{"id":"https://openalex.org/W1801710459","doi":null,"title":"Androgen receptor-dependent and independent functions of ARIP4","display_name":"Androgen receptor-dependent and independent functions of ARIP4","publication_year":2007,"publication_date":"2007-02-23","ids":{"openalex":"https://openalex.org/W1801710459","mag":"1801710459"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/20212","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/20212","pdf_url":"http://hdl.handle.net/10138/20212","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/20212","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015357087","display_name":"Andrii Domanskyi","orcid":"https://orcid.org/0000-0002-4755-5981","observed_orcids":["https://orcid.org/0000-0002-4755-5981"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Andrii Domanskyi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4755-5981","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5015357087"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.611299991607666,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.611299991607666,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.12039999663829803,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.10109999775886536,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/dna-dependent-atpase","display_name":"DNA-dependent ATPase","score":0.734000027179718},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.8629999756813049},{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.7110000252723694},{"id":"https://openalex.org/keywords/sertoli-cells","display_name":"Sertoli cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/leydig-cells","display_name":"Leydig cells","score":0.824999988079071},{"id":"https://openalex.org/keywords/haploinsufficiency","display_name":"haploinsufficiency","score":0.7990000247955322},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.32600000500679016},{"id":"https://openalex.org/keywords/testis","display_name":"testis","score":0.34299999475479126},{"id":"https://openalex.org/keywords/embryonic-lethality","display_name":"embryonic lethality","score":0.5540000200271606},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5230000019073486},{"id":"https://openalex.org/keywords/fsh-receptor","display_name":"FSH receptor","score":0.46700000762939453},{"id":"https://openalex.org/keywords/luteinizing-hormone-receptor","display_name":"luteinizing hormone receptor","score":0.753000020980835},{"id":"https://openalex.org/keywords/gene-expression-patterns","display_name":"gene expression patterns","score":0.33399999141693115}],"concepts":[{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.6375728845596313},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41685158014297485},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.4134949743747711},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3817441165447235},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3549460172653198},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3474835157394409},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3371475040912628},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3019048571586609},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2516295909881592},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.2208327054977417},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.14109548926353455},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/20212","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/20212","pdf_url":"http://hdl.handle.net/10138/20212","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"mag:1801710459","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/bitstream/10138/20212/1/androgen.