{"id":"https://openalex.org/W181243635","doi":null,"title":"[99mTc]Human telomerase reverse-transcriptase antisense mRNA oligonucleotide","display_name":"[99mTc]Human telomerase reverse-transcriptase antisense mRNA oligonucleotide","publication_year":2008,"publication_date":"2008-05-27","ids":{"openalex":"https://openalex.org/W181243635","mag":"181243635"},"language":"en","primary_location":{"id":"mag:181243635","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/article/MED/20641541","pdf_url":null,"source":{"id":"https://openalex.org/S4306476456","display_name":"National Center for Biotechnology Information (US) eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"National Center for Biotechnology Information (US) eBooks","raw_type":null},"volume":null,"type":"book","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077155083","display_name":"Arvind Chopra","orcid":"https://orcid.org/0000-0002-4347-9651","observed_orcids":["https://orcid.org/0000-0002-4347-9651"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arvind Chopra","raw_affiliation_strings":["National Center for Biotechnology Information, NLM, NIH, Bethesda, MD 20894,"],"raw_orcid":"https://orcid.org/0000-0002-4347-9651","affiliations":[{"raw_affiliation_string":"National Center for Biotechnology Information, NLM, NIH, Bethesda, MD 20894,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210109390"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077155083"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210109390"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tert","display_name":"telomerase reverse transcriptase","score":0.8529999852180481},{"id":"https://openalex.org/keywords/htert","display_name":"hTERT","score":0.8769999742507935},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.9200000166893005},{"id":"https://openalex.org/keywords/technetium-99m","display_name":"technetium-99m","score":0.9369999766349792},{"id":"https://openalex.org/keywords/radiolabeled-probes","display_name":"radiolabeled probes","score":0.6320000290870667},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.6869999766349792},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.7059999704360962},{"id":"https://openalex.org/keywords/cancer-detection","display_name":"cancer detection","score":0.414000004529953},{"id":"https://openalex.org/keywords/gene-expression-imaging","display_name":"gene expression imaging","score":0.5400000214576721},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.328000009059906},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.5649999976158142},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.35100001096725464},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.5149999856948853},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.9636257290840149},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.912975549697876},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.8765468597412109},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5907990336418152},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5259033441543579},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5231714844703674},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5062405467033386},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.5016288757324219},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4265229105949402},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.4165579080581665},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3547176718711853},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.35001206398010254},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3317387104034424},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20955383777618408},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1952621042728424},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1661236584186554}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:181243635","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/article/MED/20641541","pdf_url":null,"source":{"id":"https://openalex.org/S4306476456","display_name":"National Center for Biotechnology Information (US) eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"National Center for Biotechnology Information (US) eBooks","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W2007128892","https://openalex.org/W2012002712","https://openalex.org/W2025843494","https://openalex.org/W2078805336","https://openalex.org/W2107665433","https://openalex.org/W2119507443","https://openalex.org/W2122841130","https://openalex.org/W2130126531","https://openalex.org/W2136303436","https://openalex.org/W2145859123","https://openalex.org/W2148417602"],"related_works":["https://openalex.org/W2020016778","https://openalex.org/W2490200714","https://openalex.org/W2070094741","https://openalex.org/W2160461039","https://openalex.org/W7144090159","https://openalex.org/W2100215079","https://openalex.org/W4285232857","https://openalex.org/W2128598406","https://openalex.org/W2351061299","https://openalex.org/W2353433507"],"abstract_inverted_index":{"Telomerase":[0],"is":[1,18,76,91,98,162,215,237],"an":[2,99,331],"enzyme":[3,75],"that":[4,94,178,304,313,325],"synthesizes":[5],"telomeric":[6],"DNA":[7],"at":[8],"the":[9,21,24,33,39,45,82,102,132,158,180,191,200,204,209,238,241,278,298,302,306,310,316,338,346,365,375],"terminal":[10,41],"end":[11,42],"of":[12,20,26,38,49,73,81,104,134,157,199,243,281,301,318,340,342,349,353,371],"a":[13,54,95,105,183,234,319,343],"chromosome,":[14],"and":[15,57,70,89,127,160,176,195,208,224,248,273,369,378],"its":[16,249],"activation":[17],"one":[19,80],"mechanisms":[22,83],"for":[23,84,101,131,164,173,185,240,357],"progression":[25,166],"cancer":[27,106,124,186],"(1).":[28,212],"Telomerase,":[29],"in":[30,53,87,112,122,221,225,283,315,333,366,384],"conjunction":[31],"with":[32,287,380],"telomere-binding":[34],"proteins,":[35],"maintains":[36],"stability":[37],"chromosomal":[40],"by":[43,190],"replicating":[44],"DNA,":[46],"but":[47],"inhibition":[48],"this":[50,74],"activity":[51,219,368],"results":[52,289],"shortened":[55,96],"telomere":[56,97,159],"ultimately":[58],"leads":[59],"to":[60,78,144,147,151,276,336,359],"replicative":[61],"senescence":[62],"or":[63,107],"even":[64],"cell":[65,125,285,311],"death":[66],"(2).":[67,138,167],"The":[68,362],"repression":[69],"close":[71],"regulation":[72],"considered":[77],"be":[79,330],"tumor":[85,165,229,350],"suppression":[86],"humans,":[88],"there":[90],"much":[92],"evidence":[93],"indication":[100],"development":[103,133,242,317,351],"other":[108,152],"degenerative":[109],"disease,":[110],"especially":[111],"older":[113],"individuals":[114],"(3-6).":[115],"In":[116],"addition,":[117],"telomerases":[118,181],"are":[119,129,141],"specifically":[120],"expressed":[121,216],"most":[123],"types":[126,286],"therefore":[128],"targets":[130],"many":[135,244],"anticancer":[136,153,245],"drugs":[137,149],"Also,":[139],"tumors":[140],"less":[142],"likely":[143],"develop":[145],"resistance":[146],"anti-telomerase":[148],"compared":[150],"treatments":[154],"because":[155,352],"maintenance":[156],"immortality":[161],"crucial":[163],"Several":[168],"clinical":[170],"trials":[171],"drugs,":[174],"vaccines,":[175],"antibodies":[177],"target":[179,239],"as":[182,264],"treatment":[184],"have":[187,253,258],"been":[188],"approved":[189],"United":[192],"States":[193],"Food":[194],"Drug":[196],"Administration.Telomerase":[197],"consists":[198],"telomerase":[201,205,218],"RNA":[202],"(hTR),":[203],"reverse-transcriptase":[206],"(hTERT),":[207],"associated":[210],"proteins":[211],"Although":[213],"hTR":[214],"without":[217],"both":[220],"normal":[222],"cells":[223,230],"malignant":[226],"cells,":[227],"only":[228,260],"express":[231],"hTERT.":[232],"As":[233],"consequence,":[235],"hTERT":[236,282,376],"therapies":[246],"(7),":[247],"expression":[250,279,341],"levels":[251,280],"may":[252,294],"prognostic":[254],"value":[255],"(8).":[256],"Investigators":[257],"used":[259],"indirect":[261],"methods":[262],"such":[263],"immunohistochemistry,":[265],"reverse-transcription":[266],"polymerase":[267],"chain":[268],"reaction":[269],"(RT-PCR),":[270],"fluorescence,":[271],"bioluminescence,":[272],"radionuclide":[274],"imaging":[275],"determine":[277,337],"various":[284],"reasonable":[288],"(9,":[290],"10).":[291],"This":[292],"approach":[293],"not,":[295],"however,":[296],"yield":[297],"exact":[299],"nature":[300],"change(s)":[303],"alter":[305],"genotype":[307],"and,":[308],"ultimately,":[309],"phenotype":[312],"result":[314],"cancer.":[320],"Liu":[321],"et":[322],"al.":[323],"envisioned":[324],"antisense":[326],"oligonucleotides":[327],"(ASON)":[328],"would":[329],"excellent":[332],"vivo":[334],"tool":[335],"level":[339],"gene":[344,377],"during":[345],"early":[347],"stages":[348],"their":[354],"high":[355],"specificity":[356],"binding":[358],"nucleotides":[360],"(11).":[361],"authors":[363],"investigated":[364],"vitro":[367],"biodistribution":[370],"ASON":[372],"directed":[373],"toward":[374],"labeled":[379],"radioactive":[381],"technetium":[382],"(99mTc)":[383],"mice":[385],"bearing":[386],"xenograft":[387],"tumors.":[388]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
