{"id":"https://openalex.org/W178650192","doi":"https://doi.org/10.1055/s-0038-1651603","title":"Problems of Oral Anticoagulation in an Adult with Homozygous Protein C Deficiency and Late Onset of Thrombosis","display_name":"Problems of Oral Anticoagulation in an Adult with Homozygous Protein C Deficiency and Late Onset of Thrombosis","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W178650192","doi":"https://doi.org/10.1055/s-0038-1651603","mag":"178650192","pmid":"https://pubmed.ncbi.nlm.nih.gov/8497841"},"language":"en","primary_location":{"id":"doi:10.1055/s-0038-1651603","doi":"https://doi.org/10.1055/s-0038-1651603","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1651603","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113637620","display_name":"Paul Pescatore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133078","display_name":"H\u00f4tel-Dieu de Paris","ror":"https://ror.org/03jmjy508","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210124464","https://openalex.org/I4210133078"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P Pescatore","raw_affiliation_strings":["Laboratoire Central d'H\u00e9matologie, H\u00f4tel-Dieu, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Central d'H\u00e9matologie, H\u00f4tel-Dieu, Paris, France","institution_ids":["https://openalex.org/I4210133078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040800493","display_name":"H M Horellou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133078","display_name":"H\u00f4tel-Dieu de Paris","ror":"https://ror.org/03jmjy508","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210124464","https://openalex.org/I4210133078"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H M Horellou","raw_affiliation_strings":["Laboratoire Central d'H\u00e9matologie, H\u00f4tel-Dieu, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Central d'H\u00e9matologie, H\u00f4tel-Dieu, Paris, France","institution_ids":["https://openalex.org/I4210133078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111273232","display_name":"J. Conard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133078","display_name":"H\u00f4tel-Dieu de Paris","ror":"https://ror.org/03jmjy508","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210124464","https://openalex.org/I4210133078"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J Conard","raw_affiliation_strings":["Laboratoire Central d'H\u00e9matologie, H\u00f4tel-Dieu, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Central d'H\u00e9matologie, H\u00f4tel-Dieu, Paris, France","institution_ids":["https://openalex.org/I4210133078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083114119","display_name":"M Piffoux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Piffoux","raw_affiliation_strings":["Centre Hospitalier d'Auxerre, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier d'Auxerre, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018944214","display_name":"Patrick Van Dreden","orcid":"https://orcid.org/0000-0001-8120-4782","observed_orcids":["https://orcid.org/0000-0001-8120-4782"]},"institutions":[{"id":"https://openalex.org/I4210133078","display_name":"H\u00f4tel-Dieu de Paris","ror":"https://ror.org/03jmjy508","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210124464","https://openalex.org/I4210133078"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P Van Dreden","raw_affiliation_strings":["Laboratoire Central d'H\u00e9matologie, H\u00f4tel-Dieu, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Central d'H\u00e9matologie, H\u00f4tel-Dieu, Paris, France","institution_ids":["https://openalex.org/I4210133078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045595577","display_name":"Agnes Ruskone-Fourmestraux","orcid":"https://orcid.org/0000-0001-5876-1716","observed_orcids":["https://orcid.org/0000-0001-5876-1716"]},"institutions":[{"id":"https://openalex.org/I4210133078","display_name":"H\u00f4tel-Dieu de Paris","ror":"https://ror.org/03jmjy508","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210124464","https://openalex.org/I4210133078"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A Ruskone-Fourmestraux","raw_affiliation_strings":["Service M\u00e9decine et H\u00e9pato-Gastro-Ent\u00e9rologie, H\u00f4tel-Dieu, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service M\u00e9decine et H\u00e9pato-Gastro-Ent\u00e9rologie, H\u00f4tel-Dieu, Paris, France","institution_ids":["https://openalex.org/I4210133078"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108526255","display_name":"Meyer Michel Samama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133078","display_name":"H\u00f4tel-Dieu de Paris","ror":"https://ror.org/03jmjy508","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210124464","https://openalex.org/I4210133078"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Samama","raw_affiliation_strings":["Laboratoire Central d'H\u00e9matologie, H\u00f4tel-Dieu, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Central d'H\u00e9matologie, H\u00f4tel-Dieu, Paris, France","institution_ids":["https://openalex.org/I4210133078"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1954,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.76533501,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"69","issue":"04","first_page":"311","last_page":"315"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-c-deficiency","display_name":"protein C deficiency","score":0.843999981880188},{"id":"https://openalex.org/keywords/homozygous-protein-c-deficiency","display_name":"homozygous protein C