0.890999972820282},{"id":"https://openalex.org/keywords/non-competitive-inhibition","display_name":"non-competitive inhibition","score":0.7749999761581421},{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.8460000157356262},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.3720000088214874},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.984000027179718},{"id":"https://openalex.org/keywords/myocardium","display_name":"myocardium","score":0.9449999928474426},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.828000009059906},{"id":"https://openalex.org/keywords/electrophoretic-mobility","display_name":"electrophoretic mobility","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.8977844715118408},{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.7828191518783569},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6706984043121338},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6048136353492737},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5972865223884583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4803984463214874},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4698347747325897},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.4211769998073578},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39691364765167236},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.054345011711120605}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002621","descriptor_name":"Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003840","descriptor_name":"Deoxycholic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004587","descriptor_name":"Electrophoresis, Agar Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj1770813","doi":"https://doi.org/10.1042/bj1770813","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1770813","pdf_url":"https://portlandpress.com/biochemj/article-pdf/177/3/813/571405/bj1770813.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1186445","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1186445","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:444206","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/444206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bj1770813","doi":"https://doi.org/10.1042/bj1770813","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1770813","pdf_url":"https://portlandpress.com/biochemj/article-pdf/177/3/813/571405/bj1770813.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1813899649.pdf","grobid_xml":"https://content.openalex.org/works/W1813899649.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1599125820","https://openalex.org/W1662998834","https://openalex.org/W1775749144","https://openalex.org/W1989675515","https://openalex.org/W2004193635","https://openalex.org/W2033092378","https://openalex.org/W2052322336","https://openalex.org/W2055285732","https://openalex.org/W2083008862","https://openalex.org/W2088916110","https://openalex.org/W2410315225","https://openalex.org/W2418938186","https://openalex.org/W2424719466","https://openalex.org/W2942507508","https://openalex.org/W4232951938"],"related_works":["https://openalex.org/W2061499472","https://openalex.org/W1841308051","https://openalex.org/W2047343661","https://openalex.org/W2076156008","https://openalex.org/W2208575951","https://openalex.org/W7099312154","https://openalex.org/W2319432099","https://openalex.org/W1924487807","https://openalex.org/W2055344388","https://openalex.org/W1976408202"],"abstract_inverted_index":{"Soluble":[0],"lactate":[1,42,61,98],"dehydrogenase":[2,43,62,99],"(EC":[3],"1.1.1.27)":[4],"extracted":[5],"from":[6],"brain,":[7],"skeletal":[8],"and":[9,12,16,20,84,89],"cardiac":[10],"muscle":[11],"liver":[13],"of":[14,53,59,66,76,97,105,116,124,140,148,151],"rats,":[15],"purified":[17],"isoenzymes":[18,118],"LDH-1":[19,38],"LDH-5,":[21],"were":[22],"incubated":[23],"with":[24,102,108],"sodium":[25],"deoxycholate.":[26],"Deoxycholate":[27],"almost":[28],"totally":[29],"inactivated":[30,45],"isoenzyme":[31,37,57],"LDH-5":[32,83],"(A4),":[33],"whereas":[34],"it":[35],"left":[36],"(B4)":[39],"unaffected.":[40],"Tissue":[41],"was":[44,92],"to":[46,68,72],"different":[47],"degrees":[48],"depending":[49],"on":[50],"the":[51,54,64,73,81,85,138,141,146,149],"origin":[52],"enzyme.":[55],"Electrophoretic":[56],"studies":[58],"tissue":[60],"showed":[63],"loss":[65],"activity":[67],"be":[69],"quantitatively":[70],"related":[71],"overall":[74],"percentage":[75],"subunit":[77,95,109,154],"A":[78,96,155],"distributed":[79],"among":[80],"homotetramer":[82],"heterotetramers":[86],"LDH-2,":[87],"LDH-3":[88],"LDH-4.":[90],"It":[91],"concluded":[93],"that":[94,137],"interacts":[100],"selectively":[101],"deoxycholate,":[103],"irrespective":[104],"its":[106],"association":[107],"B.":[110],"Distinct":[111],"changes":[112],"in":[113],"electrophoretic":[114],"mobilities":[115],"deoxycholate-treated":[117],"strongly":[119],"indicated":[120],"an":[121],"indiscriminate":[122],"binding":[123],"deoxycholate":[125,152],"by":[126],"all":[127],"LDH":[128],"isoenzymes,":[129],"probably":[130],"through":[131],"hydrophobic":[132],"interactions.":[133],"The":[134],"results":[135],"suggest":[136],"inactivation":[139],"enzyme":[142],"is":[143,156],"non-competitive,":[144],"but":[145],"basis":[147],"selectivity":[150],"towards":[153],"not":[157],"known":[158],"at":[159],"present.":[160]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}