{"id":"https://openalex.org/W1801915911","doi":null,"title":"Antioxidants reduce cyclooxygenase-2 expression, prostaglandin production, and proliferation in colorectal cancer cells.","display_name":"Antioxidants reduce cyclooxygenase-2 expression, prostaglandin production, and proliferation in colorectal cancer cells.","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W1801915911","mag":"1801915911","pmid":"https://pubmed.ncbi.nlm.nih.gov/9622066"},"language":"en","primary_location":{"id":"pmid:9622066","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9622066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042784355","display_name":"Rebecca Chinery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Chinery","raw_affiliation_strings":["Department of Medicine, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089912608","display_name":"Robert Daniel Beauchamp","orcid":"https://orcid.org/0000-0002-8446-4114","observed_orcids":["https://orcid.org/0000-0002-8446-4114"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R D Beauchamp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062656698","display_name":"Yu Shyr","orcid":"https://orcid.org/0000-0003-2086-9670","observed_orcids":["https://orcid.org/0000-0003-2086-9670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Shyr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061901964","display_name":"Susan C. Kirkland","orcid":"https://orcid.org/0000-0003-1464-1063","observed_orcids":["https://orcid.org/0000-0003-1464-1063"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S C Kirkland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046249010","display_name":"Robert J. Coffey","orcid":"https://orcid.org/0000-0002-2180-3844","observed_orcids":["https://orcid.org/0000-0002-2180-3844"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R J Coffey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5044445154","display_name":"Jason D. Morrow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J D Morrow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.5152,"has_fulltext":false,"cited_by_count":135,"citation_normalized_percentile":{"value":0.98523207,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"58","issue":"11","first_page":"2323","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.7639999985694885},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9369999766349792},{"id":"https://openalex.org/keywords/prostaglandin-synthesis","display_name":"prostaglandin synthesis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.6970000267028809},{"id":"https://openalex.org/keywords/pyrrolidine-dithiocarbamate","display_name":"pyrrolidine dithiocarbamate","score":0.878000020980835},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":1.0},{"id":"https://openalex.org/keywords/trolox","display_name":"Trolox","score":0.9819999933242798},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7570000290870667},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6759999990463257},{"id":"https://openalex.org/keywords/redox-state","display_name":"redox state","score":0.7329999804496765},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.6830000281333923},{"id":"https://openalex.org/keywords/ns-398","display_name":"NS-398","score":0.9509999752044678},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.5040000081062317},{"id":"https://openalex.org/keywords/hca-7-cells","display_name":"HCA-7 cells","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.5981035828590393},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5916504263877869},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5799961686134338},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5721340775489807},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.539286732673645},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5082225799560547},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5078719258308411},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4909363090991974},{"id":"https://openalex.org/C2776231299","wikidata":"https://www.wikidata.org/wiki/Q245489","display_name":"Trolox","level":4,"score":0.453813761472702},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42493578791618347},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.41730186343193054},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38314712047576904},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3435492515563965},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3306877613067627},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2661266326904297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2576361298561096},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2557438910007477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21376001834869385},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18296349048614502},{"id":"https://openalex.org/C2993539680","wikidata":"https://www.wikidata.org/wiki/Q902552","display_name":"Antioxidant capacity","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052246","descriptor_name":"Cyclooxygenase 2 Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9622066","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9622066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1801915911","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9622066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8255882378","display_name":"Biochemistry and Pharmacology of D2/E2 Isoprostanes","funder_award_id":"R01DK048831","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8868505193","display_name":"Role of EGFR Ligands in Neoplasia","funder_award_id":"R01CA046413","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2107636032","https://openalex.org/W2156470937","https://openalex.org/W2046293893","https://openalex.org/W2138162756","https://openalex.org/W2023520601","https://openalex.org/W2398871528","https://openalex.org/W2060281370","https://openalex.org/W95197475","https://openalex.org/W3022575312","https://openalex.org/W2005055360"],"abstract_inverted_index":{"Increased":[0],"expression":[1,38,54,122],"of":[2,7,18,39,49,98,129,162,190],"cyclooxygenase":[3],"(COX)":[4],"and":[5,16,37,55,73,81,109,134,145,147,164,180],"overproduction":[6],"prostaglandins":[8],"(PGs)":[9],"have":[10],"been":[11],"implicated":[12],"in":[13,32,58,84,90,138,142,159,168,185],"the":[14,40,47,59,96,101,124,186],"development":[15],"progression":[17],"colorectal":[19],"cancer":[20],"(CRC).":[21],"Recent":[22],"observations":[23],"suggest":[24,174],"that":[25,113,175],"reactive":[26],"oxygen":[27],"intermediates":[28],"play":[29],"a":[30,85],"role":[31],"tumor":[33,157,170],"cell":[34,62],"growth":[35,57,83,92,158],"regulation":[36],"inducible":[41],"COX,":[42],"COX-2.":[43],"We":[44],"therefore":[45],"evaluated":[46],"effects":[48],"various":[50],"antioxidants":[51,66,119,152,181],"on":[52],"COX":[53,103],"cellular":[56,82,91],"human":[60],"CRC":[61],"line":[63],"HCA-7.":[64],"The":[65,88],"pyrrolidinedithiocarbamate":[67],"(PDTC),":[68],"N-acetylcysteine,":[69],"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic":[70],"acid":[71],"(Trolox),":[72],"U74006":[74],"decreased":[75,120],"PG":[76,143],"production,":[77],"intracellular":[78],"redox":[79],"status,":[80],"concentration-dependent":[86],"manner.":[87],"decrease":[89,141],"was":[93],"associated":[94],"with":[95,132,178],"induction":[97],"apoptosis.":[99],"Unlike":[100],"selective":[102],"inhibitors":[104],"1-[(4-methylsulfonyl)phenyl]-3-trifluoromethyl-5-[(4-fluoro)phenyl]pyraz":[105],"ole":[106],"(SC":[107],"58125)":[108],"(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide":[110],"(NS":[111],"398)":[112],"inhibit":[114],"COX-2":[115,121],"catalytic":[116],"activity,":[117],"these":[118],"at":[123],"transcriptional":[125],"level.":[126],"Combined":[127],"treatment":[128,189],"HCA-7":[130],"cells":[131],"PDTC":[133,163],"SC":[135,154,165],"58125":[136,155,166],"resulted":[137,167],"an":[139],"additive":[140],"levels":[144],"anchorage-dependent":[146],"-independent":[148],"growth.":[149],"Furthermore,":[150],"whereas":[151],"or":[153],"reduced":[156],"vivo,":[160],"coadministration":[161],"actual":[169],"regression.":[171],"These":[172],"results":[173],"combined":[176],"therapy":[177],"NSAIDs":[179],"might":[182],"be":[183],"useful":[184],"prevention":[187],"and/or":[188],"CRC.":[191]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
