{"id":"https://openalex.org/W1799425195","doi":"https://doi.org/10.1111/j.1600-065x.2012.01137.x","title":"A model for lupus brain disease","display_name":"A model for lupus brain disease","publication_year":2012,"publication_date":"2012-06-21","ids":{"openalex":"https://openalex.org/W1799425195","doi":"https://doi.org/10.1111/j.1600-065x.2012.01137.x","mag":"1799425195","pmid":"https://pubmed.ncbi.nlm.nih.gov/22725954","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4398143"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-065x.2012.01137.x","doi":"https://doi.org/10.1111/j.1600-065x.2012.01137.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-065x.2012.01137.x","pdf_url":null,"source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4398143","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089808423","display_name":"Betty Diamond","orcid":"https://orcid.org/0000-0002-3250-3804","observed_orcids":["https://orcid.org/0000-0002-3250-3804"]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]},{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Betty Diamond","raw_affiliation_strings":["Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, NY 11030, USA. bdiamond@nshs.edu","Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, North Shore\u2010Long Island Jewish Health System, Manhasset, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, NY 11030, USA. bdiamond@nshs.edu","institution_ids":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]},{"raw_affiliation_string":"Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, North Shore\u2010Long Island Jewish Health System, Manhasset, NY, USA","institution_ids":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046913023","display_name":"Bruce T. Volpe","orcid":"https://orcid.org/0000-0002-1098-1848","observed_orcids":["https://orcid.org/0000-0002-1098-1848"]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]},{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce T. Volpe","raw_affiliation_strings":["Laboratory of Functional Neuroanatomy, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Functional Neuroanatomy, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, NY, USA","institution_ids":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089808423"],"corresponding_institution_ids":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.0025,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.67581301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"248","issue":"1","first_page":"56","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9750000238418579},{"id":"https://openalex.org/keywords/lupus-encephalopathy","display_name":"lupus encephalopathy","score":0.8149999976158142},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.8930000066757202},{"id":"https://openalex.org/keywords/brain-damage","display_name":"brain damage","score":0.6480000019073486},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.7680000066757202},{"id":"https://openalex.org/keywords/immune-complexes","display_name":"immune complexes","score":0.7160000205039978},{"id":"https://openalex.org/keywords/fc-receptors","display_name":"Fc receptors","score":0.8339999914169312},{"id":"https://openalex.org/keywords/neuronal-activation","display_name":"neuronal activation","score":0.6290000081062317},{"id":"https://openalex.org/keywords/neuronal-survival","display_name":"neuronal survival","score":0.9679999947547913},{"id":"https://openalex.org/keywords/central-nervous-system-autoimmunity","display_name":"central nervous system autoimmunity","score":0.6970000267028809},{"id":"https://openalex.org/keywords/tissue-damage","display_name":"tissue damage","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6779268383979797},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6441352367401123},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6411420106887817},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.6316542029380798},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6082416772842407},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.5642893314361572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5223356485366821},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.4986264705657959},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.47846150398254395},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.4538884460926056},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42289817333221436},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.39682599902153015},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34006428718566895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32984206080436707},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.23158538341522217}],"mesh":[{"descriptor_ui":"D000679","descriptor_name":"Amygdala","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000679","descriptor_name":"Amygdala","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000974","descriptor_name":"Antibodies, Antinuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000974","descriptor_name":"Antibodies, Antinuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000974","descriptor_name":"Antibodies, Antinuclear","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1600-065x.2012.01137.x","doi":"https://doi.org/10.1111/j.1600-065x.2012.01137.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-065x.2012.01137.x","pdf_url":null,"source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},{"id":"pmid:22725954","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22725954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological reviews","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4398143","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4398143","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Immunol Rev","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4398143","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4398143","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Immunol Rev","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000905893","display_name":"Anti-NMDA Receptor Antibodies in Adult Brain Dysfunction: Lessons from