{"id":"https://openalex.org/W17927801","doi":null,"title":"Regulation of NKCC2 trafficking by vesicle fusion proteins VAMP2 and VAMP3 in the thick ascending limb","display_name":"Regulation of NKCC2 trafficking by vesicle fusion proteins VAMP2 and VAMP3 in the thick ascending limb","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W17927801","mag":"17927801"},"language":"en","primary_location":{"id":"mag:17927801","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1873&context=oa_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016816800","display_name":"Caceres Puzzella","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caceres Puzzella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046273544","display_name":"Paulo Sebastian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paulo Sebastian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00052216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.7354000210762024,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.7354000210762024,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.2551000118255615,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nkcc2","display_name":"NKCC2","score":0.996999979019165},{"id":"https://openalex.org/keywords/vamp2","display_name":"VAMP2","score":0.8889999985694885},{"id":"https://openalex.org/keywords/vamp3","display_name":"VAMP3","score":1.0},{"id":"https://openalex.org/keywords/thick-ascending-limb","display_name":"thick ascending limb","score":0.8679999709129333},{"id":"https://openalex.org/keywords/na-k-2cl-cotransporter","display_name":"Na+-K+-2Cl- cotransporter","score":0.8690000176429749},{"id":"https://openalex.org/keywords/protein-trafficking","display_name":"protein trafficking","score":0.7739999890327454},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.8650000095367432},{"id":"https://openalex.org/keywords/nacl-absorption","display_name":"NaCl absorption","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cell-surface-protein-expression","display_name":"surface protein expression","score":0.6299999952316284},{"id":"https://openalex.org/keywords/shrna-knockdown","display_name":"shRNA knockdown","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5997541546821594},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.5195489525794983},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5166504979133606},{"id":"https://openalex.org/C2778256703","wikidata":"https://www.wikidata.org/wiki/Q390407","display_name":"Syntaxin","level":4,"score":0.4788672626018524},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21242457628250122},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0838143527507782}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:17927801","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1873&context=oa_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8324351915","display_name":"GENETIC EPIDEMIOLOGY OF SEIZURES--A TWIN STUDY","funder_award_id":"R01NS031564","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":270,"referenced_works":["https://openalex.org/W2273543","https://openalex.org/W38610007","https://openalex.org/W40893751","https://openalex.org/W80391022","https://openalex.org/W111365110","https://openalex.org/W162915822","https://openalex.org/W167512033","https://openalex.org/W198072875","https://openalex.org/W267655585","https://openalex.org/W943754573","https://openalex.org/W1481032119","https://openalex.org/W1482873660","https://openalex.org/W1495603032","https://openalex.org/W1506518340","https://openalex.org/W1509564548","https://openalex.org/W1516161430","https://openalex.org/W1520187505","https://openalex.org/W1532206227","https://openalex.org/W1533509738","https://openalex.org/W1570678799","https://openalex.org/W1570745179","https://openalex.org/W1593682547","https://openalex.org/W1630913441","https://openalex.org/W1766189871","https://openalex.org/W1822252127","https://openalex.org/W1824067573","https://openalex.org/W1846506298","https://openalex.org/W1852938897","https://openalex.org/W1854895726","https://openalex.org/W1892746589","https://openalex.org/W1898513650","https://openalex.org/W1907311840","https://openalex.org/W1934619162","https://openalex.org/W1940205808","https://openalex.org/W1964485689","https://openalex.org/W1964893573","https://openalex.org/W1969112250","https://openalex.org/W1970987547","https://openalex.org/W1971016259","https://openalex.org/W1971775244","https://openalex.org/W1974553541","https://openalex.org/W1974557957","https://openalex.org/W1974914819","https://openalex.org/W1975559877","https://openalex.org/W1976196055","https://openalex.org/W1976476653","https://openalex.org/W1976540095","https://openalex.org/W1978367401","https://openalex.org/W1981272146","https://openalex.org/W1983395253","https://openalex.org/W1983791415","https://openalex.org/W1984479357","https://openalex.org/W1986504110","https://openalex.org/W1986930135","https://openalex.org/W1988488160","https://openalex.org/W1989222067","https://openalex.org/W1989677215","https://openalex.org/W1990