{"id":"https://openalex.org/W178552869","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1010.16","title":"Hypoglycemia increases glycolytic metabolism in the rat ventromedial hypothalamus (VMH)","display_name":"Hypoglycemia increases glycolytic metabolism in the rat ventromedial hypothalamus (VMH)","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W178552869","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1010.16","mag":"178552869"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.27.1_supplement.1010.16","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1010.16","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.1010.16","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048046297","display_name":"Jonathan Guo-Han Mun","orcid":"https://orcid.org/0000-0003-2667-8189","observed_orcids":["https://orcid.org/0000-0003-2667-8189"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I2801919071","display_name":"University of Illinois System","ror":"https://ror.org/05e94g991","country_code":"US","type":"education","lineage":["https://openalex.org/I2801919071"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Mun","raw_affiliation_strings":["Nutritional Sciences, University of Illinois, Urbana, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Sciences, University of Illinois, Urbana, IL","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I2801919071"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I2801919071","display_name":"University of Illinois System","ror":"https://ror.org/05e94g991","country_code":"US","type":"education","lineage":["https://openalex.org/I2801919071"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Cooper","raw_affiliation_strings":["Animal Sciences, University of Illinois, Urbana, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Sciences, University of Illinois, Urbana, IL","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I2801919071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051000922","display_name":"John P. Cavaretta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I2801919071","display_name":"University of Illinois System","ror":"https://ror.org/05e94g991","country_code":"US","type":"education","lineage":["https://openalex.org/I2801919071"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Cavaretta","raw_affiliation_strings":["Animal Sciences, University of Illinois, Urbana, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Sciences, University of Illinois, Urbana, IL","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I2801919071"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035932972","display_name":"Joseph Lee Beverly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I2801919071","display_name":"University of Illinois System","ror":"https://ror.org/05e94g991","country_code":"US","type":"education","lineage":["https://openalex.org/I2801919071"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Lee Beverly","raw_affiliation_strings":["Animal Sciences, University of Illinois, Urbana, IL","Nutritional Sciences, University of Illinois, Urbana, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Sciences, University of Illinois, Urbana, IL","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I2801919071"]},{"raw_affiliation_string":"Nutritional Sciences, University of Illinois, Urbana, IL","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I2801919071"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01951491,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.7505000233650208,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.7505000233650208,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.07400000095367432,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.06300000101327896,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ventromedial-hypothalamic-nucleus","display_name":"ventromedial hypothalamus","score":0.9700000286102295},{"id":"https://openalex.org/keywords/hypoglycemia-associated-autonomic-failure","display_name":"hypoglycemia-associated autonomic failure","score":0.9779999852180481},{"id":"https://openalex.org/keywords/counterregulatory-response","display_name":"counterregulatory response","score":0.8619999885559082},{"id":"https://openalex.org/keywords/glycolytic-metabolism","display_name":"glycolytic metabolism","score":0.8270000219345093},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.7089999914169312},{"id":"https://openalex.org/keywords/tca-cycle-intermediates","display_name":"TCA cycle intermediates","score":0.9150000214576721},{"id":"https://openalex.org/keywords/glycerol-3-phosphate","display_name":"glycerol-3-phosphate","score":0.8949999809265137},{"id":"https://openalex.org/keywords/phospholipid-metabolism","display_name":"phospholipid