{"id":"https://openalex.org/W1789726967","doi":null,"title":"Can an anti-fracture agent heal fractures?","display_name":"Can an anti-fracture agent heal fractures?","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1789726967","mag":"1789726967","pmid":"https://pubmed.ncbi.nlm.nih.gov/22461283","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2897998"},"language":"en","primary_location":{"id":"pmid:22461283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22461283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2897998/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081041296","display_name":"Thomas A. Einhorn","orcid":"https://orcid.org/0000-0002-5075-4885","observed_orcids":["https://orcid.org/0000-0002-5075-4885"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas A Einhorn","raw_affiliation_strings":["Professor and Chairman Department of Orthopaedic Surgery Boston University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor and Chairman Department of Orthopaedic Surgery Boston University School of Medicine","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081041296"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":null,"apc_paid":null,"fwci":1.3825,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.80497824,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":"1","first_page":"11","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.6226000189781189,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.6226000189781189,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.3418000042438507,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fracture-healing","display_name":"fracture healing","score":0.8209999799728394},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.9959999918937683},{"id":"https://openalex.org/keywords/rankl-inhibitor","display_name":"RANKL inhibitor","score":0.8429999947547913},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hypertrophic-nonunion","display_name":"hypertrophic nonunion","score":0.7879999876022339},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.7099999785423279},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/fracture-callus","display_name":"fracture callus","score":0.8050000071525574},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.703000009059906},{"id":"https://openalex.org/keywords/chondrogenesis","display_name":"chondrogenesis","score":0.7120000123977661},{"id":"https://openalex.org/keywords/weight-bearing","display_name":"weight bearing","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.7197105884552002},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.5876955986022949},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.5454509854316711},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.5332742929458618},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5180807113647461},{"id":"https://openalex.org/C35496256","wikidata":"https://www.wikidata.org/wiki/Q5104524","display_name":"Chondrogenesis","level":3,"score":0.48401352763175964},{"id":"https://openalex.org/C2910186798","wikidata":"https://www.wikidata.org/wiki/Q309438","display_name":"Anabolic Agents","level":3,"score":0.4748383164405823},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.4354708194732666},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.4112452566623688},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.327639102935791},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.32110005617141724},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2993393838405609},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.26105618476867676},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.15790393948554993},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05683663487434387}],"mesh":[],"locations_count":4,"locations":[{"id":"pmid:22461283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22461283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2897998","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2897998/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Cases Miner Bone Metab","raw_type":"Text"},{"id":"pmh:oai:eprints.bice.rm.cnr.it:5572","doi":null,"is_oa":true,"landing_page_url":"http://eprints.bice.rm.cnr.it/5572/1/portiere.php.pdf","pdf_url":"http://eprints.bice.rm.cnr.it/5572/1/portiere.php.pdf","source":{"id":"https://openalex.org/S4306402016","display_name":"CNR Solar (Scientific Open-access Literature Archive and Repository) (Consiglio Nazionale delle Ricerche)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155236","host_organization_name":"National Research Council","host_organization_lineage":["https://openalex.org/I4210155236"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"mag:1789726967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22461283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2897998","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2897998/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Cases Miner Bone Metab","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1789726967.pdf","grobid_xml":"https://content.openalex.org/works/W1789726967.