Lupus","funder_award_id":"P01AI073693","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W46255818","https://openalex.org/W137269151","https://openalex.org/W170573427","https://openalex.org/W1486919132","https://openalex.org/W1549213298","https://openalex.org/W1563286730","https://openalex.org/W1567114372","https://openalex.org/W1603632991","https://openalex.org/W1605213317","https://openalex.org/W1624485603","https://openalex.org/W1701460655","https://openalex.org/W1883960381","https://openalex.org/W1892103065","https://openalex.org/W1947991388","https://openalex.org/W1964616028","https://openalex.org/W1965778236","https://openalex.org/W1966053383","https://openalex.org/W1967014670","https://openalex.org/W1970720793","https://openalex.org/W1979972482","https://openalex.org/W1983203217","https://openalex.org/W1983364923","https://openalex.org/W1984434768","https://openalex.org/W1984676145","https://openalex.org/W1985107245","https://openalex.org/W1986218137","https://openalex.org/W1988271058","https://openalex.org/W1991882299","https://openalex.org/W1992346462","https://openalex.org/W1995307858","https://openalex.org/W1998685763","https://openalex.org/W2000055469","https://openalex.org/W2000231159","https://openalex.org/W2001953810","https://openalex.org/W2004668846","https://openalex.org/W2005278031","https://openalex.org/W2008257056","https://openalex.org/W2009137380","https://openalex.org/W2010957725","https://openalex.org/W2014033528","https://openalex.org/W2014530534","https://openalex.org/W2014688976","https://openalex.org/W2018794628","https://openalex.org/W2019348446","https://openalex.org/W2020556299","https://openalex.org/W2024119587","https://openalex.org/W2025015805","https://openalex.org/W2027520912","https://openalex.org/W2027891076","https://openalex.org/W2031011158","https://openalex.org/W2032228306","https://openalex.org/W2032801666","https://openalex.org/W2033290189","https://openalex.org/W2037598869","https://openalex.org/W2046055935","https://openalex.org/W2048678006","https://openalex.org/W2049174175","https://openalex.org/W2053220357","https://openalex.org/W2054064642","https://openalex.org/W2055959302","https://openalex.org/W2057175008","https://openalex.org/W2058373538","https://openalex.org/W2063258340","https://openalex.org/W2064108305","https://openalex.org/W2065702131","https://openalex.org/W2066959864","https://openalex.org/W2068879317","https://openalex.org/W2069255656","https://openalex.org/W2069416181","https://openalex.org/W2070467923","https://openalex.org/W2072693781","https://openalex.org/W2073090648","https://openalex.org/W2074870556","https://openalex.org/W2074894417","https://openalex.org/W2078167209","https://openalex.org/W2080677705","https://openalex.org/W2080882856","https://openalex.org/W2084306320","https://openalex.org/W2085286893","https://openalex.org/W2090955625","https://openalex.org/W2091329672","https://openalex.org/W2092145505","https://openalex.org/W2093686935","https://openalex.org/W2095180364","https://openalex.org/W2095669576","https://openalex.org/W2098194523","https://openalex.org/W2102566053","https://openalex.org/W2103470182","https://openalex.org/W2103538394","https://openalex.org/W2106654511","https://openalex.org/W2114638396","https://openalex.org/W2116431180","https://openalex.org/W2121469878","https://openalex.org/W2122849677","https://openalex.org/W2124290467","https://openalex.org/W2124618539","https://openalex.org/W2129037723","https://openalex.org/W2133340337","https://openalex.org/W2134639926","https://openalex.org/W2137640241","https://openalex.org/W2141918717","https://openalex.org/W2142360671","https://openalex.org/W2144319600","https://openalex.org/W2152692995","https://openalex.org/W2158553737","https://openalex.org/W2159073648","https://openalex.org/W2159821105","https://openalex.org/W2163963938","https://openalex.org/W2164846242","https://openalex.org/W2166446573","https://openalex.org/W2167252574","https://openalex.org/W2168449588","https://openalex.org/W2169352011","https://openalex.org/W2215409517","https://openalex.org/W2329298130","https://openalex.org/W2403011289","https://openalex.org/W2434752438","https://openalex.org/W2487344138","https://openalex.org/W2493830806","https://openalex.org/W2497447587","https://openalex.org/W4235465215"],"related_works":["https://openalex.org/W3037964288","https://openalex.org/W2249084682","https://openalex.org/W2751296018","https://openalex.org/W1989256666","https://openalex.org/W2188447356","https://openalex.org/W1607955254","https://openalex.org/W2019117813","https://openalex.org/W2112959972","https://openalex.org/W1479712824","https://openalex.org/W2097312113"],"abstract_inverted_index":{"Systemic":[0],"lupus":[1,153],"erythematosus":[2],"is":[3,128],"an":[4,52],"autoimmune":[5],"disease":[6,100,138],"characterized":[7],"by":[8],"antibodies":[9,119,158],"that":[10,97,159],"bind":[11],"target":[12],"autoantigens":[13],"in":[14,17,77,113,142],"multiple":[15],"organs":[16],"the":[18,26,74,78,147],"body.":[19],"In":[20],"peripheral":[21],"organs,":[22],"immune":[23,105],"complexes":[24],"engage":[25],"complement":[27],"cascade,":[28],"recruiting":[29],"blood-borne":[30,45],"inflammatory":[31,53],"cells":[32,46,50],"and":[33,47,116,139,154],"initiating":[34],"tissue":[35,48,59,64,71,123,140],"inflammation.":[36],"Immune":[37],"complex-mediated":[38],"activation":[39,115],"of":[40,134,136,149],"Fc":[41],"receptors":[42],"on":[43,104,110],"infiltrating":[44],"resident":[49],"amplifies":[51],"cascade":[54],"with":[55],"resulting":[56],"damage":[57],"to":[58,63,69,131,162],"function,":[60],"ultimately":[61],"leading":[62,130],"destruction.":[65],"This":[66,82,94],"pathophysiology":[67],"appears":[68],"explain":[70],"injury":[72,141],"throughout":[73],"body,":[75],"except":[76],"central":[79],"nervous":[80],"system.":[81],"review":[83],"addresses":[84],"a":[85,132],"paradigm":[86,95],"we":[87],"have":[88],"developed":[89],"for":[90,152,155],"autoantibody-mediated":[91],"brain":[92,99,122,137,163],"damage.":[93],"suggests":[96],"antibody-mediated":[98,111],"does":[101],"not":[102],"depend":[103],"complex":[106],"formation":[107],"but":[108],"rather":[109],"alterations":[112],"neuronal":[114],"survival.":[117],"Moreover,":[118],"only":[120],"access":[121],"when":[124],"blood-brain":[125],"barrier":[126],"integrity":[127],"impaired,":[129],"lack":[133],"concurrence":[135],"other":[143,157],"organs.":[144],"We":[145],"discuss":[146],"implications":[148],"this":[150],"model":[151],"identifying":[156],"may":[160],"contribute":[161],"disease.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
