{"id":"https://openalex.org/W1809052990","doi":"https://doi.org/10.1002/nbm.3240","title":"Lonidamine induces intracellular tumor acidification and ATP depletion in breast, prostate and ovarian cancer xenografts and potentiates response to doxorubicin","display_name":"Lonidamine induces intracellular tumor acidification and ATP depletion in breast, prostate and ovarian cancer xenografts and potentiates response to doxorubicin","publication_year":2014,"publication_date":"2014-12-12","ids":{"openalex":"https://openalex.org/W1809052990","doi":"https://doi.org/10.1002/nbm.3240","mag":"1809052990","pmid":"https://pubmed.ncbi.nlm.nih.gov/25504852","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4361034"},"language":"en","primary_location":{"id":"doi:10.1002/nbm.3240","doi":"https://doi.org/10.1002/nbm.3240","is_oa":false,"landing_page_url":"https://doi.org/10.1002/nbm.3240","pdf_url":null,"source":{"id":"https://openalex.org/S45012897","display_name":"NMR in Biomedicine","issn_l":"0952-3480","issn":["0952-3480","1099-1492"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NMR in Biomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4361034","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067359942","display_name":"Kavindra Nath","orcid":"https://orcid.org/0000-0002-3197-5703","observed_orcids":["https://orcid.org/0000-0002-3197-5703"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kavindra Nath","raw_affiliation_strings":["Laboratory of Molecular Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072959814","display_name":"DAVID S. NELSON","orcid":"https://orcid.org/0009-0008-5993-8710","observed_orcids":["https://orcid.org/0009-0008-5993-8710"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Nelson","raw_affiliation_strings":["Laboratory of Molecular Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026614969","display_name":"Daniel F. Heitjan","orcid":"https://orcid.org/0000-0002-1527-4472","observed_orcids":["https://orcid.org/0000-0002-1527-4472"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel F. Heitjan","raw_affiliation_strings":["Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111593529","display_name":"Dennis B. Leeper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis B. Leeper","raw_affiliation_strings":["Department of Radiation Oncology; Thomas Jefferson University School of Medicine; Philadelphia PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology; Thomas Jefferson University School of Medicine; Philadelphia PA USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069305433","display_name":"Rong Zhou","orcid":"https://orcid.org/0000-0003-4018-381X","observed_orcids":["https://orcid.org/0000-0003-4018-381X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Zhou","raw_affiliation_strings":["Laboratory of Molecular Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108442630","display_name":"Jerry D. Glickson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry D. Glickson","raw_affiliation_strings":["Laboratory of Molecular Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067359942"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":3640,"currency":"USD","value_usd":3640},"apc_paid":null,"fwci":1.9697,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.84789659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"28","issue":"3","first_page":"281","last_page":"290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.059700001031160355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.025100000202655792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lonidamine","display_name":"lonidamine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/atp-depletion","display_name":"ATP depletion","score":0.8220000267028809},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.5709999799728394},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9369999766349792},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.7059999704360962},{"id":"https://openalex.org/keywords/tumor-ph","display_name":"tumor pH","score":0.5220000147819519},{"id":"https://openalex.org/keywords/nucleoside-triphosphates","display_name":"nucleoside triphosphates","score":0.8059999942779541},{"id":"https://openalex.org/keywords/inorganic-phosphate","display_name":"inorganic phosphate","score":0.675000011920929},{"id":"https://openalex.org/keywords/multimodal-cancer-treatment","display_name":"multimodal cancer therapy","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.860759973526001},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6437375545501709},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5683601498603821},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.495578408241272},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4800197184085846},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4456612467765808},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4012776017189026},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.35240548849105835},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32592102885246277},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3040178418159485}],"mesh":[{"descriptor_ui":"D000099233","descriptor_name":"Monocarboxylate Transport Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000143","descriptor_name":"Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007191","descriptor_name":"Indazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D027501","descriptor_name":"Monocarboxylic Acid Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027981","descriptor_name":"Symporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/nbm.3240","doi":"https://doi.org/10.1002/nbm.3240","is_oa":false,"landing_page_url":"https://doi.org/10.1002/nbm.3240","pdf_url":null,"source":{"id":"https://openalex.org/S45012897","display_name":"NMR