{"id":"https://openalex.org/W1807201070","doi":null,"title":"The cancer stem cell antigens CD133, BCRP1/ABCG2 and CD117/c-KIT are not associated with prognosis in resected early-stage non-small cell lung cancer.","display_name":"The cancer stem cell antigens CD133, BCRP1/ABCG2 and CD117/c-KIT are not associated with prognosis in resected early-stage non-small cell lung cancer.","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W1807201070","mag":"1807201070","pmid":"https://pubmed.ncbi.nlm.nih.gov/22199321"},"language":"en","primary_location":{"id":"pmid:22199321","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22199321","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079261820","display_name":"Esther Herpel","orcid":"https://orcid.org/0000-0002-0110-9257","observed_orcids":["https://orcid.org/0000-0002-0110-9257"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Esther Herpel","raw_affiliation_strings":["Institute of Pathology, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048711566","display_name":"Katrin Jensen","orcid":"https://orcid.org/0000-0002-5088-5279","observed_orcids":["https://orcid.org/0000-0002-5088-5279"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katrin Jensen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085505239","display_name":"Thomas Muley","orcid":"https://orcid.org/0000-0002-8141-0604","observed_orcids":["https://orcid.org/0000-0002-8141-0604"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Muley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109226131","display_name":"Arne Warth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arne Warth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016216382","display_name":"Philipp Albert Schnabel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philipp A Schnabel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040695029","display_name":"Michael A. Meister","orcid":"https://orcid.org/0000-0002-2242-1696","observed_orcids":["https://orcid.org/0000-0002-2242-1696"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Meister","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024585720","display_name":"Felix J.F. Herth","orcid":"https://orcid.org/0000-0002-7638-2506","observed_orcids":["https://orcid.org/0000-0002-7638-2506"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Felix J F Herth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052004888","display_name":"Hendrik Dienemann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hendrik Dienemann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101492076","display_name":"Michael Thomas","orcid":"https://orcid.org/0000-0001-9511-055X","observed_orcids":["https://orcid.org/0000-0001-9511-055X","https://orcid.org/0009-0008-0971-388X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Thomas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019113386","display_name":"Sandra Gottschling","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra Gottschling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.919,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.91289186,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"31","issue":"12","first_page":"4491","last_page":"500"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.04639999940991402,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cd133","display_name":"CD133","score":0.953000009059906},{"id":"https://openalex.org/keywords/abcg2","display_name":"ABCG2","score":0.7820000052452087},{"id":"https://openalex.org/keywords/bcrp1","display_name":"BCRP1","score":0.9200000166893005},{"id":"https://openalex.org/keywords/c-kit","display_name":"CD117","score":0.9940000176429749},{"id":"https://openalex.org/keywords/early-stage-lung-cancer","display_name":"early-stage lung cancer","score":0.8479999899864197},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7620000243186951},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8149999976158142},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.8159999847412109},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.9570000171661377},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C2776839831","wikidata":"https://www.wikidata.org/wiki/Q909409","display_name":"CD117","level":4,"score":0.7555429935455322},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6258845925331116},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.601167619228363},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5709885954856873},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5630201697349548},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5529537200927734},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.545971155166626},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.527324378490448},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5192439556121826},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