{"id":"https://openalex.org/W178680177","doi":"https://doi.org/10.1182/blood.v122.21.1495.1495","title":"High BCR-ABL/GUSIS Levels At Diagnosis Are Associated With Unfavorable Responses To Imatinib","display_name":"High BCR-ABL/GUSIS Levels At Diagnosis Are Associated With Unfavorable Responses To Imatinib","publication_year":2013,"publication_date":"2013-11-15","ids":{"openalex":"https://openalex.org/W178680177","doi":"https://doi.org/10.1182/blood.v122.21.1495.1495","mag":"178680177"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v122.21.1495.1495","doi":"https://doi.org/10.1182/blood.v122.21.1495.1495","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.1495.1495","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043599930","display_name":"Paolo Giovanni Vigneri","orcid":"https://orcid.org/0000-0002-5943-6066","observed_orcids":["https://orcid.org/0000-0002-5943-6066"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo G Vigneri","raw_affiliation_strings":["Clinical and Molecular Bio-Medicine, University of Catania, Catania, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical and Molecular Bio-Medicine, University of Catania, Catania, Italy,","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078324992","display_name":"Fabio Stagno","orcid":"https://orcid.org/0000-0002-7947-158X","observed_orcids":["https://orcid.org/0000-0002-7947-158X"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Stagno","raw_affiliation_strings":["Dept. of Clinical and Experimental Bio-Medicine, Section of Hematology, Oncology, General and Clinical Pathology and Bioinformatics, Catania, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Clinical and Experimental Bio-Medicine, Section of Hematology, Oncology, General and Clinical Pathology and Bioinformatics, Catania, Italy,","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052162438","display_name":"Stefania Stella","orcid":"https://orcid.org/0000-0002-7189-2312","observed_orcids":["https://orcid.org/0000-0002-7189-2312"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Stefania Stella","raw_affiliation_strings":["Dept. of Clinical and Experimental Bio-Medicine, Section of Hematology, Oncology, General and Clinical Pathology and Bioinformatics, Catania, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Clinical and Experimental Bio-Medicine, Section of Hematology, Oncology, General and Clinical Pathology and Bioinformatics, Catania, Italy,","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080919495","display_name":"Alessandra Cupri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160210","display_name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico - San Marco\"","ror":"https://ror.org/051tt6c85","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210160210"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Alessandra Cupri","raw_affiliation_strings":["Bone Marrow Transplantation Unit, Azienda Policlinico Vittorio Emanuele, Catania, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Marrow Transplantation Unit, Azienda Policlinico Vittorio Emanuele, Catania, Italy,","institution_ids":["https://openalex.org/I4210160210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033252383","display_name":"Stefano Forte","orcid":"https://orcid.org/0000-0001-5746-7451","observed_orcids":["https://orcid.org/0000-0001-5746-7451"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Stefano Forte","raw_affiliation_strings":["Istituto Oncologico del Mediterraneo, Viagrande, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Oncologico del Mediterraneo, Viagrande, Italy,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053466740","display_name":"Michele Massimino","orcid":"https://orcid.org/0000-0001-5896-8573","observed_orcids":["https://orcid.org/0000-0001-5896-8573"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Michele Massimino","raw_affiliation_strings":["Dept. of Clinical and Experimental Bio-Medicine, Section of Hematology, Oncology, General and Clinical Pathology and Bioinformatics, Catania, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Clinical and Experimental Bio-Medicine, Section of Hematology, Oncology, General and Clinical Pathology and Bioinformatics, Catania, Italy,","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063005110","display_name":"Agostino Antolino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Agostino Antolino","raw_affiliation_strings":["3Department