{"id":"https://openalex.org/W1803623716","doi":"https://doi.org/10.1093/genetics/145.4.911","title":"Increased Length of Long Terminal Repeats Inhibits Ty1 Transposition and Leads to the Formation of Tandem Multimers","display_name":"Increased Length of Long Terminal Repeats Inhibits Ty1 Transposition and Leads to the Formation of Tandem Multimers","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W1803623716","doi":"https://doi.org/10.1093/genetics/145.4.911","mag":"1803623716","pmid":"https://pubmed.ncbi.nlm.nih.gov/9093846","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1207896"},"language":"en","primary_location":{"id":"doi:10.1093/genetics/145.4.911","doi":"https://doi.org/10.1093/genetics/145.4.911","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/145.4.911","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013473083","display_name":"Vit Lauermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vit Lauermann","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061065113","display_name":"Monika Hermankova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monika Hermankova","raw_affiliation_strings":["Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075536007","display_name":"Jef D. Boeke","orcid":"https://orcid.org/0000-0001-5322-4946","observed_orcids":["https://orcid.org/0000-0001-5322-4946"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jef D Boeke","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Mayland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Mayland 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":2.2745,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.87313988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":97},"biblio":{"volume":"145","issue":"4","first_page":"911","last_page":"922"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ty1-retrotransposon","display_name":"Ty1 retrotransposon","score":0.996999979019165},{"id":"https://openalex.org/keywords/long-terminal-repeat","display_name":"long terminal repeat","score":0.9639999866485596},{"id":"https://openalex.org/keywords/transposition-frequency","display_name":"transposition frequency","score":0.722000002861023},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9089999794960022},{"id":"https://openalex.org/keywords/transposon-insertion","display_name":"transposon insertion","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C7029365","wikidata":"https://www.wikidata.org/wiki/Q413988","display_name":"Retrotransposon","level":5,"score":0.9302836060523987},{"id":"https://openalex.org/C199491388","wikidata":"https://www.wikidata.org/wiki/Q1869477","display_name":"Long terminal repeat","level":4,"score":0.8571535348892212},{"id":"https://openalex.org/C12455157","wikidata":"https://www.wikidata.org/wiki/Q7835331","display_name":"Transposition (logic)","level":2,"score":0.8027790784835815},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7666345238685608},{"id":"https://openalex.org/C27149982","wikidata":"https://www.wikidata.org/wiki/Q3456514","display_name":"Tandem repeat","level":4,"score":0.731945276260376},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.6875150203704834},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.666118860244751},{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.5809428095817566},{"id":"https://openalex.org/C51603236","wikidata":"https://www.wikidata.org/wiki/Q4852694","display_name":"Inverted repeat","level":4,"score":0.47763291001319885},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4370061159133911},{"id":"https://openalex.org/C2777814067","wikidata":"https://www.wikidata.org/wiki/Q1752317","display_name":"Tandem","level":2,"score":0.4236377775669098},{"id":"https://openalex.org/C29511175","wikidata":"https://www.wikidata.org/wiki/Q5280381","display_name":"Direct repeat","level":4,"score":0.4115602374076843},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.18094253540039062},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16583597660064697},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018626","descriptor_name":"Retroelements","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051721","descriptor_name":"Rad52 DNA Repair and Recombination Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/genetics/145.4.911","doi":"https://doi.org/10.1093/genetics/145.4.911","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/145.4.911","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},{"id":"pmid:9093846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9093846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1878841760","display_name":null,"funder_award_id":"GM-36481","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3813019498","display_name":null,"funder_award_id":"CA-16319","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5432442139","display_name":"Transposition Mechanisms","funder_award_id":"R01GM036481","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1749321702","https://openalex.org/W1753864123","https://openalex.org/W1784860041","https://openalex.org/W1853845900","https://openalex.org/W1873126638","https://openalex.org/W1894675486","https://openalex.org/W1906249372","https://openalex.org/W1911887027","https://openalex.org/W1918885191","https://openalex.org/W1941003312","https://openalex.org/W1946909565","https://openalex.org/W1966903120","https://openalex.org/W1969937359","https://openalex.org/W1973643623","https://openalex.org/W1973751387","https://openalex.org/W1978862919","https://openalex.org/W1983353035","https://openalex.org/W1995489647","https://openalex.org/W2000254114","https://openalex.org/W2005663625","https://openalex.org/W2006132678","https://openalex.org/W2014669590","https://openalex.org/W2018442148","https://openalex.org/W2019526440","https://openalex.org/W2036931150","https://openalex.org/W2043249063","https://openalex.org/W2050194148","https://openalex.org/W2059653960","https://openalex.org/W2067354942","https://openalex.org/W2070172523","https://openalex.org/W2071941492","https://openalex.org/W2095779387","https://openalex.org/W2098089385","https://openalex.org/W2108053853","https://openalex.org/W2110925400","https://openalex.org/W2111953151","https://openalex.org/W2115895870","https://openalex.org/W2121900438","https://openalex.org/W2160733626","https://openalex.org/W2170808509"],"related_works":["https://openalex.org/W889211313","https://openalex.org/W2098544789","https://openalex.org/W2044180304","https://openalex.org/W1023460740","https://openalex.org/W7151851085","https://openalex.org/W1993288106","https://openalex.org/W2121900438","https://openalex.org/W1953861638","https://openalex.org/W2553130520","https://openalex.org/W1819474806"],"abstract_inverted_index":{"The":[0],"Ty1":[1,18,77],"retrotransposon":[2],"of":[3,17,32,71],"Saccharomyces":[4],"cerevisiae":[5],"is":[6],"bounded":[7],"by":[8],"long-terminal":[9],"repeats":[10],"(LTRs).":[11],"We":[12],"have":[13,45],"constructed":[14],"a":[15,67],"variety":[16],"elements":[19,57],"in":[20,42],"which":[21],"the":[22,29,43,64],"LTR":[23,44],"length":[24,31],"has":[25],"been":[26],"increased":[27],"from":[28],"normal":[30],"334":[33],"bp":[34],"to":[35,80],">":[36],"2":[37],"kb.":[38],"Although":[39],"small":[40],"insertions":[41,52],"minimal":[46],"effects":[47],"on":[48],"transposition":[49],"frequency,":[50],"larger":[51],"dramatically":[53],"reduce":[54],"it.":[55],"Nevertheless,":[56],"with":[58],"long":[59],"LTRs":[60],"are":[61],"incorporated":[62],"into":[63],"genome":[65],"at":[66],"low":[68],"frequency.":[69],"Most":[70],"these":[72],"rare":[73],"insertion":[74],"events":[75],"represent":[76],"tandem":[78],"(head":[79],"tail)":[81],"multimers.":[82]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}