{"id":"https://openalex.org/W1784856208","doi":"https://doi.org/10.1523/jneurosci.16-14-04335.1996","title":"Modulation of Conduction Block in Leech Mechanosensory Neurons","display_name":"Modulation of Conduction Block in Leech Mechanosensory Neurons","publication_year":1996,"publication_date":"1996-07-15","ids":{"openalex":"https://openalex.org/W1784856208","doi":"https://doi.org/10.1523/jneurosci.16-14-04335.1996","mag":"1784856208","pmid":"https://pubmed.ncbi.nlm.nih.gov/8699244","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6578854"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.16-14-04335.1996","doi":"https://doi.org/10.1523/jneurosci.16-14-04335.1996","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.16-14-04335.1996","pdf_url":"https://www.jneurosci.org/content/jneuro/16/14/4335.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/16/14/4335.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022062828","display_name":"Adam C. Mar","orcid":"https://orcid.org/0000-0002-2095-2936","observed_orcids":["https://orcid.org/0000-0002-2095-2936"]},"institutions":[{"id":"https://openalex.org/I2800293973","display_name":"Montreal General Hospital","ror":"https://ror.org/04gbhgc79","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800293973","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Adam Mar","raw_affiliation_strings":["Department of Biology, Department of Neurology and Neurosurgery, and Center for Research in Neuroscience, McGill University, and The Montr\u00e9al General Hospital Research Institute, Montr\u00e9al, Qu\u00e9bec, Canada H3G 1A4","Department of Biology McGill University Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Department of Neurology and Neurosurgery, and Center for Research in Neuroscience, McGill University, and The Montr\u00e9al General Hospital Research Institute, Montr\u00e9al, Qu\u00e9bec, Canada H3G 1A4","institution_ids":["https://openalex.org/I2800293973","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Department of Biology McGill University Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061437247","display_name":"Pierre Drapeau","orcid":"https://orcid.org/0000-0001-9063-0142","observed_orcids":["https://orcid.org/0000-0001-9063-0142"]},"institutions":[{"id":"https://openalex.org/I2800293973","display_name":"Montreal General Hospital","ror":"https://ror.org/04gbhgc79","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800293973","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Pierre Drapeau","raw_affiliation_strings":["Department of Biology, Department of Neurology and Neurosurgery, and Center for Research in Neuroscience, McGill University, and The Montr\u00e9al General Hospital Research Institute, Montr\u00e9al, Qu\u00e9bec, Canada H3G 1A4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Department of Neurology and Neurosurgery, and Center for Research in Neuroscience, McGill University, and The Montr\u00e9al General Hospital Research Institute, Montr\u00e9al, Qu\u00e9bec, Canada H3G 1A4","institution_ids":["https://openalex.org/I2800293973","https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.519,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.5475474,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"16","issue":"14","first_page":"4335","last_page":"4343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.44780001044273376,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.44780001044273376,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.20730000734329224,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.1445000022649765,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/conduction-block","display_name":"conduction block","score":0.9980000257492065},{"id":"https://openalex.org/keywords/retzius-neurons","display_name":"Retzius neurons","score":0.7900000214576721},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9409999847412109},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"neuromodulation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/activity-dependent-plasticity","display_name":"activity-dependent plasticity","score":0.8799999952316284},{"id":"https://openalex.org/keywords/touch-neurons","display_name":"touch neurons","score":0.5389999747276306},{"id":"https://openalex.org/keywords/nociceptors","display_name":"nociceptors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/receptive-fields","display_name":"receptive fields","score":0.6679999828338623},{"id":"https://openalex.org/keywords/wind-up","display_name":"wind-up","score":0.7409999966621399},{"id":"https://openalex.org/keywords/methysergide","display_name":"methysergide","score":0.8579999804496765},{"id":"https://openalex.org/keywords/ketanserin","display_name":"ketanserin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/5-ht2-receptor","display_name":"5-HT2 receptor","score":0.746999979019165},{"id":"https://openalex.org/keywords/leeches","display_name":"leeches","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C2781005078","wikidata":"https://www.wikidata.org/wiki/Q424442","display_name":"Methysergide","level":4,"score":0.7940927743911743},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.5567147135734558},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.556451141834259},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.47185492515563965},{"id":"https://openalex.org/C180746962","wikidata":"https://www.wikidata.org/wiki/Q243147","display_name":"Leech","level":2,"score":0.4667074382305145},{"id":"https://openalex.org/C2777785214","wikidata":"https://www.wikidata.org/wiki/Q415997","display_name":"Ketanserin","level":5,"score":0.4666799306869507},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.46544039249420166},{"id":"https://openalex.org/C19071747","wikidata":"https://www.wikidata.org/wiki/Q1755207","display_name":"Receptive field","level":2,"score":0.4366842210292816},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43219631910324097},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4021456241607666},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3792777955532074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32709795236587524},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.31713539361953735},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2938285768032074},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2837779223918915},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14126786589622498},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007865","descriptor_name":"Leeches","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009431","descriptor_name":"Neural Conduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009475","descriptor_name":"Neurons, Afferent","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.16-14-04335.1996","doi":"https://doi.org/10.1523/jneurosci.16-14-04335.1996","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.16-14-04335.1996","pdf_url":"https://www.jneurosci.org/content/jneuro/16/14/4335.