of Transfusional Medicine, SIMMT, Maria Patern\u00f2-Arezzo Hospital, Ragusa, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Transfusional Medicine, SIMMT, Maria Patern\u00f2-Arezzo Hospital, Ragusa, Italy,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016246130","display_name":"Clementina Caracciolo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Clementina Caracciolo","raw_affiliation_strings":["Dept. of Hematology, University of Palermo, Palermo, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Hematology, University of Palermo, Palermo, Italy,","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007333218","display_name":"Laura Nocilli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166183","display_name":"Azienda Ospedaliera Ospedali Riuniti Papardo Piemonte","ror":"https://ror.org/05b5q0t82","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210166183"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Laura Nocilli","raw_affiliation_strings":["Papardo Hospital, Messina, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Papardo Hospital, Messina, Italy,","institution_ids":["https://openalex.org/I4210166183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024883827","display_name":"Stefana Stella Impera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105999","display_name":"Ospedale Garibaldi","ror":"https://ror.org/01q6hrg49","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210105999"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Stefana Impera","raw_affiliation_strings":["Garibaldi Hospital, Catania, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garibaldi Hospital, Catania, Italy,","institution_ids":["https://openalex.org/I4210105999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046416905","display_name":"Caterina Musolino","orcid":"https://orcid.org/0000-0003-1534-014X","observed_orcids":["https://orcid.org/0000-0003-1534-014X"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Caterina Musolino","raw_affiliation_strings":["Division of Hematology, University of Messina, Messina, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, University of Messina, Messina, Italy,","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042884349","display_name":"Diamante Turri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Diamante Turri","raw_affiliation_strings":["University of Palermo, Palermo, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Palermo, Palermo, Italy,","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111636901","display_name":"Mario Russo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mario Russo","raw_affiliation_strings":["S. Vincenzo Hospital, Taormina, Hematology Section, Taormina, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S. Vincenzo Hospital, Taormina, Hematology Section, Taormina, Italy,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075092827","display_name":"Carmen Tomaselli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Carmen Tomaselli","raw_affiliation_strings":["Civico Hospital, Palermo, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Civico Hospital, Palermo, Italy,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103959781","display_name":"Michele Rizzo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michele Rizzo","raw_affiliation_strings":["S'Elia Hospital, Hematology Section, Caltanissetta, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S'Elia Hospital, Hematology Section, Caltanissetta, Italy,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105406088","display_name":"Maurizio Musso","orcid":"https://orcid.org/0009-0008-9407-1112","observed_orcids":["https://orcid.org/0009-0008-9407-1112"]},"institutions":[{"id":"https://openalex.org/I4210163675","display_name":"La Maddalena","ror":"https://ror.org/04st1y556","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210163675"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Maurizio Musso","raw_affiliation_strings":["Hematology and Bone Marrow Transplant Unit, Dept. of Oncology, La Maddalena, Palermo, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Bone Marrow Transplant Unit, Dept. of Oncology, La Maddalena, Palermo, Italy,","institution_ids":["https://openalex.org/I4210163675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022153283","display_name":"Fortunato