{"id":"https://openalex.org/W1811240141","doi":null,"title":"beta PP and Tau interaction. A possible link between amyloid and neurofibrillary tangles in Alzheimer's disease.","display_name":"beta PP and Tau interaction. A possible link between amyloid and neurofibrillary tangles in Alzheimer's disease.","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W1811240141","mag":"1811240141","pmid":"https://pubmed.ncbi.nlm.nih.gov/8546229","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861592"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1544453","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861592","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861592","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025292977","display_name":"Giorgio Giaccone","orcid":"https://orcid.org/0000-0002-4803-0802","observed_orcids":["https://orcid.org/0000-0002-4803-0802"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Giaccone","raw_affiliation_strings":["Divisione di Neuropatologia, Istituto Nazionale Neurologico Carlo Besta, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisione di Neuropatologia, Istituto Nazionale Neurologico Carlo Besta, Milano, Italy","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053183271","display_name":"Barbara Pedrotti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Pedrotti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080009873","display_name":"Antonio Migheli","orcid":"https://orcid.org/0000-0001-5986-4872","observed_orcids":["https://orcid.org/0000-0001-5986-4872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Migheli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"L Verga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Verga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J Perez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Perez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040561724","display_name":"Giorgio Racagni","orcid":"https://orcid.org/0000-0002-9396-4647","observed_orcids":["https://orcid.org/0000-0002-9396-4647"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Racagni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021420538","display_name":"Mark A. Smith","orcid":"https://orcid.org/0000-0003-1474-5225","observed_orcids":["https://orcid.org/0000-0003-1474-5225"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075477128","display_name":"George L. Perry","orcid":"https://orcid.org/0000-0002-6547-0172","observed_orcids":["https://orcid.org/0000-0002-6547-0172"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Perry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062442747","display_name":"Luca DE GIOIA","orcid":"https://orcid.org/0000-0003-2873-3663","observed_orcids":["https://orcid.org/0000-0003-2873-3663"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L De Gioia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058605401","display_name":"Carlo Selvaggini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Selvaggini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020722865","display_name":"Mario Salmona","orcid":"https://orcid.org/0000-0002-9098-9873","observed_orcids":["https://orcid.org/0000-0002-9098-9873"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Salmona","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081547926","display_name":"Jorge A. Ghiso","orcid":"https://orcid.org/0000-0002-0870-0437","observed_orcids":["https://orcid.org/0000-0002-0870-0437"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Ghiso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041419276","display_name":"Blas Frangione","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Frangione","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039200436","display_name":"Khalid Islam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Islam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040498388","display_name":"Orso Bugiani","orcid":"https://orcid.org/0000-0002-0999-4756","observed_orcids":["https://orcid.org/0000-0002-0999-4756"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Bugiani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004166000","display_name":"Fabrizio Tagliavini","orcid":"https://orcid.org/0000-0003-1039-7315","observed_orcids":["https://orcid.org/0000-0003-1039-7315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Tagliavini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6262,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.83110596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"148","issue":"1","first_page":"79","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.9120000004768372},{"id":"https://openalex.org/keywords/paired-helical-filaments","display_name":"paired helical filaments","score":0.9539999961853027},{"id":"https://openalex.org/keywords/amyloid-fibrils","display_name":"amyloid fibrils","score":0.9020000100135803},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.9419999718666077},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8479999899864197},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"transmembrane domain","score":0.6539999842643738},{"id":"https://openalex.org/keywords/antibody-epitopes","display_name":"antibody epitopes","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.639281153678894},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.6112188100814819},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.6095216274261475},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5946632027626038},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.5685676336288452},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5654444694519043},{"id":"https://openalex.org/C177907266","wikidata":"https://www.wikidata.org/wiki/Q17155455","display_name":"P3 peptide","level":5,"score":0.5492045283317566},{"id":"https://openalex.org/C2779721402","wikidata":"https://www.wikidata.org/wiki/Q767442","display_name":"Neurofibrillary