{"id":"https://openalex.org/W180647282","doi":null,"title":"Is the level of C-reactive protein correlated with the extent of carotid atherosclerosis?","display_name":"Is the level of C-reactive protein correlated with the extent of carotid atherosclerosis?","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W180647282","mag":"180647282","pmid":"https://pubmed.ncbi.nlm.nih.gov/16076060"},"language":"en","primary_location":{"id":"pmid:16076060","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16076060","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta neurologica Belgica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056742023","display_name":"G\u00fcl\u00e7in Benbir \u015eenel","orcid":"https://orcid.org/0000-0003-4585-2840","observed_orcids":["https://orcid.org/0000-0003-4585-2840"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Gulcin Benbir","raw_affiliation_strings":["Istanbul University, Cerrahpasa Medical School, Department of Neurology, Istanbul, Turkey. drgbenbir@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istanbul University, Cerrahpasa Medical School, Department of Neurology, Istanbul, Turkey. drgbenbir@hotmail.com","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039034246","display_name":"Melda Bozluol\u00e7ay","orcid":"https://orcid.org/0000-0002-3501-5160","observed_orcids":["https://orcid.org/0000-0002-3501-5160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melda Bozluolcay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015623344","display_name":"Birsen \u0130nce","orcid":"https://orcid.org/0000-0002-6446-4897","observed_orcids":["https://orcid.org/0000-0002-6446-4897"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Birsen Ince","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.865,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.76810117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"105","issue":"2","first_page":"73","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.6547999978065491,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.6547999978065491,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.1339000016450882,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.11339999735355377,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9430000185966492},{"id":"https://openalex.org/keywords/carotid-atherosclerosis","display_name":"carotid atherosclerosis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/intima-media-thickness","display_name":"intima-media thickness","score":0.9200000166893005},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.8659999966621399},{"id":"https://openalex.org/keywords/stroke-risk-factors","display_name":"stroke risk factors","score":0.8679999709129333},{"id":"https://openalex.org/keywords/internal-carotid-artery-stenosis","display_name":"internal carotid artery stenosis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.7829999923706055},{"id":"https://openalex.org/keywords/carotid-ultrasound","display_name":"carotid ultrasound","score":0.7329999804496765},{"id":"https://openalex.org/keywords/atherosclerotic-plaque","display_name":"atherosclerotic plaque","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9217755794525146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7587407827377319},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.7360483407974243},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.7301472425460815},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.6124457120895386},{"id":"https://openalex.org/C2779889316","wikidata":"https://www.wikidata.org/wiki/Q642836","display_name":"Neuroradiology","level":3,"score":0.6100370287895203},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5690628290176392},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5267038941383362},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.5030106902122498},{"id":"https://openalex.org/C2987047532","wikidata":"https://www.wikidata.org/wiki/Q214275","display_name":"Carotid arteries","level":2,"score":0.4634409248828888},{"id":"https://openalex.org/C2779339615","wikidata":"https://www.wikidata.org/wiki/Q2698596","display_name":"Intima-media thickness","level":3,"score":0.45587652921676636},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.20013675093650818},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002340","descriptor_name":"Carotid Artery Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002340","descriptor_name":"Carotid Artery Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002340","descriptor_name":"Carotid Artery Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017536","descriptor_name":"Carotid