{"id":"https://openalex.org/W1803698528","doi":"https://doi.org/10.1046/j.1432-1327.2000.01100.x","title":"Expression and regulation of alkaline phosphatases in human breast cancer MCF\u20107 cells","display_name":"Expression and regulation of alkaline phosphatases in human breast cancer MCF\u20107 cells","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W1803698528","doi":"https://doi.org/10.1046/j.1432-1327.2000.01100.x","mag":"1803698528","pmid":"https://pubmed.ncbi.nlm.nih.gov/10691970"},"language":"en","primary_location":{"id":"doi:10.1046/j.1432-1327.2000.01100.x","doi":"https://doi.org/10.1046/j.1432-1327.2000.01100.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1432-1327.2000.01100.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113595273","display_name":"Lai\u2010Chen Tsai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]},{"id":"https://openalex.org/I4405277201","display_name":"Veterans General Hospital","ror":"https://ror.org/01v20dp61","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4405277201"]},{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TH","TW","US"],"is_corresponding":false,"raw_author_name":"Lai\u2010Chen Tsai","raw_affiliation_strings":["Department of Medical Research, Veterans General Hospital, National Defense Medical Center, Taipei, Taiwan","Department of Medical Research, Veterans General Hospital and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, Veterans General Hospital, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286","https://openalex.org/I68171755"]},{"raw_affiliation_string":"Department of Medical Research, Veterans General Hospital and","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4405277201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109999575","display_name":"Mei\u2010Whey Hung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4405277201","display_name":"Veterans General Hospital","ror":"https://ror.org/01v20dp61","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4405277201"]}],"countries":["TH","US"],"is_corresponding":false,"raw_author_name":"Mei\u2010Whey Hung","raw_affiliation_strings":["Department of Medical Research, Veterans General Hospital and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, Veterans General Hospital and","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4405277201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057229168","display_name":"Yu\u2010Hou Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu\u2010Hou Chen","raw_affiliation_strings":["\u00a7 Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7 Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I68171755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103869847","display_name":"Wen\u2010Cheng Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4405277201","display_name":"Veterans General Hospital","ror":"https://ror.org/01v20dp61","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4405277201"]}],"countries":["TH","US"],"is_corresponding":false,"raw_author_name":"Wen\u2010Cheng Su","raw_affiliation_strings":["Department of Medical Research, Veterans General Hospital and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, Veterans General Hospital and","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4405277201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111742968","display_name":"Gu\u2010Gang Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Gu\u2010Gang Chang","raw_affiliation_strings":["\u00a7 Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7 Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I68171755"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006439714","display_name":"Tsu\u2010Chung Chang","orcid":"https://orcid.org/0000-0001-6368-7717","observed_orcids":["https://orcid.org/0000-0001-6368-7717","https://orcid.org/0000-0003-3532-5713"]},"institutions":[{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tsu\u2010Chung Chang","raw_affiliation_strings":["\u00a7 Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7 Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I68171755"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0519,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.7567224,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"267","issue":"5","first_page":"1330","last_page":"1339"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8830000162124634},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":1.0},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.9710000157356262},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":1.0},{"id":"https://openalex.org/keywords/tissue-nonspecific-alkaline-phosphatase","display_name":"tissue-nonspecific