{"id":"https://openalex.org/W1786517400","doi":"https://doi.org/10.1152/ajpendo.1990.259.3.e378","title":"Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid.","display_name":"Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid.","publication_year":1990,"publication_date":"1990-09-01","ids":{"openalex":"https://openalex.org/W1786517400","doi":"https://doi.org/10.1152/ajpendo.1990.259.3.e378","mag":"1786517400","pmid":"https://pubmed.ncbi.nlm.nih.gov/2205107"},"language":"en","primary_location":{"id":"doi:10.1152/ajpendo.1990.259.3.e378","doi":"https://doi.org/10.1152/ajpendo.1990.259.3.e378","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.1990.259.3.e378","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053926256","display_name":"Michael W. Schwartz","orcid":"https://orcid.org/0000-0003-1619-0331","observed_orcids":["https://orcid.org/0000-0003-1619-0331"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M W Schwartz","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle 98105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle 98105","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004494424","display_name":"Alfred J. Sipols","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Sipols","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle 98105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle 98105","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066700951","display_name":"Steven E. Kahn","orcid":"https://orcid.org/0000-0001-7307-9002","observed_orcids":["https://orcid.org/0000-0001-7307-9002"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S E Kahn","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle 98105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle 98105","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046785493","display_name":"Dianne Figlewicz Lattemann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D F Lattemann","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle 98105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle 98105","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035495914","display_name":"Gerald J. Taborsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G J Taborsky","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle 98105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle 98105","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030791389","display_name":"Richard N. Bergman","orcid":"https://orcid.org/0000-0003-1539-4471","observed_orcids":["https://orcid.org/0000-0003-1539-4471"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R N Bergman","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle 98105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle 98105","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072321501","display_name":"Stephen C. Woods","orcid":"https://orcid.org/0000-0002-9130-4098","observed_orcids":["https://orcid.org/0000-0002-9130-4098"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S C Woods","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle 98105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle 98105","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108238933","display_name":"Daniel Porte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Porte","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle 98105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle 98105","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":6.8285,"has_fulltext":false,"cited_by_count":192,"citation_normalized_percentile":{"value":0.97164461,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"259","issue":"3","first_page":"E378","last_page":"E378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.8598999977111816,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.8598999977111816,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.061500001698732376,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.5740000009536743},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hyperinsulinemia","display_name":"hyperinsulinemia","score":0.7570000290870667},{"id":"https://openalex.org/keywords/proinsulin","display_name":"proinsulin","score":0.8289999961853027},{"id":"https://openalex.org/keywords/insulin-receptor-affinity","display_name":"insulin receptor affinity","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.9032363891601562},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8601481914520264},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8518341779708862},{"id":"https://openalex.org/C90061646","wikidata":"https://www.wikidata.org/wiki/Q426173","display_name":"Proinsulin","level":3,"score":0.8404974937438965},{"id":"https://openalex.org/C2780988686","wikidata":"https://www.wikidata.org/wiki/Q14375936","display_name":"Hyperinsulinemia","level":4,"score":0.7444363236427307},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.7061265110969543},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4674537777900696},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.4251851737499237},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.301861047744751},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.25270771980285645}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D007332","descriptor_name":"Insulin Infusion Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011384","descriptor_name":"Proinsulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011384","descriptor_name":"Proinsulin","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpendo.1990.259.3.e378","doi":"https://doi.org/10.1152/ajpendo.1990.259.3.e378","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.1990.259.3.e378","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmid:2205107","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2205107","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3274514309","display_name":"PEPTIDE TRANSPORT FROM PLASMA TO CSF IN PRIMATES","funder_award_id":"F32DK008025","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G642268167","display_name":"Integration of Long- and Short-Term Control of Feeding","funder_award_id":"R01DK012829","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000881174","display_name":"Diabetes Research Center","funder_award_id":"P30DK017047","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2033390091","https://openalex.org/W2047780911","https://openalex.org/W2113447833"],"related_works":["https://openalex.org/W2135456335","https://openalex.org/W6987073550","https://openalex.org/W1967708672","https://openalex.org/W2023398079","https://openalex.org/W2069594727","https://openalex.org/W2030111077","https://openalex.org/W2125641405","https://openalex.org/W2263019966","https://openalex.org/W1992443748","https://openalex.org/W2044489607"],"abstract_inverted_index":{"To":[0,142],"characterize":[1],"the":[2,17,21,30,35,56,103,117,144,170,234,239],"relationship":[3],"between":[4],"insulin":[5,24,33,45,53,78,83,115,121,148,158,171,200,218,242],"levels":[6,40,54,182,215],"in":[7,11,85,236],"plasma":[8,28,77,213,237],"and":[9,29],"those":[10],"cerebrospinal":[12],"fluid":[13],"(CSF),":[14],"we":[15,152],"studied":[16],"kinetics":[18],"of":[19,23,32,41,119,136,146,162,179,199,241,248],"both":[20],"uptake":[22,149,155,240],"into":[25],"CSF":[26,36,52,82,120,137,147,180],"from":[27,150],"turnover":[31,138],"within":[34,55],"compartment.":[37],"Sustained":[38],"physiological":[39],"euglycemic":[42],"hyperinsulinemia":[43],"(plasma":[44],"approximately":[46,79],"500":[47],"pM)":[48],"did":[49],"not":[50],"alter":[51],"1st":[57],"h,":[58],"but":[59],"by":[60,93,98,139],"90":[61],"min":[62,126,185],"a":[63,86,99,164,175],"significant":[64],"increase":[65,101],"was":[66,91,122,243],"observed":[67,174],"(P":[68],"less":[69,209,228],"than":[70,210,217,229,246],"0.01).":[71],"During":[72],"graded":[73],"hyperinsulinemic":[74],"clamps":[75],"(mean":[76],"500-15,000":[80],"pM),":[81],"rose":[84],"dose-dependent":[87],"fashion.":[88],"This":[89],"rise":[90],"characterized":[92],"an":[94],"initial":[95],"delay":[96],"followed":[97],"continuous":[100],"for":[102,169,233],"next":[104],"150":[105],"min.":[106],"We":[107,173],"also":[108],"found":[109],"that":[110,135,161,198,247],"after":[111],"brief,":[112],"high-dose":[113],"intravenous":[114,157],"infusions,":[116],"t1/2":[118],"143":[123],"+/-":[124,128,187,191,202,220,224],"7":[125],"(means":[127],"SE;":[129,192],"n":[130,193,205],"=":[131,194,206],"4),":[132],"similar":[133],"to":[134],"bulk":[140],"flow.":[141],"test":[143],"specificity":[145],"plasma,":[151],"compared":[153,196],"this":[154],"during":[156],"infusions":[159],"with":[160,166,197],"proinsulin,":[163],"peptide":[165],"reduced":[167],"affinity":[168],"receptor.":[172],"significantly":[176],"lower":[177],"increment":[178],"proinsulin":[181,214],"over":[183],"180":[184],"(13.6":[186],"1.6":[188],"pM;":[189,204,226],"means":[190],"4)":[195],"(22.4":[201],"0.6":[203],"4;":[207],"P":[208,227],"0.01),":[211],"despite":[212],"higher":[216],"(1,890":[219],"287":[221],"vs.":[222],"1,283":[223],"192":[225],"0.001).":[230],"When":[231],"corrected":[232],"difference":[235],"levels,":[238],"fivefold":[244],"greater":[245],"proinsulin.(ABSTRACT":[249],"TRUNCATED":[250],"AT":[251],"250":[252],"WORDS)":[253]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}