{"id":"https://openalex.org/W1794422305","doi":null,"title":"Foot reflexology can increase vagal modulation, decrease sympathetic modulation, and lower blood pressure in healthy subjects and patients with coronary artery disease.","display_name":"Foot reflexology can increase vagal modulation, decrease sympathetic modulation, and lower blood pressure in healthy subjects and patients with coronary artery disease.","publication_year":2011,"publication_date":"2011-07-01","ids":{"openalex":"https://openalex.org/W1794422305","mag":"1794422305","pmid":"https://pubmed.ncbi.nlm.nih.gov/22314629"},"language":"en","primary_location":{"id":"pmid:22314629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22314629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alternative therapies in health and medicine","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029540791","display_name":"Wan-An Lu","orcid":"https://orcid.org/0000-0002-9092-9643","observed_orcids":["https://orcid.org/0000-0002-9092-9643"]},"institutions":[{"id":"https://openalex.org/I85148518","display_name":"Fo Guang University","ror":"https://ror.org/046wjy580","country_code":"TW","type":"education","lineage":["https://openalex.org/I85148518"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wan-An Lu","raw_affiliation_strings":["Institute of Cultural Asset and Reinvention, Fo-Guang University, Ilan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cultural Asset and Reinvention, Fo-Guang University, Ilan, Taiwan","institution_ids":["https://openalex.org/I85148518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057681306","display_name":"Gau-Yang Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gau-Yang Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067175625","display_name":"Cheng\u2010Deng Kuo","orcid":"https://orcid.org/0000-0002-3989-1950","observed_orcids":["https://orcid.org/0000-0002-3989-1950"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cheng-Deng Kuo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6441,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.73285629,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"17","issue":"4","first_page":"8","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13044","display_name":"Biofield Effects and Biophysics","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foot-reflexology","display_name":"foot reflexology","score":0.9980000257492065},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9559999704360962},{"id":"https://openalex.org/keywords/vagal-modulation","display_name":"vagal modulation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/sympathetic-modulation","display_name":"sympathetic modulation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/autonomic-nervous-system","display_name":"autonomic nervous system","score":0.8600000143051147},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":0.8650000095367432},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.9589999914169312},{"id":"https://openalex.org/keywords/alternative-medicine","display_name":"complementary and alternative medicine","score":0.925000011920929},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.9070000052452087},{"id":"https://openalex.org/keywords/coronary-artery-bypass-grafting","display_name":"coronary artery bypass grafting","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8529599905014038},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.7003653049468994},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6567090153694153},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6009700298309326},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.5961415767669678},{"id":"https://openalex.org/C71635504","wikidata":"https://www.wikidata.org/wiki/Q933954","display_name":"Heart rate variability","level":4,"score":0.5475980043411255},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5204867720603943},{"id":"https://openalex.org/C79752029","wikidata":"https://www.wikidata.org/wiki/Q808732","display_name":"Baroreceptor","level":4,"score":0.4707299470901489},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.4694273769855499},{"id":"https://openalex.org/C2777372248","wikidata":"https://www.wikidata.org/wiki/Q171064","display_name":"Autonomic nervous system","level":4,"score":0.4448617398738861},{"id":"https://openalex.org/C175259745","wikidata":"https://www.wikidata.org/wiki/Q179415","display_name":"Massage","level":3,"score":0.43777257204055786},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.34360432624816895},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07337743043899536},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001341","descriptor_name":"Autonomic Nervous System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000534","qualifier_name":"rehabilitation","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005528","descriptor_name":"Foot","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008405","descriptor_name":"Massage","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22314629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22314629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alternative therapies in health and medicine","raw_type":"Comparative