{"id":"https://openalex.org/W1784385208","doi":null,"title":"Myocardial blood flow, function, and metabolism in repetitive stunning.","display_name":"Myocardial blood flow, function, and metabolism in repetitive stunning.","publication_year":2000,"publication_date":"2000-07-01","ids":{"openalex":"https://openalex.org/W1784385208","mag":"1784385208","pmid":"https://pubmed.ncbi.nlm.nih.gov/10914914"},"language":"en","primary_location":{"id":"pmid:10914914","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10914914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086342448","display_name":"Marcelo F. Di Carli","orcid":"https://orcid.org/0000-0003-3119-025X","observed_orcids":["https://orcid.org/0000-0003-3119-025X"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M F Di Carli","raw_affiliation_strings":["Department of Internal Medicine, Center for Health Care Effectiveness Research, Wayne State University School of Medicine, Detroit, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Center for Health Care Effectiveness Research, Wayne State University School of Medicine, Detroit, Michigan, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065364607","display_name":"Petar Prcevski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Prcevski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062132806","display_name":"Tajinder P. Singh","orcid":"https://orcid.org/0000-0001-7310-7966","observed_orcids":["https://orcid.org/0000-0001-7310-7966"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T P Singh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079172044","display_name":"James J. Janisse","orcid":"https://orcid.org/0000-0002-5022-4104","observed_orcids":["https://orcid.org/0000-0002-5022-4104"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Janisse","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111857428","display_name":"J.W. Ager","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Ager","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039332211","display_name":"Otto Muzik","orcid":"https://orcid.org/0000-0002-5483-4452","observed_orcids":["https://orcid.org/0000-0002-5483-4452"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Muzik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059174611","display_name":"Richard Vander Heide","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Vander Heide","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6939,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.84583142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"41","issue":"7","first_page":"1227","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.8628000020980835,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.8628000020980835,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.13179999589920044,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-stunning","display_name":"myocardial stunning","score":0.9739999771118164},{"id":"https://openalex.org/keywords/hibernating-myocardium","display_name":"hibernating myocardium","score":0.8899999856948853},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8090000152587891},{"id":"https://openalex.org/keywords/myocardial-blood-flow","display_name":"myocardial blood flow","score":0.734000027179718},{"id":"https://openalex.org/keywords/myocardial-glucose-uptake","display_name":"myocardial glucose uptake","score":0.8169999718666077},{"id":"https://openalex.org/keywords/myocardial-oxidative-metabolism","display_name":"myocardial oxidative metabolism","score":0.871999979019165},{"id":"https://openalex.org/keywords/regional-wall-motion","display_name":"regional wall motion","score":0.7929999828338623},{"id":"https://openalex.org/keywords/coronary-artery-occlusion","display_name":"coronary artery occlusion","score":0.7049999833106995},{"id":"https://openalex.org/keywords/fdg-pet","display_name":"FDG-PET","score":0.6430000066757202},{"id":"https://openalex.org/keywords/13n-ammonia-pet","display_name":"13N-ammonia PET","score":0.7829999923706055},{"id":"https://openalex.org/keywords/canine-model","display_name":"canine model","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C2780062172","wikidata":"https://www.wikidata.org/wiki/Q2834369","display_name":"Hibernating myocardium","level":4,"score":0.8284622430801392},{"id":"https://openalex.org/C2775992611","wikidata":"https://www.wikidata.org/wiki/Q2075261","display_name":"Myocardial stunning","level":3,"score":0.7661923170089722},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.7562118768692017},{"id":"https://openalex.org/C2778492669","wikidata":"https://www.wikidata.org/wiki/Q7628762","display_name":"Stunning","level":3,"score":0.669651985168457},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6338549852371216},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6203911900520325},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6193390488624573},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5821039080619812},{"id":"https://openalex.org/C2776894844","wikidata":"https://www.wikidata.org/wiki/Q1197437","display_name":"Fissipedia","level":2,"score":0.5263296961784363},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.506269097328186},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.4806462824344635},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4712921679019928},{"id":"https://openalex.org/C119865680","wikidata":"https://www.wikidata.org/wiki/Q681126","display_name":"Hibernation (computing)","level":3,"score":0.46213120222091675},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.4505676031112671},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38377752900123596},{"id":"https://openalex.org/C2779464278","wikidata":"https://www.wikidata.org/wiki/Q7317735","display_name":"Revascularization","level":3,"score":0.37612980604171753},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.1334492564201355},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0882178246974945},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014055","descriptor_name":"Tomography, Emission-Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015425","descriptor_name":"Myocardial Reperfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017682","descriptor_name":"Myocardial Stunning","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D017682","descriptor_name":"Myocardial Stunning","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017682","descriptor_name":"Myocardial Stunning","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:10914914","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10914914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.552.3846","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.552.3846","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnm.snmjournals.org/content/41/7/1227.full.pdf","raw_type":"text"},{"id":"mag:1784385208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10914914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W597834667","https://openalex.org/W1851711805","https://openalex.org/W1986560596","https://openalex.org/W1991113353","https://openalex.org/W1996080498","https://openalex.org/W2003676736","https://openalex.org/W2020971669","https://openalex.org/W2022105200","https://openalex.org/W2023076242","https://openalex.org/W2033211270","https://openalex.org/W2039156216","https://openalex.org/W2067060403","https://openalex.org/W2067991743","https://openalex.org/W2072312403","https://openalex.org/W2076674564","https://openalex.org/W2078059060","https://openalex.org/W2083994164","https://openalex.org/W2084243081","https://openalex.org/W2095378814","https://openalex.org/W2146217294","https://openalex.org/W2163794208","https://openalex.org/W2222265791","https://openalex.org/W2256748338","https://openalex.org/W2302187456","https://openalex.org/W2315383124","https://openalex.org/W2322445769","https://openalex.org/W2327640792","https://openalex.org/W2403387837","https://openalex.org/W2411555268"],"related_works":["https://openalex.org/W2007087224","https://openalex.org/W2019409510","https://openalex.org/W2079747437","https://openalex.org/W2131809466","https://openalex.org/W2403387837","https://openalex.org/W2158360082","https://openalex.org/W1715474380","https://openalex.org/W1978966576","https://openalex.org/W2130336078","https://openalex.org/W2048684464"],"abstract_inverted_index":{"UNLABELLED:":[0],"Myocardial":[1],"hibernation":[2,48],"refers":[3],"to":[4,43,69,208,305,341],"a":[5,14,80,345,357,375],"state":[6],"of":[7,58,83,95,98,110,159,186,237,247,252,266,286,298,311,316,324,333,360,367,394],"persistent":[8,51],"left":[9],"ventricular":[10],"dysfunction":[11,328],"resulting":[12,54],"from":[13,55,64,385],"chronically":[15],"reduced":[16,32],"blood":[17,33,74,113,146,201,370],"flow,":[18,75,114],"which":[19],"is":[20,383],"improved":[21],"or":[22,102],"reversed":[23],"with":[24,31,143,150,170,330,356],"revascularization.":[25],"Increased":[26],"glucose":[27,163,223,361],"uptake":[28,164,224],"in":[29,79,124,135,203,225,274,326,350,379,389],"areas":[30],"flow":[34,147,202],"at":[35,231,260,280,292],"rest":[36],"on":[37],"PET":[38],"has":[39],"been":[40],"used":[41],"successfully":[42],"diagnose":[44],"hibernating":[45],"myocardium.":[46],"However,":[47,222],"may":[49],"represent":[50],"myocardial":[52,85,369],"stunning":[53,343,381],"repeated":[56],"episodes":[57],"ischemia":[59],"and":[60,77,116,127,130,153,156,162,173,194,257,291,303,362,391],"reperfusion":[61,123,134,312],"rather":[62],"than":[63],"chronic":[65],"underperfusion.":[66],"We":[67],"sought":[68],"determine":[70],"the":[71,99,183,331],"inter-relationship":[72],"between":[73],"metabolism,":[76,115],"function":[78,117,352],"canine":[81],"model":[82],"repetitive":[84,342,380],"stunning.":[86],"METHODS:":[87],"Ten":[88],"dogs":[89,126],"underwent":[90],"4":[91,184,232,281],"sequential":[92],"5-min":[93],"intervals":[94],"balloon":[96],"occlusion":[97],"anterior":[100],"descending":[101],"circumflex":[103],"arteries,":[104],"each":[105],"separated":[106],"by":[107,154],"5":[108,136],"min":[109],"reperfusion.":[111],"Regional":[112,138,145,176],"were":[118,168],"evaluated":[119,142],"3-4":[120],"h":[121,129,191,233,246,282,294],"after":[122,133,182,192,196,244,308],"all":[125],"24":[128,190,245,293],"1":[131,197,261,309],"wk":[132,262,310],"dogs.":[137],"wall":[139,177],"motion":[140,178],"was":[141,148,179,206,228,277,354],"echocardiography.":[144],"assessed":[149],"radioactive":[151],"microspheres":[152],"[(13)N]ammonia":[155],"PET.":[157,174],"Measurements":[158],"oxidative":[160,272,334,363],"metabolism":[161,273,335,364],"(during":[165],"hyperinsulinemic-euglycemic":[166],"clamping)":[167],"derived":[169],"[(11)C]-acetate,":[171],"FDG,":[172],"RESULTS:":[175],"severely":[180],"decreased":[181,230,279],"cycles":[185],"ischemia,":[187],"remained":[188,242],"impaired":[189],"reperfusion,":[193],"normalized":[195],"wk.":[198],"During":[199],"reflow,":[200],"stunned":[204,226,275],"regions":[205,227,276],"restored":[207],"near-normal":[209,306],"levels":[210,307],"(0.89":[211],"+/-":[212,216,235,250,264,284,296,314],"0.07":[213,217],"versus":[214],"0.95":[215],"mL/g/min,":[218],"P":[219,239,254,268,288,300,318],"=":[220,255,269,301,319],"0.023).":[221],"significantly":[229,278],"(73%":[234],"5%":[236],"remote,":[238,253,267,287,299,317],"<":[240,289],"0.001),":[241],"depressed":[243],"reflow":[248],"(83%":[249],"4%":[251],"0.013),":[256],"fully":[258],"recovered":[259,304],"(101%":[263],"10%":[265],"0.88).":[270],"Similarly,":[271],"(84%":[283],"2%":[285,297],"0.001)":[290],"(90%":[295],"0.005)":[302],"(97%":[313],"1%":[315],"0.024).":[320],"The":[321],"time":[322],"course":[323],"change":[325],"postischemic":[327],"correlated":[329],"recovery":[332],"(r=0.57;":[336],"P=0.009).":[337],"CONCLUSION:":[338],"Myocardium":[339],"subjected":[340],"showed":[344],"prolonged":[346],"yet":[347],"reversible":[348],"reduction":[349],"systolic":[351],"that":[353,382,386],"associated":[355],"significant":[358],"downregulation":[359],"despite":[365],"restoration":[366],"normal":[368],"flow.":[371],"These":[372],"findings":[373],"suggest":[374],"unique":[376],"metabolic":[377],"adaptation":[378],"different":[384],"typically":[387],"seen":[388],"clinical":[390],"experimental":[392],"models":[393],"hibernation.":[395]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
