{"id":"https://openalex.org/W1784491184","doi":"https://doi.org/10.3109/10799893.2015.1086883","title":"Electrolytically generated acid functional water inhibits NF-\u03baB activity by attenuating nuclear-cytoplasmic shuttling of p65 and p50 subunits","display_name":"Electrolytically generated acid functional water inhibits NF-\u03baB activity by attenuating nuclear-cytoplasmic shuttling of p65 and p50 subunits","publication_year":2015,"publication_date":"2015-10-19","ids":{"openalex":"https://openalex.org/W1784491184","doi":"https://doi.org/10.3109/10799893.2015.1086883","mag":"1784491184","pmid":"https://pubmed.ncbi.nlm.nih.gov/26480200"},"language":"en","primary_location":{"id":"doi:10.3109/10799893.2015.1086883","doi":"https://doi.org/10.3109/10799893.2015.1086883","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10799893.2015.1086883","pdf_url":null,"source":{"id":"https://openalex.org/S116485566","display_name":"Journal of Receptors and Signal Transduction","issn_l":"1079-9893","issn":["1079-9893","1532-4281"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Receptors and Signal Transduction","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021528394","display_name":"Takahiro Gojoubori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takahiro Gojoubori","raw_affiliation_strings":["a Department of Pathobiology , Nihon University School of Dentistry , Tokyo , Japan ","b Division of Immunology and Pathobiology , Nihon University School of Dentistry , Tokyo , Japan ","Department of Pathobiology, Nihon University School of Dentistry, Tokyo, Japan,","Division of Immunology and Pathobiology, Nihon University School of Dentistry, Tokyo, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Department of Pathobiology , Nihon University School of Dentistry , Tokyo , Japan ","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"b Division of Immunology and Pathobiology , Nihon University School of Dentistry , Tokyo , Japan ","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"Department of Pathobiology, Nihon University School of Dentistry, Tokyo, Japan,","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"Division of Immunology and Pathobiology, Nihon University School of Dentistry, Tokyo, Japan,","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hirotaka Ota","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotaka Ota","raw_affiliation_strings":["c Division of Applied Oral Sciences , Nihon University Graduate School of Dentistry , Tokyo , Japan ","Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry, Tokyo, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"c Division of Applied Oral Sciences , Nihon University Graduate School of Dentistry , Tokyo , Japan ","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry, Tokyo, Japan,","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masafumi Kusunoki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masafumi Kusunoki","raw_affiliation_strings":["c Division of Applied Oral Sciences , Nihon University Graduate School of Dentistry , Tokyo , Japan ","Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry, Tokyo, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"c Division of Applied Oral Sciences , Nihon University Graduate School of Dentistry , Tokyo , Japan ","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry, Tokyo, Japan,","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030818546","display_name":"Yukina Nishio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukina Nishio","raw_affiliation_strings":["d Division of Oral Structural and Functional Biology , Nihon University Graduate School of Dentistry , Tokyo , Japan , and","Division of Oral Structural and Functional Biology, Nihon University Graduate School of Dentistry, Tokyo, Japan, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"d Division of Oral Structural and Functional Biology , Nihon University Graduate School of Dentistry , Tokyo , Japan , and","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"Division of Oral Structural and Functional Biology, Nihon University Graduate School of Dentistry, Tokyo, Japan, and","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084226948","display_name":"Kensuke Nishio","orcid":"https://orcid.org/0000-0002-7450-3124","observed_orcids":["https://orcid.org/0000-0002-7450-3124"]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kensuke Nishio","raw_affiliation_strings":["c Division of Applied Oral Sciences , Nihon University Graduate School of Dentistry , Tokyo , Japan ","Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry, Tokyo, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"c Division of Applied Oral Sciences , Nihon University Graduate School of Dentistry , Tokyo , Japan ","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry, Tokyo, Japan,","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078961340","display_name":"Satoko Iwasa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoko Iwasa","raw_affiliation_strings":["e Division of Oral Health Sciences , Nihon University Graduate School of Dentistry , Tokyo , Japan","Division of Oral Health Sciences, Nihon University Graduate School of Dentistry, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"e Division of Oral Health Sciences , Nihon University Graduate School of Dentistry , Tokyo , Japan","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"Division of Oral Health Sciences, Nihon University Graduate School of Dentistry, Tokyo, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113200791","display_name":"Yasuhide Kaneko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhide Kaneko","raw_affiliation_strings":["a Department of Pathobiology , Nihon University School of Dentistry , Tokyo , Japan ","Department of Pathobiology, Nihon University School of Dentistry, Tokyo, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Department of Pathobiology , Nihon University School of Dentistry , Tokyo , Japan ","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"Department of Pathobiology, Nihon University School of Dentistry, Tokyo, Japan,","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073195143","display_name":"Masatake Asano","orcid":"https://orcid.org/0000-0003-0028-8262","observed_orcids":["https://orcid.org/0000-0003-0028-8262"]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masatake Asano","raw_affiliation_strings":["a Department of Pathobiology , Nihon University School of Dentistry , Tokyo , Japan ","b Division of Immunology and Pathobiology , Nihon University School of Dentistry , Tokyo , Japan ","Department of Pathobiology, Nihon University School of Dentistry, Tokyo, Japan,","Division of Immunology and Pathobiology, Nihon University School of Dentistry, Tokyo, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Department of Pathobiology , Nihon University School of Dentistry , Tokyo , Japan ","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"b Division of Immunology and Pathobiology , Nihon University School of Dentistry , Tokyo , Japan ","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"Department of Pathobiology, Nihon University School of Dentistry, Tokyo, Japan,","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"Division of Immunology and Pathobiology, Nihon University School of Dentistry, Tokyo, Japan,","institution_ids":["https://openalex.org/I104946051"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021528394"],"corresponding_institution_ids":["https://openalex.org/I104946051"],"apc_list":null,"apc_paid":null,"fwci":0.1101,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.47488334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"36","issue":"3","first_page":"248","last_page":"253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electrolyzed-water","display_name":"electrolyzed water","score":0.781000018119812},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8930000066757202},{"id":"https://openalex.org/keywords/nf-kappab-p65","display_name":"NF-\u03baB p65","score":0.8769999742507935},{"id":"https://openalex.org/keywords/p50","display_name":"P50","score":0.8970000147819519},{"id":"https://openalex.org/keywords/nucleocytoplasmic-shuttling","display_name":"nucleocytoplasmic shuttling","score":0.9670000076293945},{"id":"https://openalex.org/keywords/interleukin-8-secretion","display_name":"interleukin-8 secretion","score":0.8190000057220459},{"id":"https://openalex.org/keywords/human-beta-defensin-2","display_name":"human beta-defensin 2","score":0.8790000081062317},{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.9700000286102295},{"id":"https://openalex.org/keywords/ca9-22-cells","display_name":"Ca9-22 cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/nf-kappab-binding-site","display_name":"NF-kappaB binding site","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6445577144622803},{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.6332521438598633},{"id":"https://openalex.org/C98270193","wikidata":"https://www.wikidata.org/wiki/Q3359522","display_name":"P50","level":4,"score":0.6052286028862},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.5911360383033752},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5809527635574341},{"id":"https://openalex.org/C2779730028","wikidata":"https://www.wikidata.org/wiki/Q15325101","display_name":"I\u03baB\u03b1","level":4,"score":0.5447278618812561},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.5434702634811401},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5366935133934021},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4974665939807892},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.47428470849990845},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4678507447242737},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.459472119808197},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4579213857650757},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4236980974674225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35358643531799316},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34798920154571533},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3154146671295166},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2858280539512634},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19401335716247559},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.13040414452552795},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004572","descriptor_name":"Electrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051996","descriptor_name":"Transcription