{"id":"https://openalex.org/W1787372014","doi":null,"title":"Antitumor necrosis factor treatment for pediatric inflammatory bowel disease","display_name":"Antitumor necrosis factor treatment for pediatric inflammatory bowel disease","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W1787372014","mag":"1787372014"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:6e16af45d2c84defbd30906a9600058a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6e16af45d2c84defbd30906a9600058a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zdravni\u0161ki Vestnik, Vol 82, Iss 0 (2013)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/6e16af45d2c84defbd30906a9600058a","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000476160","display_name":"Darja Urlep","orcid":"https://orcid.org/0000-0002-7297-538X","observed_orcids":["https://orcid.org/0000-0002-7297-538X"]},"institutions":[{"id":"https://openalex.org/I2801323708","display_name":"Ljubljana University Medical Centre","ror":"https://ror.org/01nr6fy72","country_code":"SI","type":"healthcare","lineage":["https://openalex.org/I2801323708"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Darja Urlep","raw_affiliation_strings":["Department of \r\nGastroenterology, \r\nHepatology and \r\nNutrition, University \r\nChildren\u2019s Hospital \r\nLjubljana, University \r\nMedical Centre Ljubljana, \r\nSlovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of \r\nGastroenterology, \r\nHepatology and \r\nNutrition, University \r\nChildren\u2019s Hospital \r\nLjubljana, University \r\nMedical Centre Ljubljana, \r\nSlovenia","institution_ids":["https://openalex.org/I2801323708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113657695","display_name":"Vojislav N. Perisic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142671","display_name":"University Children's Hospital, Belgrade","ror":"https://ror.org/05422jd13","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210142671"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Vojislav N. Perisic","raw_affiliation_strings":["University Children\u2019s \r\nHospital, Belgrade, \r\nSerbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children\u2019s \r\nHospital, Belgrade, \r\nSerbia","institution_ids":["https://openalex.org/I4210142671"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072904429","display_name":"Rok Orel","orcid":"https://orcid.org/0000-0002-1631-3998","observed_orcids":["https://orcid.org/0000-0002-1631-3998","https://orcid.org/0009-0001-2050-237X"]},"institutions":[{"id":"https://openalex.org/I2801323708","display_name":"Ljubljana University Medical Centre","ror":"https://ror.org/01nr6fy72","country_code":"SI","type":"healthcare","lineage":["https://openalex.org/I2801323708"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Rok Orel","raw_affiliation_strings":["department \r\nof gastroenterology, \r\nHepatology and \r\nnutrition, University \r\nChildren\u2019s Hospital \r\nLjubljana, University \r\nMedical Centre Ljubljana, \r\nBohori\u010deva 20, 1000 \r\nLjubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"department \r\nof gastroenterology, \r\nHepatology and \r\nnutrition, University \r\nChildren\u2019s Hospital \r\nLjubljana, University \r\nMedical Centre Ljubljana, \r\nBohori\u010deva 20, 1000 \r\nLjubljana, Slovenia","institution_ids":["https://openalex.org/I2801323708"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0168,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.77690351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-tumor-necrosis-factor-therapy","display_name":"anti-tumor necrosis factor therapy","score":0.9369999766349792},{"id":"https://openalex.org/keywords/pediatric-inflammatory-bowel-disease","display_name":"pediatric inflammatory bowel disease","score":0.9549999833106995},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.8610000014305115},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/infliximab","display_name":"infliximab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/adalimumab","display_name":"adalimumab","score":1.0},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.9319999814033508},{"id":"https://openalex.org/keywords/refractory-ibd","display_name":"refractory IBD","score":0.6570000052452087},{"id":"https://openalex.org/keywords/anti-drug-antibodies","display_name":"anti-drug antibodies","score":0.7839999794960022},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8209999799728394},{"id":"https://openalex.org/keywords/infection","display_name":"infection","score":0.3869999945163727},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.6990000009536743},{"id":"https://openalex.org/keywords/treatment-guidelines","display_name":"treatment guidelines","score":0.3330000042915344}],"concepts":[{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.7743945121765137},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7397671937942505},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5579038858413696},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.5030540823936462},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45440763235092163},{"id":"https://openalex.org/C2777572184","wikidata":"https://www.wikidata.org/wiki/Q15749161","display_name":"Inflammatory Bowel