{"id":"https://openalex.org/W1784119622","doi":null,"title":"Multicentre evaluation of an antigen-detection ELISA for the diagnosis of Trypanosoma brucei rhodesiense sleeping sickness.","display_name":"Multicentre evaluation of an antigen-detection ELISA for the diagnosis of Trypanosoma brucei rhodesiense sleeping sickness.","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W1784119622","mag":"1784119622","pmid":"https://pubmed.ncbi.nlm.nih.gov/1568281","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2393338"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1444873","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2393338","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2393338","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041898767","display_name":"Eva Komba","orcid":"https://orcid.org/0009-0002-9749-7625","observed_orcids":["https://orcid.org/0009-0002-9749-7625"]},"institutions":[{"id":"https://openalex.org/I4210164902","display_name":"National Institute for Medical Research","ror":"https://ror.org/05fjs7w98","country_code":"TZ","type":"facility","lineage":["https://openalex.org/I2801810276","https://openalex.org/I4210164902"]}],"countries":["TZ"],"is_corresponding":false,"raw_author_name":"E Komba","raw_affiliation_strings":["National Institute for Medical Research, Tabora, United Republic of Tanzania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Medical Research, Tabora, United Republic of Tanzania","institution_ids":["https://openalex.org/I4210164902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037580996","display_name":"Martin Odiit","orcid":"https://orcid.org/0000-0003-2803-7561","observed_orcids":["https://orcid.org/0000-0003-2803-7561"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Odiit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032106177","display_name":"Dawson Mbulamberi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D B Mbulamberi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084808862","display_name":"E. Chimfwembe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E C Chimfwembe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063698292","display_name":"VINAND M. NANTULYA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V M Nantulya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5908,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.64308713,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"70","issue":"1","first_page":"57","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trypanosoma-brucei-rhodesiense","display_name":"Trypanosoma brucei rhodesiense","score":0.9810000061988831},{"id":"https://openalex.org/keywords/human-african-trypanosomiasis","display_name":"sleeping sickness","score":0.9039999842643738},{"id":"https://openalex.org/keywords/trypanosome-antigens","display_name":"trypanosome antigens","score":0.800000011920929},{"id":"https://openalex.org/keywords/serological-diagnosis","display_name":"serological diagnosis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/diagnostic-sensitivity","display_name":"diagnostic sensitivity","score":0.44999998807907104},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8209999799728394},{"id":"https://openalex.org/keywords/serum","display_name":"serum","score":0.7160000205039978},{"id":"https://openalex.org/keywords/cross-reactivity","display_name":"cross-reactivity","score":0.8460000157356262},{"id":"https://openalex.org/keywords/false-positive-results","display_name":"false positives","score":0.7369999885559082},{"id":"https://openalex.org/keywords/blood-donor-screening","display_name":"blood donor screening","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C2778792689","wikidata":"https://www.wikidata.org/wiki/Q203133","display_name":"African trypanosomiasis","level":3,"score":0.921573281288147},{"id":"https://openalex.org/C2909346784","wikidata":"https://www.wikidata.org/wiki/Q33244","display_name":"Trypanosoma brucei rhodesiense","level":4,"score":0.7447384595870972},{"id":"https://openalex.org/C2778143080","wikidata":"https://www.wikidata.org/wiki/Q2443552","display_name":"Trypanosomiasis","level":2,"score":0.642256498336792},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6267403364181519},{"id":"https://openalex.org/C2779502636","wikidata":"https://www.wikidata.org/wiki/Q33244","display_name":"Trypanosoma brucei","level":3,"score":0.6014547944068909},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5912333130836487},{"id":"https://openalex.org/C2779357621","wikidata":"https://www.wikidata.org/wiki/Q655495","display_name":"Tanzania","level":2,"score":0.5754169821739197},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5335332155227661},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.422235906124115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28082722425460815},{"id":"https://openalex.org/C91375879","wikidata":"https://www.wikidata.org/wiki/Q15473274","display_name":"Environmental