{"id":"https://openalex.org/W1785029484","doi":null,"title":"From gene mutation to gene expression : studies on multiple endocrine neoplasia type 1 and vascular endothelial growth factors","display_name":"From gene mutation to gene expression : studies on multiple endocrine neoplasia type 1 and vascular endothelial growth factors","publication_year":2006,"publication_date":"2006-10-27","ids":{"openalex":"https://openalex.org/W1785029484","mag":"1785029484"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26914714","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/From_gene_mutation_to_gene_expression_studies_on_multiple_endocrine_neoplasia_type_1_and_vascular_endothelial_growth_factors/26914714","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/38726","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015231590","display_name":"Emma Tham","orcid":"https://orcid.org/0000-0001-6079-164X","observed_orcids":["https://orcid.org/0000-0001-6079-164X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Emma Tham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5015231590"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-endocrine-neoplasia-type-1","display_name":"multiple endocrine neoplasia type 1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/men1-gene","display_name":"MEN1 gene","score":0.8330000042915344},{"id":"https://openalex.org/keywords/men1-mutation","display_name":"MEN1 gene mutation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/mutation-detection","display_name":"mutation detection","score":0.6980000138282776},{"id":"https://openalex.org/keywords/multiplex-ligation-dependent-probe-amplification","display_name":"multiplex ligation-dependent probe amplification","score":0.847000002861023},{"id":"https://openalex.org/keywords/vegf-b","display_name":"VEGF-B","score":0.7900000214576721},{"id":"https://openalex.org/keywords/vegf-a","display_name":"VEGF-A","score":0.8880000114440918},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.576840877532959},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5164673328399658},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4958389699459076},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.48398685455322266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4725320637226105},{"id":"https://openalex.org/C2780103800","wikidata":"https://www.wikidata.org/wiki/Q1553018","display_name":"Multiple endocrine neoplasia","level":3,"score":0.4676871597766876},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4236878454685211},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4109393358230591},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35820484161376953},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33986806869506836},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.30910396575927734}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26914714","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/From_gene_mutation_to_gene_expression_studies_on_multiple_endocrine_neoplasia_type_1_and_vascular_endothelial_growth_factors/26914714","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/38726","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38726","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1785029484","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/bitstream/10616/38726/1/thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/38726","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38726","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":295,"referenced_works":["https://openalex.org/W7317053","https://openalex.org/W62872458","https://openalex.org/W69595455","https://openalex.org/W89717606","https://openalex.org/W98447479","https://openalex.org/W135569227","https://openalex.org/W207250171","https://openalex.org/W292067595","https://openalex.org/W304295984","https://openalex.org/W1001024467","https://openalex.org/W1489130191","https://openalex.org/W1489873347","https://openalex.org/W1493104239","https://openalex.org/W1495287184","https://openalex.org/W1495712810","https://openalex.org/W1509507152","https://openalex.org/W1514100422","https://openalex.org/W1531163264","https://openalex.org/W1535851682","https://openalex.org/W1542836032","https://openalex.org/W1548912336","https://openalex.org/W1582316077","https://openalex.org/W1587020653","https://openalex.org/W1591674373","https://openalex.org/W1598900543","https://openalex.org