{"id":"https://openalex.org/W1807960484","doi":"https://doi.org/10.1371/journal.pone.0133869","title":"A Global Perspective on Pyrazinamide Resistance: Systematic Review and Meta-Analysis","display_name":"A Global Perspective on Pyrazinamide Resistance: Systematic Review and Meta-Analysis","publication_year":2015,"publication_date":"2015-07-28","ids":{"openalex":"https://openalex.org/W1807960484","doi":"https://doi.org/10.1371/journal.pone.0133869","mag":"1807960484","pmid":"https://pubmed.ncbi.nlm.nih.gov/26218737","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4517823"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0133869","doi":"https://doi.org/10.1371/journal.pone.0133869","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0133869","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0133869&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0133869&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078238023","display_name":"Michael Gordon Whitfield","orcid":"https://orcid.org/0000-0002-5956-8384","observed_orcids":["https://orcid.org/0000-0002-5956-8384"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Michael G. Whitfield","raw_affiliation_strings":["SA MRC Centre for TB Research, Stellenbosch University, South Africa; DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa; Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa; Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa","Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa","Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","SA MRC Centre for TB Research, Stellenbosch University, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SA MRC Centre for TB Research, Stellenbosch University, South Africa; DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa; Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa; Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"SA MRC Centre for TB Research, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052463521","display_name":"Heidi M. Soeters","orcid":"https://orcid.org/0000-0002-9415-9340","observed_orcids":["https://orcid.org/0000-0002-9415-9340"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heidi M. Soeters","raw_affiliation_strings":["Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021801489","display_name":"Robin M. Warren","orcid":"https://orcid.org/0000-0001-5741-7358","observed_orcids":["https://orcid.org/0000-0001-5741-7358"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Robin M. Warren","raw_affiliation_strings":["SA MRC Centre for TB Research, Stellenbosch University, South Africa; DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa; Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa; Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa","Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa","Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","SA MRC Centre for TB Research, Stellenbosch University, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SA MRC Centre for TB Research, Stellenbosch University, South Africa; DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa; Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa; Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"SA MRC Centre for TB Research, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027525644","display_name":"Talita York","orcid":"https://orcid.org/0000-0003-2884-3010","observed_orcids":["https://orcid.org/0000-0003-2884-3010"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Talita York","raw_affiliation_strings":["SA MRC Centre for TB Research, Stellenbosch University, South Africa; DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa; Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa; Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa","Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa","Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","SA MRC Centre for TB Research, Stellenbosch University, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SA MRC Centre for TB Research, Stellenbosch University, South Africa; DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa; Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa; Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"SA MRC Centre for TB Research, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018951921","display_name":"Samantha Leigh Sampson","orcid":"https://orcid.org/0000-0002-9596-8019","observed_orcids":["https://orcid.org/0000-0002-9596-8019"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Samantha L. Sampson","raw_affiliation_strings":["SA MRC Centre for TB Research, Stellenbosch University, South Africa; DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa; Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa; Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa","Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa","Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","SA MRC Centre for TB Research, Stellenbosch University, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SA MRC Centre for TB Research, Stellenbosch University, South Africa; DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa; Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa; Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"SA MRC Centre for TB Research, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062490980","display_name":"Elizabeth Maria Streicher","orcid":"https://orcid.org/0000-0003-3901-1981","observed_orcids":["https://orcid.org/0000-0003-3901-1981"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Elizabeth M. Streicher","raw_affiliation_strings":["SA MRC Centre for TB Research, Stellenbosch University, South