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6578854","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6578854","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:8699244","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8699244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.16-14-04335.1996","doi":"https://doi.org/10.1523/jneurosci.16-14-04335.1996","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.16-14-04335.1996","pdf_url":"https://www.jneurosci.org/content/jneuro/16/14/4335.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6000000238418579,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324195","display_name":"Medical Research Council Canada","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1784856208.pdf","grobid_xml":"https://content.openalex.org/works/W1784856208.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1853572663","https://openalex.org/W1872585649","https://openalex.org/W1902428143","https://openalex.org/W1932094717","https://openalex.org/W1950855598","https://openalex.org/W1973406013","https://openalex.org/W1982317081","https://openalex.org/W1985024007","https://openalex.org/W1988059170","https://openalex.org/W1988354120","https://openalex.org/W1998308407","https://openalex.org/W1999668334","https://openalex.org/W2004859763","https://openalex.org/W2007946757","https://openalex.org/W2008998885","https://openalex.org/W2013696064","https://openalex.org/W2024417066","https://openalex.org/W2038170923","https://openalex.org/W2046317880","https://openalex.org/W2048035298","https://openalex.org/W2055568369","https://openalex.org/W2063957486","https://openalex.org/W2063978774","https://openalex.org/W2065245499","https://openalex.org/W2067065070","https://openalex.org/W2081599487","https://openalex.org/W2081611679","https://openalex.org/W2086729362","https://openalex.org/W2091288137","https://openalex.org/W2093474353","https://openalex.org/W2132224384","https://openalex.org/W2137836504","https://openalex.org/W2158248534","https://openalex.org/W2159460364","https://openalex.org/W2182996063","https://openalex.org/W2260534654","https://openalex.org/W2266324655","https://openalex.org/W2270283363","https://openalex.org/W2395908351","https://openalex.org/W2403786428","https://openalex.org/W2410708907","https://openalex.org/W2413002250","https://openalex.org/W2414723798","https://openalex.org/W2415369909","https://openalex.org/W2415567272","https://openalex.org/W2460995592"],"related_works":["https://openalex.org/W2065624008","https://openalex.org/W2067065070","https://openalex.org/W2091288137","https://openalex.org/W2024417066","https://openalex.org/W2464145143","https://openalex.org/W2418965115","https://openalex.org/W2024853323","https://openalex.org/W1967049492","https://openalex.org/W2413322237","https://openalex.org/W2225911642"],"abstract_inverted_index":{"Conduction":[0],"block":[1,33,47,72,101,124,201,231],"is":[2,11],"a":[3,171,177,193,222],"mechanism":[4],"of":[5,34,45,59,63,70,99,122,130,156,182,199,215,229],"activity-dependent":[6],"neuronal":[7],"plasticity,":[8],"but":[9,80],"little":[10],"known":[12],"about":[13],"its":[14],"possible":[15],"neuromodulation.":[16],"Extensive":[17],"activity":[18],"in":[19,31,73,102,109,125,196,232],"leech":[20],"touch":[21],"(T),":[22],"pressure":[23],"(P),":[24],"and":[25,75,84,105,113,143,169,235],"nociceptive":[26],"(N)":[27],"mechanosensory":[28],"neurons":[29,55],"results":[30],"conduction":[32,46,71,100,123,200,230],"their":[35,81],"minor":[36],"receptive":[37],"fields.":[38,127],"We":[39,211],"have":[40],"examined":[41],"whether":[42],"the":[43,52,68,97,110,120,138,148,154,159,185,197,218,227],"duration":[44,69,98,198,228],"could":[48],"be":[49],"modulated":[50],"by":[51,57,137,147,209,217],"serotonergic":[53],"Retzius":[54,65,219],"or":[56,116,162],"application":[58,181],"serotonin":[60],"(5-HT).":[61],"Activation":[62],"one":[64],"cell":[66,77,86],"reduced":[67],"T":[74,168],"P":[76,174],"posterior":[78,111,133],"fields,":[79],"anterior":[82,126],"fields":[83,87,112,134],"N":[85,107,190,237],"were":[88,135,144],"unaffected.":[89],"Perfusion":[90],"with":[91],"5-HT":[92,131,140,157,183,216],"had":[93],"stronger":[94],"effects,":[95],"reducing":[96,115],"T,":[103,233],"P,":[104,234],"lateral":[106,236],"cells":[108,175,191,220],"either":[114],"more":[117],"often":[118],"enhancing":[119],"expression":[121],"The":[128],"effects":[129],"on":[132,226],"blocked":[136],"nonspecific":[139],"antagonist":[141,150],"methysergide":[142],"partly":[145],"suppressed":[146],"5-HT2":[149],"ketanserin.":[151],"To":[152],"determine":[153],"site":[155],"action,":[158],"central":[160,186,223],"ganglion":[161],"peripheral":[163],"skin":[164],"was":[165,207],"perfused":[166],"independently.":[167],"to":[170,180],"greater":[172],"extent":[173],"showed":[176],"preferential":[178],"sensitivity":[179],"onto":[184],"ganglion.":[187],"Interestingly,":[188],"medial":[189],"exhibited":[192],"progressive":[194],"decrease":[195],"during":[202],"repeated":[203],"trials":[204],"(\"wind-up\")":[205],"that":[206,213],"unaffected":[208],"5-HT.":[210],"conclude":[212],"secretion":[214],"has":[221],"modulatory":[224],"effect":[225],"cells.":[238]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
