{"id":"https://openalex.org/W1803818890","doi":"https://doi.org/10.3109/15376516.2015.1077362","title":"Safety and efficacy of a novel Prunus domestica extract (Sitoprin, CR002) on testosterone-induced benign prostatic hyperplasia (BPH) in male Wistar rats","display_name":"Safety and efficacy of a novel Prunus domestica extract (Sitoprin, CR002) on testosterone-induced benign prostatic hyperplasia (BPH) in male Wistar rats","publication_year":2015,"publication_date":"2015-08-31","ids":{"openalex":"https://openalex.org/W1803818890","doi":"https://doi.org/10.3109/15376516.2015.1077362","mag":"1803818890","pmid":"https://pubmed.ncbi.nlm.nih.gov/26337762"},"language":"en","primary_location":{"id":"doi:10.3109/15376516.2015.1077362","doi":"https://doi.org/10.3109/15376516.2015.1077362","is_oa":false,"landing_page_url":"https://doi.org/10.3109/15376516.2015.1077362","pdf_url":null,"source":{"id":"https://openalex.org/S93207707","display_name":"Toxicology Mechanisms and Methods","issn_l":"1537-6516","issn":["1537-6516","1537-6524"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Mechanisms and Methods","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Anand Swaroop","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anand Swaroop","raw_affiliation_strings":["Cepham Research Center, Piscataway, NJ, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cepham Research Center, Piscataway, NJ, USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025047849","display_name":"Manashi Bagchi","orcid":"https://orcid.org/0000-0002-1527-6419","observed_orcids":["https://orcid.org/0000-0002-1527-6419"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manashi Bagchi","raw_affiliation_strings":["Cepham Research Center, Piscataway, NJ, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cepham Research Center, Piscataway, NJ, USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102020476","display_name":"Pawan Kumar","orcid":"https://orcid.org/0000-0002-9324-2812","observed_orcids":["https://orcid.org/0000-0002-9324-2812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pawan Kumar","raw_affiliation_strings":["Chemical Resources, Panchkula, Haryana, India,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Resources, Panchkula, Haryana, India,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047768346","display_name":"Harry G. Preuss","orcid":"https://orcid.org/0000-0002-9170-4913","observed_orcids":["https://orcid.org/0000-0002-9170-4913"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry G. Preuss","raw_affiliation_strings":["Departments of Biochemistry, Medicine and Pathology, Georgetown University Medical Center, Washington, DC, USA, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry, Medicine and Pathology, Georgetown University Medical Center, Washington, DC, USA, and","institution_ids":["https://openalex.org/I2799903593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019498762","display_name":"Debasis Bagchi","orcid":"https://orcid.org/0000-0001-9478-6427","observed_orcids":["https://orcid.org/0000-0001-9478-6427"]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Debasis Bagchi","raw_affiliation_strings":["Cepham Research Center, Piscataway, NJ, USA,","Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cepham Research Center, Piscataway, NJ, USA,","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX, USA","institution_ids":["https://openalex.org/I44461941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019498762"],"corresponding_institution_ids":["https://openalex.org/I44461941"],"apc_list":null,"apc_paid":null,"fwci":0.312,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.62142897,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"25","issue":"9","first_page":"653","last_page":"664"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plum","display_name":"plum","score":0.8650000095367432},{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.890999972820282},{"id":"https://openalex.org/keywords/testosterone-propionate-induced-bph","display_name":"testosterone propionate-induced BPH","score":0.9129999876022339},{"id":"https://openalex.org/keywords/prostate-histopathology","display_name":"prostate histopathology","score":0.7960000038146973},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.578000009059906},{"id":"https://openalex.org/keywords/safety-assessment","display_name":"safety assessment","score":0.38100001215934753},{"id":"https://openalex.org/keywords/wistar-rats","display_name":"Wistar rats","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.8351184129714966},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.8167860507965088},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.604800820350647},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5992133021354675},{"id":"https://openalex.org/C2781115071","wikidata":"https://www.wikidata.org/wiki/Q10354588","display_name":"Testosterone propionate","level":4,"score":0.548983097076416},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.4999408721923828},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45933547616004944},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4340308904647827},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.42879530787467957},{"id":"https://openalex.org/C2778124894","wikidata":"https://www.wikidata.org/wiki/Q2336398","display_name":"Pallor","level":2,"score":0.42730849981307983},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.35040485858917236},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33433493971824646},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.23095941543579102},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.17861536145210266},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.12913039326667786}],"mesh":[{"descriptor_ui":"D000068242","descriptor_name":"Prunus