metabolism","score":0.7910000085830688},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6470000147819519},{"id":"https://openalex.org/keywords/insulin-induced-hypoglycemia","display_name":"insulin-induced hypoglycemia","score":0.9449999928474426},{"id":"https://openalex.org/keywords/recurrent-hypoglycemia","display_name":"recurrent hypoglycemia","score":0.9129999876022339},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7049999833106995},{"id":"https://openalex.org/keywords/energy-sensing","display_name":"energy sensing","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.8385044932365417},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8104643821716309},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8046550154685974},{"id":"https://openalex.org/C165135838","wikidata":"https://www.wikidata.org/wiki/Q133895","display_name":"Citric acid cycle","level":3,"score":0.5334686636924744},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.50797039270401},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.4895559251308441},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.4872831106185913},{"id":"https://openalex.org/C2780881558","wikidata":"https://www.wikidata.org/wiki/Q132501","display_name":"Glycerol","level":2,"score":0.4460853636264801},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.4249238967895508},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3863966464996338},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3058657646179199},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2876570224761963},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.2759532630443573},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22915193438529968}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.27.1_supplement.1010.16","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.1010.16","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.1010.16","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1486849669","https://openalex.org/W2269508502","https://openalex.org/W2808924987","https://openalex.org/W2562906284","https://openalex.org/W4377233200","https://openalex.org/W2607436680","https://openalex.org/W4389027263","https://openalex.org/W7131667329","https://openalex.org/W2157015644","https://openalex.org/W7097000268"],"abstract_inverted_index":{"The":[0],"VMH":[1,39,103,169,191],"is":[2,175],"a":[3,52,150],"critical":[4],"brain\u2010area":[5],"involved":[6],"in":[7,142,156,167,184,189],"energy":[8],"sensing":[9],"and":[10,40,89,93,99,112,114,119,153,160,186],"responsible":[11],"for":[12],"initiating":[13],"the":[14,37,65,102,168,181,190],"counter":[15],"regulatory":[16],"response":[17],"(CRR)":[18],"during":[19],"hypoglycemia.":[20],"We":[21],"hypothesize":[22],"local":[23],"metabolic":[24],"changes":[25,138,183],"following":[26,51,64,126,144],"hypoglycemia":[27,57],"contribute":[28,192],"to":[29,193],"hypoglycemia\u2010associated":[30],"autonomic":[31],"failure":[32],"(HAAF),":[33],"an":[34],"impairment":[35],"of":[36,55,67,71],"CRR.":[38],"CA1":[41],"hippocampus":[42],"(HPC)":[43],"were":[44,83,97,121,129,139],"collected":[45],"from":[46],"rats":[47],"(n=30)":[48],"6":[49,124],"hours":[50],"single":[53],"episode":[54],"insulin\u2010induced":[56],"(IIH)":[58],"(acute":[59],"hypoglycemia;":[60,74],"AH),":[61],"24":[62,133,170],"h":[63,125,134,171],"third":[66],"3":[68],"recurrent":[69],"episodes":[70],"IIH":[72],"(recurrent":[73],"RH),":[75],"or":[76],"saline\u2010treated":[77],"euglycemia":[78],"(control;":[79],"SC).":[80],"Tissue":[81],"samples":[82],"randomly":[84],"pooled":[85],"before":[86],"methanol":[87],"extraction":[88],"analysis":[90,148],"by":[91,196],"GC/MS":[92],"LC/MS/MS.":[94],"180":[95],"metabolites":[96],"identified":[98],"quantified.":[100],"In":[101],"lactate,":[104],"tricarboxylic":[105],"acid":[106],"(TCA)":[107],"cycle":[108],"intermediates":[109],"(citrate,":[110],"cis\u2010aconitate,":[111],"malate),":[113],"phospholipid":[115],"metabolism":[116,188],"products":[117],"(glycerol":[118],"glycerol\u20103\u2010phosphate)":[120],"increased":[122],"(p\u22640.05)":[123],"AH,":[127],"but":[128],"not":[130,140],"significantly":[131],"different":[132],"after":[135,172],"RH.":[136,173],"These":[137],"observed":[141],"HPC":[143],"IIH.":[145],"RNA":[146],"sequencing":[147],"showed":[149],"0.9,":[151],"0.2,":[152],"0.1":[154],"fold\u2010increase":[155],"glycerol\u20103\u2010phosphate":[157],"dehydrogenase,":[158],"GLUT1,":[159],"2\u2010oxoglutarate":[161],"dehydrogenase":[162],"gene":[163],"expression,":[164],"respectively":[165],"(p\u22640.01),":[166],"It":[174],"unclear":[176],"at":[177],"this":[178],"time":[179],"whether":[180],"hypoglycemia\u2010induced":[182],"carbohydrate":[185],"lipid":[187],"HAAF.":[194],"Supported":[195],"DK082609":[197]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}