{"id":"https://openalex.org/W179393573","doi":null,"title":"Tissue engineering in wound repair.","display_name":"Tissue engineering in wound repair.","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W179393573","mag":"179393573","pmid":"https://pubmed.ncbi.nlm.nih.gov/11074998"},"language":"en","primary_location":{"id":"pmid:11074998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11074998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in skin & wound care","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026511947","display_name":"Vincent Falanga","orcid":"https://orcid.org/0000-0003-2292-2017","observed_orcids":["https://orcid.org/0000-0003-2292-2017"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"V J Falanga","raw_affiliation_strings":["Department of Dermatology, Boston University, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Boston University, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026511947"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":null,"apc_paid":null,"fwci":2.8342,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.89134736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":"2 Suppl","first_page":"15","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11453","display_name":"Diagnosis and Treatment of Venous Diseases","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.7200000286102295},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.8759999871253967},{"id":"https://openalex.org/keywords/apligraf","display_name":"Apligraf","score":0.8339999914169312},{"id":"https://openalex.org/keywords/tissue-engineered-skin-substitutes","display_name":"bioengineered skin substitutes","score":0.8799999952316284},{"id":"https://openalex.org/keywords/venous-ulcers","display_name":"venous ulcers","score":0.8769999742507935},{"id":"https://openalex.org/keywords/compression-therapy","display_name":"compression therapy","score":0.8420000076293945},{"id":"https://openalex.org/keywords/wound-closure","display_name":"wound closure","score":0.7860000133514404},{"id":"https://openalex.org/keywords/chronic-wounds","display_name":"chronic wounds","score":0.8399999737739563},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.8560000061988831},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9100000262260437},{"id":"https://openalex.org/keywords/neonatal-foreskin","display_name":"neonatal foreskin","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9288794994354248},{"id":"https://openalex.org/C2781140480","wikidata":"https://www.wikidata.org/wiki/Q673203","display_name":"Foreskin","level":3,"score":0.772150993347168},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7192943096160889},{"id":"https://openalex.org/C2777624698","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermis","level":2,"score":0.7019064426422119},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.6074674129486084},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.4646557867527008},{"id":"https://openalex.org/C190567982","wikidata":"https://www.wikidata.org/wiki/Q7535422","display_name":"Skin repair","level":3,"score":0.46308237314224243},{"id":"https://openalex.org/C2779899204","wikidata":"https://www.wikidata.org/wiki/Q7075718","display_name":"Occlusive dressing","level":3,"score":0.4515588879585266},{"id":"https://openalex.org/C2993873987","wikidata":"https://www.wikidata.org/wiki/Q184753","display_name":"Wound closure","level":3,"score":0.44280683994293213},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11547079682350159},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.07328546047210693},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001458","descriptor_name":"Bandages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005780","descriptor_name":"Gelatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014647","descriptor_name":"Varicose Ulcer","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014647","descriptor_name":"Varicose Ulcer","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017967","descriptor_name":"Zinc Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11074998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11074998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in skin & wound care","raw_type":"Clinical Trial"},{"id":"mag:179393573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11074998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2025780832","https://openalex.org/W1982886587","https://openalex.org/W2358161059","https://openalex.org/W2360374968","https://openalex.org/W152502414","https://openalex.org/W2044990776","https://openalex.org/W2071452008","https://openalex.org/W1564038818","https://openalex.org/W3025585068","https://openalex.org/W2383406004"],"abstract_inverted_index":{"Tissue-engineering":[0],"products":[1],"can":[2],"cover":[3],"wounds":[4,139],"and":[5,21,46,54,126,168],"provide":[6],"a":[7,37,44,47,74,85],"microenvironment":[8],"that":[9,195],"stimulates":[10],"their":[11],"repair.":[12],"To":[13],"date,":[14],"Graftskin":[15,35,66,94,111,144,182],"(APLIGRAF,":[16],"Organogenesis":[17],"Inc,":[18],"Canton,":[19],"MA,":[20],"Novartis":[22],"Pharmaceuticals":[23],"Corporation,":[24],"East":[25],"Hanover,":[26],"NJ)":[27],"is":[28,36,183],"the":[29],"most":[30],"advanced":[31],"bioengineered":[32],"skin":[33,40],"product.":[34],"bilayered":[38],"living":[39],"construct":[41],"consisting":[42],"of":[43,65,78,128,192],"dermis":[45],"well-differentiated":[48],"epidermis.":[49],"The":[50,63],"epidermal":[51],"cells":[52,56],"(keratinocytes)":[53],"dermal":[55],"(fibroblasts)":[57],"are":[58],"obtained":[59],"from":[60],"neonatal":[61],"foreskin.":[62],"efficacy":[64,102],"in":[67,73,154,186],"healing":[68,187],"venous":[69,188],"ulcers":[70],"was":[71,103,112,145],"evaluated":[72],"prospective,":[75],"randomized":[76],"study":[77],"240":[79],"patients":[80],"at":[81,159],"14":[82],"centers":[83],"over":[84],"6-month":[86],"period.":[87],"Patients":[88],"received":[89],"either":[90],"compression":[91,96,116,151],"therapy":[92,97,152],"plus":[93],"or":[95],"alone":[98,117,153],"(active":[99],"control).":[100],"Clinical":[101],"defined":[104],"as":[105,118],"complete":[106,123,129,156],"wound":[107,124,130,157],"closure.":[108],"Treatment":[109],"with":[110,201],"more":[113,148,171],"effective":[114,149,172,185],"than":[115,150],"measured":[119],"by":[120,132,173],"time":[121],"to":[122,137,199],"closure":[125,131,158],"frequency":[127],"6":[133],"months.":[134],"When":[135],"applied":[136],"hard-to-heal":[138],"(>":[140],"1":[141],"year's":[142],"duration),":[143],"3":[146],"times":[147,170],"achieving":[155],"8":[160],"weeks":[161,175],"(32%":[162],"vs":[163,177],"10%,":[164],"P":[165,179],"=":[166,180],".008)":[167],"2":[169],"24":[174],"(47%":[176],"19%,":[178],".002).":[181],"highly":[184],"ulcers,":[189],"particularly":[190],"those":[191],"long":[193],"duration,":[194],"have":[196],"proved":[197],"hard":[198],"heal":[200],"conventional":[202],"modalities.":[203]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}