{"id":"https://openalex.org/W1789892124","doi":null,"title":"Biodistribution and dosimetry of TRODAT-1: a technetium-99m tropane for imaging dopamine transporters.","display_name":"Biodistribution and dosimetry of TRODAT-1: a technetium-99m tropane for imaging dopamine transporters.","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W1789892124","mag":"1789892124","pmid":"https://pubmed.ncbi.nlm.nih.gov/9867143"},"language":"en","primary_location":{"id":"pmid:9867143","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9867143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037656770","display_name":"P. David Mozley","orcid":"https://orcid.org/0000-0002-1651-4212","observed_orcids":["https://orcid.org/0000-0002-1651-4212"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P D Mozley","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078685289","display_name":"James B. Stubbs","orcid":"https://orcid.org/0000-0002-0885-5244","observed_orcids":["https://orcid.org/0000-0002-0885-5244"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J B Stubbs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112418107","display_name":"Karl Pl\u00f6\u00dfl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Pl\u00f6ssl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112003924","display_name":"Stefan H. J. Dresel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S H Dresel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038315892","display_name":"Elizabeth D. Barraclough","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E D Barraclough","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088003622","display_name":"Abass A. Alavi","orcid":"https://orcid.org/0000-0002-2442-7901","observed_orcids":["https://orcid.org/0000-0002-2442-7901"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Alavi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111734657","display_name":"Luis I. Araujo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L I Araujo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055131918","display_name":"Hank F. Kung","orcid":"https://orcid.org/0000-0003-3254-8049","observed_orcids":["https://orcid.org/0000-0003-3254-8049"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H F Kung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.0495,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.94819378,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"39","issue":"12","first_page":"2069","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/technetium-99m","display_name":"technetium-99m","score":0.953000009059906},{"id":"https://openalex.org/keywords/dopamine-transporter-imaging","display_name":"dopamine transporter imaging","score":0.906000018119812},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.847000002861023},{"id":"https://openalex.org/keywords/radiation-dosimetry","display_name":"radiation dosimetry","score":0.9710000157356262},{"id":"https://openalex.org/keywords/renal-excretion","display_name":"renal excretion","score":0.7860000133514404},{"id":"https://openalex.org/keywords/liver-dose","display_name":"liver dose","score":0.5070000290870667},{"id":"https://openalex.org/keywords/medical-internal-radiation-dose","display_name":"medical internal radiation dose","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cocaine-analogs","display_name":"cocaine analogues","score":0.4880000054836273},{"id":"https://openalex.org/keywords/spect","display_name":"SPECT","score":0.4259999990463257},{"id":"https://openalex.org/keywords/pharmacological-safety","display_name":"pharmacological safety","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2776995303","wikidata":"https://www.wikidata.org/wiki/Q410271","display_name":"Tropane","level":2,"score":0.7544195652008057},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.7519125938415527},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.7352358102798462},{"id":"https://openalex.org/C75088862","wikidata":"https://www.wikidata.org/wiki/Q2291081","display_name":"Dosimetry","level":2,"score":0.7129460573196411},{"id":"https://openalex.org/C2776755682","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine transporter","level":4,"score":0.6840802431106567},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5723563432693481},{"id":"https://openalex.org/C2781069445","wikidata":"https://www.wikidata.org/wiki/Q7279814","display_name":"Raclopride","level":4,"score":0.4783691465854645},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4694366455078125},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.44705668091773987},{"id":"https://openalex.org/C2984398910","wikidata":"https://www.wikidata.org/wiki/Q849737","display_name":"Spect imaging","level":2,"score":0.4442998766899109},{"id":"https://openalex.org/C149857219","wikidata":"https://www.wikidata.org/wiki/Q5239054","display_name":"Effective dose (radiation)","level":2,"score":0.41908133029937744},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3617059588432312},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3348332345485687},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.23746109008789062},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19889357686042786},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09278076887130737},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.08322328329086304},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014326","descriptor_name":"Tropanes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015609","descriptor_name":"Organotechnetium