deficiency","score":0.9750000238418579},{"id":"https://openalex.org/keywords/oral-anticoagulation","display_name":"oral anticoagulation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/skin-necrosis","display_name":"skin necrosis","score":0.7419999837875366},{"id":"https://openalex.org/keywords/deep-vein-thrombosis","display_name":"deep vein thrombosis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/disseminated-intravascular-coagulation","display_name":"disseminated intravascular coagulation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/low-molecular-weight-heparin","display_name":"low molecular weight heparin","score":0.953000009059906}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8492738604545593},{"id":"https://openalex.org/C2779683630","wikidata":"https://www.wikidata.org/wiki/Q1504570","display_name":"Protein C deficiency","level":4,"score":0.6997888088226318},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.694096565246582},{"id":"https://openalex.org/C2778959117","wikidata":"https://www.wikidata.org/wiki/Q430892","display_name":"Deep vein","level":3,"score":0.6440167427062988},{"id":"https://openalex.org/C2781287897","wikidata":"https://www.wikidata.org/wiki/Q412810","display_name":"Protein C","level":2,"score":0.6151517033576965},{"id":"https://openalex.org/C2778734968","wikidata":"https://www.wikidata.org/wiki/Q823027","display_name":"Disseminated intravascular coagulation","level":2,"score":0.6122940182685852},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.5960731506347656},{"id":"https://openalex.org/C2776884760","wikidata":"https://www.wikidata.org/wiki/Q2750727","display_name":"Low molecular weight heparin","level":3,"score":0.5791417360305786},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5172591805458069},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.43013498187065125},{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.4151083827018738},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4008554220199585},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34112322330474854},{"id":"https://openalex.org/C2780011451","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thrombosis","level":3,"score":0.241496741771698}],"mesh":[{"descriptor_ui":"D000074","descriptor_name":"Acenocoumarol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000074","descriptor_name":"Acenocoumarol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000075202","descriptor_name":"Contraindications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001778","descriptor_name":"Blood Coagulation Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004211","descriptor_name":"Disseminated Intravascular Coagulation","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D013924","descriptor_name":"Thrombophlebitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013924","descriptor_name":"Thrombophlebitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020151","descriptor_name":"Protein C Deficiency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0038-1651603","doi":"https://doi.org/10.1055/s-0038-1651603","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1651603","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmid:8497841","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8497841","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and haemostasis","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2403320274","https://openalex.org/W2418305971","https://openalex.org/W2411051784","https://openalex.org/W2022526300","https://openalex.org/W2014138762","https://openalex.org/W2274143839","https://openalex.org/W2036880754","https://openalex.org/W2140455780","https://openalex.org/W1966282846","https://openalex.org/W1517803687"],"abstract_inverted_index":{"We":[0],"describe":[1],"a":[2,80],"57-year-old":[3],"woman":[4],"with":[5,119],"homozygous":[6],"protein":[7,38,120,135],"C":[8,39,121,136],"deficiency":[9,137],"and":[10,30,41,66],"mild":[11],"thrombotic":[12],"manifestations":[13],"consisting":[14],"of":[15,26,51,63,69,77,95,110,132,134,144],"three":[16],"spontaneous":[17],"distal":[18],"deep":[19],"vein":[20],"thromboses":[21],"occurring":[22],"after":[23],"the":[24,49,75,108,124,130,141],"age":[25],"45.":[27],"Previous":[28],"surgery":[29],"pregnancies":[31],"had":[32],"been":[33],"uneventful.":[34],"Low":[35],"but":[36],"detectable":[37],"antigen":[40],"activity":[42],"levels":[43],"(both":[44],"20%)":[45],"were":[46],"discovered":[47],"on":[48],"occasion":[50],"skin":[52,64],"necrosis":[53,65],"induced":[54],"by":[55],"oral":[56,116],"anticoagulation.":[57],"This":[58,127],"therapy":[59],"was":[60],"interrupted":[61],"because":[62],"several":[67],"episodes":[68],"disseminated":[70],"intravascular":[71],"coagulation":[72],"(DIC)":[73],"at":[74],"initiation":[76],"treatment":[78],"despite":[79],"cautious":[81],"protocol.":[82],"No":[83],"recurrent":[84],"thromboembolic":[85],"event":[86],"has":[87],"occurred":[88],"in":[89,123,148],"our":[90],"patient":[91],"using":[92],"prophylactic":[93],"doses":[94],"low":[96,111],"molecular":[97,112],"weight":[98,113],"heparin":[99,114],"for":[100],"24":[101],"months.":[102],"New":[103],"therapeutic":[104],"approaches":[105],"might":[106],"be":[107],"administration":[109],"or":[115],"anticoagulation":[117,147],"associated":[118],"replacement":[122],"induction":[125],"period.":[126],"case":[128],"reflects":[129],"variability":[131],"expression":[133],"as":[138,140],"well":[139],"potential":[142],"hazards":[143],"antivitamin":[145],"K":[146],"this":[149],"disorder.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}