{"id":"https://openalex.org/W179893808","doi":null,"title":"Aspiration pneumonia: beneficial and harmful effects of positive end-expiratory pressure.","display_name":"Aspiration pneumonia: beneficial and harmful effects of positive end-expiratory pressure.","publication_year":1977,"publication_date":"1977-08-01","ids":{"openalex":"https://openalex.org/W179893808","mag":"179893808","pmid":"https://pubmed.ncbi.nlm.nih.gov/327600"},"language":"en","primary_location":{"id":"pmid:327600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/327600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091099055","display_name":"Thomas J. K. Toung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Toung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"P Saharia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Saharia","raw_affiliation_strings":["Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113602044","display_name":"Solbert Permutt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Permutt","raw_affiliation_strings":["Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059901699","display_name":"Zuidema Gd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G D Zuidema","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103804691","display_name":"John L. Cameron","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L Cameron","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4395,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.79338327,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"82","issue":"2","first_page":"279","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10830","display_name":"Airway Management and Intubation Techniques","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspiration-pneumonia","display_name":"aspiration pneumonia","score":0.9700000286102295},{"id":"https://openalex.org/keywords/positive-end-expiratory-pressure","display_name":"positive end-expiratory pressure","score":1.0},{"id":"https://openalex.org/keywords/acid-induced-lung-injury","display_name":"acid-induced lung injury","score":0.7049999833106995},{"id":"https://openalex.org/keywords/hydrochloric-acid","display_name":"hydrochloric acid","score":0.7860000133514404},{"id":"https://openalex.org/keywords/intrapulmonary-shunt","display_name":"intrapulmonary shunt","score":0.8370000123977661},{"id":"https://openalex.org/keywords/pulmonary-edema","display_name":"pulmonary edema","score":0.8989999890327454},{"id":"https://openalex.org/keywords/interstitial-edema","display_name":"interstitial edema","score":0.7429999709129333},{"id":"https://openalex.org/keywords/isolated-perfused-lung","display_name":"isolated perfused lung","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C2778917391","wikidata":"https://www.wikidata.org/wiki/Q352381","display_name":"Positive end-expiratory pressure","level":3,"score":0.8957949876785278},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.88686603307724},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6007100343704224},{"id":"https://openalex.org/C2781101014","wikidata":"https://www.wikidata.org/wiki/Q754031","display_name":"Atelectasis","level":3,"score":0.5575359463691711},{"id":"https://openalex.org/C2776468924","wikidata":"https://www.wikidata.org/wiki/Q857667","display_name":"Pulmonary edema","level":3,"score":0.549006462097168},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5057346820831299},{"id":"https://openalex.org/C2781338923","wikidata":"https://www.wikidata.org/wiki/Q677449","display_name":"Aspiration pneumonia","level":3,"score":0.42676621675491333},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.3725050091743469},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.32783496379852295},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2516602873802185}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011015","descriptor_name":"Pneumonia, Aspiration","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011015","descriptor_name":"Pneumonia, Aspiration","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011175","descriptor_name":"Positive-Pressure Respiration","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011175","descriptor_name":"Positive-Pressure Respiration","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:327600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/327600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"Journal Article"},{"id":"mag:179893808","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/327600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2022756590","https://openalex.org/W2081519858","https://openalex.org/W1756024667","https://openalex.org/W2092647613","https://openalex.org/W1985880743","https://openalex.org/W1968194710","https://openalex.org/W2014440780","https://openalex.org/W1970665764","https://openalex.org/W2170319572","https://openalex.org/W2418083110"],"abstract_inverted_index":{"With":[0],"an":[1],"ex":[2],"vivo,":[3],"isolated,":[4],"ventilated,":[5],"perfused":[6],"canine":[7],"pulmonary":[8],"lobe,":[9],"the":[10,126,133],"effects":[11,135],"of":[12,15,28,38,40,47,55,75,125,136,149],"various":[13],"levels":[14,148],"positive":[16],"end-expiratory":[17],"pressure":[18],"(PEEP)":[19],"were":[20,33],"evaluated":[21],"following":[22],"acid":[23],"injury.":[24],"Following":[25],"intrabronchial":[26],"instillation":[27],"hydrochloric":[29],"acid,":[30],"eight":[31,50],"lobes":[32,43,51],"ventilated":[34],"with":[35,44,52,72],"5":[36,73],"cm":[37,46,54,74],"H2O":[39],"PEEP,":[41,48],"12":[42],"10":[45,93],"and":[49,82,162],"15":[53,112],"PEEP":[56,76,89,107,137,150],"during":[57],"a":[58,78,157],"4":[59],"hour":[60],"perfusion":[61],"period.":[62],"Blood":[63],"flow":[64],"was":[65,90,97,108],"kept":[66],"constant":[67],"in":[68,138,160],"all":[69],"preparations.":[70],"Lobes":[71],"developed":[77],"39%":[79],"intrapulmonary":[80],"shunt":[81],"increased":[83,91,109,121],"their":[84],"weight":[85,95,119],"by":[86,155],"220%.":[87],"When":[88,106],"to":[92,104,111,123],"cm,":[94,113],"gain":[96,120],"similar":[98],"(184%),":[99],"but":[100,118,141],"shunting":[101,114],"decreased":[102],"markedly,":[103,122],"7%.":[105],"further":[110,158],"remained":[115],"low":[116],"(13%),":[117],"411%":[124],"initial":[127],"lobe":[128],"weight.":[129],"This":[130],"study":[131],"demonstrates":[132],"beneficial":[134],"aspiration":[139],"pneumonia,":[140],"it":[142],"also":[143],"points":[144],"out":[145],"that":[146],"increasing":[147],"can":[151],"magnify":[152],"acid-pulmonary":[153],"injury":[154],"causing":[156],"increase":[159],"interstitial":[161],"intralveolar":[163],"edema.":[164]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
