{"id":"https://openalex.org/W180920641","doi":null,"title":"Health-related quality of life of patients receiving extended-release tolterodine for overactive bladder.","display_name":"Health-related quality of life of patients receiving extended-release tolterodine for overactive bladder.","publication_year":2002,"publication_date":"2002-12-01","ids":{"openalex":"https://openalex.org/W180920641","mag":"180920641","pmid":"https://pubmed.ncbi.nlm.nih.gov/12516955"},"language":"en","primary_location":{"id":"pmid:12516955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12516955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of managed care","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090695716","display_name":"Con J. Kelleher","orcid":"https://orcid.org/0009-0002-9065-6208","observed_orcids":["https://orcid.org/0009-0002-9065-6208"]},"institutions":[{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Con J Kelleher","raw_affiliation_strings":["Guy's and St Thomas' NHS Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guy's and St Thomas' NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067271647","display_name":"Karl J. Kreder","orcid":"https://orcid.org/0000-0002-8981-5286","observed_orcids":["https://orcid.org/0000-0002-8981-5286"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karl J Kreder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054448346","display_name":"Andreas M. Pleil","orcid":"https://orcid.org/0000-0003-2322-9329","observed_orcids":["https://orcid.org/0000-0003-2322-9329"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas M Pleil","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045140420","display_name":"Somali Misra Burgess","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Somali Misra Burgess","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035806447","display_name":"Pat Ray Reese","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pat Ray Reese","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.3425,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.94282497,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"19 Suppl","first_page":"S608","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10418","display_name":"Pelvic floor disorders treatments","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/overactive-bladder","display_name":"overactive bladder","score":0.890999972820282},{"id":"https://openalex.org/keywords/tolterodine-extended-release","display_name":"tolterodine extended release","score":0.9570000171661377},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.9940000176429749},{"id":"https://openalex.org/keywords/king-s-health-questionnaire","display_name":"King's Health Questionnaire","score":0.8569999933242798},{"id":"https://openalex.org/keywords/sf-36","display_name":"SF-36","score":0.9160000085830688},{"id":"https://openalex.org/keywords/urinary-incontinence","display_name":"urinary incontinence","score":0.8600000143051147},{"id":"https://openalex.org/keywords/urinary-frequency","display_name":"urinary frequency","score":0.8259999752044678},{"id":"https://openalex.org/keywords/anticholinergic-therapy","display_name":"anticholinergic therapy","score":0.7440000176429749},{"id":"https://openalex.org/keywords/bladder-control","display_name":"bladder control","score":0.5270000100135803},{"id":"https://openalex.org/keywords/role-limitations","display_name":"role limitations","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C2781020410","wikidata":"https://www.wikidata.org/wiki/Q424312","display_name":"Tolterodine","level":4,"score":0.9754958152770996},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9067544937133789},{"id":"https://openalex.org/C2778941218","wikidata":"https://www.wikidata.org/wiki/Q331231","display_name":"Overactive bladder","level":3,"score":0.8482099771499634},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.6470323801040649},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.589333713054657},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5288040637969971},{"id":"https://openalex.org/C2778531004","wikidata":"https://www.wikidata.org/wiki/Q281490","display_name":"Urinary incontinence","level":2,"score":0.4938269555568695},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.44116532802581787},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.44098711013793945},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3689606189727783},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3429911136627197},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.08021911978721619},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.07296878099441528},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068737","descriptor_name":"Tolterodine Tartrate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001315","descriptor_name":"Australia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001559","descriptor_name":"Benzhydryl Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001559","descriptor_name":"Benzhydryl Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001745","descriptor_name":"Urinary Bladder Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001745","descriptor_name":"Urinary Bladder Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003408","descriptor_name":"Cresols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003408","descriptor_name":"Cresols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005060","descriptor_name":"Europe","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006302","descriptor_name":"Health Services Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009520","descriptor_name":"New