in Biomedicine","issn_l":"0952-3480","issn":["0952-3480","1099-1492"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NMR in Biomedicine","raw_type":"journal-article"},{"id":"pmid:25504852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25504852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NMR in biomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4361034","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4361034","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"NMR Biomed","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4361034","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4361034","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"NMR Biomed","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6107618112","display_name":"Systemic Chemotherapy of Melanoma: NMR Studies of Lonidamine & N-Mustard Activity","funder_award_id":"R01CA129544","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7338439814","display_name":"Mechanism of Activity of Lonidamine","funder_award_id":"R01CA172820","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W79564126","https://openalex.org/W1538136353","https://openalex.org/W1541456484","https://openalex.org/W1547870600","https://openalex.org/W1574382468","https://openalex.org/W1582806874","https://openalex.org/W1591823312","https://openalex.org/W1596511424","https://openalex.org/W1966372709","https://openalex.org/W1969586509","https://openalex.org/W1984081057","https://openalex.org/W1996954612","https://openalex.org/W2003597150","https://openalex.org/W2004630726","https://openalex.org/W2006350488","https://openalex.org/W2009429164","https://openalex.org/W2010790253","https://openalex.org/W2011877623","https://openalex.org/W2012878757","https://openalex.org/W2020439084","https://openalex.org/W2028831882","https://openalex.org/W2030418886","https://openalex.org/W2046292319","https://openalex.org/W2049683923","https://openalex.org/W2058498380","https://openalex.org/W2066693212","https://openalex.org/W2070806047","https://openalex.org/W2074411972","https://openalex.org/W2081349330","https://openalex.org/W2083488730","https://openalex.org/W2084445393","https://openalex.org/W2086546470","https://openalex.org/W2089410394","https://openalex.org/W2102839148","https://openalex.org/W2108168247","https://openalex.org/W2112688502","https://openalex.org/W2116669615","https://openalex.org/W2125245203","https://openalex.org/W2130746306","https://openalex.org/W2131887263","https://openalex.org/W2141628882","https://openalex.org/W2148812205","https://openalex.org/W2161372685","https://openalex.org/W2167883934","https://openalex.org/W2255521357","https://openalex.org/W2260594589","https://openalex.org/W2412964568"],"related_works":["https://openalex.org/W2418557710","https://openalex.org/W2893074769","https://openalex.org/W2006350488","https://openalex.org/W7074001412","https://openalex.org/W2049683923","https://openalex.org/W1596511424","https://openalex.org/W2048746306","https://openalex.org/W2023169708","https://openalex.org/W2229497644","https://openalex.org/W1978249092"],"abstract_inverted_index":{"We":[0,75,107],"demonstrate":[1],"that":[2,79,186],"the":[3,167,174,236],"effects":[4],"of":[5,16,19,41,86,159,166,177,182,213,243,246,249],"lonidamine":[6],"(LND,":[7],"100":[8],"mg/kg,":[9,93,133],"i.p.)":[10],"are":[11],"similar":[12],"for":[13],"a":[14,45,51,57,71,146,195,210,244],"number":[15,245],"xenograft":[17],"models":[18],"human":[20,183,250],"cancer":[21,184],"including":[22],"DB-1":[23,113,129],"melanoma":[24,88,114,130,178],"and":[25,32,64,115,136,144,179,218,225,238],"HCC1806":[26,116,151],"breast,":[27,29],"BT-474":[28],"LNCaP":[30],"prostate":[31],"A2870":[33],"ovarian":[34],"carcinomas.":[35],"Following":[36],"treatment":[37,176],"with":[38,173],"LND,":[39],"each":[40],"these":[42,187],"tumors":[43],"exhibits":[44],"rapid":[46],"decrease":[47,53,60],"in":[48,54,61,67,111,128,150,235],"intracellular":[49,81],"pH,":[50,56],"small":[52],"extracellular":[55],"concomitant":[58],"monotonic":[59],"nucleoside":[62],"triphosphate":[63],"an":[65,96,231],"increase":[66],"inorganic":[68],"phosphate":[69],"over":[70],"2-3":[72],"h":[73],"period.":[74],"have":[76],"previously":[77],"demonstrated":[78],"selective":[80],"tumor":[82,103,214,223],"acidification":[83],"potentiates":[84,120],"response":[85,121,215],"this":[87],"model":[89],"to":[90,122,216,229],"melphalan":[91],"(7.5":[92],"i.v.),":[94],"producing":[95,124,145],"estimated":[97],"89%":[98],"cell":[99,126,138,148],"kill":[100,127,139,149],"based":[101],"on":[102],"growth":[104],"delay":[105],"analysis.":[106],"now":[108],"show":[109],"that,":[110],"both":[112],"breast":[117,152],"carcinoma,":[118],"LND":[119,227],"doxorubicin,":[123,143],"95%":[125,147],"at":[131,140,154],"7.5":[132],"i.v.":[134],"doxorubicin":[135,160],"98%":[137],"10.0":[141],"mg/kg":[142,156],"carcinoma":[153],"12.0":[155],"doxorubicin.":[157],"Potentiation":[158],"may":[161],"result":[162],"from":[163],"cation":[164],"trapping":[165],"weakly":[168],"basic":[169],"anthracycline.":[170],"Recent":[171],"experience":[172],"clinical":[175,233],"other":[180,199],"forms":[181,248],"suggests":[185],"diseases":[188],"will":[189,206],"probably":[190],"not":[191],"be":[192,207],"cured":[193],"by":[194],"single":[196],"therapeutic":[197,204],"procedure":[198],"than":[200],"surgery.":[201],"A":[202],"multimodality":[203],"approach":[205],"required.":[208],"As":[209],"potent":[211],"modulator":[212],"N-mustards":[217],"anthracyclines":[219],"as":[220,222],"well":[221],"thermo-":[224],"radiosensitivity,":[226],"promises":[228],"play":[230],"important":[232],"role":[234],"management":[237],"possible":[239],"complete":[240],"local":[241],"control":[242],"prevalent":[247],"cancer.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