Artery, Common","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D017536","descriptor_name":"Carotid Artery, Common","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017536","descriptor_name":"Carotid Artery, Common","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018608","descriptor_name":"Ultrasonography, Doppler","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16076060","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16076060","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta neurologica Belgica","raw_type":"Journal Article"},{"id":"mag:180647282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16076060","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W174616066","https://openalex.org/W202019503","https://openalex.org/W226102167","https://openalex.org/W1975643906","https://openalex.org/W2011589019","https://openalex.org/W2013521697","https://openalex.org/W2029198912","https://openalex.org/W2043117079","https://openalex.org/W2048683669","https://openalex.org/W2050798863","https://openalex.org/W2069980302","https://openalex.org/W2070195189","https://openalex.org/W2072005929","https://openalex.org/W2077415712","https://openalex.org/W2089520473","https://openalex.org/W2102512891","https://openalex.org/W2104545300","https://openalex.org/W2107037375","https://openalex.org/W2124434517","https://openalex.org/W2127038926","https://openalex.org/W2135479614","https://openalex.org/W2136641821","https://openalex.org/W2151494532","https://openalex.org/W2159193498","https://openalex.org/W2159643279","https://openalex.org/W2160173921","https://openalex.org/W2163701553","https://openalex.org/W2170372043","https://openalex.org/W2316167515"],"related_works":["https://openalex.org/W2347606802","https://openalex.org/W2136641821","https://openalex.org/W2367755683","https://openalex.org/W2362069748","https://openalex.org/W2378714629","https://openalex.org/W2086415913","https://openalex.org/W4253118393","https://openalex.org/W7218045281","https://openalex.org/W7038875024","https://openalex.org/W2381070564"],"abstract_inverted_index":{"BACKGROUND:":[0],"Increased":[1],"intima-media":[2],"thickness":[3,136],"(IMT)":[4],"of":[5,14,29,45,49,68,173,194,210,248,257],"the":[6,27,42,46,55,60,66,171,174,208,213,239,246,249],"common":[7],"carotid":[8,69,162,250],"arteries":[9],"(CCA)":[10],"and":[11,58,65,103,153,170,223,252],"elevated":[12,34,230],"levels":[13,115,169],"highly":[15],"sensitive":[16],"C-reactive":[17],"protein":[18],"(hsCRP)":[19],"are":[20],"both":[21],"shown":[22],"to":[23,81,87,134,191],"be":[24,192],"associated":[25],"with":[26,91,109,160,207,245],"occurrence":[28],"stroke.":[30,94],"We":[31,74,227],"investigated":[32],"whether":[33],"hsCRP":[35,63,114,122,168,211,222,231],"level":[36,64,123,209,232],"is":[37,233,255],"a":[38,98,177,204],"risk":[39,52,197,236,260],"factor":[40,237],"for":[41,54,238],"increased":[43,132],"IMT":[44],"CCA":[47],"independent":[48,193,256],"other":[50,195,258],"proven":[51,196],"factors":[53],"ischemic":[56,93,240],"stroke":[57,241],"studied":[59,75],"interaction":[61],"between":[62,79,221],"extent":[67,172,247],"atherosclerosis.":[70],"METHODS":[71],"AND":[72],"RESULTS:":[73],"104":[76],"patients":[77,96,108,130,145,159],"aged":[78],"30":[80],"92":[82],"years":[83],"who":[84,146],"were":[85],"admitted":[86],"our":[88],"neurology":[89],"department":[90],"acute":[92],"All":[95],"underwent":[97],"clinical":[99],"evaluation,":[100],"laboratory":[101],"investigations,":[102],"neuroultrasonographic":[104],"examination.":[105],"In":[106,183],"24":[107],"normal":[110],"ultrasonographic":[111],"examination,":[112],"mean":[113],"was":[116,124,189,212,219],"8.6":[117],"+":[118,126,141,155],"6.7":[119],"mg/L.":[120],"Mean":[121],"18.0":[125],"25.6":[127],"mg/L":[128,143,157],"in":[129,144,158],"having":[131],"intima":[133],"media":[135],"(>":[137],"1.2":[138],"mm);":[139],"32.7":[140],"49.1":[142],"had":[147],"atheromatous":[148],"plaques":[149],"without":[150],"significant":[151,178,205],"narrowing;":[152],"23.9":[154],"27.3":[156],"internal":[161],"artery":[163],"stenosis":[164],"more":[165],"than":[166],"50%.":[167],"atherosclerosis":[175],"showed":[176,203],"relationship":[179,188],"(p":[180],"=":[181],"0.040).":[182],"multiple":[184],"regression":[185],"analyses,":[186],"this":[187,253],"found":[190,220],"factors.":[198,261],"The":[199],"only":[200],"variable":[201],"that":[202,229],"relation":[206,244,254],"HDL":[214,224],"level.":[215],"A":[216],"negative":[217],"correlation":[218],"levels.":[225],"CONCLUSIONS:":[226],"conclude":[228],"an":[234],"indirect":[235],"through":[242],"its":[243],"atherosclerosis,":[251],"known":[259]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}