/W1600542667","https://openalex.org/W1618949780","https://openalex.org/W1624346216","https://openalex.org/W1679229092","https://openalex.org/W1697537733","https://openalex.org/W1783580437","https://openalex.org/W1859671474","https://openalex.org/W1872790762","https://openalex.org/W1875554126","https://openalex.org/W1894493322","https://openalex.org/W1963128268","https://openalex.org/W1963876488","https://openalex.org/W1964102342","https://openalex.org/W1964377967","https://openalex.org/W1964429954","https://openalex.org/W1964714244","https://openalex.org/W1965157961","https://openalex.org/W1965575731","https://openalex.org/W1965621019","https://openalex.org/W1965823016","https://openalex.org/W1967244780","https://openalex.org/W1967365012","https://openalex.org/W1967487654","https://openalex.org/W1970614272","https://openalex.org/W1971417820","https://openalex.org/W1972167991","https://openalex.org/W1972719168","https://openalex.org/W1973677429","https://openalex.org/W1977758702","https://openalex.org/W1977980079","https://openalex.org/W1978607702","https://openalex.org/W1979524266","https://openalex.org/W1979890116","https://openalex.org/W1980241898","https://openalex.org/W1980969801","https://openalex.org/W1981612052","https://openalex.org/W1981684494","https://openalex.org/W1983297228","https://openalex.org/W1983763042","https://openalex.org/W1985043086","https://openalex.org/W1985712533","https://openalex.org/W1986469266","https://openalex.org/W1986559037","https://openalex.org/W1986663988","https://openalex.org/W1987259861","https://openalex.org/W1987278634","https://openalex.org/W1987306181","https://openalex.org/W1987961062","https://openalex.org/W1988097332","https://openalex.org/W1988553916","https://openalex.org/W1988723210","https://openalex.org/W1988970641","https://openalex.org/W1989146112","https://openalex.org/W1990803898","https://openalex.org/W1990965435","https://openalex.org/W1990983421","https://openalex.org/W1993721679","https://openalex.org/W1994014733","https://openalex.org/W1994360534","https://openalex.org/W1994682147","https://openalex.org/W1994981945","https://openalex.org/W1996360654","https://openalex.org/W1996430165","https://openalex.org/W1996781360","https://openalex.org/W1997300044","https://openalex.org/W1998761401","https://openalex.org/W1998767340","https://openalex.org/W2000000541","https://openalex.org/W2000757618","https://openalex.org/W2002068595","https://openalex.org/W2003598961","https://openalex.org/W2004453973","https://openalex.org/W2004741542","https://openalex.org/W2004907588","https://openalex.org/W2006351633","https://openalex.org/W2006355752","https://openalex.org/W2007396515","https://openalex.org/W2008403821","https://openalex.org/W2008632796","https://openalex.org/W2012255417","https://openalex.org/W2012485042","https://openalex.org/W2013038209","https://openalex.org/W2013184812","https://openalex.org/W2014148719","https://openalex.org/W2014386715","https://openalex.org/W2014571799","https://openalex.org/W2016934775","https://openalex.org/W2017205210","https://openalex.org/W2017369013","https://openalex.org/W2017556192","https://openalex.org/W2017879489","https://openalex.org/W2018484601","https://openalex.org/W2019583759","https://openalex.org/W2019769423","https://openalex.org/W2019839655","https://openalex.org/W2020968632","https://openalex.org/W2021087194","https://openalex.org/W2023453327","https://openalex.org/W2024327925","https://openalex.org/W2025343582","https://openalex.org/W2025933554","https://openalex.org/W2026038921","https://openalex.org/W2027831359","https://openalex.org/W2028437938","https://openalex.org/W2029193079","https://openalex.org/W2029273592","https://openalex.org/W2029763523","https://openalex.org/W2029915133","https://openalex.org/W2031671233","https://openalex.org/W2033303857","https://openalex.org/W2034646933","https://openalex.org/W2035371785","https://openalex.org/W2037028884","https://openalex.org/W2042427065","https://openalex.org/W2043863730","https://openalex.org/W2044067295","https://openalex.org/W2044144820","https://openalex.org/W2045247659","https://openalex.org/W2046516822","https://openalex.org/W2046809698","https://openalex.org/W2047019694","https://openalex.org/W2047193221","https://openalex.org/W2047408781","https://openalex.org/W2049320716","https://openalex.org/W2049708133","https://openalex.org/W2049827480","https://openalex.org/W2049895460","https://openalex