Study"},{"id":"mag:1794422305","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22314629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W18562578","https://openalex.org/W46103474","https://openalex.org/W60084911","https://openalex.org/W1043193445","https://openalex.org/W1593247204","https://openalex.org/W1967900132","https://openalex.org/W1973206057","https://openalex.org/W1974180074","https://openalex.org/W1990580658","https://openalex.org/W1991751851","https://openalex.org/W1995421025","https://openalex.org/W1996016040","https://openalex.org/W1997535715","https://openalex.org/W2000659208","https://openalex.org/W2015197170","https://openalex.org/W2016549920","https://openalex.org/W2020581135","https://openalex.org/W2029916807","https://openalex.org/W2031679826","https://openalex.org/W2033322261","https://openalex.org/W2033744253","https://openalex.org/W2035775523","https://openalex.org/W2040902020","https://openalex.org/W2042324951","https://openalex.org/W2043157990","https://openalex.org/W2045490095","https://openalex.org/W2046714951","https://openalex.org/W2049803512","https://openalex.org/W2057591537","https://openalex.org/W2062618262","https://openalex.org/W2064608775","https://openalex.org/W2066941357","https://openalex.org/W2069575900","https://openalex.org/W2074775163","https://openalex.org/W2082111570","https://openalex.org/W2083087083","https://openalex.org/W2101704470","https://openalex.org/W2120303646","https://openalex.org/W2123181530","https://openalex.org/W2126859690","https://openalex.org/W2133589238","https://openalex.org/W2134343469","https://openalex.org/W2135748953","https://openalex.org/W2139470316","https://openalex.org/W2142086823","https://openalex.org/W2143954917","https://openalex.org/W2156121263","https://openalex.org/W2158288346","https://openalex.org/W2159093301","https://openalex.org/W2163183941","https://openalex.org/W2403565097","https://openalex.org/W2403869308","https://openalex.org/W2412492859","https://openalex.org/W2477872031","https://openalex.org/W4249825849"],"related_works":["https://openalex.org/W2595306923","https://openalex.org/W2093963335","https://openalex.org/W4409119290","https://openalex.org/W2154151581","https://openalex.org/W2153815168","https://openalex.org/W2079147325","https://openalex.org/W4413114111","https://openalex.org/W4411520976","https://openalex.org/W4319442136","https://openalex.org/W4295834241"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Complementary":[1],"and":[2,17,36,74,91,108,121,128,143,159,183,195,221,236,277,285],"alternative":[3],"medicine":[4],"(CAM)":[5],"has":[6],"long":[7],"been":[8],"used":[9,101,263],"by":[10,59],"people":[11,68,284],"to":[12,18,30,268,272],"postpone":[13],"the":[14,34,41,48,89,103,109,116,131,137,173,176,193,196,210,244,257,269,274],"aging":[15],"process":[16],"reverse":[19],"disease":[20,57],"progression.":[21],"Reflexology":[22],"is":[23],"a":[24,214],"CAM":[25],"method":[26],"that":[27,191,208,255],"involves":[28],"massage":[29],"reflex":[31],"areas":[32],"in":[33,52,167,179,192,199,209,233,243,248,256,281],"feet":[35],"hands.":[37],"This":[38],"study":[39],"investigated":[40],"effect":[42],"of":[43,105,118,170,231,241],"foot":[44],"reflexology":[45],"(FR)":[46],"on":[47],"autonomic":[49,245],"nervous":[50,246],"modulation":[51,107,247,276],"patients":[53,76,250],"with":[54,69,77,150],"coronary":[55,72,81],"artery":[56,82],"(CAD)":[58],"using":[60],"heart":[61,180],"rate":[62,181],"variability":[63],"analysis.":[64],"STUDY":[65],"METHODS:":[66],"Seventeen":[67],"angiographically":[70],"patent":[71],"arteries":[73],"20":[75],"CAD":[78,92,129,174,237,249,286],"scheduled":[79],"for":[80],"bypass":[83],"graft":[84],"surgery":[85],"were":[86,162],"recruited":[87],"as":[88,102,115,148,264],"control":[90,127],"groups,":[93,130],"respectively.":[94],"The":[95,154,239],"normalized":[96,110],"high-frequency":[97],"power":[98,113],"(nHFP)":[99],"was":[100,133,139,188,205,251],"index":[104,117],"vagal":[106,119,216,275],"very":[111],"low-frequency":[112],"(nVLFP)":[114],"withdrawal":[120],"renin-angiotensin":[122],"modulation.":[123],"RESULTS:":[124],"In":[125,172,212],"both":[126,168,234,282],"nHFP":[132],"increased":[134],"significantly":[135,141,163],"whereas":[136],"nVLFP":[138,200],"decreased":[140,164],"30":[142,182],"60":[144,184,201,229],"minutes":[145,185,202,230],"after":[146,165,186,203],"FR,":[147],"compared":[149],"those":[151],"before":[152],"FR.":[153],"systolic,":[155],"diastolic,":[156],"mean":[157],"arterial,":[158],"pulse":[160],"pressures":[161],"FR":[166,187,204,232,260],"groups":[169],"participants.":[171],"group,":[175],"percentage":[177,197],"change":[178,198,242],"smaller":[189,206,253],"than":[190,207,254],"control,":[194],"control.":[211],"conclusion,":[213],"higher":[215],"modulation,":[217,220],"lower":[218,222],"sympathetic":[219],"blood":[223,279],"pressure":[224,280],"can":[225],"be":[226,262],"observed":[227],"following":[228],"controls":[235],"patients.":[238,287],"magnitude":[240],"slightly":[252],"controls.":[258],"CONCLUSION:":[259],"may":[261],"an":[265],"efficient":[266],"adjunct":[267],"therapeutic":[270],"regimen":[271],"increase":[273],"decrease":[278],"healthy":[283]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}