100874","https://openalex.org/W1990690213","https://openalex.org/W1990782826","https://openalex.org/W1990843666","https://openalex.org/W1994423882","https://openalex.org/W1994436935","https://openalex.org/W1996856159","https://openalex.org/W1997671401","https://openalex.org/W1998265268","https://openalex.org/W1998983314","https://openalex.org/W1999744850","https://openalex.org/W2000142886","https://openalex.org/W2000302106","https://openalex.org/W2005745123","https://openalex.org/W2006605262","https://openalex.org/W2007089466","https://openalex.org/W2007928275","https://openalex.org/W2008111893","https://openalex.org/W2008787988","https://openalex.org/W2009396659","https://openalex.org/W2011494098","https://openalex.org/W2012162324","https://openalex.org/W2016269093","https://openalex.org/W2018435413","https://openalex.org/W2018652427","https://openalex.org/W2018779154","https://openalex.org/W2019191967","https://openalex.org/W2019420937","https://openalex.org/W2020506380","https://openalex.org/W2023106617","https://openalex.org/W2025937578","https://openalex.org/W2026527234","https://openalex.org/W2026848616","https://openalex.org/W2026926575","https://openalex.org/W2027775552","https://openalex.org/W2029018698","https://openalex.org/W2029118543","https://openalex.org/W2029714163","https://openalex.org/W2030751527","https://openalex.org/W2030792479","https://openalex.org/W2032226073","https://openalex.org/W2033344378","https://openalex.org/W2033500343","https://openalex.org/W2033595361","https://openalex.org/W2034468530","https://openalex.org/W2035865918","https://openalex.org/W2035982833","https://openalex.org/W2036212752","https://openalex.org/W2037245313","https://openalex.org/W2037336334","https://openalex.org/W2037932554","https://openalex.org/W2039148832","https://openalex.org/W2041137533","https://openalex.org/W2041415511","https://openalex.org/W2041800748","https://openalex.org/W2043365258","https://openalex.org/W2044485703","https://openalex.org/W2045468803","https://openalex.org/W2047746821","https://openalex.org/W2047872096","https://openalex.org/W2048019766","https://openalex.org/W2048141509","https://openalex.org/W2048842346","https://openalex.org/W2049095669","https://openalex.org/W2049828277","https://openalex.org/W2051275839","https://openalex.org/W2051341672","https://openalex.org/W2052539926","https://openalex.org/W2052771339","https://openalex.org/W2053487364","https://openalex.org/W2053533223","https://openalex.org/W2055153155","https://openalex.org/W2056293200","https://openalex.org/W2056496907","https://openalex.org/W2058128000","https://openalex.org/W2058633925","https://openalex.org/W2058810129","https://openalex.org/W2060802404","https://openalex.org/W2060877224","https://openalex.org/W2063253252","https://openalex.org/W2063526391","https://openalex.org/W2064776082","https://openalex.org/W2065991901","https://openalex.org/W2066835749","https://openalex.org/W2067590274","https://openalex.org/W2068064646","https://openalex.org/W2068276977","https://openalex.org/W2069487926","https://openalex.org/W2069910519","https://openalex.org/W2072279008","https://openalex.org/W2073557349","https://openalex.org/W2073908428","https://openalex.org/W2076004015","https://openalex.org/W2077451533","https://openalex.org/W2078514758","https://openalex.org/W2081330632","https://openalex.org/W2082414348","https://openalex.org/W2084807003","https://openalex.org/W2085680244","https://openalex.org/W2085871244","https://openalex.org/W2086240693","https://openalex.org/W2089936416","https://openalex.org/W2090105320","https://openalex.org/W2090362914","https://openalex.org/W2090442630","https://openalex.org/W2090515467","https://openalex.org/W2092229320","https://openalex.org/W2092965283","https://openalex.org/W2093465143","https://openalex.org/W2094355581","https://openalex.org/W2094670002","https://openalex.org/W2094779328","https://openalex.org/W2096696183","https://openalex.org/W2097595798","https://openalex.org/W2098009074","https://openalex.org/W2098136511","https://openalex.org/W2099063290","https://openalex.org/W2100338365","https://openalex.org/W2100509843","https://openalex.org/W2100781600","https://openalex.org/W2101044263","https://openalex.org/W2106567560","https://openalex.org/W2107459112","https://openalex.org/W2107505306","https://openalex.org/W2109305556","https://openalex.org/W2110490143","https://openalex.org/W2111350618","https://openalex.org/W2115703401","https://openalex.org/W2115944029","https://openalex.org/W2117086426","https://openalex.org/W2117602113","https://openalex.org/W2119466361","https://openalex.org/W2120323419","https://openalex.org/W2122137443","https://openalex.org/W2122168489","https://openalex.org/W2122704962","https://openalex.org/W2124173184","https://openalex.org/W2126547490","https://openalex.org/W2128242002","https://openalex.org/W2129275107","https://openalex.org/W2129536504","https://openalex.org/W2129728306","https://openalex.org/W2129904159","https://openalex.org/W2130483595","https://openalex.org/W2131830033","https://openalex.org/W2131844352","https://openalex.org/W2132218454","https://openalex.org/W2135607580","https://openalex.org/W2135927075","https://openalex.org/W2135932038","https://openalex.org/W2136178051","https://openalex.org/W2137498550","https://openalex.org/W2140242622","https://openalex.org/W2141459857","https://openalex.org/W2142441668","https://openalex.org/W2144830324","https://openalex.org/W2145634179","https://openalex.org/W2145692420","https://openalex.org/W2146362515","https://openalex.org/W2146754621","https://openalex.org/W2146867677","https://openalex.org/W2147318152","https://openalex.org/W2148157392","https://openalex.org/W2148786460","https://openalex.org/W2150380575","https://openalex.org/W2151821871","https://openalex.org/W2154827556","https://openalex.org/W2155288742","https://openalex.org/W2160333109","https://openalex.org/W2160420424","https://openalex.org/W2160446373","https://openalex.org/W2160516357","https://openalex.org/W2161168230","https://openalex.org/W2161834399","https://openalex.org/W2161993137","https://openalex.org/W2162239065","https://openalex.org/W2166086043","https://openalex.org/W2166780502","https://openalex.org/W2168818279","https://openalex.org/W2169250706","https://openalex.org/W2169913167","https://openalex.org/W2170694386","https://openalex.org/W2171151713","https://openalex.org/W2171624087","https://openalex.org/W2182992980","https://openalex.org/W2183255607","https://openalex.org/W2186746184","https://openalex.org/W2189010174","https://openalex.org/W2203303016","https://openalex.org/W2234942960","https://openalex.org/W2236700690","https://openalex.org/W2248128568","https://openalex.org/W2265630203","https://openalex.org/W2268401053","https://openalex.org/W2274481877","https://openalex.org/W2285472727","https://openalex.org/W2293215869","https://openalex.org/W2304609717","https://openalex.org/W2306740047","https://openalex.org/W2307567208","https://openalex.org/W2314835400","https://openalex.org/W2319841016","https://openalex.org/W2332205806","https://openalex.org/W2335626713","https://openalex.org/W2335927080","https://openalex.org/W2336701702","https://openalex.org/W2339572467","https://openalex.org/W2343923988","https://openalex.org/W2409364584","https://openalex.org/W2409575661","https://openalex.org/W2412915627","https://openalex.org/W2418120303","https://openalex.org/W2418136452"],"related_works":["https://openalex.org/W3176674102","https://openalex.org/W2515573747","https://openalex.org/W82131079","https://openalex.org/W2031184481","https://openalex.org/W2944478001","https://openalex.org/W2168818279","https://openalex.org/W2259800276","https://openalex.org/W2049095669","https://openalex.org/W920610515","https://openalex.org/W4405201387"],"abstract_inverted_index":{"REGULATION":[0],"OF":[1],"NKCC2":[2,52,66,78,89,105,137,155,168,187,193,212,216],"TRAFFICKING":[3],"BY":[4],"VESICLE":[5],"FUSION":[6],"PROTEINS":[7],"VAMP2":[8,97,130,150,175,206],"AND":[9],"VAMP3":[10,99,132,152,177],"IN":[11],"THE":[12],"THICK":[13],"ASCENDING":[14],"LIMB":[15],"by":[16,60,114,194],"PAULO":[17],"SEBASTIAN":[18],"CACERES":[19],"PUZZELLA":[20],"May":[21],"2014":[22],"Advisor:":[23],"Dr.":[24],"Pablo":[25],"A.":[26],"Ortiz":[27],"Major:":[28],"Physiology":[29],"Degree:":[30],"Doctor":[31],"of":[32,92,122,167,211],"Philosophy":[33],"The":[34,49],"thick":[35],"ascending":[36],"limb":[37],"(TAL)":[38],"in":[39,57,103,110,156,178,182],"the":[40,61,69,85,93,101,126,141,157,170],"kidney":[41],"regulates":[42],"extracellular":[43],"fluid":[44],"volume":[45],"and":[46,63,98,107,131,151,159,163,176,185,190,198,213],"blood":[47,64],"pressure.":[48,65],"Na/K/2Cl":[50],"cotransporter":[51],"plays":[53],"a":[54,73],"central":[55],"role":[56],"NaCl":[58,108],"absorption":[59,109],"TAL":[62,158],"trafficking":[67],"to":[68,76,112,140,169],"apical":[70],"membrane":[71,143],"is":[72,82,144],"major":[74],"mechanism":[75],"control":[77],"activity.":[79],"However,":[80],"little":[81],"known":[83],"about":[84],"proteins":[86,96],"that":[87,149,204],"mediate":[88,120,133,161],"trafficking.":[90],"Inhibition":[91],"vesicle":[94],"fusion":[95,121],"blunts":[100],"increase":[102],"surface":[104,192,195,215],"expression":[106],"response":[111],"stimulation":[113],"cAMP.":[115],"In":[116],"other":[117],"cells,":[118],"VAMPs":[119],"exocytic":[123,138,165,188,209],"vesicles":[124],"with":[125,154],"plasma":[127,142,171],"membrane.":[128,172],"Whether":[129],"different":[134],"pathways":[135],"for":[136],"delivery":[139,166,189,210],"not":[145,221],"known.":[146],"We":[147,173,202],"hypothesized":[148],"interact":[153],"differentially":[160],"constitutive":[162],"cAMP-stimulated":[164,208],"silenced":[174],"vivo":[179],"via":[180],"shRNAs":[181],"rat":[183],"TALs":[184],"measured":[186],"steady-state":[191,214],"biotinylation":[196],"before":[197],"after":[199],"cAMP":[200],"stimulation.":[201],"observed":[203],"silencing":[205],"decreased":[207],"expression,":[217],"whereas":[218],"it":[219],"did":[220],"affect":[222]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}