.org/W2050358495","https://openalex.org/W2051487747","https://openalex.org/W2052398489","https://openalex.org/W2053026927","https://openalex.org/W2053221827","https://openalex.org/W2053272214","https://openalex.org/W2053429350","https://openalex.org/W2054050668","https://openalex.org/W2054166179","https://openalex.org/W2054241501","https://openalex.org/W2054749956","https://openalex.org/W2055299311","https://openalex.org/W2055996155","https://openalex.org/W2056146626","https://openalex.org/W2056840154","https://openalex.org/W2057168818","https://openalex.org/W2057380297","https://openalex.org/W2058402992","https://openalex.org/W2059108446","https://openalex.org/W2059176107","https://openalex.org/W2060458521","https://openalex.org/W2062310894","https://openalex.org/W2062594120","https://openalex.org/W2063027760","https://openalex.org/W2063461894","https://openalex.org/W2063709616","https://openalex.org/W2064640860","https://openalex.org/W2064982871","https://openalex.org/W2066808094","https://openalex.org/W2066888615","https://openalex.org/W2067121396","https://openalex.org/W2067200113","https://openalex.org/W2067817921","https://openalex.org/W2068499444","https://openalex.org/W2070053830","https://openalex.org/W2070452909","https://openalex.org/W2071126398","https://openalex.org/W2071499027","https://openalex.org/W2072143836","https://openalex.org/W2073045469","https://openalex.org/W2073855870","https://openalex.org/W2074342738","https://openalex.org/W2074770401","https://openalex.org/W2076234186","https://openalex.org/W2076374640","https://openalex.org/W2077858999","https://openalex.org/W2077861409","https://openalex.org/W2077866529","https://openalex.org/W2078158468","https://openalex.org/W2078297463","https://openalex.org/W2084452119","https://openalex.org/W2084498863","https://openalex.org/W2084506573","https://openalex.org/W2084941500","https://openalex.org/W2084947524","https://openalex.org/W2085689908","https://openalex.org/W2086121277","https://openalex.org/W2088177336","https://openalex.org/W2090194773","https://openalex.org/W2091430552","https://openalex.org/W2091774189","https://openalex.org/W2093498435","https://openalex.org/W2093757389","https://openalex.org/W2095147658","https://openalex.org/W2095850556","https://openalex.org/W2097731330","https://openalex.org/W2098582960","https://openalex.org/W2098732827","https://openalex.org/W2100057942","https://openalex.org/W2100121582","https://openalex.org/W2101831526","https://openalex.org/W2101844076","https://openalex.org/W2102526923","https://openalex.org/W2102911949","https://openalex.org/W2105239075","https://openalex.org/W2105681978","https://openalex.org/W2107445027","https://openalex.org/W2108560269","https://openalex.org/W2109680555","https://openalex.org/W2109726055","https://openalex.org/W2109749250","https://openalex.org/W2112264347","https://openalex.org/W2113145680","https://openalex.org/W2114257111","https://openalex.org/W2116061755","https://openalex.org/W2118282739","https://openalex.org/W2119481249","https://openalex.org/W2119803906","https://openalex.org/W2120895512","https://openalex.org/W2121039615","https://openalex.org/W2121594719","https://openalex.org/W2123796764","https://openalex.org/W2124364681","https://openalex.org/W2124400751","https://openalex.org/W2125989442","https://openalex.org/W2127230663","https://openalex.org/W2127574969","https://openalex.org/W2128482858","https://openalex.org/W2131262959","https://openalex.org/W2131950918","https://openalex.org/W2134114031","https://openalex.org/W2134473118","https://openalex.org/W2134563904","https://openalex.org/W2135743455","https://openalex.org/W2137812597","https://openalex.org/W2139841128","https://openalex.org/W2140459348","https://openalex.org/W2140627582","https://openalex.org/W2141811262","https://openalex.org/W2146718153","https://openalex.org/W2147153812","https://openalex.org/W2147358575","https://openalex.org/W2149158668","https://openalex.org/W2149749420","https://openalex.org/W2150193735","https://openalex.org/W2150444870","https://openalex.org/W2151752381","https://openalex.org/W2152215024","https://openalex.org/W2153375705","https://openalex.org/W2155306535","https://openalex.org/W2156529086","https://openalex.org/W2156830567","https://openalex.org/W2157087666","https://openalex.org/W2157199565","https://openalex.org/W2157212789","https://openalex.org/W2158316748","https://openalex.org/W2159129963","https://openalex