{"id":"https://openalex.org/W1785933656","doi":null,"title":"The Differential Effects of Buprenorphine and Methadone on Adolescent Mice.","display_name":"The Differential Effects of Buprenorphine and Methadone on Adolescent Mice.","publication_year":2013,"publication_date":"2013-03-01","ids":{"openalex":"https://openalex.org/W1785933656","mag":"1785933656"},"language":"en","primary_location":{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/154899","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1969.1/154899","pdf_url":"https://hdl.handle.net/1969.1/154899","source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/1969.1/154899","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023397912","display_name":"Joseph Barwatt","orcid":"https://orcid.org/0000-0003-3362-6424","observed_orcids":["https://orcid.org/0000-0003-3362-6424"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joseph Barwatt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5023397912"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.5810999870300293,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.5810999870300293,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.38280001282691956,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/buprenorphine","display_name":"buprenorphine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/methadone","display_name":"methadone","score":1.0},{"id":"https://openalex.org/keywords/opioid-maintenance-treatment","display_name":"opioid maintenance treatment","score":0.8870000243186951},{"id":"https://openalex.org/keywords/adolescent-brain-development","display_name":"adolescent brain development","score":0.8859999775886536},{"id":"https://openalex.org/keywords/d2-d3-dopamine-receptors","display_name":"D2/D3 dopamine receptors","score":0.9190000295639038},{"id":"https://openalex.org/keywords/opioid-addiction-treatment","display_name":"opioid dependence treatment","score":0.5690000057220459},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.5839999914169312},{"id":"https://openalex.org/keywords/dopamine-receptor-signaling","display_name":"dopamine receptor signaling","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C2778949969","wikidata":"https://www.wikidata.org/wiki/Q407721","display_name":"Buprenorphine","level":4,"score":0.9079091548919678},{"id":"https://openalex.org/C2778767360","wikidata":"https://www.wikidata.org/wiki/Q179996","display_name":"Methadone","level":2,"score":0.8647350072860718},{"id":"https://openalex.org/C93226319","wikidata":"https://www.wikidata.org/wiki/Q193137","display_name":"Differential (mechanical device)","level":2,"score":0.5149129629135132},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5104281306266785},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4231812357902527},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3927448093891144},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.36015889048576355},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3451962471008301},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.3367154002189636},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20261770486831665},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08272436261177063},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.04120296239852905},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/154899","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1969.1/154899","pdf_url":"https://hdl.handle.net/1969.1/154899","source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:1785933656","doi":null,"is_oa":false,"landing_page_url":"https://oaktrust.library.tamu.edu/bitstream/1969.1/154899/1/BARWATT-THESIS-2013.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/154899","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1969.1/154899","pdf_url":"https://hdl.handle.net/1969.1/154899","source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1785933656.pdf","grobid_xml":"https://content.openalex.org/works/W1785933656.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W1978744396","https://openalex.org/W1999632124","https://openalex.org/W2038538575","https://openalex.org/W2097994890","https://openalex.org/W2099849656","https://openalex.org/W2135293200","https://openalex.org/W2155432713","https://openalex.org/W2403703083"],"related_works":["https://openalex.org/W2093789826","https://openalex.org/W2208646176","https://openalex.org/W2739026118","https://openalex.org/W1999632124","https://openalex.org/W2102769905","https://openalex.org/W2520873324","https://openalex.org/W2056852555","https://openalex.org/W4411111326","https://openalex.org/W4281620444","https://openalex.org/W2140252239"],"abstract_inverted_index":{"This":[0,21,226,258],"study":[1,63,87,142,296],"focuses":[2],"on":[3,17,54,74],"understanding":[4],"the":[5,18,48,55,75,112,149,152,181,206,234,254,286],"consequences":[6],"of":[7,42,50,61,78,114,151,205,237],"administering":[8,266],"opioid":[9,31,51],"maintenance":[10,52],"drugs,":[11],"such":[12],"as":[13,239,273,275],"buprenorphine":[14,145,282],"and":[15,33,37,137,146],"methadone,":[16,167,238,281],"adolescent":[19,57,119,159,197,224,310],"brain.":[20,58],"is":[22,39,64],"because":[23],"that":[24,44,82,204,260,299],"there":[25,38],"are":[26],"growing":[27],"needs":[28],"to":[29,65,68,99,110,135,189,203,213,241,268,280,284,301],"treat":[30],"dependence":[32],"addiction":[34,271],"in":[35,89,96,118,130,157,210,222,247,291,308],"adolescents":[36,269,292],"a":[40,70,191,200],"lack":[41],"studies":[43],"aim":[45],"at":[46],"explaining":[47],"effects":[49],"drugs":[53],"still-developing":[56],"The":[59,121],"goal":[60],"this":[62,141,248,295],"enable":[66],"physicians":[67],"conduct":[69],"science-based":[71],"risk":[72],"assessment":[73],"proper":[76],"use":[77],"these":[79],"treatments":[80],"for":[81,172,185,270],"age":[83],"group.":[84],"A":[85],"recent":[86],"conducted":[88],"our":[90],"lab":[91],"has":[92],"indicated":[93],"potential":[94],"risks":[95],"chronic":[97],"exposure":[98,107,251,300],"certain":[100],"opioids,":[101],"specifically,":[102],"morphine":[103],"during":[104],"adolescence.":[105],"Morphine":[106],"was":[108,220,228],"observed":[109,221],"change":[111],"signaling":[113,290],"D2/D3":[115,122,153,192,255,287],"dopamine":[116,123,154,193,288],"receptors":[117,155],"mice.":[120],"receptor":[124,194,289],"may":[125,297],"mediate":[126],"long-term":[127],"mental":[128],"changes":[129,133],"adolescents,":[131],"specifically":[132,307],"linked":[134],"mood":[136],"psychotic":[138],"disorders.":[139],"Thus,":[140],"examined":[143],"whether":[144],"methadone":[147,250,267],"alter":[148],"responses":[150],"differently":[156],"an":[158,217,309],"population.":[160,311],"Adolescent":[161],"mice":[162,182,198],"were":[163,183],"orally":[164],"administered":[165],"buprenorphine,":[166],"or":[168,177],"saline":[169],"once":[170],"daily":[171],"6":[173],"days.":[174],"Two":[175],"hours":[176,232],"three":[178,242],"days":[179,243],"later,":[180],"tested":[184],"their":[186,211],"locomotor":[187],"response":[188,202,212,219],"quinpirole,":[190],"agonist.":[195],"Buprenorphine-treated":[196],"showed":[199],"similar":[201],"drug-na\u00efve":[207],"(saline-injected)":[208],"group":[209],"quinpirole.":[214],"In":[215,278],"contrast,":[216],"enhanced":[218],"methadone-treated":[223],"animals.":[225],"effect":[227],"significantly":[229],"higher":[230],"two":[231],"following":[233],"final":[235],"dose":[236],"compared":[240],"afterwards.":[244],"As":[245],"shown":[246],"study,":[249],"greatly":[252],"disturbs":[253],"receptor\u2019s":[256],"signaling.":[257],"indicates":[259],"care":[261],"should":[262],"be":[263],"taken":[264],"when":[265],"therapies":[272],"well":[274],"pain":[276],"management.":[277],"contrast":[279],"appears":[283],"disrupt":[285],"less.":[293],"Therefore,":[294],"confirm":[298],"different":[302,305],"opioids":[303],"carries":[304],"risks,":[306]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}