{"id":"https://openalex.org/W180742453","doi":"https://doi.org/10.1096/fasebj.21.6.a1030-a","title":"Inhibition of AP\u20101 activation in DMBA\u2010induced rat breast tumors by dietary soy protein","display_name":"Inhibition of AP\u20101 activation in DMBA\u2010induced rat breast tumors by dietary soy protein","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W180742453","doi":"https://doi.org/10.1096/fasebj.21.6.a1030-a","mag":"180742453"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.6.a1030-a","doi":"https://doi.org/10.1096/fasebj.21.6.a1030-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1030-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102128752","display_name":"Sutapa Mukhopadhyay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sutapa Mukhopadhyay","raw_affiliation_strings":["Biomedical Sciences Meharry Medical College 1005 David Todd Blvd Nashville TN 37208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Meharry Medical College 1005 David Todd Blvd Nashville TN 37208","institution_ids":["https://openalex.org/I118073183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112520459","display_name":"Shyamali Mukherjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shyamali Mukherjee","raw_affiliation_strings":["Biomedical Sciences Meharry Medical College 1005 David Todd Blvd Nashville TN 37208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Meharry Medical College 1005 David Todd Blvd Nashville TN 37208","institution_ids":["https://openalex.org/I118073183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103404831","display_name":"Salil K. Das","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salil K Das","raw_affiliation_strings":["Biomedical Sciences Meharry Medical College 1005 David Todd Blvd Nashville TN 37208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Meharry Medical College 1005 David Todd Blvd Nashville TN 37208","institution_ids":["https://openalex.org/I118073183"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I118073183"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02621336,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soy-protein","display_name":"soy protein","score":0.9750000238418579},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8489999771118164},{"id":"https://openalex.org/keywords/ap-1-activation","display_name":"AP-1 activation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8560000061988831},{"id":"https://openalex.org/keywords/jnk-phosphorylation","display_name":"JNK phosphorylation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.777999997138977},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.921999990940094},{"id":"https://openalex.org/keywords/dietary-protein","display_name":"dietary protein","score":0.6919999718666077},{"id":"https://openalex.org/keywords/dmba-induced-tumors","display_name":"DMBA-induced tumors","score":0.9150000214576721},{"id":"https://openalex.org/keywords/casein","display_name":"casein","score":0.6830000281333923},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.49399998784065247},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C2777014122","wikidata":"https://www.wikidata.org/wiki/Q7571993","display_name":"Soy protein","level":2,"score":0.7943227887153625},{"id":"https://openalex.org/C2778938436","wikidata":"https://www.wikidata.org/wiki/Q5205596","display_name":"DMBA","level":4,"score":0.7934223413467407},{"id":"https://openalex.org/C2776142715","wikidata":"https://www.wikidata.org/wiki/Q193970","display_name":"Casein","level":2,"score":0.6878718137741089},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4898674190044403},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48892489075660706},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4825426936149597},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.46973928809165955},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40440869331359863},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38424065709114075},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3621896505355835},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32811450958251953},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20203900337219238},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.09052252769470215},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07007494568824768}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.6.a1030-a","doi":"https://doi.org/10.1096/fasebj.21.6.a1030-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1030-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.6735000014305115,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4285501764","https://openalex.org/W1431934857","https://openalex.org/W2070890040","https://openalex.org/W2125869834","https://openalex.org/W2063576046","https://openalex.org/W1549287888","https://openalex.org/W1861279169","https://openalex.org/W3174013234","https://openalex.org/W1990153471","https://openalex.org/W164494182"],"abstract_inverted_index":{"Soy":[0,102],"protein":[1,24,63,103,143,172,180,215,219],"is":[2,14,192],"beneficial":[3,223],"for":[4],"the":[5,11,20,71,113,149,178,184,197],"control":[6],"of":[7,22,39,42,68,112,116,199],"breast":[8,30],"cancer;":[9],"however":[10],"molecular":[12],"mechanism":[13],"not":[15,169],"clear.":[16],"This":[17,145],"study":[18],"examines":[19],"effects":[21],"soy":[23,62,142,171,179,214,218],"on":[25,52,225],"MAPK":[26],"signaling":[27],"in":[28,119,130,136,141,146,152,154,160,165,170,177,204,211],"rat":[29],"cancer":[31,226],"model.":[32],"Tumor":[33],"was":[34,121,128,134,162,182],"developed":[35],"by":[36,78,123,228,233],"gavage":[37],"administration":[38],"single":[40],"dose":[41],"DMBA":[43,69],"(80":[44],"mg/kg)":[45],"into":[46],"50\u2010day":[47],"old":[48],"female":[49],"rats,":[50],"maintained":[51],"a":[53],"standard":[54],"AIN\u201076A":[55],"diet":[56],"containing":[57],"either":[58],"casein":[59,88,137,166,207],"(20%)":[60],"or":[61],"(20%).":[64],"After":[65],"122":[66],"days":[67],"administration,":[70],"animals":[72],"were":[73,76,85],"sacrificed.":[74],"Tumors":[75],"detected":[77],"palpation":[79],"and":[80,97,168,189],"at":[81,183],"autopsy":[82],"biopsy":[83],"specimens":[84],"graded.":[86],"The":[87,110,132,174],"group":[89,104,138,167,181,208],"had":[90,105],"20%":[91,98],"grade":[92,95,99,107],"I,":[93],"60%":[94],"II":[96],"III":[100],"adenocarcinoma.":[101],"100%":[106],"I":[108],"tumors.":[109,131],"expression":[111,151,159,176],"AP\u20101":[114,200,230],"family":[115],"transcription":[117],"factors":[118],"tumors":[120,153,161,205,212],"analyzed":[122],"Western":[124],"blot.":[125],"JNK":[126],"activation/phosphorylation":[127],"increased":[129,148,163],"increase":[133],"more":[135],"than":[139,209],"that":[140,210],"group.":[144,173,216],"turn":[147],"c\u2010jun":[150,190],"both":[155],"groups.":[156],"However,":[157],"c\u2010fos":[158,175,188],"only":[164],"basal":[185],"level.":[186],"Since":[187],"dimerization":[191],"necessary":[193],"to":[194],"activate":[195],"AP\u20101,":[196],"activation":[198],"will":[201],"be":[202],"higher":[203],"from":[206,213],"Hence":[217],"may":[220],"impart":[221],"its":[222],"effect":[224],"progression":[227],"regulating":[229],"activation.":[231],"(Supported":[232],"Grant":[234],"DAMD\u201017\u201003\u20101\u20100352)":[235]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
