{"id":"https://openalex.org/W1800570554","doi":null,"title":"Organ-specific insulin resistance in patients with noninsulin-dependent diabetes mellitus and hypertension.","display_name":"Organ-specific insulin resistance in patients with noninsulin-dependent diabetes mellitus and hypertension.","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W1800570554","mag":"1800570554","pmid":"https://pubmed.ncbi.nlm.nih.gov/9591594"},"language":"en","primary_location":{"id":"pmid:9591594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9591594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"I Yokoyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"I Yokoyama","raw_affiliation_strings":["The Second Department of Internal Medicine, University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Internal Medicine, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034622115","display_name":"Tohru Ohtake","orcid":"https://orcid.org/0000-0002-1345-5210","observed_orcids":["https://orcid.org/0000-0002-1345-5210"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Ohtake","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053906986","display_name":"Shin\u2010ichi Momomura","orcid":"https://orcid.org/0000-0001-6019-5629","observed_orcids":["https://orcid.org/0000-0001-6019-5629"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Momomura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030974165","display_name":"Katsunori Yonekura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Yonekura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111186665","display_name":"N Yamada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Yamada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111880458","display_name":"J Nishikawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Nishikawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057634452","display_name":"Yasuhito Sasaki","orcid":"https://orcid.org/0000-0001-6192-7596","observed_orcids":["https://orcid.org/0000-0001-6192-7596"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Sasaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034244372","display_name":"Masao Omata","orcid":"https://orcid.org/0000-0001-7977-1497","observed_orcids":["https://orcid.org/0000-0001-7977-1497"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Omata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6256,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.66267302,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"39","issue":"5","first_page":"884","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.027899999171495438,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7770000100135803},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.902999997138977},{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.9150000214576721},{"id":"https://openalex.org/keywords/myocardial-glucose-utilization","display_name":"myocardial glucose utilization","score":0.9869999885559082},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.843999981880188},{"id":"https://openalex.org/keywords/plasma-free-fatty-acids","display_name":"plasma free fatty acids","score":0.9020000100135803},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8215422630310059},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7669233083724976},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7231823205947876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6928228139877319},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6562730669975281},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6345497369766235},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6078377366065979},{"id":"https://openalex.org/C2777097880","wikidata":"https://www.wikidata.org/wiki/Q988405","display_name":"Essential hypertension","level":3,"score":0.48312899470329285},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.45147788524627686},{"id":"https://openalex.org/C2778808658","wikidata":"https://www.wikidata.org/wiki/Q2975183","display_name":"Glucose clamp technique","level":5,"score":0.44954460859298706},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.44164079427719116},{"id":"https://openalex.org/C2780352109","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic hormone","level":4,"score":0.20144417881965637}],"mesh":[{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005462","descriptor_name":"Fluorine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014055","descriptor_name":"Tomography, Emission-Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015309","descriptor_name":"Glucose Clamp Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9591594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9591594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"mag:1800570554","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9591594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1833829642","https://openalex.org/W1955901897","https://openalex.org/W1968764560","https://openalex.org/W2012898950","https://openalex.org/W2084243081","https://openalex.org/W2090730793","https://openalex.org/W2099191279","https://openalex.org/W2131031199","https://openalex.org/W2155605721","https://openalex.org/W2328895879","https://openalex.org/W2338570515"],"related_works":["https://openalex.org/W1968764560","https://openalex.org/W2047982974","https://openalex.org/W2163199948","https://openalex.org/W1995071272","https://openalex.org/W2080415680","https://openalex.org/W1968583683","https://openalex.org/W2319850088","https://openalex.org/W2009509125","https://openalex.org/W2412441957","https://openalex.org/W2322316119"],"abstract_inverted_index":{"UNLABELLED:":[0],"Abnormal":[1],"heart":[2,22,38,81],"and":[3,23,39,46,64,67,82,119,157,236],"skeletal":[4,24,40,83,269],"muscle":[5,25,41,84,101,270],"glucose":[6,26,42,49,85,102,185,266],"metabolism":[7],"in":[8,21,28,56,135,192,206,248,271],"diabetes":[9,29,61],"or":[10],"essential":[11,65],"hypertension":[12,20,66,73,79,196,209],"has":[13,30,225],"been":[14,32],"demonstrated.":[15],"However,":[16,182],"the":[17,47,76,152,183],"role":[18],"of":[19,78,252,268],"utilization":[27,43,103,186,267],"not":[31],"clarified":[33],"yet.":[34],"METHODS:":[35],"We":[36],"compared":[37,90,138,169],"using":[44],"PET":[45],"whole-body":[48],"disposal":[50],"rate":[51,104,188,256],"(GDR)":[52],"during":[53],"insulin":[54,244,263],"clamping":[55],"9":[57],"patients":[58,69,110,122,168,194,250,273],"with":[59,70,91,139,170,208,232,274],"noninsulin-dependent":[60],"mellitus":[62],"(NIDDM)":[63],"11":[68],"NIDDM":[71,109,121,193,249],"without":[72,195],"to":[74,261],"examine":[75],"effect":[77],"on":[80],"utilization.":[86],"Results":[87],"also":[88],"were":[89],"those":[92,207],"for":[93,167,179],"8":[94],"asymptomatic":[95],"healthy":[96],"control":[97,140,180],"participants.":[98],"RESULTS:":[99],"Skeletal":[100],"was":[105,132,151,189,229,246],"comparable":[106],"between":[107],"hypertensive":[108,272],"(61.2":[111],"+/-":[112,124,143,155,159,172,198,211],"55.5":[113],"micromol":[114,126,145,161,174,200,213],"x":[115,117,127,129,146,148,162,164,175,177,201,203,214,216],"min(-1)":[116,128,147,163,176,202,215],"kg(-1))":[118,130,204],"normotensive":[120],"(50.9":[123],"25.2":[125],"but":[131],"significantly":[133,190,230],"reduced":[134,191],"both":[136],"groups":[137],"subjects":[141],"(94.2":[142],"57.3":[144],"kg(-1)),":[149,165],"as":[150],"GDR":[153],"(25.2":[154],"11.3":[156],"24.0":[158],"7.5":[160],"respectively,":[166],"38.5":[171],"11.5":[173],"kg(-1)":[178],"participants).":[181],"myocardial":[184],"(MGU)":[187],"(389":[197],"185":[199],"than":[205,265],"(616":[210],"86.4":[212],"kg(-1),":[217],"p":[218],"<":[219],"0.01).":[220],"Multivariate":[221],"stepwise":[222],"regression":[223],"analysis":[224],"shown":[226],"that":[227],"MGU":[228,255],"correlated":[231],"systolic":[233],"blood":[234],"pressure":[235],"plasma":[237],"free":[238],"fatty":[239],"acid":[240],"concentration.":[241],"CONCLUSION:":[242],"Whole-body":[243],"resistance":[245,264],"observed":[247],"independent":[251],"hypertension.":[253],"The":[254],"may":[257],"have":[258],"different":[259],"properties":[260],"oppose":[262],"NIDDM.":[275]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