Africa; DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa; Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa; Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa","Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa","Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","SA MRC Centre for TB Research, Stellenbosch University, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SA MRC Centre for TB Research, Stellenbosch University, South Africa; DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa; Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa; Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"SA MRC Centre for TB Research, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026225819","display_name":"Paul D. van Helden","orcid":"https://orcid.org/0000-0002-1557-2496","observed_orcids":["https://orcid.org/0000-0002-1557-2496"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Paul D. van Helden","raw_affiliation_strings":["SA MRC Centre for TB Research, Stellenbosch University, South Africa; DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa; Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa; Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa","Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa","Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","SA MRC Centre for TB Research, Stellenbosch University, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SA MRC Centre for TB Research, Stellenbosch University, South Africa; DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa; Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa; Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"SA MRC Centre for TB Research, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053345229","display_name":"Annelies Van Rie","orcid":"https://orcid.org/0000-0001-7666-3263","observed_orcids":["https://orcid.org/0000-0001-7666-3263"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Annelies van Rie","raw_affiliation_strings":["Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America; International Health Unit, Epidemiology and Social Medicine, Faculty of Medicine, University of Antwerp, Antwerp, Belgium","Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","International Health Unit, Epidemiology and Social Medicine, Faculty of Medicine, University of Antwerp, Antwerp, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America; International Health Unit, Epidemiology and Social Medicine, Faculty of Medicine, University of Antwerp, Antwerp, Belgium","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I149213910"]},{"raw_affiliation_string":"Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"International Health Unit, Epidemiology and Social Medicine, Faculty of Medicine, University of Antwerp, Antwerp, Belgium","institution_ids":["https://openalex.org/I149213910"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021801489"],"corresponding_institution_ids":["https://openalex.org/I26092322"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.4486,"has_fulltext":true,"cited_by_count":154,"citation_normalized_percentile":{"value":0.92661035,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"10","issue":"7","first_page":"e0133869","last_page":"e0133869"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyrazinamide-resistance","display_name":"pyrazinamide resistance","score":1.0},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/multidrug-resistant-tuberculosis","display_name":"multidrug-resistant tuberculosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/pnca","display_name":"pncA","score":0.9380000233650208},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.984000027179718},{"id":"https://openalex.org/keywords/global-burden-of-disease","display_name":"global burden of disease","score":0.7049999833106995},{"id":"https://openalex.org/keywords/drug-susceptibility-testing","display_name":"drug susceptibility testing","score":0.7429999709129333},{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.5870000123977661},{"id":"https://openalex.org/keywords/drug-resistant-tuberculosis","display_name":"drug-resistant tuberculosis","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C2780459521","wikidata":"https://www.wikidata.org/wiki/Q417571","display_name":"Pyrazinamide","level":4,"score":0.7952996492385864},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.632340669631958},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5885826945304871},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.5048554539680481},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48644328117370605},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.4517473876476288},{"id":"https://openalex.org/C2777107064","wikidata":"https://www.wikidata.org/wiki/Q1040214","display_name":"Extensively drug-resistant tuberculosis","level":4,"score":0.43801364302635193},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.42805033922195435},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.42330577969551086},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.4146421253681183},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4005311131477356},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32100629806518555},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2766575217247009},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22645503282546997},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.21183863282203674},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12314650416374207}],"mesh":[{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011718","descriptor_name":"Pyrazinamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1371/journal.pone.0133869","doi":"https://doi.org/10.1371/journal.pone.0133869","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0133869","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0133869&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:26218737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26218737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4517823","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4517823/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:cdr.lib.unc.edu:3197xv33f","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/eh5e-1v29","pdf_url":"https://cdr.lib.unc.edu/downloads/41687r62p","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PloS