domestica","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009152","descriptor_name":"Mutagenicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012486","descriptor_name":"Salmonella typhimurium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012486","descriptor_name":"Salmonella typhimurium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023382","descriptor_name":"Toxicity Tests, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024301","descriptor_name":"Plant Bark","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D059550","descriptor_name":"Toxicity Tests, Subchronic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/15376516.2015.1077362","doi":"https://doi.org/10.3109/15376516.2015.1077362","is_oa":false,"landing_page_url":"https://doi.org/10.3109/15376516.2015.1077362","pdf_url":null,"source":{"id":"https://openalex.org/S93207707","display_name":"Toxicology Mechanisms and Methods","issn_l":"1537-6516","issn":["1537-6516","1537-6524"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Mechanisms and Methods","raw_type":"journal-article"},{"id":"pmid:26337762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26337762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology mechanisms and methods","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W260302597","https://openalex.org/W1547385668","https://openalex.org/W1599271627","https://openalex.org/W1952795390","https://openalex.org/W1975625100","https://openalex.org/W1979093971","https://openalex.org/W1983702648","https://openalex.org/W1984383485","https://openalex.org/W1997298137","https://openalex.org/W1999962914","https://openalex.org/W2002205097","https://openalex.org/W2004913260","https://openalex.org/W2005156172","https://openalex.org/W2011159693","https://openalex.org/W2020396959","https://openalex.org/W2022838574","https://openalex.org/W2027043574","https://openalex.org/W2028292035","https://openalex.org/W2030629629","https://openalex.org/W2040416376","https://openalex.org/W2041862493","https://openalex.org/W2042366482","https://openalex.org/W2069083739","https://openalex.org/W2071165605","https://openalex.org/W2076416909","https://openalex.org/W2076843888","https://openalex.org/W2077488673","https://openalex.org/W2078835648","https://openalex.org/W2079505665","https://openalex.org/W2085588479","https://openalex.org/W2090836517","https://openalex.org/W2095751953","https://openalex.org/W2098605255","https://openalex.org/W2107792936","https://openalex.org/W2109912505","https://openalex.org/W2116247256","https://openalex.org/W2141932304","https://openalex.org/W2144655743","https://openalex.org/W2150324777","https://openalex.org/W2166865388","https://openalex.org/W2168290638","https://openalex.org/W2317621186","https://openalex.org/W2321413400","https://openalex.org/W2410410625","https://openalex.org/W2415306666","https://openalex.org/W2417950888"],"related_works":["https://openalex.org/W1145270596","https://openalex.org/W4380681786","https://openalex.org/W2408546435","https://openalex.org/W2103548037","https://openalex.org/W3190888999","https://openalex.org/W3214543585","https://openalex.org/W2916079239","https://openalex.org/W4408074271","https://openalex.org/W3200339024","https://openalex.org/W4404144478"],"abstract_inverted_index":{"The":[0,199],"efficacy":[1,58,212],"of":[2,32,39,67,100,110,147,150,156,185,190,203,213],"a":[3,37,70,78,164],"novel":[4],"Prunus":[5,81],"domestica":[6],"bark":[7],"extract":[8,83],"(Sitoprin,":[9],"CR002)":[10],"was":[11,26,194,205],"investigated":[12],"on":[13,91,121],"testosterone":[14],"propionate":[15],"(TP)-induced":[16],"benign":[17],"prostatic":[18],"hyperplasia":[19,182,200],"(BPH)":[20],"in":[21,225,228],"male":[22],"Wistar":[23],"rats.":[24,198],"BPH":[25,227],"induced":[27],"by":[28],"daily":[29],"subcutaneous":[30],"administration":[31],"TP":[33],"(3.0":[34],"mg/kg)":[35],"over":[36],"period":[38,102],"15":[40,123],"days":[41,50,92,122],"(interim":[42],"sacrifice":[43,52],"group)":[44],"and":[45,62,69,75,98,108,117,124,139,173,177,183,201,215],"for":[46],"an":[47],"additional":[48],"21":[49],"(terminal":[51],"group).":[53],"We":[54],"evaluated":[55],"the":[56,105,211],"dose-dependent":[57],"(0,":[59],"50,":[60],"100":[61],"200":[63,178],"mg/kg":[64],"body":[65],"weight/day)":[66],"CR002":[68,172,214,221],"control":[71,151,197],"group":[72],"against":[73],"BPH,":[74],"compared":[76],"with":[77,163,167,196],"reference":[79],"standard":[80],"africana":[82],"(CR001).":[84],"Extensive":[85],"clinical":[86,111],"examinations":[87],"were":[88,119,130,141],"carried":[89],"out":[90],"1,":[93],"7,":[94],"14,":[95],"21,":[96],"28":[97],"35":[99],"treatment":[101],"to":[103,127,134,207,233],"determine":[104],"onset,":[106],"duration":[107],"severity":[109],"signs.":[112],"Clinical":[113],"pathology,":[114],"hematology,":[115],"biochemistry":[116],"histopathology":[118,146,189],"performed":[120],"35,":[125],"prior":[126,133],"necropsy.":[128],"Animals":[129],"fasted":[131],"overnight":[132],"blood":[135],"collection.":[136],"Prostate":[137,188],"glands":[138],"tissues":[140],"examined.":[142],"On":[143],"day":[144],"36,":[145],"ventral":[148],"prostrate":[149,204],"rats":[152],"demonstrates":[153],"single":[154],"layer":[155],"columnar":[157],"mucin":[158],"secreting":[159],"epithelial":[160,186],"cells":[161],"along":[162],"lumen":[165],"occupied":[166],"eosinophilic":[168],"secretion.":[169],"In":[170],"contrast,":[171],"CR001":[174],"groups":[175,193],"(100":[176],"mg/kg/day)":[179],"exhibited":[180],"no":[181],"proliferation":[184],"cells.":[187],"these":[191],"treated":[192],"comparable":[195,232],"hypertrophy":[202],"reduced":[206],"single-layered":[208],"cell":[209],"indicating":[210],"CR001.":[216,234],"Overall,":[217],"results":[218],"demonstrate":[219],"that":[220],"exhibits":[222],"therapeutic":[223],"efficacy/activity":[224],"TP-induced":[226],"rats,":[229],"which":[230],"is":[231]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}