{"id":"https://openalex.org/W1786838147","doi":null,"title":"Acute idiosyncratic reaction to hydrochlorothiazide ingestion.","display_name":"Acute idiosyncratic reaction to hydrochlorothiazide ingestion.","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W1786838147","mag":"1786838147","pmid":"https://pubmed.ncbi.nlm.nih.gov/6837011","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1010654"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1010654","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1010654","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1010654/pdf/westjmed00197-0103.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"West J Med","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1010654/pdf/westjmed00197-0103.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020119020","display_name":"H. Malin Prupas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H M Prupas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"D Brown","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6814,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.66066312,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"138","issue":"1","first_page":"101","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.8184000253677368,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.8184000253677368,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.11330000311136246,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrochlorothiazide","display_name":"hydrochlorothiazide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/idiosyncratic-adverse-drug-reactions","display_name":"idiosyncratic drug reactions","score":0.9309999942779541},{"id":"https://openalex.org/keywords/acute-pulmonary-edema","display_name":"acute pulmonary edema","score":0.8529999852180481},{"id":"https://openalex.org/keywords/leukopenia","display_name":"leukopenia","score":0.906000018119812},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":1.0},{"id":"https://openalex.org/keywords/thiazide-diuretics","display_name":"thiazide diuretics","score":0.9779999852180481},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C2780361556","wikidata":"https://www.wikidata.org/wiki/Q423930","display_name":"Hydrochlorothiazide","level":3,"score":0.8857653141021729},{"id":"https://openalex.org/C193230392","wikidata":"https://www.wikidata.org/wiki/Q1663054","display_name":"Ingestion","level":2,"score":0.7125387787818909},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3659652769565582},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2069292664527893},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.04302781820297241}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006852","descriptor_name":"Hydrochlorothiazide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007970","descriptor_name":"Leukopenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1010654","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1010654","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1010654/pdf/westjmed00197-0103.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"West J Med","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:248236","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1010654","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:6837011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6837011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Western journal of medicine","raw_type":"Case Reports"},{"id":"mag:1786838147","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6837011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1010654","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1010654","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1010654/pdf/westjmed00197-0103.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"West J Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1786838147.pdf","grobid_xml":"https://content.openalex.org/works/W1786838147.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1964496946","https://openalex.org/W2023190399","https://openalex.org/W2036837901","https://openalex.org/W2064893687","https://openalex.org/W2067738313","https://openalex.org/W2069402598","https://openalex.org/W2073360297","https://openalex.org/W2090056788","https://openalex.org/W2140626313","https://openalex.org/W2394708846","https://openalex.org/W3149446795","https://openalex.org/W4229696510"],"related_works":["https://openalex.org/W1989492937","https://openalex.org/W183163814","https://openalex.org/W2463200684","https://openalex.org/W2234363748","https://openalex.org/W2993512952","https://openalex.org/W2401560215","https://openalex.org/W4245973880","https://openalex.org/W1481455367","https://openalex.org/W2122206833","https://openalex.org/W2113375928"],"abstract_inverted_index":{"ADMINISTRATION":[0],"OF":[1],"THIAZIDE":[2],"DIURETICS":[3],"has":[4],"been":[5,27,47],"re-ported":[6],"to":[7],"produce":[8],"various":[9],"idiosyncratic":[10,32],"reactions":[11,35],"in-":[12],"cluding":[13],"skin":[14],"rash,'":[15],"urticaria,":[16],"photosensitivity,'":[17],"jaundice,":[18],"necrotizing":[19],"vasculitis'":[20],"and":[21,62,66],"bone":[22,50],"marrow":[23],"depression.-":[24],"There":[25],"have":[26,45],"six":[28],"reported":[29,43],"cases":[30,44],"of":[31,40,57,79],"pulmonary":[33,60],"edema":[34,61],"immediately":[36],"following":[37],"the":[38],"ingestion":[39],"hydrochlorothiazide.8-12These":[41],"previously":[42],"not":[46],"associated":[48,63],"with":[49],"mar-":[51],"row":[52],"depression.We":[53],"report":[54],"a":[55,69,75],"case":[56],"hydrochlorothiazide-induced":[58],"acute":[59],"severe":[64],"leukopenia":[65],"thrombocytopenia":[67],"in":[68],"patient":[70],"shortly":[71],"after":[72],"she":[73],"ingested":[74],"single":[76],"50-mg":[77],"tablet":[78],"hydrochlorothiazide.":[80]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}