Morabito","orcid":"https://orcid.org/0000-0002-2585-7073","observed_orcids":["https://orcid.org/0000-0002-2585-7073"]},"institutions":[{"id":"https://openalex.org/I4210102769","display_name":"Azienda Ospedaliera di Cosenza","ror":"https://ror.org/01884b046","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210102769"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Fortunato Morabito","raw_affiliation_strings":["Cosenza Hospital, Hematology Section, Cosenza, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cosenza Hospital, Hematology Section, Cosenza, Italy,","institution_ids":["https://openalex.org/I4210102769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018496231","display_name":"Luciano Levato","orcid":"https://orcid.org/0000-0003-0032-2977","observed_orcids":["https://orcid.org/0000-0003-0032-2977"]},"institutions":[{"id":"https://openalex.org/I4210148440","display_name":"Azienda Ospedaliera Pugliese Ciaccio","ror":"https://ror.org/053y0qd29","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210148440"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Luciano Levato","raw_affiliation_strings":["Department of Hematology, \u201cAzienda Ospedaliera Pugliese Ciaccio\u201d, Catanzaro, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, \u201cAzienda Ospedaliera Pugliese Ciaccio\u201d, Catanzaro, Italy,","institution_ids":["https://openalex.org/I4210148440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003798152","display_name":"Livia Manzella","orcid":"https://orcid.org/0000-0002-9908-6443","observed_orcids":["https://orcid.org/0000-0002-9908-6443"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Livia Manzella","raw_affiliation_strings":["Dept. Clinical and Molecular Bio-Medicine, University of Catania, Catania, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Clinical and Molecular Bio-Medicine, University of Catania, Catania, Italy,","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088450042","display_name":"Martin C. M\u00fcller","orcid":"https://orcid.org/0000-0002-8269-1583","observed_orcids":["https://orcid.org/0000-0002-8269-1583"]},"institutions":[{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Martin C Muller","raw_affiliation_strings":["III. Med. Klinik, Universitatsmedizin Mannheim, Mannheim, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"III. Med. Klinik, Universitatsmedizin Mannheim, Mannheim, Germany,","institution_ids":["https://openalex.org/I4210156450","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035964802","display_name":"Andreas Hochhaus","orcid":"https://orcid.org/0000-0003-0626-0834","observed_orcids":["https://orcid.org/0000-0003-0626-0834"]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Hochhaus","raw_affiliation_strings":["Universit\u00e4tsklinikum Jena Klinik f\u00fcr Innere Medizin II, Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Jena Klinik f\u00fcr Innere Medizin II, Jena, Germany","institution_ids":["https://openalex.org/I4210134900"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034393745","display_name":"Francesco Di Raimondo","orcid":"https://orcid.org/0000-0002-7749-0293","observed_orcids":["https://orcid.org/0000-0002-7749-0293"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Di Raimondo","raw_affiliation_strings":["Dept. Clinical and Molecular Bio-Medicine, University of Catania, Catania, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Clinical and Molecular Bio-Medicine, University of Catania, Catania, Italy,","institution_ids":["https://openalex.org/I39063666"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5007333218","https://openalex.org/A5016246130","https://openalex.org/A5018496231","https://openalex.org/A5022153283","https://openalex.org/A5024883827","https://openalex.org/A5033252383","https://openalex.org/A5042884349","https://openalex.org/A5046416905","https://openalex.org/A5052162438","https://openalex.org/A5053466740","https://openalex.org/A5063005110","https://openalex.org/A5075092827","https://openalex.org/A5080919495","https://openalex.org/A5088450042","https://openalex.org/A5103959781","https://openalex.org/A5105406088","https://openalex.org/A5111636901"],"corresponding_institution_ids":["https://openalex.org/I112862951","https://openalex.org/I39063666","https://openalex.org/I4210102769","https://openalex.org/I4210105999","https://openalex.org/I4210148440","https://openalex.org/I4210156450","https://openalex.org/I4210160210","https://openalex.org/I4210163675","https://openalex.org/I4210166183","https://openalex.org/I4387153978","https://openalex.org/I900890020"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.6389,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.70354985,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"122","issue":"21","first_page":"1495","last_page":"1495"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/bcr-abl1-transcript","display_name":"BCR-ABL