Compounds","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050483","descriptor_name":"Dopamine Plasma Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9867143","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9867143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"mag:1789892124","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9867143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2345675572","display_name":"IPT--IMAGING DA REUPTAKE SITES DURING COCAINE WITHDRAWAL","funder_award_id":"5r01da009469-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8744409861","display_name":"NEW CNS DOPAMINE RECEPTOR IMAGING AGENTS","funder_award_id":"5r01ns024538-17","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2387461385","https://openalex.org/W1989120239","https://openalex.org/W1974357360","https://openalex.org/W1998437592","https://openalex.org/W2088496323","https://openalex.org/W3005453332","https://openalex.org/W2369691665","https://openalex.org/W2143369814","https://openalex.org/W2149432912","https://openalex.org/W2371683435"],"abstract_inverted_index":{"UNLABELLED:":[0],"Technetium-99m":[1],"TRODAT-1":[2],"is":[3],"an":[4,279,296],"analog":[5],"of":[6,18,68,88,108,115,190,195,244,281],"cocaine":[7],"that":[8,42,215,226,236],"selectively":[9],"binds":[10],"the":[11,85,109,124,169,191,196,207,216,220,237,245,249,263,275,290,309,325,328],"presynaptic":[12],"dopamine":[13,322],"transporters.":[14],"The":[15,34,52,95,106,198,265],"primary":[16],"purpose":[17],"this":[19],"study":[20,35],"was":[21,36,121,227,274,294],"to":[22,47,81,140,156,304,308],"measure":[23],"its":[24,44],"whole-body":[25,70],"biokinetics":[26],"and":[27,57,117,126,210,242,272,317,327],"radiation":[28,163],"dosimetry":[29],"in":[30,61,112,132,206,219,223,262,269,324],"healthy":[31],"human":[32],"volunteers.":[33],"conducted":[37],"within":[38],"a":[39,76,145,224,315],"regulatory":[40],"framework":[41],"required":[43],"pharmacological":[45,188],"safety":[46],"be":[48,260,314],"assessed":[49],"simultaneously.":[50],"METHODS:":[51],"sample":[53],"included":[54],"4":[55],"men":[56,271],"6":[58],"women":[59,273],"ranging":[60],"age":[62],"from":[63,101,123],"22-54":[64],"yr.":[65],"An":[66],"average":[67,280],"20":[69],"scans":[71],"were":[72,99,137,153,165,182,186],"acquired":[73],"sequentially":[74],"on":[75,193],"dual-head":[77],"camera":[78],"for":[79,175,320],"up":[80],"46":[82],"hr":[83,252],"after":[84,254],"intravenous":[86],"administration":[87],"370+/-16":[89],"MBq":[90],"(10.0+/-0.42":[91],"mCi)":[92],"99mTc":[93],"TRODAT.":[94],"renal":[96],"excretion":[97],"fractions":[98],"measured":[100],"12-24":[102],"discrete":[103],"urine":[104,119],"specimens.":[105],"fraction":[107],"administered":[110],"dose":[111,247,266],"17":[113],"regions":[114],"interest":[116],"each":[118,141,176],"specimen":[120],"quantified":[122],"attenuation":[125],"background":[127],"corrected":[128],"geometric":[129],"mean":[130],"counts":[131],"conjugate":[133],"views.":[134],"Multiexponential":[135],"functions":[136],"iteratively":[138],"fit":[139],"time-activity":[142],"curve":[143],"using":[144],"nonlinear,":[146],"least":[147],"squares":[148],"regression":[149],"algorithm.":[150],"These":[151],"curves":[152],"numerically":[154],"integrated":[155],"yield":[157],"source":[158],"organ":[159,268],"residence":[160],"times.":[161],"Gender-specific":[162],"doses":[164],"then":[166],"estimated":[167],"with":[168,229],"Medical":[170],"Internal":[171],"Radiation":[172],"Dose":[173],"technique":[174],"subject":[177],"individually":[178],"before":[179],"any":[180,194],"results":[181],"averaged.":[183],"RESULTS:":[184],"There":[185],"no":[187,256],"effects":[189],"radiotracer":[192,319],"subjects.":[197],"early":[199],"planar":[200],"images":[201,213],"showed":[202,235],"differentially":[203],"increased":[204],"activity":[205,258],"nose,":[208],"pudendum":[209],"stomach.":[211],"SPECT":[212],"demonstrated":[214],"radiopharmaceutical":[217],"localized":[218],"basal":[221],"ganglia":[222],"distribution":[225],"consistent":[228],"selective":[230],"transporter":[231],"binding.":[232],"Image":[233],"analysis":[234],"kidneys":[238],"excreted":[239],"between":[240],"20%":[241],"32%":[243],"injected":[246],"during":[248],"first":[250],"22-28":[251],"postadministration,":[253],"which":[255,277,293],"more":[257],"could":[259],"recovered":[261],"urine.":[264],"limiting":[267],"both":[270],"liver,":[276],"received":[278],"0.046":[282],"mGy/MBq":[283],"(0.17":[284],"rads/mCi,":[285],"range":[286],"0.14-0.22":[287],"rad/mCi).":[288],"In":[289],"worst":[291],"case,":[292],"clearly":[295],"over-estimation,":[297],"it":[298],"would":[299],"have":[300],"taken":[301],"22.7":[302],"mCi":[303],"deliver":[305],"5":[306],"rad":[307],"liver.":[310],"CONCLUSION:":[311],"TRODAT":[312],"may":[313],"safe":[316],"effective":[318],"imaging":[321],"transporters":[323],"brain":[326],"body.":[329]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}