Factor RelA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3109/10799893.2015.1086883","doi":"https://doi.org/10.3109/10799893.2015.1086883","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10799893.2015.1086883","pdf_url":null,"source":{"id":"https://openalex.org/S116485566","display_name":"Journal of Receptors and Signal Transduction","issn_l":"1079-9893","issn":["1079-9893","1532-4281"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Receptors and Signal Transduction","raw_type":"journal-article"},{"id":"pmid:26480200","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26480200","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of receptor and signal transduction research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W153879847","https://openalex.org/W1521868200","https://openalex.org/W1557673276","https://openalex.org/W1564674105","https://openalex.org/W1839029331","https://openalex.org/W1963906419","https://openalex.org/W1968931227","https://openalex.org/W1970159404","https://openalex.org/W1992996065","https://openalex.org/W2022324063","https://openalex.org/W2029790299","https://openalex.org/W2031576296","https://openalex.org/W2054300680","https://openalex.org/W2055096175","https://openalex.org/W2058059173","https://openalex.org/W2071060425","https://openalex.org/W2122794487","https://openalex.org/W2145846794","https://openalex.org/W2145921423","https://openalex.org/W2149122802","https://openalex.org/W2155831428","https://openalex.org/W2158364865","https://openalex.org/W4312427153"],"related_works":["https://openalex.org/W2002877292","https://openalex.org/W1557673276","https://openalex.org/W2076515829","https://openalex.org/W2375919361","https://openalex.org/W2759176603","https://openalex.org/W7038515376","https://openalex.org/W1992996065","https://openalex.org/W2355305742","https://openalex.org/W3132726143","https://openalex.org/W4240012884"],"abstract_inverted_index":{"BACKGROUND:":[0],"Human":[1],"\u03b2-defensin":[2],"2":[3],"(hBD2)":[4],"gene":[5],"expression":[6,29],"is":[7,74],"dependent":[8,48,76],"on":[9,49,77,90],"nuclear":[10],"factor":[11],"kappa":[12],"B":[13],"(NF-\u03baB)":[14],"activity.":[15,57,79,92],"We":[16],"have":[17],"previously":[18],"demonstrated":[19,176],"that":[20,61,250],"electrolytically":[21],"generated":[22],"acid":[23],"functional":[24],"water":[25],"(FW)":[26],"induces":[27],"the":[28,33,44,85,115,119,135,151,177,188,198,202,212,215,220,229,232,237,260,264],"of":[30,88,118,124,134,180,187,200,259],"hBD2":[31],"in":[32,52,153,211,228],"human":[34],"oral":[35],"squamous":[36],"cell":[37,40],"carcinoma":[38],"(OSCC)":[39],"line":[41],"Ca9-22.":[42],"However,":[43],"induction":[45],"was":[46,104,112,146,165,183,209],"not":[47],"NF-\u03baB":[50,56,78,91,125,136,154,189,261],"activity;":[51],"fact,":[53],"FW":[54,62,89,129,171,195,223,241,251],"inhibited":[55,169],"Therefore,":[58],"we":[59],"hypothesized":[60],"might":[63,252],"reduce":[64],"spontaneous":[65,101,254],"interleukin":[66],"8":[67],"(IL-8)":[68],"secretion":[69,103,256],"by":[70,106,128,132,141,170,185,257],"Ca9-22":[71,94,159],"cells,":[72],"which":[73,164,182,208],"heavily":[75],"This":[80],"study":[81,248],"aimed":[82],"at":[83],"demonstrating":[84],"inhibitory":[86,178],"effect":[87],"METHODS:":[93],"cells":[95,160],"were":[96,130],"incubated":[97],"with":[98],"FW,":[99,181],"and":[100,139,167,204],"IL-8":[102,120,255],"observed":[105],"enzyme-linked":[107],"immunosorbent":[108],"assay.":[109],"Luciferase":[110],"assay":[111,175],"performed":[113,148],"using":[114],"5'-untranslated":[116],"region":[117],"gene.":[121],"The":[122,158,173,244],"steps":[123],"activation":[126],"blocked":[127],"evaluated":[131],"localization":[133],"subunits":[137,262],"p65":[138,203],"p50":[140,205],"immunofluorescence":[142],"staining.":[143],"Western":[144],"blotting":[145],"further":[147],"to":[149,219,236,240],"confirm":[150],"changes":[152],"subunit":[155],"localization.":[156],"RESULTS:":[157],"spontaneously":[161],"secreted":[162],"IL-8,":[163],"rapidly":[166],"drastically":[168],"treatment.":[172,242],"luciferase":[174],"action":[179],"diminished":[184],"deletion":[186],"binding":[190],"site":[191],"from":[192,246],"this":[193,247],"construct.":[194],"treatment":[196],"altered":[197],"distribution":[199],"both":[201],"subunits.":[206],"P65,":[207],"localized":[210,227],"nucleus":[213,238],"during":[214,231],"resting":[216,233],"state,":[217,234],"moved":[218,235],"cytoplasm":[221,230],"after":[222],"treatment,":[224],"whereas,":[225],"p50,":[226],"subsequent":[239],"CONCLUSIONS:":[243],"results":[245],"indicate":[249],"inhibit":[253],"redistribution":[258],"within":[263],"cells.":[265]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