alkaline phosphatase","score":0.9359999895095825},{"id":"https://openalex.org/keywords/intestinal-alkaline-phosphatase","display_name":"intestinal alkaline phosphatase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/isoenzymes","display_name":"isozymes","score":0.7289999723434448},{"id":"https://openalex.org/keywords/superinduction","display_name":"superinduction","score":0.8230000138282776},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.8379999995231628},{"id":"https://openalex.org/keywords/ru486","display_name":"RU486","score":0.968999981880188},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/synergistic-induction","display_name":"synergistic induction","score":0.625}],"concepts":[{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.8354201316833496},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.6541813611984253},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.5948852300643921},{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.5381179451942444},{"id":"https://openalex.org/C2780004078","wikidata":"https://www.wikidata.org/wiki/Q4774743","display_name":"Antiglucocorticoid","level":4,"score":0.5253279209136963},{"id":"https://openalex.org/C19431177","wikidata":"https://www.wikidata.org/wiki/Q18031041","display_name":"Retinoic acid receptor beta","level":5,"score":0.5025589466094971},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.47564077377319336},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46728309988975525},{"id":"https://openalex.org/C120197328","wikidata":"https://www.wikidata.org/wiki/Q2838685","display_name":"Retinoic acid receptor","level":4,"score":0.46720144152641296},{"id":"https://openalex.org/C109541995","wikidata":"https://www.wikidata.org/wiki/Q1881253","display_name":"MCF-7","level":5,"score":0.46535876393318176},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4239903688430786},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.42240411043167114},{"id":"https://openalex.org/C2779963572","wikidata":"https://www.wikidata.org/wiki/Q29417","display_name":"Tretinoin","level":4,"score":0.42104703187942505},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41527557373046875},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3987720012664795},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3815244436264038},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3495878279209137},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.34478849172592163},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.24396544694900513},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21732568740844727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1037817895412445},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.10213559865951538},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.07381108403205872},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1432-1327.2000.01100.x","doi":"https://doi.org/10.1046/j.1432-1327.2000.01100.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1432-1327.2000.01100.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:10691970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10691970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W43140830","https://openalex.org/W79191144","https://openalex.org/W193081368","https://openalex.org/W566534948","https://openalex.org/W1487283064","https://openalex.org/W1489213275","https://openalex.org/W1505304474","https://openalex.org/W1516191286","https://openalex.org/W1517429411","https://openalex.org/W1535479800","https://openalex.org/W1573490657","https://openalex.org/W1585512120","https://openalex.org/W1586044524","https://openalex.org/W1602345641","https://openalex.org/W1637675880","https://openalex.org/W1643056575","https://openalex.org/W1779726318","https://openalex.org/W1874452234","https://openalex.org/W1885911413","https://openalex.org/W1927684145","https://openalex.org/W1928260425","https://openalex.org/W1942490905","https://openalex.org/W1968085816","https://openalex.org/W1970036878","https://openalex.org/W1976986472","https://openalex.org/W1977031949","https://openalex.org/W1979561177","https://openalex.org/W1981442223","https://openalex.org/W1982314306","https://openalex.org/W1988054107","https://openalex.org/W1989095709","https://openalex.org/W1990342690","https://openalex.org/W1997261857","https://openalex.org/W2005725141","https://openalex.org/W2006742182","https://openalex.org/W2007609212","https://openalex.org/W2012761399","https://openalex.org/W2014558679","https://openalex.org/W2018017340","https://openalex.org/W2035213793","https://openalex.org/W2038941478","https://openalex.org