48256009817123413},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4603580832481384},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.43424856662750244},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.382254958152771},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.381169855594635},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3221166729927063},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2337668240070343},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2286212146282196},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.21790295839309692},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.09863337874412537},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000070997","descriptor_name":"ATP Binding Cassette Transporter, Subfamily G, Member 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071916","descriptor_name":"AC133 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:22199321","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22199321","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:1807201070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22199321","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W239251301","https://openalex.org/W1963841924","https://openalex.org/W1970192479","https://openalex.org/W1980429328","https://openalex.org/W1983357205","https://openalex.org/W1994599132","https://openalex.org/W2022881840","https://openalex.org/W2023690110","https://openalex.org/W2025103171","https://openalex.org/W2026470671","https://openalex.org/W2027116501","https://openalex.org/W2029231546","https://openalex.org/W2045476312","https://openalex.org/W2054930937","https://openalex.org/W2062891843","https://openalex.org/W2071541060","https://openalex.org/W2074982201","https://openalex.org/W2083998563","https://openalex.org/W2084001490","https://openalex.org/W2093146854","https://openalex.org/W2096984065","https://openalex.org/W2104134194","https://openalex.org/W2104471512","https://openalex.org/W2105283525","https://openalex.org/W2108035852","https://openalex.org/W2117767331","https://openalex.org/W2120693009","https://openalex.org/W2133538214","https://openalex.org/W2162647147","https://openalex.org/W2167650288","https://openalex.org/W2182149483","https://openalex.org/W2219090764","https://openalex.org/W2315753416","https://openalex.org/W2318707702"],"related_works":["https://openalex.org/W2045476312","https://openalex.org/W2062891843","https://openalex.org/W2089653838","https://openalex.org/W1580903680","https://openalex.org/W2128614119","https://openalex.org/W192112995","https://openalex.org/W2008915989","https://openalex.org/W2317623922","https://openalex.org/W2602716948","https://openalex.org/W7163196410"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,152],"various":[2],"tumor":[3],"entities,":[4],"expression":[5,72,120,172],"of":[6,51,68,104,121,173],"cancer":[7,39,60],"stem":[8],"cell":[9,58],"(CSC)":[10],"antigens":[11,34,141,157],"has":[12],"been":[13],"proven":[14],"to":[15,75,145],"be":[16],"prognostically":[17],"unfavorable.":[18],"However,":[19,100,163],"for":[20,130],"lung":[21,59],"cancer,":[22],"the":[23,102,139],"data":[24],"are":[25],"scant":[26],"and":[27,37,80,108,168],"conflicting.":[28],"PATIENTS":[29],"AND":[30],"METHODS:":[31],"The":[32],"CSC":[33,92,140,156],"CD117/c-KIT,":[35],"CD133":[36],"breast":[38],"resistance":[40],"protein-1":[41],"(BCRP1/ABCG2)":[42],"were":[43,142],"immunohistochemically":[44],"analyzed":[45],"in":[46,101,135,164],"tissues":[47],"from":[48],"a":[49,64,114],"total":[50],"133":[52],"completely":[53],"resected":[54,153],"stage":[55],"I/II":[56],"non-small":[57],"(NSCLC)":[61],"patients":[62,105,165],"with":[63,106,161,166],"median":[65],"follow-up":[66],"time":[67],"53.8":[69],"months.":[70],"Their":[71],"was":[73,113,133],"related":[74],"clinicopathological":[76],"characteristics,":[77],"angiogenic":[78,149],"features":[79],"prognosis.":[81,162],"RESULTS:":[82],"Cox":[83],"proportional":[84],"hazards":[85],"regression":[86],"analysis":[87],"revealed":[88],"no":[89,159],"association":[90,160],"between":[91],"antigens,":[93],"disease-free":[94],"survival":[95,98],"or":[96,148],"overall":[97],"(OS).":[99],"subgroup":[103],"relapse":[107,167],"tumors":[109,137,169],">3":[110,170],"cm,":[111,171],"there":[112],"trend":[115],"towards":[116],"worse":[117,177],"OS":[118],"upon":[119],"CD117":[122,174],"(hazard":[123],"ratio=2.6,":[124],"95%,":[125],"confidence":[126],"interval=0.8-8.3,":[127],"p=0.080).":[128],"Except":[129],"CD133,":[131],"which":[132],"overrepresented":[134],"T1":[136],"(p=0.001),":[138],"not":[143],"linked":[144],"clinico-pathological":[146],"characteristics":[147],"features.":[150],"CONCLUSION:":[151],"early-stage":[154],"NSCLC,":[155],"show":[158],"might":[175],"predict":[176],"OS.":[178]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
