{"id":"https://openalex.org/W178408938","doi":null,"title":"Amyloid A protein amyloidosis induced in apolipoprotein-E-deficient mice.","display_name":"Amyloid A protein amyloidosis induced in apolipoprotein-E-deficient mice.","publication_year":1997,"publication_date":"1997-10-01","ids":{"openalex":"https://openalex.org/W178408938","mag":"178408938","pmid":"https://pubmed.ncbi.nlm.nih.gov/9327723","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858060"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1532845","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858060","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858060","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015671899","display_name":"Yoshinobu Hoshii","orcid":"https://orcid.org/0000-0003-0192-7791","observed_orcids":["https://orcid.org/0000-0003-0192-7791"]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Hoshii","raw_affiliation_strings":["First Department of Pathology, Yamaguchi University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Pathology, Yamaguchi University School of Medicine, Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021000463","display_name":"Hiroyuki Kawano","orcid":"https://orcid.org/0000-0001-8497-3659","observed_orcids":["https://orcid.org/0000-0001-8497-3659"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Kawano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101874566","display_name":"Dan Cui","orcid":"https://orcid.org/0000-0003-3710-1131","observed_orcids":["https://orcid.org/0000-0003-3710-1131"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Cui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100680389","display_name":"Tetsuro Takeda","orcid":"https://orcid.org/0000-0002-9087-1314","observed_orcids":["https://orcid.org/0000-0002-9087-1314"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Takeda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058812352","display_name":"Toshikazu Gondo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Gondo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034040686","display_name":"Masazumi Takahashi","orcid":"https://orcid.org/0000-0002-5123-9914","observed_orcids":["https://orcid.org/0000-0002-5123-9914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Takahashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111451693","display_name":"Katsumi Kogishi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Kogishi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101939729","display_name":"Keiichi Higuchi","orcid":"https://orcid.org/0000-0003-0482-9214","observed_orcids":["https://orcid.org/0000-0003-0482-9214"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Higuchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049053885","display_name":"Tokuhiro Ishihara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Ishihara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7588,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.93311989,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"151","issue":"4","first_page":"911","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.8840000033378601},{"id":"https://openalex.org/keywords/amyloid-a-protein","display_name":"amyloid A protein","score":0.8379999995231628},{"id":"https://openalex.org/keywords/aa-amyloidosis","display_name":"AA amyloidosis","score":0.984000027179718},{"id":"https://openalex.org/keywords/amyloid-deposition","display_name":"amyloid deposition","score":0.777999997138977},{"id":"https://openalex.org/keywords/apoe-deficient-mice","display_name":"ApoE-deficient mice","score":0.8889999985694885},{"id":"https://openalex.org/keywords/amyloidogenesis","display_name":"amyloidogenesis","score":0.703000009059906},{"id":"https://openalex.org/keywords/inflammatory-stimulation","display_name":"inflammatory stimulation","score":0.531000018119812},{"id":"https://openalex.org/keywords/mycobacterium-butyricum","display_name":"Mycobacterium butyricum","score":0.9070000052452087},{"id":"https://openalex.org/keywords/amyloid-enhancing-factor","display_name":"amyloid enhancing factor","score":0.8539999723434448},{"id":"https://openalex.org/keywords/silver-nitrate","display_name":"silver nitrate","score":0.9559999704360962},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.593999981880188},{"id":"https://openalex.org/keywords/fibril-formation","display_name":"fibril formation","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.8253772258758545},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.6903342604637146},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.6724442839622498},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5600728988647461},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5011205673217773},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.480868399143219},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43206456303596497},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.28682875633239746},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2867673337459564},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24407485127449036},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22872799634933472},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000685","descriptor_name":"Serum