transcript","score":0.7799999713897705},{"id":"https://openalex.org/keywords/imatinib-mesylate","display_name":"imatinib mesylate","score":0.9139999747276306},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6669999957084656},{"id":"https://openalex.org/keywords/molecular-response","display_name":"molecular response","score":0.5550000071525574},{"id":"https://openalex.org/keywords/complete-cytogenetic-response","display_name":"complete cytogenetic response","score":0.9120000004768372},{"id":"https://openalex.org/keywords/major-molecular-response","display_name":"major molecular response","score":0.8220000267028809},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.5109999775886536},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7170000076293945},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.5609999895095825},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.859000027179718},{"id":"https://openalex.org/keywords/early-molecular-response","display_name":"early molecular response","score":0.3310000002384186},{"id":"https://openalex.org/keywords/prognostic-score","display_name":"prognostic score","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.806610107421875},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.7095284461975098},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6281628608703613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5945544838905334},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5454472303390503},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5022873878479004},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47756320238113403},{"id":"https://openalex.org/C2778904597","wikidata":"https://www.wikidata.org/wiki/Q1129111","display_name":"Philadelphia chromosome","level":4,"score":0.4324575364589691},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.41252046823501587},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3462942838668823},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3274485766887665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2564050555229187},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15191644430160522},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0920972228050232},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07378259301185608},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v122.21.1495.1495","doi":"https://doi.org/10.1182/blood.v122.21.1495.1495","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.1495.1495","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2565946135","https://openalex.org/W2554604754","https://openalex.org/W2754863652","https://openalex.org/W2510598749","https://openalex.org/W2980189821","https://openalex.org/W2943298525","https://openalex.org/W2979820029","https://openalex.org/W2582626551","https://openalex.org/W1965169783","https://openalex.org/W2556804084"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"approval":[2],"of":[3,14,28,54,61,96,104,132,185,188,195,206,225,271,278,283,295,433,442,454,459,472,495,508],"three":[4,334],"tyrosine":[5],"kinase":[6],"inhibitors":[7],"(TKIs)":[8],"for":[9,24,369,373,376,379,383],"the":[10,68,102,148,174,183,186,196,237,254,304,333,398,419,493],"first":[11],"line":[12],"treatment":[13],"Chronic":[15],"Myeloid":[16],"Leukemia":[17,257,307],"(CML)":[18],"has":[19,154],"generated":[20],"an":[21,435],"urgent":[22],"need":[23],"molecular":[25,40,216,408],"parameters":[26],"predictive":[27],"unfavorable":[29,85],"therapeutic":[30],"outcomes.":[31],"Recent":[32],"evidence":[33,153],"suggests":[34],"that":[35,110,156,326,357,385,440,477,503],"failure":[36,250],"to":[37,73,87,113,129,236,310,396,423,499],"achieve":[38],"early":[39,407],"responses":[41,86,409],"(i.e.":[42],"BCR-ABL/ABLIS":[43,449,468],"levels":[44,98,361,403,450],"<10%":[45,448],"after":[46,51,280,451,469],"3":[47,412,452],"months":[48,53,282,453,471],"or":[49,240,429],"<1%":[50,467],"6":[52,414,470],"TKI":[55],"treatment)":[56],"results":[57],"in":[58,142,164,190,315],"inferior":[59,269],"rates":[60,277,400