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W119837863","https://openalex.org/W136147971","https://openalex.org/W1922299222","https://openalex.org/W1966994557","https://openalex.org/W1971689675","https://openalex.org/W1975107690","https://openalex.org/W1976999342","https://openalex.org/W1993232754","https://openalex.org/W1996656034","https://openalex.org/W1996898338","https://openalex.org/W2000456607","https://openalex.org/W2010486222","https://openalex.org/W2030113150","https://openalex.org/W2031148025","https://openalex.org/W2039731841","https://openalex.org/W2052316112","https://openalex.org/W2054180787","https://openalex.org/W2079933145","https://openalex.org/W2092369211","https://openalex.org/W2093164779","https://openalex.org/W2136953476","https://openalex.org/W2150144784","https://openalex.org/W2160005424","https://openalex.org/W2162971151","https://openalex.org/W2163830908"],"related_works":["https://openalex.org/W2150144784","https://openalex.org/W2095049210","https://openalex.org/W2079296558","https://openalex.org/W2134621908","https://openalex.org/W2230229821","https://openalex.org/W3157100208","https://openalex.org/W2028196104","https://openalex.org/W2064244463","https://openalex.org/W2141261224","https://openalex.org/W2019967416"],"abstract_inverted_index":{"Anti-fracture":[0],"agents":[1,14,42,53,252],"typically":[2],"prevent":[3],"fractures":[4,63,68],"by":[5,18,73,181],"augmenting":[6],"bone":[7,29,34,56,85,151,173,206],"mass":[8],"and":[9,100,118,153,189,215],"enhancing":[10],"skeletal":[11,50,226],"integrity.":[12],"These":[13],"exert":[15],"their":[16],"effects":[17,113],"means":[19],"of":[20,62,77,96,106,131,134,138,157,250,256],"anti-catabolic":[21],"or":[22,64,83],"anabolic":[23],"actions.":[24],"Because":[25],"fracture":[26,98,107,115,179,257],"healing":[27,61,187,258],"involves":[28],"formation":[30,152],"as":[31,33,208,210],"well":[32,209],"resorption,":[35,57],"it":[36,147],"is":[37,122],"reasonable":[38],"to":[39,69,80,86,128,171],"hypothesize":[40],"that":[41,43,54,123,222],"affect":[44],"these":[45,232],"activities":[46],"may":[47,58,141,165,177,224],"also":[48,166],"modulate":[49,142],"repair.":[51],"Bisphosphonates,":[52],"inhibit":[55],"enhance":[59,178,225],"the":[60,75,94,97,104,135,149,186,202,254],"permit":[65],"patients":[66],"with":[67],"bear":[70],"weight":[71],"earlier":[72],"delaying":[74],"conversion":[76],"calcified":[78],"cartilage":[79],"woven":[81,84],"bone,":[82],"lamellar":[87],"bone.":[88],"In":[89],"doing":[90],"so,":[91],"they":[92],"increase":[93],"size":[95],"callus":[99,108,116,199],"small":[101],"increases":[102],"in":[103,185,228],"radius":[105],"can":[109],"have":[110,159,220],"dramatic":[111],"positive":[112],"on":[114,168,236],"stiffness":[117],"strength.":[119],"Another":[120],"possibility":[121],"certain":[124],"hypertrophic":[125],"nonunions":[126],"fail":[127],"unite":[129],"because":[130],"excessive":[132],"remodeling":[133],"callus.":[136],"Use":[137],"a":[139,192],"bisphosphonate":[140],"this":[143,246],"catabolic":[144],"activity,":[145],"uncouple":[146],"from":[148,266],"associated":[150],"promote":[154],"healing.":[155],"Inhibitors":[156],"RANKL":[158],"undergone":[160],"far":[161],"less":[162],"investigation":[163],"but":[164],"act":[167],"osteoclast":[169],"precursors":[170],"down-regulate":[172],"resorption.":[174],"Parathyroid":[175],"hormone":[176],"repair":[180,227],"promoting":[182],"chondrogenesis":[183],"early":[184],"process":[188],"osteogenesis":[190],"at":[191,245],"later":[193],"time.":[194,247],"The":[195,248],"former":[196],"effect":[197,204],"improves":[198,205],"geometry":[200],"while":[201],"latter":[203],"quality":[207,264],"quantity.":[211],"Several":[212],"anecdotal":[213],"reports":[214,233],"one":[216],"randomized,":[217],"controlled":[218],"trial":[219],"suggested":[221],"parathyroid":[223],"specific":[229],"clinical":[230,243,269],"settings.Although":[231],"are":[234,241],"based":[235],"solid":[237],"scientific":[238],"data,":[239],"there":[240],"limited":[242],"data":[244],"use":[249],"anti-fracture":[251],"for":[253],"enhancement":[255],"will":[259],"ultimately":[260],"depend":[261],"upon":[262],"high":[263],"evidence":[265],"well-designed,":[267],"well-controlled":[268],"trials.":[270]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}