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/20212","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/20212","pdf_url":"http://hdl.handle.net/10138/20212","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310467","display_name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","ror":"https://ror.org/020cpqb94"},{"id":"https://openalex.org/F4320314997","display_name":"Strong","ror":"https://ror.org/041vyzr56"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1801710459.pdf","grobid_xml":"https://content.openalex.org/works/W1801710459.grobid-xml"},"referenced_works_count":221,"referenced_works":["https://openalex.org/W6756839","https://openalex.org/W41338256","https://openalex.org/W45411047","https://openalex.org/W1483357717","https://openalex.org/W1484163259","https://openalex.org/W1498970130","https://openalex.org/W1501286679","https://openalex.org/W1508200717","https://openalex.org/W1516316082","https://openalex.org/W1551890621","https://openalex.org/W1607777232","https://openalex.org/W1676891985","https://openalex.org/W1760824447","https://openalex.org/W1829371983","https://openalex.org/W1832796895","https://openalex.org/W1919133853","https://openalex.org/W1945378141","https://openalex.org/W1964858195","https://openalex.org/W1965331111","https://openalex.org/W1966826515","https://openalex.org/W1968455126","https://openalex.org/W1969964108","https://openalex.org/W1971358793","https://openalex.org/W1971829574","https://openalex.org/W1972108825","https://openalex.org/W1973092405","https://openalex.org/W1973571827","https://openalex.org/W1975658312","https://openalex.org/W1975795769","https://openalex.org/W1977873240","https://openalex.org/W1979753264","https://openalex.org/W1981977553","https://openalex.org/W1982603939","https://openalex.org/W1983057459","https://openalex.org/W1983710007","https://openalex.org/W1987476804","https://openalex.org/W1988749905","https://openalex.org/W1990586926","https://openalex.org/W1992013972","https://openalex.org/W1993122912","https://openalex.org/W1993442317","https://openalex.org/W1993979753","https://openalex.org/W1995216272","https://openalex.org/W1996234697","https://openalex.org/W1997083861","https://openalex.org/W1998878897","https://openalex.org/W2000272292","https://openalex.org/W2000463885","https://openalex.org/W2000537062","https://openalex.org/W2002218819","https://openalex.org/W2002653885","https://openalex.org/W2002662963","https://openalex.org/W2005783395","https://openalex.org/W2006044949","https://openalex.org/W2006895915","https://openalex.org/W2007801101","https://openalex.org/W2011286091","https://openalex.org/W2012224269","https://openalex.org/W2014454255","https://openalex.org/W2015284522","https://openalex.org/W2015472477","https://openalex.org/W2017494354","https://openalex.org/W2019904951","https://openalex.org/W2020663303","https://openalex.org/W2020719725","https://openalex.org/W2021544762","https://openalex.org/W2021908852","https://openalex.org/W2023822954","https://openalex.org/W2026276647","https://openalex.org/W2028525051","https://openalex.org/W2031146912","https://openalex.org/W2031636974","https://openalex.org/W2031915712","https://openalex.org/W2033042516","https://openalex.org/W2033527028","https://openalex.org/W2035711037","https://openalex.org/W2035895518","https://openalex.org/W2039099840","https://openalex.org/W2040053707","https://openalex.org/W2040070665","https://openalex.org/W2041860345","https://openalex.org/W2042411910","https://openalex.org/W2042973817","https://openalex.org/W2044715689","https://openalex.org/W2045711328","https://openalex.org/W2046702207","https://openalex.org/W2050581082","https://openalex.org/W2051078744","https://openalex.org/W2051166632","https://openalex.org/W2051448662","https://openalex.org/W2052420006","https://openalex.org/W2054621094","https://openalex.org/W2054923884","https://openalex.org/W2055520830","https://openalex.org/W2055689986","https://openalex.org/W2055965454","https://openalex.org/W2056059870","https://openalex.org/W2057194500","https://openalex.org/W2060584995","https://openalex.org/W2060817283","https://openalex.org/W2060945266","https://openalex.org/W2061497413","https://openalex.org/W2063334947","https://openalex.org/W2063486767","https://openalex.org/W2064293531","https://openalex.org/W2066079419","https://openalex.org/W2066992571","https://openalex.org/W2069511698","https://openalex.org/W2071709406","https://openalex.org/W2071880474","https://openalex.org/W2072733361","https://openalex.org/W2074974586","https://openalex.org/W2075296693","https://openalex.org/W2076024644","https://openalex.org/W2076466919","https://openalex.org/W2076503198","https://openalex.org/W2076811906","https://openalex.org/W2077251