Zealand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010665","descriptor_name":"Phenylpropanolamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012426","descriptor_name":"Russia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014555","descriptor_name":"Urination Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014555","descriptor_name":"Urination Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018727","descriptor_name":"Muscarinic Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018727","descriptor_name":"Muscarinic Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:12516955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12516955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of managed care","raw_type":"Clinical Trial"},{"id":"pmid:12516956","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12516956","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of managed care","raw_type":"Clinical Trial"},{"id":"mag:180920641","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12516956","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W112952723","https://openalex.org/W281674839","https://openalex.org/W614531583","https://openalex.org/W1267586634","https://openalex.org/W1493773294","https://openalex.org/W1590256680","https://openalex.org/W1603091860","https://openalex.org/W1603915265","https://openalex.org/W1836884707","https://openalex.org/W1965263807","https://openalex.org/W1970559779","https://openalex.org/W1970894908","https://openalex.org/W1971653502","https://openalex.org/W1982589773","https://openalex.org/W1986143238","https://openalex.org/W1987549100","https://openalex.org/W1998270091","https://openalex.org/W2004944131","https://openalex.org/W2023110392","https://openalex.org/W2023402912","https://openalex.org/W2026599479","https://openalex.org/W2030038103","https://openalex.org/W2039558180","https://openalex.org/W2043328831","https://openalex.org/W2055768795","https://openalex.org/W2056166146","https://openalex.org/W2062919742","https://openalex.org/W2066288167","https://openalex.org/W2068456101","https://openalex.org/W2071925544","https://openalex.org/W2074323366","https://openalex.org/W2082587373","https://openalex.org/W2086099172","https://openalex.org/W2088252790","https://openalex.org/W2088679190","https://openalex.org/W2089375870","https://openalex.org/W2091636139","https://openalex.org/W2096317263","https://openalex.org/W2152791010","https://openalex.org/W2156000474","https://openalex.org/W2323242870","https://openalex.org/W4298202246"],"related_works":["https://openalex.org/W2096317263","https://openalex.org/W2107821510","https://openalex.org/W1975761784","https://openalex.org/W2081888020","https://openalex.org/W2160686867","https://openalex.org/W2044472572","https://openalex.org/W1867893402","https://openalex.org/W2125328880","https://openalex.org/W2156991300","https://openalex.org/W2134380415"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"compare":[2],"the":[3,97,124,211,224,234],"health-related":[4],"quality":[5],"of":[6,9,60,126,131,206,216,229],"life":[7],"(HRQoL)":[8],"overactive":[10],"bladder":[11,115,207],"(OAB)":[12],"patients":[13],"foilowing":[14],"treatment":[15,187,219,241],"with":[16,36,77,155,188,210,242,250,267],"tolterodine":[17,78,156,189,192,243,256],"extended-release":[18],"(ER)":[19],"4":[20],"mg":[21],"once":[22],"daily":[23],"versus":[24],"placebo.":[25],"STUDY":[26],"DESIGN:":[27],"Multinational,":[28],"placebo-controlled,":[29],"randomized,":[30],"double-blind":[31],"12-week":[32],"study.":[33],"POPULATION:":[34],"Patients":[35,71,111,254],"urinary":[37],"frequency":[38],"(":[39,52],">":[40,53],"or":[41,54,83,152,183],"=":[42,55,81,86,153,184],"8":[43],"micturitions/24":[44],"hours":[45],"over":[46],"a":[47,136,160],"7-day":[48],"period),":[49],"urge":[50],"incontinence":[51],"5":[56],"episodes/week),":[57],"and":[58,102,122,145,169,174,199],"symptoms":[59],"OAB":[61],"for":[62,69,88],"at":[63,120,123,214],"least":[64],"6":[65],"months":[66],"were":[67,118,177,221,248],"eligible":[68],"inclusion.":[70],"(81%":[72],"female)":[73],"received":[74],"oral":[75],"therapy":[76],"ER":[79,193,257],"(n":[80,85],"507)":[82],"placebo":[84,212],"508)":[87],"12":[89],"weeks.":[90],"OUTCOMES":[91],"MEASURED:":[92],"HRQoL":[93,140,246],"was":[94,265],"assessed":[95],"using":[96,223],"King's":[98],"Health":[99],"Questionnaire":[100],"(KHQ)":[101],"Medical":[103],"Outcomes":[104],"Study":[105],"Short":[106],"Form":[107],"36-item":[108],"questionnaire":[109],"(SF-36).":[110],"also":[112,178],"rated":[113],"their":[114,262,272],"condition.":[116],"Assessments":[117],"performed":[119],"baseline":[121],"end":[125,130,141,164,215],"treatment.":[127,217],"RESULTS:":[128],"At":[129],"treatment,":[132],"KHQ":[133],"domains":[134],"selected":[135,159],"priori":[137,161],"as":[138,162,231],"primary":[139],"points":[142,165],"(incontinence":[143],"impact":[144,270],"role":[146],"limitations)":[147],"significantly":[148,179],"improved":[149,180],"(P":[150,181],"<":[151,182],".001)":[154],"ER.":[157,190,244],"Domains":[158],"secondary":[163],"(physical":[166],"limitations,":[167],"sleep":[168],"energy,":[170],"severity":[171,198],"[coping]":[172],"measures,":[173],"symptom":[175,197],"severity)":[176],".006)":[185],"following":[186,240],"The":[191],"group":[194,213],"had":[195],"decreased":[196],"statistically":[200,237],"significant":[201,238],"improvements":[202,247],"in":[203,261],"patient":[204],"rating":[205],"control":[208],"compared":[209],"No":[218],"differences":[220],"detected":[222],"SF-36.":[225],"CONCLUSION:":[226],"Many":[227],"aspects":[228],"HRQoL,":[230],"measured":[232],"by":[233],"KHQ,":[235],"showed":[236],"improvement":[239,260],"These":[245],"consistent":[249],"clinical":[251],"efficacy":[252],"benefits.":[253],"receiving":[255],"experienced":[258],"overall":[259],"condition":[263],"that":[264],"associated":[266],"an":[268],"important":[269],"on":[271],"HRQoL.":[273]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}