.org/W2161929126","https://openalex.org/W2163301034","https://openalex.org/W2164122959","https://openalex.org/W2164481346","https://openalex.org/W2164735544","https://openalex.org/W2166156136","https://openalex.org/W2168445578","https://openalex.org/W2168909179","https://openalex.org/W2170356169","https://openalex.org/W2174848253","https://openalex.org/W2295763141","https://openalex.org/W2323939613","https://openalex.org/W2344433860","https://openalex.org/W2346048525","https://openalex.org/W2516580226","https://openalex.org/W3128370515"],"related_works":["https://openalex.org/W2077801297","https://openalex.org/W7097539125","https://openalex.org/W2116275464","https://openalex.org/W2085331766","https://openalex.org/W2469586271","https://openalex.org/W2348836331","https://openalex.org/W1976382522","https://openalex.org/W2133824926","https://openalex.org/W1965533582","https://openalex.org/W7095286429"],"abstract_inverted_index":{"Multiple":[0,719],"Endocrine":[1],"Neoplasia":[2],"type":[3,645],"1,":[4],"MEN1,":[5],"is":[6,45],"an":[7,131,512],"inherited":[8],"cancer":[9],"syndrome":[10],"whose":[11],"gene":[12,30,157,232,236,246,610,647],"was":[13,31,160,233,247,258,287,317,329,345,357,398,413,427,450],"localised":[14],"to":[15,39,50,63,106,171,238,282,318,324,358,408,457,487,524,556,559,612],"chromosome":[16],"11q13":[17],"in":[18,33,43,183,208,220,260,347,364,370,401,417,429,435,473,476,506,514,536,540,550,569,640,648,672,705,711],"1988.":[19],"A":[20,243],"number":[21],"of":[22,37,57,66,76,89,118,134,139,146,174,180,202,215,224,267,293,308,343,362,372,380,405,422,439,492,564,572,606,668,676,703],"!candidate":[23],"genes":[24,226],"were":[25,61,116,152,313,468],"characterised":[26],"before":[27],"the":[28,64,87,110,137,144,156,172,200,209,221,225,306,360,382,430,442,451,460,490,501,541,547,561,641],"MEN1":[29,38,128,149,184,196,230],"cloned":[32],"1997.":[34],"DNA":[35,90],"sequencing":[36,91],"search":[40],"for":[41,69,127,195,638],"mutations":[42,78,105,115,204,639],"patients":[44,185,485],"used":[46],"as":[47,176,228,289,516,529],"a":[48,55,148,177,229,234,290,402,436,471,517,530,607,650,673],"complement":[49],"clinical":[51,80,107,552,567],"diagnosis.":[52],"Since":[53],"1997,":[54],"total":[56],"202":[58,653],"index":[59],"cases":[60],"referred":[62],"Department":[65],"Clinical":[67,636],"Genetics":[68],"mutation":[70,181],"screening,":[71],"but":[72,411,441],"no":[73,161,340,414],"systematic":[74],"review":[75],"their":[77],"or":[79,129,350],"characteristics":[81],"has":[82],"been":[83,123],"performed.":[84],"By":[85],"analysing":[86],"results":[88,165,467],"and":[92,103,136,158,186,205,253,265,272,298,323,332,387,497,511,532,604,710],"deletion":[93],"detection":[94,182],"(using":[95],"multiplex-ligationdependent":[96],"probe":[97],"amplification,":[98],"MLPA)":[99],"on":[100,652],"blood":[101,294],"samples":[102],"correlating":[104],"data":[108,499],"from":[109,166,334,479,483,716],"referring":[111],"physicians,":[112],"37":[113],"unique":[114],"found,":[117],"which":[119,191,544],"19":[120],"have":[121,169,187],"not":[122,396,425,521],"previously":[124],"reported.":[125],"Heredity":[126],"hyperparathyroidism,":[130],"early":[132],"age":[133],"onset":[135],"presence":[138],"multiple":[140,642],"tumours":[141],"greatly":[142],"enhanced":[143],"risk":[145],"carrying":[147],"mutation.":[150],"Mutations":[151],"spread":[153],"all":[154,261],"over":[155],"there":[159,412],"genotype-phenotype":[162],"correlation.":[163],"The":[164,315,354,420],"this":[167],"study":[168,305,359],"led":[170],"addition":[173],"MLPA":[175],"standard":[178],"method":[179],"identified":[188],"patient":[189],"categories":[190],"should":[192],"be":[193,557],"tested":[194],"mutations.":[197],"In":[198],"addition,":[199],"compilation":[201],"missense":[203],"polymorphisms":[206],"found":[207,346],"Swedish":[210],"population":[211],"will":[212],"facilitate":[213],"interpretation":[214],"single":[216,518],"base":[217],"pair":[218],"substitutions":[219],"future.":[222],"One":[223],"isolated":[227],"candidate":[231],"novel":[235,608],"related":[237,611],"vascular":[239,613],"endothelial":[240,614],"growth":[241,296,615],"factor":[242,519,534],"(VEGF-A).":[244],"This":[245],"called":[248],"VEGF":[249],"Related":[250],"Factor":[251],"(VRF)":[252],"later":[254],"renamed":[255],"VEGF-B.":[256],"It":[257,449],"expressed":[259],"normal":[262],"tissues":[263],"examined":[264],"consisted":[266],"two