{"id":"https://openalex.org/W1784537671","doi":null,"title":"Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck.","display_name":"Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck.","publication_year":1996,"publication_date":"1996-12-15","ids":{"openalex":"https://openalex.org/W1784537671","mag":"1784537671","pmid":"https://pubmed.ncbi.nlm.nih.gov/8971156"},"language":"en","primary_location":{"id":"pmid:8971156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8971156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029626497","display_name":"Ravi Shridhar","orcid":"https://orcid.org/0000-0002-0799-4074","observed_orcids":["https://orcid.org/0000-0002-0799-4074"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Shridhar","raw_affiliation_strings":["Department of Internal Medicine, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103279653","display_name":"Viji Shridhar","orcid":"https://orcid.org/0000-0001-7232-0802","observed_orcids":["https://orcid.org/0000-0001-7232-0802"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Shridhar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"S Rivard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Rivard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031746829","display_name":"Jill M. Siegfried","orcid":"https://orcid.org/0000-0002-0887-5448","observed_orcids":["https://orcid.org/0000-0002-0887-5448"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Siegfried","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111407275","display_name":"Haline Pietraszkiewicz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Pietraszkiewicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021506059","display_name":"John F. Ensley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Ensley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082192246","display_name":"Robert J. Pauley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Pauley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014281092","display_name":"David J. Grignon","orcid":"https://orcid.org/0000-0001-5287-8497","observed_orcids":["https://orcid.org/0000-0001-5287-8497"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Grignon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113827582","display_name":"Wael Sakr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Sakr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109547015","display_name":"O. J. Miller","orcid":"https://orcid.org/0009-0009-6729-6049","observed_orcids":["https://orcid.org/0009-0009-6729-6049"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O J Miller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"D I Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D I Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1606,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.44300808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"56","issue":"24","first_page":"5576","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.6753000020980835,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.6753000020980835,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.08470000326633453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.04859999939799309,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arginine-rich-proteins","display_name":"arginine-rich proteins","score":0.9449999928474426},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7559999823570251},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9890000224113464},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":1.0},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9409999847412109},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.8410000205039978},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9700000286102295},{"id":"https://openalex.org/keywords/early-tumorigenesis","display_name":"early tumorigenesis","score":0.7639999985694885},{"id":"https://openalex.org/keywords/metastatic-cancer","display_name":"metastatic cancer","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6534185409545898},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6515293717384338},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5931642651557922},{"id":"https://openalex.org/C163005120","wikidata":"https://www.wikidata.org/wiki/Q4115252","display_name":"Subcloning","level":4,"score":0.5727733969688416},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5623037219047546},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5159114599227905},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4617137908935547},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4540990889072418},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.424257755279541},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.41585785150527954},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22132408618927002},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1902202069759369},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8971156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8971156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1784537671","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8971156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G7715774693","display_name":"CHROMOSOME BREAKPOINTS, RENAL &SMALL CELL LUNG CANCER","funder_award_id":"R01CA048031","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W136491056","https://openalex.org/W1563700300","https://openalex.org/W2099742439","https://openalex.org/W2139397808","https://openalex.org/W2156872475","https://openalex.org/W2167105480"],"related_works":["https://openalex.org/W136491056","https://openalex.org/W273845459","https://openalex.org/W4398202178","https://openalex.org/W2013874918","https://openalex.org/W2184606375","https://openalex.org/W2108190602","https://openalex.org/W7199912680","https://openalex.org/W2521483632","https://openalex.org/W4303645915","https://openalex.org/W2154790575"],"abstract_inverted_index":{"Arginine-rich":[0],"protein":[1],"(ARP)":[2],"is":[3],"a":[4,24,31,118,141],"highly":[5],"conserved":[6],"gene":[7,16,40,125],"that":[8,158],"maps":[9],"to":[10],"human":[11],"chromosomal":[12],"band":[13],"3p21.1.":[14],"This":[15,97],"contains":[17],"an":[18,110],"imperfect":[19],"trinucleotide":[20],"repeat":[21],"which":[22],"encodes":[23],"string":[25],"of":[26,38,43,54,60,65,71,80,87,93,123,160],"arginines.":[27],"We":[28,115],"previously":[29],"detected":[30,117],"specific":[32],"mutation":[33,57,98,119],"(ATG50-->AGG)":[34],"within":[35],"this":[36,124],"region":[37],"the":[39,52,55,66,149,172],"in":[41,58,101,113,126,140,151,171],"10":[42],"21":[44,61],"sporadic":[45],"renal":[46],"cell":[47,63,74,77,83],"carcinomas.":[48],"Here,":[49],"we":[50],"report":[51],"detection":[53],"same":[56,150],"5":[59,92],"squamous":[62],"carcinomas":[64],"head":[67],"and":[68,91,106,129,154],"neck,":[69],"1":[70],"2":[72],"small":[73],"lung":[75,84],"cancer":[76],"lines,":[78],"6":[79],"18":[81],"non-small":[82],"carcinomas,":[85],"9":[86],"22":[88],"breast":[89],"tumors,":[90],"13":[94],"prostate":[95],"tumors.":[96],"was":[99,148],"seen":[100],"several":[102],"early":[103,111],"stage":[104],"tumors":[105,131],"may":[107],"thus":[108],"be":[109],"event":[112],"tumorigenesis.":[114],"also":[116],"at":[120],"codon":[121],"53":[122],"both":[127,152],"primary":[128],"metastatic":[130],"from":[132],"one":[133],"patient.":[134],"Other":[135],"nucleotide":[136],"changes":[137,162],"were":[138,163],"observed":[139],"few":[142],"PCR":[143,164],"subclones,":[144],"but":[145],"their":[146],"frequency":[147],"tumor":[153,173],"control":[155],"samples,":[156],"suggesting":[157],"many":[159],"these":[161],"or":[165],"subcloning":[166],"artifacts":[167],"rather":[168],"than":[169],"mutations":[170],"cells":[174],"themselves.":[175]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