/W2041451989","https://openalex.org/W2042993666","https://openalex.org/W2046147052","https://openalex.org/W2057247299","https://openalex.org/W2059039694","https://openalex.org/W2060102821","https://openalex.org/W2060275385","https://openalex.org/W2060903877","https://openalex.org/W2061560661","https://openalex.org/W2065544256","https://openalex.org/W2079145995","https://openalex.org/W2080074942","https://openalex.org/W2081214185","https://openalex.org/W2089313885","https://openalex.org/W2092483871","https://openalex.org/W2102074953","https://openalex.org/W2107909669","https://openalex.org/W2129917732","https://openalex.org/W2135464666","https://openalex.org/W2152998856","https://openalex.org/W2156423290","https://openalex.org/W2166160962","https://openalex.org/W2168006710","https://openalex.org/W2168636604","https://openalex.org/W2260751386","https://openalex.org/W2304206918","https://openalex.org/W2314225431","https://openalex.org/W2315883859","https://openalex.org/W2330273832","https://openalex.org/W2395453235","https://openalex.org/W2475144702","https://openalex.org/W2782045341","https://openalex.org/W4230948051"],"related_works":["https://openalex.org/W43140830","https://openalex.org/W1985784075","https://openalex.org/W1983428554","https://openalex.org/W1586091975","https://openalex.org/W2032567649","https://openalex.org/W2030118676","https://openalex.org/W2066203492","https://openalex.org/W1516191286","https://openalex.org/W2074348965","https://openalex.org/W2072994306"],"abstract_inverted_index":{"The":[0],"effect":[1,124],"of":[2,41,77,80,195,204,215,221,229,236,247,265,273,294],"retinoic":[3,27,109,128,156,237,285],"acid":[4,28,110,129,157,286],"and":[5,34,60,83,96,111,158,162,244,270],"dexamethasone":[6,30,120,269,276,300],"on":[7,86,125],"alkaline":[8],"phosphatase":[9],"(AP)":[10],"expression":[11,250,297],"was":[12,23,44,105,114,130,141,176,207,223],"investigated":[13],"in":[14,31,68,98,226,233,251,291],"human":[15],"breast":[16],"cancer":[17],"MCF-7":[18,69],"cells.":[19],"Cellular":[20],"AP":[21,42,56],"activity":[22,43,104,113,135,148,206,267],"induced":[24,106,115],"significantly":[25],"by":[26,73,108,117,136,268,275,298],"or":[29,189],"a":[32],"time-dependent":[33],"dose-dependent":[35],"fashion.":[36],"A":[37],"marked":[38],"synergistic":[39],"induction":[40,203,264],"observed":[45],"when":[46,150],"the":[47,74,87,91,145,151,171,182,187,193,196,201,213,219,234,252,263,271,292],"cells":[48,70,152],"were":[49,63,101,153,165,277],"incubated":[50],"with":[51,155],"both":[52],"agents":[53],"simultaneously.":[54],"Two":[55],"isozymes,":[57],"tissue-nonspecific":[58],"(TNAP)":[59],"intestinal":[61],"(IAP),":[62],"shown":[64,131],"to":[65,132,143,168,217,301],"be":[66,144],"expressed":[67],"as":[71,210,241,255],"confirmed":[72],"differential":[75],"rate":[76],"thermal":[78],"inactivation":[79],"these":[81,259],"isozymes":[82],"RT-PCR.":[84],"Based":[85],"two-isozyme":[88],"thermal-inactivation":[89],"model,":[90],"specific":[92],"activities":[93],"for":[94],"TNAP":[95,103,126,140,173,230,248,274,295],"IAP":[97,112,134,205,266],"each":[99],"sample":[100],"analyzed.":[102],"only":[107,116,146],"dexamethasone.":[118,159,256],"Whereas":[119],"conferred":[121,245],"no":[122,309],"significant":[123],"activity,":[127,305],"inhibit":[133],"approximately":[137],"50%.":[138],"Interestingly,":[139],"found":[142],"isozyme":[147],"superinduced":[149],"costimulated":[154],"Northern":[160],"blot":[161],"RT-PCR":[163],"analysis":[164],"then":[166],"used":[167],"demonstrate":[169],"that":[170,181,262],"steady-state":[172],"mRNA":[174],"level":[175],"also":[177],"superinduced,":[178],"which":[179,306],"indicates":[180],"superinduction":[183,228,246,272,293],"is":[184],"regulated":[185],"at":[186],"transcriptional":[188],"post-transcriptional":[190],"levels.":[191],"In":[192,283],"presence":[194,235],"glucocorticoid":[197,222],"receptor":[198],"antagonist":[199],"RU486,":[200],"dexamethasone-mediated":[202,227],"blocked":[208],"completely":[209],"expected.":[211],"However,":[212],"ability":[214],"RU486":[216,239],"antagonize":[218],"action":[220],"greatly":[224],"compromised":[225],"activity.":[231],"Furthermore,":[232],"acid,":[238],"behaved":[240],"an":[242,288],"agonist,":[243],"gene":[249,296],"same":[253],"way":[254],"Taken":[257],"together,":[258],"observations":[260],"suggest":[261],"mediated":[278],"through":[279],"distinct":[280],"regulatory":[281],"pathways.":[282],"addition,":[284],"plays":[287],"essential":[289],"role":[290],"enabling":[299],"exert":[302],"its":[303],"agonist":[304],"otherwise":[307],"has":[308],"effect.":[310]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}