One, 10(7)","raw_type":"Article"},{"id":"pmh:oai:figshare.com:article/1496020","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_A_Global_Perspective_on_Pyrazinamide_Resistance_Systematic_Review_and_Meta_Analysis_/1496020","pdf_url":"https://figshare.com/articles/dataset/_A_Global_Perspective_on_Pyrazinamide_Resistance_Systematic_Review_and_Meta_Analysis_/1496020","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:RePEc:plo:pone00:0133869","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133869","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:555a7cf2464d4b76baa09c577035ef0c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/555a7cf2464d4b76baa09c577035ef0c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 7, p e0133869 (2015)","raw_type":"article"},{"id":"pmh:oai:scholar.sun.ac.za:10019.1/99433","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10019.1/99433","pdf_url":null,"source":{"id":"https://openalex.org/S4306400300","display_name":"SUNScholar (Stellenbosch University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I26092322","host_organization_name":"Stellenbosch University","host_organization_lineage":["https://openalex.org/I26092322"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/90709","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/90709","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"16","raw_type":"Journal Article"},{"id":"doi:10.17615/eh5e-1v29","doi":"https://doi.org/10.17615/eh5e-1v29","is_oa":true,"landing_page_url":"https://doi.org/10.17615/eh5e-1v29","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0133869","doi":"https://doi.org/10.1371/journal.pone.0133869","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0133869","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0133869&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[{"id":"https://openalex.org/G3211525955","display_name":null,"funder_award_id":"86539","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G5827419890","display_name":"Optimizing the impact of Xpert MTB/RIF on treatment outcomes of drug resistant TB","funder_award_id":"R01AI099026","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6785635824","display_name":null,"funder_award_id":"UID 86539","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G9000857854","display_name":"Training in Infectious Disease Epidemiology (TIDE)","funder_award_id":"T32AI070114","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1807960484.pdf","grobid_xml":"https://content.openalex.org/works/W1807960484.grobid-xml"},"referenced_works_count":141,"referenced_works":["https://openalex.org/W832665","https://openalex.org/W12336293","https://openalex.org/W67148332","https://openalex.org/W76479888","https://openalex.org/W89888408","https://openalex.org/W108806092","https://openalex.org/W128341503","https://openalex.org/W152298748","https://openalex.org/W246286872","https://openalex.org/W380668015","https://openalex.org/W1502467014","https://openalex.org/W1513899899","https://openalex.org/W1538374398","https://openalex.org/W1593448845","https://openalex.org/W1805880101","https://openalex.org/W1867457677","https://openalex.org/W1880202664","https://openalex.org/W1890317675","https://openalex.org/W1923394711","https://openalex.org/W1942613564","https://openalex.org/W1942834216","https://openalex.org/W1964379161","https://openalex.org/W1964997170","https://openalex.org/W1969763839","https://openalex.org/W1971477608","https://openalex.org/W1972783452","https://openalex.org/W1973502713","https://openalex.org/W1975610050","https://openalex.org/W1977856193","https://openalex.org/W1980086670","https://openalex.org/W1989194067","https://openalex.org/W1990319970","https://openalex.org/W1991974760","https://openalex.org/W1993044233","https://openalex.org/W1993743724","https://openalex.org/W1995236717","https://openalex.org/W1995309322","https://openalex.org/W1997237947","https://openalex.org/W1997347159","https://openalex.org/W1998828531","https://openalex.org/W2001328692","https://openalex.org/W2001880071","https://openalex.org/W2004753123","https://openalex.org/W2010161656","https://openalex.org/W2014347011","https://openalex.org/W2022717946","https://openalex.org/W2023013236","https://openalex.org/W2023351019","https://openalex.org/W2025206827","https://openalex.org/W2031018624","https://openalex.org/W2034229074","https://openalex.org/W2036499901","https://openalex.org/W2041910120","https://openalex.org/W2042087596","https://openalex.org/W2046231351","https://openalex.org/W2046352089","https://openalex.org/W2049185919","https://openalex.org/W2049273999","https://openalex.org/W2053336930","https://openalex.org/W2057921766","https://openalex.org/W2058805348","https://openalex.org/W2065130119","https://openalex.org/W2071192895","https://openalex.org/W2071746515","https://openalex.org/W2072782389","https://openalex.org/W2073198823","https://openalex.org/W2074338643","https://openalex.org/W2075449118","https://openalex.org/W2075450278","https://openalex.org/W2075666807","https://openalex.org/W2077892389","https://openalex.org/W2082445705","https://openalex.org/W2083155903","https://openalex.org/W2085687922","https://openalex.org/W2089154924","https://openalex.org/W2089688015","https://openalex.org/W2091131312","https://openalex.org/W2091863304","https://openalex.org/W2093165547","https://openalex.org/W2093397591","https://openalex.org/W2094566796","https://openalex.org/W2098335911","https://openalex.org/W2099109129","https://openalex.org/W2102030486","https://openalex.org/W2109719233","https://openalex.org/W2110255974","https://openalex.org/W2112754012","https://openalex.org/W2114029801","https://openalex.org/W2115180923","https://openalex.org/W2115822252","https://openalex.org/W2115859184","https://openalex.org/W2116120730","https://openalex.org/W2116554109","https://openalex.org/W2119636838","https://openalex.org/W2129716166","https://openalex.org/W2130610060","https://openalex.org/W2132533539","https://openalex.org/W2133515801","https://openalex.org/W2133783230","https://openalex.org/W2134476763","https://openalex.org/W2135378152","https://openalex.org/W2136433194","https://openalex.org/W2137812922","https://openalex.org/W2139980869","https://openalex.org/W2140803600","https://openalex.org/W2140934532","https://openalex.org/W2141443223","https://openalex.org/W2142086874","https://openalex.org/W2143867022","https://openalex.org/W2146817473","https://openalex.org/W2150700849","https://openalex.org/W2150863863","https://openalex.org/W2150867622","https://openalex.org/W2153221130","https://openalex.org/W2154609178","https://openalex.org/W2154718868","https://openalex.org/W2155412373","https://openalex.org/W2156098321","https://openalex.org/W2156272262","https://openalex.org/W2158658436","https://openalex.org/W2159500985","https://openalex.org/W2161089254","https://openalex.org/W2161340676","https://openalex.org/W2162519786","https://openalex.org/W2164918529","https://openalex.org/W2166784242","https://openalex.org/W2166849360","https://openalex.org/W2167190401","https://openalex.org/W2169735855","https://openalex.org/W2171541901","https://openalex.org/W2171796124","https://openalex.org/W2184366769","https://openalex.org/W2312680562","https://openalex.org/W2398743953","https://openalex.org/W2411862817","https://openalex.org/W2413160538","https://openalex.org/W2415793766","https://openalex.org/W2416847361","https://openalex.org/W2991792334","https://openalex.org/W3013818615","https://openalex.org/W4294215472"],"related_works":["https://openalex.org/W2885496504","https://openalex.org/W6920914042","https://openalex.org/W4406188571","https://openalex.org/W6981944749","https://openalex.org/W2060662594","https://openalex.org/W7223447650","https://openalex.org/W2438287361","https://openalex.org/W2767301115","https://openalex.org/W2276558485","https://openalex.org/W2542640108"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pyrazinamide":[1],"(PZA)":[2],"is":[3,146,180],"crucial":[4],"for":[5,34],"tuberculosis":[6],"(TB)":[7],"treatment,":[8],"given":[9],"its":[10],"unique":[11,166],"ability":[12],"to":[13,88,108,200],"eradicate":[14],"persister":[15],"bacilli.":[16],"The":[17,142,203],"worldwide":[18],"burden":[19,92,145],"of":[20,72,93,195,205,214],"PZA":[21,55,94,115,150,178,201,224],"resistance":[22,116,179],"remains":[23],"poorly":[24],"described.":[25],"METHODS:":[26],"Systematic":[27],"PubMed,":[28],"Science":[29],"Direct":[30],"and":[31,58,136,191,227],"Scopus":[32],"searches":[33],"articles":[35],"reporting":[36],"phenotypic":[37],"(liquid":[38],"culture":[39],"drug":[40,230],"susceptibility":[41],"testing":[42],"or":[43,52,70],"pyrazinamidase":[44],"activity":[45],"assays)":[46],"and/or":[47],"genotypic":[48],"(polymerase":[49],"chain":[50],"reaction":[51],"DNA":[53],"sequencing)":[54],"resistance.":[56,95],"Global":[57],"regional":[59,83],"summary":[60,78],"estimates":[61,79,87],"were":[62,80],"obtained":[63],"from":[64],"random-effects":[65],"meta-analysis,":[66],"stratified":[67],"by":[68],"presence":[69],"risk":[71],"multidrug":[73],"resistant":[74,151,163,199],"TB":[75,85,126,152,189,229],"(MDR-TB).":[76],"Regional":[77],"combined":[81],"with":[82,182],"WHO":[84],"incidence":[86],"determine":[89],"the":[90,103,174,208,212],"annual":[91],"Information":[96],"on":[97,223],"single":[98],"nucleotide":[99],"polymorphisms":[100],"(SNPs)":[101],"in":[102,157,186,225,233],"pncA":[104,175,209],"gene":[105,210],"was":[106,119],"aggregated":[107],"obtain":[109],"a":[110],"global":[111,144],"summary.":[112],"RESULTS:":[113],"Pooled":[114],"prevalence":[117],"estimate":[118],"16.2%":[120],"(95%":[121],"CI":[122],"11.2-21.2)":[123],"among":[124,130,139],"all":[125,196],"cases,":[127],"41.3%":[128],"(29.0-53.7)":[129],"patients":[131],"at":[132,169],"high":[133],"MDR-TB":[134,140,158,197,234],"risk,":[135],"60.5%":[137],"(52.3-68.6)":[138],"cases.":[141],"estimated":[143,184],"1.4":[147],"million":[148],"new":[149],"cases":[153,190,198],"annually,":[154],"about":[155],"270,000":[156],"patients.":[159,235],"Among":[160],"1,815":[161],"phenotypically":[162],"isolates,":[164],"608":[165],"SNPs":[167,206],"occurred":[168],"397":[170],"distinct":[171],"positions":[172],"throughout":[173],"gene.":[176],"INTERPRETATION:":[177],"ubiquitous,":[181],"an":[183],"one":[185],"six":[187],"incident":[188],"more":[192],"than":[193],"half":[194],"globally.":[202],"diversity":[204],"across":[207],"complicates":[211],"development":[213],"rapid":[215],"molecular":[216],"diagnostics.":[217],"These":[218],"findings":[219],"caution":[220],"against":[221],"relying":[222],"current":[226],"future":[228],"regimens,":[231],"especially":[232]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":22},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":12}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
