{"id":"https://openalex.org/W1800414161","doi":"https://doi.org/10.1128/iai.43.2.664-669.1984","title":"Killing of human malaria parasites by macrophage secretory products","display_name":"Killing of human malaria parasites by macrophage secretory products","publication_year":1984,"publication_date":"1984-02-01","ids":{"openalex":"https://openalex.org/W1800414161","doi":"https://doi.org/10.1128/iai.43.2.664-669.1984","mag":"1800414161","pmid":"https://pubmed.ncbi.nlm.nih.gov/6363296","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/264351"},"language":"en","primary_location":{"id":"doi:10.1128/iai.43.2.664-669.1984","doi":"https://doi.org/10.1128/iai.43.2.664-669.1984","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.43.2.664-669.1984","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC264351","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080806053","display_name":"Anne O. Wozencraft","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A O Wozencraft","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089522455","display_name":"Hazel M. Dockrell","orcid":"https://orcid.org/0000-0003-1869-9107","observed_orcids":["https://orcid.org/0000-0003-1869-9107"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H M Dockrell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067910790","display_name":"Janice Taverne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Taverne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075676481","display_name":"Geoffrey A. T. Targett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G A Targett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111454303","display_name":"John H.L. Playfair","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J H Playfair","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":22.7244,"has_fulltext":false,"cited_by_count":130,"citation_normalized_percentile":{"value":0.99559362,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"43","issue":"2","first_page":"664","last_page":"669"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12178","display_name":"Bird parasitology and diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.996999979019165},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7440000176429749},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8270000219345093},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9300000071525574},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9369999766349792},{"id":"https://openalex.org/keywords/xanthine-xanthine-oxidase-system","display_name":"xanthine-xanthine oxidase system","score":0.859000027179718},{"id":"https://openalex.org/keywords/erythrocyte-membrane-damage","display_name":"erythrocyte membrane damage","score":0.6370000243186951},{"id":"https://openalex.org/keywords/parasite-viability","display_name":"parasite viability","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7633850574493408},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.7554277181625366},{"id":"https://openalex.org/C2778102346","wikidata":"https://www.wikidata.org/wiki/Q412509","display_name":"Xanthine oxidase","level":3,"score":0.6892267465591431},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6471556425094604},{"id":"https://openalex.org/C2781116151","wikidata":"https://www.wikidata.org/wiki/Q410305","display_name":"Hypoxanthine","level":3,"score":0.6383400559425354},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.6294676661491394},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5750052332878113},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5381195545196533},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4073573648929596},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31346040964126587},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2782840132713318},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.22522753477096558},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21270820498466492}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005949","descriptor_name":"Glucose Oxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007042","descriptor_name":"Hypoxanthines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014969","descriptor_name":"Xanthine Oxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014970","descriptor_name":"Xanthines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019271","descriptor_name":"Hypoxanthine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019820","descriptor_name":"Xanthine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/iai.43.2.664-669.1984","doi":"https://doi.org/10.1128/iai.43.2.664-669.1984","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.43.2.664-669.1984","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1458898","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC264351","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:264351","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/264351","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:6363296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6363296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1458898","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC264351","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W117390686","https://openalex.org/W1553490378","https://openalex.org/W1580002784","https://openalex.org/W1751790428","https://openalex.org/W1823552513","https://openalex.org/W1926917528","https://openalex.org/W1942269991","https://openalex.org/W1965977591","https://openalex.org/W1969503178","https://openalex.org/W1976615521","https://openalex.org/W2007121116","https://openalex.org/W2023122744","https://openalex.org/W2037299483","https://openalex.org/W2053098962","https://openalex.org/W2057123987","https://openalex.org/W2078613739","https://openalex.org/W2092416359","https://openalex.org/W2101422765","https://openalex.org/W2109131304","https://openalex.org/W2124247208","https://openalex.org/W2147144911","https://openalex.org/W2149460783","https://openalex.org/W2161966806","https://openalex.org/W2171070360","https://openalex.org/W2364282361","https://openalex.org/W2410078837"],"related_works":["https://openalex.org/W1498421874","https://openalex.org/W2109131304","https://openalex.org/W2023750774","https://openalex.org/W1769152148","https://openalex.org/W1575114551","https://openalex.org/W1861750951","https://openalex.org/W2066178292","https://openalex.org/W2105418996","https://openalex.org/W2092404417","https://openalex.org/W2615916782"],"abstract_inverted_index":{"The":[0,19,95],"susceptibility":[1],"of":[2,21,40,47,64,97,117,164,183],"the":[3,38,45,62,71,75,87,118,124,151,162,165,172,184],"human":[4],"malaria":[5],"parasite,":[6],"Plasmodium":[7],"falciparum,":[8],"to":[9,54,114,171,202],"killing":[10,125,185],"in":[11,123,200],"vitro":[12],"by":[13,36,44,61],"macrophage":[14,194],"secretory":[15],"products":[16,163,195],"was":[17,31,52,59,77,111,154],"investigated.":[18],"effect":[20,58],"O2":[22,83,99,119],"radicals":[23,84,120],"and":[24,35,49],"tumor":[25,133,158],"necrosis":[26,134,159],"factor":[27,160],"on":[28],"parasite":[29,81],"viability":[30],"assessed":[32],"both":[33],"morphologically":[34],"following":[37],"uptake":[39],"[3H]hypoxanthine.":[41],"H2O2":[42],"produced":[43,85],"interaction":[46,90,168],"glucose":[48,50],"oxidase":[51,89,167],"found":[53],"reduce":[55],"viability;":[56],"this":[57,107],"reversed":[60],"addition":[63,96],"exogenous":[65],"catalase.":[66],"Further":[67],"studies":[68],"indicated":[69],"that":[70,157,175,192],"catalase":[72],"level":[73],"within":[74],"erythrocyte":[76,173],"not":[78,105,112],"altered":[79],"upon":[80],"invasion.":[82],"during":[86],"xanthine-xanthine":[88,166],"also":[91,149],"killed":[92,150],"P.":[93],"falciparum.":[94],"various":[98],"radical":[100],"scavengers":[101],"(including":[102],"catalase)":[103],"did":[104],"reverse":[106],"effect;":[108],"therefore,":[109],"it":[110],"possible":[113],"determine":[115],"which":[116],"were":[121],"involved":[122],"process.":[126,186],"Samples":[127],"from":[128,141],"three":[129],"different":[130],"sources":[131],"containing":[132],"factor,":[135],"a":[136],"nonspecific":[137],"soluble":[138],"mediator":[139],"derived":[140],"Mycobacterium":[142],"bovis":[143],"BCG-activated":[144],"macrophages":[145],"treated":[146],"with":[147],"endotoxin,":[148],"parasite.":[152],"There":[153],"no":[155],"evidence":[156],"or":[161],"caused":[169],"damage":[170],"membrane":[174],"could":[176],"be":[177],"implicated":[178],"as":[179],"an":[180,197],"important":[181,198],"aspect":[182],"These":[187],"findings":[188],"all":[189],"strongly":[190],"suggest":[191],"such":[193],"play":[196],"role":[199],"immunity":[201],"malaria.":[203]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