tangle","level":5,"score":0.5074254870414734},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.49046894907951355},{"id":"https://openalex.org/C180081513","wikidata":"https://www.wikidata.org/wiki/Q4914721","display_name":"Biochemistry of Alzheimer's disease","level":5,"score":0.489895761013031},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4638208746910095},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.436281681060791},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42977991700172424},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.4159352481365204},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33288538455963135},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.30396339297294617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2907037138938904},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2568001449108124},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15584349632263184},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12449389696121216},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11929970979690552},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1076490581035614},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016253","descriptor_name":"Microscopy, Immunoelectron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1544453","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861592","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:8546229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8546229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1861592","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1861592/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"mag:1811240141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8546229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1544453","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861592","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4260073904","display_name":"AMYLOID ANGIOPATHY, EARLY PLAQUES &AGING","funder_award_id":"R01AG008721","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W137525261","https://openalex.org/W1484194388","https://openalex.org/W1521446312","https://openalex.org/W1584916210","https://openalex.org/W1758831574","https://openalex.org/W1791072074","https://openalex.org/W1966614543","https://openalex.org/W1973774127","https://openalex.org/W1977177481","https://openalex.org/W1980906872","https://openalex.org/W1984266565","https://openalex.org/W1986394856","https://openalex.org/W1989657037","https://openalex.org/W1991192790","https://openalex.org/W1991435932","https://openalex.org/W1995305819","https://openalex.org/W1995515835","https://openalex.org/W1996917933","https://openalex.org/W1997020728","https://openalex.org/W2003313975","https://openalex.org/W2003518588","https://openalex.org/W2013833879","https://openalex.org/W2018908557","https://openalex.org/W2022446410","https://openalex.org/W2032920422","https://openalex.org/W2036755018","https://openalex.org/W2038682806","https://openalex.org/W2046847750","https://openalex.org/W2048253888","https://openalex.org/W2060204934","https://openalex.org/W2064093411","https://openalex.org/W2065235688","https://openalex.org/W2069682857","https://openalex.org/W2072340217","https://openalex.org/W2078658743","https://openalex.org/W2081881251","https://openalex.org/W2082429191","https://openalex.org/W2089331767","https://openalex.org/W2090150925","https://openalex.org/W2141133962","https://openalex.org/W2141839336"],"related_works":["https://openalex.org/W1953476109","https://openalex.org/W2003873096","https://openalex.org/W1991192790","https://openalex.org/W2003518588","https://openalex.org/W1996917933","https://openalex.org/W2032355088","https://openalex.org/W2141133962","https://openalex.org/W2058592144","https://openalex.org/W1000345611","https://openalex.org/W1983955783"],"abstract_inverted_index":{"Extracellular":[0],"deposition":[1],"of":[2,8,17,23,51,67,88,95,108,124,143,172],"amyloid":[3,24],"fibrils":[4,25,136],"and":[5,86],"intraneuronal":[6],"accumulation":[7],"paired":[9],"helical":[10],"filaments":[11],"(PHFs)":[12],"are":[13,167],"the":[14,57,92,106,141,163,170],"neuropathological":[15],"hallmarks":[16],"Alzheimer's":[18,175],"disease.":[19,176],"The":[20,48],"major":[21],"constituent":[22],"is":[26,36,56,63],"a":[27,39,116],"39-":[28],"to":[29,41,79,99,119,122],"43-residue":[30],"peptide":[31,117,133],"(termed":[32,45],"A":[33,100],"beta),":[34],"which":[35],"derived":[37],"from":[38],"695-":[40],"770-amino-acid":[42],"precursor":[43],"protein":[44,59],"beta":[46,89,96,125,131,156,159],"PP).":[47],"main":[49],"component":[50],"PHFs":[52,104,173],"identified":[53],"so":[54],"far":[55],"microtubule-associated":[58],"tau.":[60],"Yet,":[61],"there":[62],"no":[64],"direct":[65],"evidence":[66],"interconnection":[68],"between":[69,83],"these":[70],"two":[71],"pathological":[72],"states.":[73],"We":[74],"report":[75],"here":[76],"that":[77,115,155],"antibodies":[78],"an":[80],"epitope":[81],"located":[82],"residues":[84,120],"713":[85,121],"723":[87],"PP770":[90,126],"(ie,":[91],"transmembrane":[93],"region":[94],"PP":[97,132,157,160],"distal":[98],"beta)":[101],"consistently":[102],"labeled":[103],"in":[105,137,140,169,174],"brain":[107],"Alzheimer":[109],"patients.":[110],"Solid":[111],"phase":[112],"immunoassay":[113],"showed":[114],"homologous":[118],"730":[123],"bound":[127],"tau":[128,164],"proteins.":[129],"This":[130],"spontaneously":[134],"formed":[135],"vitro":[138],"and,":[139],"presence":[142],"tau,":[144],"generated":[145],"dense":[146],"fibrillary":[147],"assemblies":[148],"containing":[149,162],"both":[150],"molecules.":[151],"These":[152],"data":[153],"suggest":[154],"or":[158],"fragments":[161],"binding":[165],"site":[166],"involved":[168],"pathogenesis":[171]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