Amyloid A Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000685","descriptor_name":"Serum Amyloid A Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1532845","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858060","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:9327723","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9327723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1858060","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1858060/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"mag:178408938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9327723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1532845","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858060","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W2182237","https://openalex.org/W98152484","https://openalex.org/W100202513","https://openalex.org/W123436181","https://openalex.org/W1555517932","https://openalex.org/W1565039861","https://openalex.org/W1597318742","https://openalex.org/W1597396112","https://openalex.org/W1601260221","https://openalex.org/W1965496447","https://openalex.org/W1972023888","https://openalex.org/W1976632394","https://openalex.org/W1982652047","https://openalex.org/W1997913988","https://openalex.org/W1999631936","https://openalex.org/W2021333248","https://openalex.org/W2023483363","https://openalex.org/W2034968148","https://openalex.org/W2035252462","https://openalex.org/W2050723290","https://openalex.org/W2060937867","https://openalex.org/W2062108627","https://openalex.org/W2071461578","https://openalex.org/W2072682191","https://openalex.org/W2076096651","https://openalex.org/W2112357968","https://openalex.org/W2294568590","https://openalex.org/W2335785112","https://openalex.org/W2439506426"],"related_works":["https://openalex.org/W83881960","https://openalex.org/W2439506426","https://openalex.org/W2063955089","https://openalex.org/W1804478794","https://openalex.org/W1565039861","https://openalex.org/W2022393180","https://openalex.org/W7117233859","https://openalex.org/W2155934745","https://openalex.org/W1965496447","https://openalex.org/W2138955227"],"abstract_inverted_index":{"Apolipoprotein":[0],"E":[1],"(apoE)":[2],"is":[3,27,210],"a":[4,28,39,42],"constituent":[5,30],"of":[6,21,31,34,47,65,91,99,110,113,139,148,177,181,190,200,221,233],"lipoproteins":[7],"other":[8],"than":[9,158],"low-density":[10],"lipoprotein,":[11],"and":[12,19,24,36,56,96,107,117,142,217],"it":[13],"principally":[14],"acts":[15],"in":[16,67,69,71,89,97,123,151,160,173,186,196,229],"the":[17,52,63,105,111,146,174,178,187,197,219,230],"transport":[18],"metabolism":[20],"plasma":[22],"cholesterol":[23],"triglyceride.":[25],"ApoE":[26],"minor":[29],"various":[32],"kinds":[33],"amyloidoses":[35],"may":[37],"play":[38],"role":[40,64],"as":[41,126,128],"pathological":[43],"chaperone":[44],"for":[45,214],"fibrillogenesis":[46],"amyloid":[48,53,76,121,149,164,188,198,215,227,235],"fibril":[49],"protein":[50,78],"with":[51,75,167],"P":[54],"component":[55],"proteoglycans.":[57],"In":[58],"this":[59],"study,":[60],"we":[61,206],"examined":[62],"apoE":[66,182,209,222],"amyloidogenesis":[68],"vivo":[70],"apoE-deficient":[72,101,124,161,201],"mutant":[73,102],"mice":[74,95,103,125,131,154,193],"A":[77],"(AA)":[79],"amyloidosis":[80],"induced":[81],"by":[82],"inflammatory":[83],"stimulation.":[84],"Amyloid":[85],"deposition":[86,122,216,228],"was":[87,155,183],"seen":[88,172,184],"six":[90,98],"nine":[92],"C57BL/6J":[93,129,152,191],"control":[94,130,153,192],"eight":[100],"after":[104,137],"intraperitoneal":[106],"subcutaneous":[108],"injections":[109],"mixture":[112],"complete":[114],"Freund's":[115],"adjuvant":[116],"Mycobacterium":[118],"butyricum.":[119],"Moreover,":[120],"well":[127],"started":[132],"48":[133],"or":[134],"72":[135],"hours":[136],"injection":[138],"amyloid-enhancing":[140],"factor":[141],"silver":[143],"nitrate,":[144],"although":[145],"amount":[147],"deposit":[150,199],"slightly":[156,224],"larger":[157],"that":[159,208,218],"mice.":[162,202],"These":[163],"deposits":[165,189],"reacted":[166],"anti-mouse":[168],"AA":[169,226,234],"antibody":[170],"were":[171],"perifollicular":[175],"area":[176],"spleen.":[179],"Immunoreactivity":[180],"irregularly":[185],"but":[194],"not":[195,211],"From":[203],"these":[204],"results,":[205],"concluded":[207],"always":[212],"necessary":[213],"existence":[220],"might":[223],"accelerate":[225],"earliest":[231],"phase":[232],"deposition.":[236]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