071","https://openalex.org/W2077907808","https://openalex.org/W2077995563","https://openalex.org/W2078381702","https://openalex.org/W2078503449","https://openalex.org/W2078638321","https://openalex.org/W2079628366","https://openalex.org/W2081365151","https://openalex.org/W2081676666","https://openalex.org/W2081800082","https://openalex.org/W2084253425","https://openalex.org/W2086086427","https://openalex.org/W2087388899","https://openalex.org/W2091095324","https://openalex.org/W2092304427","https://openalex.org/W2092653631","https://openalex.org/W2092723228","https://openalex.org/W2094323432","https://openalex.org/W2098737213","https://openalex.org/W2102203964","https://openalex.org/W2102806129","https://openalex.org/W2102827103","https://openalex.org/W2103693642","https://openalex.org/W2103991023","https://openalex.org/W2104577103","https://openalex.org/W2106235028","https://openalex.org/W2106571316","https://openalex.org/W2106770461","https://openalex.org/W2108958077","https://openalex.org/W2109243666","https://openalex.org/W2109431926","https://openalex.org/W2109992434","https://openalex.org/W2111369394","https://openalex.org/W2111490168","https://openalex.org/W2113333419","https://openalex.org/W2114108429","https://openalex.org/W2116472345","https://openalex.org/W2117658058","https://openalex.org/W2118342658","https://openalex.org/W2118410873","https://openalex.org/W2119301405","https://openalex.org/W2119935765","https://openalex.org/W2120585869","https://openalex.org/W2121779606","https://openalex.org/W2123331216","https://openalex.org/W2125069527","https://openalex.org/W2126496338","https://openalex.org/W2126695143","https://openalex.org/W2127647846","https://openalex.org/W2128786355","https://openalex.org/W2128931073","https://openalex.org/W2128995137","https://openalex.org/W2130209773","https://openalex.org/W2130749378","https://openalex.org/W2131422252","https://openalex.org/W2133148543","https://openalex.org/W2133761023","https://openalex.org/W2134484762","https://openalex.org/W2136002991","https://openalex.org/W2136294116","https://openalex.org/W2136401958","https://openalex.org/W2136790545","https://openalex.org/W2136796186","https://openalex.org/W2136968773","https://openalex.org/W2137347518","https://openalex.org/W2140459477","https://openalex.org/W2140997010","https://openalex.org/W2142785868","https://openalex.org/W2143920112","https://openalex.org/W2144064755","https://openalex.org/W2144908726","https://openalex.org/W2146027649","https://openalex.org/W2147154230","https://openalex.org/W2148515234","https://openalex.org/W2149290739","https://openalex.org/W2151464048","https://openalex.org/W2151922331","https://openalex.org/W2152302131","https://openalex.org/W2152719103","https://openalex.org/W2156281856","https://openalex.org/W2156933633","https://openalex.org/W2158526159","https://openalex.org/W2159639995","https://openalex.org/W2160534562","https://openalex.org/W2161123101","https://openalex.org/W2164175615","https://openalex.org/W2164284287","https://openalex.org/W2164787718","https://openalex.org/W2167212154","https://openalex.org/W2168149052","https://openalex.org/W2168224930","https://openalex.org/W2168439225","https://openalex.org/W2169457085","https://openalex.org/W2170549904","https://openalex.org/W2170778160","https://openalex.org/W2267558770","https://openalex.org/W2303001272","https://openalex.org/W2319691036","https://openalex.org/W2342997665","https://openalex.org/W2397867867","https://openalex.org/W3150202998","https://openalex.org/W7095234180","https://openalex.org/W7099717845","https://openalex.org/W7099883201"],"related_works":["https://openalex.org/W2162825225","https://openalex.org/W2012617905","https://openalex.org/W2069144415","https://openalex.org/W2087388899","https://openalex.org/W1975760694","https://openalex.org/W4211031270","https://openalex.org/W2051078744","https://openalex.org/W2143131510","https://openalex.org/W171538712","https://openalex.org/W1995453257"],"abstract_inverted_index":{"Androgen":[0],"receptor":[1,19,34],"(AR)":[2],"is":[3,15,74,83,160,171,209,225,232,245,281],"necessary":[4],"for":[5,12,85],"normal":[6],"male":[7,23],"phenotype":[8],"development":[9],"and":[10,27,35,62,66,69,79,118,127,176,194,216