Diseases","level":4,"score":0.4516514837741852},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4374251961708069},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42137882113456726},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3271819055080414}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:doaj.org/article:6e16af45d2c84defbd30906a9600058a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6e16af45d2c84defbd30906a9600058a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zdravni\u0161ki Vestnik, Vol 82, Iss 0 (2013)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:6e16af45d2c84defbd30906a9600058a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6e16af45d2c84defbd30906a9600058a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zdravni\u0161ki Vestnik, Vol 82, Iss 0 (2013)","raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1545513659","https://openalex.org/W1605572692","https://openalex.org/W1964215887","https://openalex.org/W1968331553","https://openalex.org/W1971331540","https://openalex.org/W1973651333","https://openalex.org/W1973716870","https://openalex.org/W1978908714","https://openalex.org/W1981017999","https://openalex.org/W1982704769","https://openalex.org/W1989167852","https://openalex.org/W1990649907","https://openalex.org/W1991810959","https://openalex.org/W1997106678","https://openalex.org/W1999016084","https://openalex.org/W2000518155","https://openalex.org/W2003498729","https://openalex.org/W2003618866","https://openalex.org/W2007289031","https://openalex.org/W2008497900","https://openalex.org/W2008629972","https://openalex.org/W2023994599","https://openalex.org/W2024162533","https://openalex.org/W2028018177","https://openalex.org/W2028547258","https://openalex.org/W2029791051","https://openalex.org/W2042649865","https://openalex.org/W2043780895","https://openalex.org/W2047158379","https://openalex.org/W2048234986","https://openalex.org/W2049575817","https://openalex.org/W2051096775","https://openalex.org/W2055485216","https://openalex.org/W2057220303","https://openalex.org/W2062702732","https://openalex.org/W2064661856","https://openalex.org/W2065907185","https://openalex.org/W2067202307","https://openalex.org/W2072738451","https://openalex.org/W2073117875","https://openalex.org/W2080116899","https://openalex.org/W2082961210","https://openalex.org/W2086415546","https://openalex.org/W2086721113","https://openalex.org/W2087559826","https://openalex.org/W2087663450","https://openalex.org/W2090393370","https://openalex.org/W2091029404","https://openalex.org/W2091211366","https://openalex.org/W2097183141","https://openalex.org/W2099029129","https://openalex.org/W2114558488","https://openalex.org/W2117102124","https://openalex.org/W2119825284","https://openalex.org/W2120539905","https://openalex.org/W2122667831","https://openalex.org/W2126510103","https://openalex.org/W2126807394","https://openalex.org/W2131882149","https://openalex.org/W2140326865","https://openalex.org/W2144518079","https://openalex.org/W2144550346","https://openalex.org/W2144803794","https://openalex.org/W2171059179","https://openalex.org/W2171297959","https://openalex.org/W2171341132","https://openalex.org/W2319303028","https://openalex.org/W2321453230","https://openalex.org/W2333201330","https://openalex.org/W4254978707"],"related_works":["https://openalex.org/W7216837903","https://openalex.org/W4322581713","https://openalex.org/W75828196","https://openalex.org/W4414019950","https://openalex.org/W4386292949","https://openalex.org/W2946188292","https://openalex.org/W2972065798","https://openalex.org/W2622521938","https://openalex.org/W4387518607","https://openalex.org/W3165254260"],"abstract_inverted_index":{"Over":[0],"the":[1,8,17,33,51,65,94,97,107,123],"last":[2],"10":[3],"years,":[4],"biologic":[5],"treatment":[6,67,86,153],"with":[7,23,158],"antitumor":[9],"necrosis":[10],"factor":[11],"(anti-TNF)":[12],"antibodies":[13,148],"has":[14],"dramatically":[15],"changed":[16],"therapeutic":[18],"approach":[19],"in":[20,43,57,103,163],"pediatric":[21,45,59,77,104,155],"patients":[22,137,157],"inflammatory":[24],"bowel":[25],"disease":[26,47],"(IBD).":[27],"Currently,":[28],"infliximab":[29,50],"and":[30,49,75,120],"adalimumab":[31],"are":[32,169],"only":[34,52],"anti-TNF":[35,53,69,101,130,150],"drugs":[36,102],"that":[37],"have":[38],"been":[39],"approved":[40],"for":[41,55,73,172],"use":[42,56,128],"refractory":[44,58],"Crohn\u2019s":[46],"(CD)":[48],"agent":[54],"ulcerative":[60],"colitis":[61],"(UC).":[62],"According":[63],"to":[64,141,145],"current":[66],"recommendations,":[68],"therapy":[70,89],"is":[71,81,90],"indicated":[72],"moderate":[74],"severe":[76,116],"IBD":[78,105,156],"when":[79],"remission":[80],"not":[82,91],"achieved":[83],"using":[84],"conventional":[85,88],"or":[87],"tolerated":[92],"by":[93],"patients.":[95],"Despite":[96],"demonstrated":[98],"efficacy":[99],"of":[100,110,125,129,136,147,154],"patients,":[106],"potential":[108],"development":[109],"serious":[111],"adverse":[112],"events,":[113],"such":[114],"as":[115],"immune":[117],"reactions,":[118],"infections,":[119],"malignancies,":[121],"limit":[122],"possibility":[124],"a":[126,133],"wider":[127],"drugs.":[131],"Moreover,":[132],"substantial":[134],"percentage":[135],"gradually":[138],"develop":[139],"non-responsiveness":[140],"these":[142],"therapeutics,":[143],"due":[144],"generation":[146],"against":[149],"antibodies.":[151],"Therefore,":[152],"biologics":[159],"should":[160],"be":[161],"undertaken":[162],"specialized":[164],"tertiary":[165],"medical":[166],"centers,":[167],"which":[168],"specially":[170],"qualified":[171],"this":[173],"purpose.":[174]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}