planning","level":1,"score":0.0},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000953","descriptor_name":"Antigens, Protozoan","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014353","descriptor_name":"Trypanosomiasis, African","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016833","descriptor_name":"Trypanosoma brucei rhodesiense","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:1444873","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2393338","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:1568281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1568281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of the World Health Organization","raw_type":"Clinical Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:2393338","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2393338/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bull World Health Organ","raw_type":"Text"},{"id":"pmh:oai:cgspace.cgiar.org:10568/32865","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10568/32865","pdf_url":null,"source":{"id":"https://openalex.org/S4306402055","display_name":"CGSPace A Repository of Agricultural Research Outputs (Consultative Group for International Agricultural Research)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1286583668","host_organization_name":"CGIAR","host_organization_lineage":["https://openalex.org/I1286583668"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bulletin of the World Health Organization;70: 57-61","raw_type":"Journal Article"},{"id":"mag:1784119622","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1568281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1444873","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2393338","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W65016395","https://openalex.org/W236227114","https://openalex.org/W1488869440","https://openalex.org/W1995823137","https://openalex.org/W2125210008","https://openalex.org/W2141466247","https://openalex.org/W2313399670","https://openalex.org/W2336531597","https://openalex.org/W2409878248","https://openalex.org/W2411145670","https://openalex.org/W2417058566","https://openalex.org/W2467331916"],"related_works":["https://openalex.org/W2125210008","https://openalex.org/W2424667206","https://openalex.org/W2005486221","https://openalex.org/W2187659375","https://openalex.org/W2288294787","https://openalex.org/W2026717219","https://openalex.org/W3209110835","https://openalex.org/W1976109221","https://openalex.org/W154515585","https://openalex.org/W4415701210"],"abstract_inverted_index":{"The":[0,36,114,144,157],"performance":[1],"of":[2,17,50,68,72,87,102,127],"an":[3,18],"enzyme-linked":[4],"immunosorbent":[5],"assay":[6],"(antigen":[7],"ELISA)":[8],"for":[9,62,172],"the":[10,59,77,92,107,125,128,137,140],"detection,":[11],"in":[12,31,42,47,136],"serum":[13],"or":[14,132],"cerebrospinal":[15],"fluid,":[16],"invariant":[19],"trypanosome":[20],"antigen":[21],"to":[22,161],"diagnose":[23],"Trypanosoma":[24],"brucei":[25],"rhodesiense":[26],"sleeping":[27],"sickness":[28],"was":[29,39,45,118,121,159,163],"evaluated":[30],"four":[32],"clinical":[33],"treatment":[34],"centres.":[35],"test,":[37],"which":[38],"carried":[40],"out":[41],"polystyrene":[43],"test-tubes,":[44],"positive":[46],"88":[48],"(88.9%)":[49],"99":[51,70],"parasitologically":[52],"confirmed":[53],"cases":[54,74,89,104],"that":[55],"were":[56,142],"tested":[57,75,90,105],"at":[58,76,91,106],"National":[60,78],"Institute":[61],"Medical":[63],"Research,":[64],"Tabora,":[65],"United":[66],"Republic":[67],"Tanzania;":[69],"(94.3%)":[71],"105":[73],"Sleeping":[79],"Sickness":[80],"Control":[81],"Programme,":[82],"Jinja,":[83],"Uganda;":[84,98],"86":[85],"(87.8%)":[86],"98":[88],"Uganda":[93],"Trypanosomiasis":[94],"Research":[95,110],"Organisation,":[96],"Tororo,":[97],"and":[99,166],"59":[100],"(96.7%)":[101],"61":[103],"Tropical":[108],"Diseases":[109],"Centre,":[111],"Ndola,":[112],"Zambia.":[113],"overall":[115],"detection":[116],"rate":[117],"91.5%.":[119],"There":[120],"no":[122],"cross-reactivity":[123],"with":[124],"agents":[126],"common":[129],"bacterial,":[130],"viral,":[131],"parasitic":[133],"diseases":[134],"prevalent":[135],"areas":[138],"where":[139],"studies":[141],"conducted.":[143],"only":[145],"false-positive":[146],"result":[147],"involved":[148],"a":[149,153,169],"blood":[150],"donor":[151],"from":[152],"trypanosomiasis":[154],"endemic":[155],"focus.":[156],"test":[158],"simple":[160],"perform,":[162],"read":[164],"visually,":[165],"is":[167],"therefore":[168],"potential":[170],"tool":[171],"diagnosing":[173],"human":[174],"African":[175],"trypanosomiasis.":[176]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