,256,271,287,296,304,335,355,368,374,400],"essential":[11,84,390],"spermatogenesis.":[13],"AR":[14,37,59,92,196,401],"a":[16,135,241,347,370,407],"classical":[17,136],"steroid":[18],"mediating":[20],"actions":[21],"of":[22,48,88,97,110,178,187,237,251,262,277,350,404,409,416],"sex":[24],"steroids":[25],"testosterone":[26],"5-alpha-dihydrotestosterone.":[28],"Numerous":[29],"coregulators":[30],"interact":[31],"with":[32,45,58,311],"the":[33,46,86,95,107,185,213,235,249,275,413,417],"regulate":[36],"activity":[38,82,403],"on":[39,166],"target":[40],"genes.":[41],"This":[42],"study":[43],"deals":[44],"characterization":[47],"androgen":[49,314],"receptor-interacting":[50],"protein":[51,139,149],"4":[52],"(ARIP4).":[53],"ARIP4":[54,73,89,104,129,159,170,188,198,208,223,231,244,263,280,387,405],"binds":[55],"DNA,":[56,191],"interacts":[57],"in":[60,63,100,113,140,151,156,201,212,234,240,248,268,284,294,316,392,412],"vitro":[61],"cultured":[64],"yeast":[65],"mammalian":[67],"cells,":[68,253],"modulates":[70],"AR-dependent":[71],"transactivation.":[72],"an":[75,389],"active":[76],"DNA-dependent":[77],"ATPase,":[78],"this":[80],"enzymatic":[81],"ability":[87,186],"to":[90,106,122,133,146,162,189,313,340],"modulate":[91],"function.":[93,197],"On":[94],"basis":[96],"sequence":[98],"homology":[99],"its":[101,123],"ATPase":[102],"domain,":[103],"belongs":[105],"SNF2":[108],"family":[109],"proteins":[111],"involved":[112],"chromatin":[114,137],"remodeling,":[115],"DNA":[116,168],"repair,":[117],"homologous":[119],"recombination.":[120],"Similar":[121],"closest":[124],"homologs":[125],"ATRX":[126],"Rad54,":[128],"does":[130,143,264],"not":[131,144,265,325],"seem":[132],"be":[134],"remodeling":[138],"that":[141,386],"it":[142],"appear":[145,305],"form":[147],"large":[148],"complexes":[150],"vivo":[152],"or":[153],"remodel":[154],"mononucleosomes":[155],"vitro.":[157],"However,":[158],"able":[161],"generate":[163],"superhelical":[164],"torsion":[165],"linear":[167],"fragments.":[169],"covalently":[172],"modified":[173],"by":[174,337],"SUMO-1,":[175],"mutation":[177],"six":[179],"potential":[180],"SUMO":[181],"attachment":[182],"sites":[183],"abolishes":[184],"bind":[190],"hydrolyze":[192],"ATP,":[193],"activate":[195],"expression":[199,224,260,293,399],"starts":[200],"early":[202],"embryonic":[203,394],"development.":[204,395],"In":[205,219,228,274,319,396],"mouse":[206,221,229,393],"embryo":[207],"present":[210,247],"mainly":[211,283],"neural":[214],"tube":[215],"limb":[217],"buds.":[218],"adult":[220],"tissues":[222],"virtually":[226],"ubiquitous.":[227],"testis":[230,276],"expressed":[233],"nuclei":[236,250],"Sertoli":[238,295,317],"cells":[239,286,352,379,415],"stage-dependent":[242],"manner.":[243],"also":[246],"Leydig":[252],"spermatogonia,":[254],"pachytene":[255],"diplotene":[257],"spermatocytes.":[258],"Testicular":[259],"pattern":[261],"differ":[266],"significantly":[267,329,371],"wild-type,":[269],"FSHRKO,":[270],"LuRKO":[272],"mice.":[273],"hpg":[278],"mice,":[279],"found":[282],"interstitial":[285],"has":[288],"very":[289],"low,":[290],"if":[291],"any,":[292],"germ":[297],"cells.":[298,318],"Heterozygous":[299],"Arip4+/":[300],"mice":[301],"are":[302,309,324],"fertile":[303],"normal;":[306],"however,":[307],"they":[308],"haploinsufficient":[310],"regard":[312],"action":[315],"contrast,":[320],"Arip4":[321,343,360],"/":[322,344,361],"embryos":[323,345,362],"viable.":[326],"They":[327],"have":[328],"reduced":[330],"body":[331],"size":[332],"at":[333,353],"E9.5":[334,354],"die":[336],"E11.5.":[338],"Compared":[339],"wild-type":[341,381],"littermates,":[342],"possess":[346],"higher":[348],"percentage":[349],"apoptotic":[351],"E10.5.":[356],"Fibroblasts":[357],"derived":[358],"from":[359,380],"cease":[363],"growing":[364],"after":[365],"2-3":[366],"passages":[367],"exhibit":[369],"increased":[372],"apoptosis":[373],"decreased":[375],"proliferation":[376],"rate":[377],"than":[378],"embryos.":[382],"Our":[383],"findings":[384],"demonstrate":[385],"plays":[388],"role":[391,408],"addition,":[397],"testicular":[398],"coregulatory":[402],"suggest":[406],"ARIP4-AR":[410],"interaction":[411],"somatic":[414],"testis.":[418]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