],"both":[62],"overall":[63,226],"and":[64,214,221,243,263,275,298,320,381,406,413,438],"progression-free":[65],"survival.":[66],"With":[67],"current":[69],"study,":[70],"we":[71,92,302,324,355,394],"wanted":[72,395],"establish":[74],"if":[75],"high":[76,287,390,427,478],"BCR-ABL":[77,97,118,479],"transcripts":[78,119,289,330,480],"at":[79,99,167,362,404,411,464,481],"diagnosis":[80,100,363,405,465,482],"would":[81],"be":[82],"associated":[83,291],"with":[84,101,268,292,426],"Imatinib":[88],"Mesylate":[89],"(IM).":[90],"Thus,":[91],"correlated":[93,267],"quantitative":[94,365],"determinations":[95,138],"outcome":[103],"230":[105],"newly":[106],"diagnosed":[107],"CML":[108,496],"patients":[109,443,497],"were":[111,120,139,170,218,260,290],"assigned":[112],"receive":[114,505],"IM":[115,249,284,455,502],"400":[116],"mg/die.":[117],"measured":[121,483],"from":[122,182,389,501],"peripheral":[123],"blood":[124],"samples":[125,165],"drawn":[126],"before":[127],"exposure":[128],"any":[130],"form":[131],"treatment.":[133,509],"Real-Time":[134],"Quantitative":[135],"PCR":[136],"(RQ-PCR)":[137],"subsequently":[140],"performed":[141],"triplicates":[143],"using":[144,350],"glucuronidase-beta":[145],"(GUS)":[146],"as":[147,251,488],"reference":[149,490],"gene,":[150],"since":[151],"previous":[152],"demonstrated":[155],"ABL":[157],"is":[158],"not":[159],"a":[160,178,489],"reliable":[161],"control":[162],"gene":[163,491],"collected":[166],"diagnosis.":[168],"Values":[169],"then":[171],"reported":[172],"on":[173],"International":[175],"Scale":[176],"employing":[177,486],"conversion":[179],"factor":[180],"obtained":[181],"laboratory":[184],"University":[187],"Heidelberg":[189],"Mannheim,":[191],"Germany.":[192],"Median":[193],"follow-up":[194],"study":[197],"population":[198],"was":[199],"50":[200],"months.":[201,415],"Estimated":[202],"5-year":[203],"cumulative":[204],"incidences":[205],"complete":[207,210],"hematologic":[208],"response,":[209],"cytogenetic":[211],"response":[212,217,273],"(CCyR)":[213],"major":[215],"97.9%,":[219],"89.5%":[220],"64.7%.":[222],"Five-year":[223],"probabilities":[224,270,294,432],"survival":[227,230,232,245,247],"(OS),":[228],"transformation-free":[229],"(TFS:":[231],"without":[233,248],"disease":[234],"transformation":[235],"accelerated":[238],"phase":[239],"blast":[241],"crisis)":[242],"failure-free":[244],"(FFS:":[246],"defined":[252,364],"by":[253,484],"2009":[255,305],"European":[256,306],"Net":[258,308],"recommendations)":[259],"93.8%,":[261],"97.8%":[262],"76%.":[264],"Elevated":[265],"BCR-ABL/GUSIS":[266,288,329,360,402,421,446,463],"optimal":[272,316,341],"(p<0.001),":[274],"lower":[276,293],"CCyR":[279],"12":[281],"(p<0.001).":[285,456,474],"Moreover,":[286],"FFS":[296],"(p<0.001)":[297],"TFS":[299,380],"(p=0.01).":[300],"When":[301],"employed":[303,418],"criteria":[309],"subdivide":[311],"our":[312],"patient":[313,335],"cohort":[314],"responders,":[317],"suboptimal":[318,339,345],"responders":[319],"individuals":[321],"failing":[322],"IM,":[323],"found":[325,356,439],"increasingly":[327],"elevated":[328],"accurately":[331],"distinguished":[332],"groups":[336],"(optimal":[337],"vs":[338,342,346],"p<0.001;":[340,344],"resistant":[343,347],"p<0.001).":[348],"Furthermore,":[349],"receiver":[351],"operating":[352],"characteristic":[353],"curves":[354],"progressively":[358],"higher":[359],"transcript":[366],"thresholds":[367],"(15.96%":[368],"Optimal":[370,436],"Response,":[371],"16.01%":[372],"EFS,":[374],"16.09%":[375],"FFS,":[377],"20.36%":[378],"22.04%":[382],"OS)":[384],"separated":[386],"low":[387,430],"risk":[388,391],"patients.":[392],"Finally,":[393],"determine":[397],"concordance":[399],"between":[401],"(eMRs)":[410],"We":[416,475],"therefore":[417],"15.96%":[420],"threshold":[422],"identify":[424],"subjects":[425,460],"(<15.96%)":[428],"(>15.96%)":[431],"obtaining":[434],"Response":[437],"69%":[441],"displaying":[444],"<15.96%":[445,462],"achieved":[447],"Likewise,":[457],"78%":[458],"presenting":[461],"attained":[466],"therapy":[473],"conclude":[476],"RQ-PCR":[485],"GUS":[487],"allow":[492],"identification":[494],"unlikely":[498],"benefit":[500],"should":[504],"alternative":[506],"forms":[507],"Disclosures:":[510],"Muller:":[511],"Novartis,":[512,516,520],"BMS,":[513,521],"ARIAD:":[514,522],"Consultancy;":[515],"BMS:":[517],"Research":[518],"Funding;":[519],"Honoraria.":[523]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}