":[268,310],"splice":[269,453],"forms:":[270],"VEGF-B167":[271,328],"VEGF-B186.":[273],"They":[274],"had":[275],"completely":[276],"different":[277,283,311,537],"carboxyl":[278],"-terminal":[279],"ends":[280],"due":[281,407],"reading":[284],"frames.":[285],"VEGF-A":[286,394,423,474,504,515,526,565,669,704],"known":[288],"potent":[291],"inducer":[292],"vessel":[295],"(angiogenesis)":[297],"can":[299],"also":[300],"cause":[301],"inflammation.":[302],"To":[303],"further":[304,545],"role":[307,491],"VEGF-B,":[309],"strategies":[312],"used.":[314],"first":[316],"produce":[319],"recombinant":[320],"VEGF-B":[321,344,363,381,493],"protein":[322],"test":[325],"its":[326],"function.":[327],"successfully":[330],"produced":[331],"purified":[333],"retrovirally":[335],"infected":[336],"HEK293":[337],"cells.":[338],"However,":[339],"detectable":[341],"effect":[342,563],"cell":[348,538],"proliferation":[349],"monocyte":[351],"migration":[352],"assays.":[353],"second":[355],"strategy":[356],"expression":[361,379,421],"concert":[365,507],"with":[366,377,508,566,718],"other":[367,509],"angiogenic":[368],"factors":[369,510],"models":[371],"disease":[373],"that":[374,455,503],"affected":[375],"organs":[376],"high":[378],"heart":[383],"(dilated":[384],"cardiomyopathy,":[385],"DCM)":[386],"central":[388],"nervous":[389],"system":[390],"(multiple":[391],"sclerosis,":[392],"MS).":[393],"(but":[395,424],"VEGF-B)":[397,426],"significantly":[399],"increased":[400],"mouse":[403,674],"model":[404,438,675],"DCM":[406],"mitochondrial":[409,681],"dysfunction,":[410],"parallel":[415],"increase":[416,513],"capillary":[418],"density.":[419],"decreased":[428],"spinal":[431],"cord":[432],"resident":[433],"cells":[434,445,478],"rat":[437],"MS,":[440],"invading":[443],"inflammatory":[444],"did":[446],"express":[447],"VEGF-A.":[448],"heparin-binding":[452],"forms":[454],"tended":[456],"decrease":[458,472],"while":[459],"soluble":[461],"VEGF-A120":[462],"isoform":[463],"remained":[464],"unaltered.":[465],"These":[466],"corroborated":[469],"by":[470,680],"mRNA":[475],"mononuclear":[477],"cerebrospinal":[480],"fluid":[481],"(CSF)":[482],"MS":[484],"compared":[486],"controls.":[488],"Thus,":[489],"remains":[494],"largely":[495],"unknown":[496],"our":[498],"support":[500],"idea":[502],"functions":[505],"does":[520],"always":[522],"lead":[523],"angiogenesis.":[525],"may":[527],"function":[528],"neuroprotective":[531],"proinflammatory":[533],"simultaneously":[535],"types":[539],"same":[542],"tissue,":[543],"complicates":[546],"picture.":[548],"Studies":[549],"larger":[551],"materials":[553],"are":[554],"warranted":[555],"able":[558],"correlate":[560],"net":[562],"outcome":[568],"MS.":[570],"List":[571],"scientific":[573],"papers":[574],"I.":[575],"Grimmond":[576],"S,":[577,585,593],"Lagercrantz":[578],"J,":[579,661],"Drinkwater":[580],"C,":[581,697],"Silins":[582],"G,":[583,630],"Townson":[584],"Pollock":[586],"P,":[587],"Gotley":[588],"D,":[589],"Carson":[590],"E,":[591,624,628,659,691],"Rakar":[592],"Nordenskjold":[594],"M,":[595,695],"Ward":[596],"L,":[597],"Hayward":[598],"N,":[599],"Weber":[600,664],"G":[601,665],"(1996).":[602],"Cloning":[603],"characterization":[605],"human":[609],"factor.":[616],"Genome":[617],"Res.":[618],"6(2):":[619],"124-31.":[620],"https://pubmed.ncbi.nlm.nih.gov/8919691":[621],"II.":[622],"Tham":[623,658,690],"Grandell":[625],"U,":[626],"Lindgren":[627],"Toss":[629],"Skogseid":[631],"B,":[632],"Nordenskj\u00f6ld":[633],"M":[634],"(2006).":[635,700],"testings":[637],"endocrine":[643],"neoplasia":[644],"I":[646],"Sweden,":[649],"report":[651],"unrelated":[654],"cases.":[655],"[Manuscript]":[656],"III.":[657],"Wang":[660],"Piehl":[662,698],"F,":[663],"(2002).":[666],"Upregulation":[667],"without":[670],"angiogenesis":[671],"dilated":[677],"cardiomyopathy":[678],"caused":[679],"dysfunction.":[682],"J":[683,722],"Histochem":[684],"Cytochem.":[685],"50(7):":[686],"935-44.":[687],"https://pubmed.ncbi.nlm.nih.gov/12070272":[688],"IV.":[689],"Gielen":[692],"AW,":[693],"Khademi":[694],"Martin":[696],"F":[699],"Decreased":[701],"Expression":[702],"Rat":[706],"Experimental":[707],"Autoimmune":[708],"Encephalomyelitis":[709],"Cerebrospinal":[712],"Fluid":[713],"Mononuclear":[714],"Cells":[715],"Patients":[717],"Sclerosis.":[720],"Scand":[721],"Immunol.":[723],"64(6):":[724],"609-22.":[725],"https://pubmed.ncbi.nlm.nih.gov/17083617":[726]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
