{"id":"https://openalex.org/W17837392","doi":null,"title":"Testosterone treatments: why, when, and how?","display_name":"Testosterone treatments: why, when, and how?","publication_year":2006,"publication_date":"2006-05-01","ids":{"openalex":"https://openalex.org/W17837392","mag":"17837392","pmid":"https://pubmed.ncbi.nlm.nih.gov/16719252"},"language":"en","primary_location":{"id":"pmid:16719252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16719252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American family physician","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000207502","display_name":"Katherine L. Margo","orcid":"https://orcid.org/0000-0002-2219-6222","observed_orcids":["https://orcid.org/0000-0002-2219-6222"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Margo","raw_affiliation_strings":["Department of Family Practice and Community Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. margok@uphs.upenn.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family Practice and Community Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. margok@uphs.upenn.edu","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":null,"display_name":"Robert Winn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Winn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2613,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.91875449,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"73","issue":"9","first_page":"1591","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/testosterone-replacement-therapy","display_name":"testosterone replacement therapy","score":0.8029999732971191},{"id":"https://openalex.org/keywords/sexual-dysfunction","display_name":"sexual dysfunction","score":0.6650000214576721},{"id":"https://openalex.org/keywords/hot-flashes","display_name":"hot flashes","score":0.8429999947547913},{"id":"https://openalex.org/keywords/sexual-desire","display_name":"sexual desire","score":0.6729999780654907},{"id":"https://openalex.org/keywords/bone-mass","display_name":"bone mass","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.4880000054836273},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.6520000100135803},{"id":"https://openalex.org/keywords/polycythemia","display_name":"polycythemia","score":0.843999981880188},{"id":"https://openalex.org/keywords/acne-vulgaris","display_name":"acne","score":0.7549999952316284},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.8569999933242798},{"id":"https://openalex.org/keywords/masculinization","display_name":"masculinization","score":0.9879999756813049},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7160000205039978},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.7990000247955322},{"id":"https://openalex.org/keywords/prostate-specific-antigen-monitoring","display_name":"prostate-specific antigen monitoring","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hematocrit-monitoring","display_name":"hematocrit monitoring","score":0.925000011920929},{"id":"https://openalex.org/keywords/lipid-monitoring","display_name":"lipid monitoring","score":0.7409999966621399},{"id":"https://openalex.org/keywords/mammography","display_name":"mammography","score":0.5149999856948853},{"id":"https://openalex.org/keywords/men","display_name":"men","score":0.48500001430511475},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9177168607711792},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.8454578518867493},{"id":"https://openalex.org/C2779366285","wikidata":"https://www.wikidata.org/wiki/Q178066","display_name":"Libido","level":2,"score":0.7463874220848083},{"id":"https://openalex.org/C2776631543","wikidata":"https://www.wikidata.org/wiki/Q1433654","display_name":"Virilization","level":4,"score":0.6625347137451172},{"id":"https://openalex.org/C2777673923","wikidata":"https://www.wikidata.org/wiki/Q79928","display_name":"Acne","level":2,"score":0.6621782779693604},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6078798174858093},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4731237292289734},{"id":"https://openalex.org/C2778093883","wikidata":"https://www.wikidata.org/wiki/Q1137463","display_name":"Sexual dysfunction","level":2,"score":0.47274553775787354},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.383955717086792},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.33942681550979614},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31840673089027405},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.3163433074951172},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.15650206804275513},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.11592262983322144}],"mesh":[{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004333","descriptor_name":"Drug Administration Routes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012735","descriptor_name":"Sexual Dysfunction, Physiological","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16719252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16719252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American family physician","raw_type":"Journal Article"},{"id":"mag:17837392","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16719252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1361700","https://openalex.org/W105897893","https://openalex.org/W187393396","https://openalex.org/W1518867335","https://openalex.org/W1593442063","https://openalex.org/W1605353467","https://openalex.org/W1968654828","https://openalex.org/W1969632703","https://openalex.org/W1980883512","https://openalex.org/W1983630457","https://openalex.org/W1985592735","https://openalex.org/W1991376015","https://openalex.org/W2008675752","https://openalex.org/W2015069488","https://openalex.org/W2028034231","https://openalex.org/W2041920285","https://openalex.org/W2043724130","https://openalex.org/W2046428578","https://openalex.org/W2054235149","https://openalex.org/W2055598996","https://openalex.org/W2061259561","https://openalex.org/W2067814588","https://openalex.org/W2076608288","https://openalex.org/W2080266804","https://openalex.org/W2087582756","https://openalex.org/W2092972068","https://openalex.org/W2098752121","https://openalex.org/W2099393002","https://openalex.org/W2102076625","https://openalex.org/W2104095843","https://openalex.org/W2106872870","https://openalex.org/W2110649702","https://openalex.org/W2116271944","https://openalex.org/W2120158027","https://openalex.org/W2122023537","https://openalex.org/W2123684828","https://openalex.org/W2127219068","https://openalex.org/W2134710844","https://openalex.org/W2135959338","https://openalex.org/W2136650535","https://openalex.org/W2136743230","https://openalex.org/W2138364455","https://openalex.org/W2138822479","https://openalex.org/W2139893960","https://openalex.org/W2143878458","https://openalex.org/W2153768594","https://openalex.org/W2161057551","https://openalex.org/W2163118201","https://openalex.org/W2163320305","https://openalex.org/W2166327326","https://openalex.org/W2169634362","https://openalex.org/W2169716893","https://openalex.org/W2336273414","https://openalex.org/W2398308923","https://openalex.org/W2408735271","https://openalex.org/W3024864164"],"related_works":["https://openalex.org/W1971287689","https://openalex.org/W2756704582","https://openalex.org/W7095905232","https://openalex.org/W2142096866","https://openalex.org/W2153475442","https://openalex.org/W2601308019","https://openalex.org/W4410733316","https://openalex.org/W4231046593","https://openalex.org/W116377058","https://openalex.org/W4255310183"],"abstract_inverted_index":{"Testosterone":[0,26,86],"treatment":[1],"is":[2,27,121],"controversial":[3],"for":[4,10,20,157],"men":[5,37,101],"and":[6,38,40,53,76,104,113,115,138,146,152],"even":[7,79],"more":[8,24],"so":[9],"women.":[11,44],"Although":[12],"long-term":[13],"outcome":[14],"data":[15],"are":[16,22,155],"not":[17,142],"available,":[18],"prescriptions":[19],"testosterone":[21,69,84,120,132],"becoming":[23],"common.":[25],"used":[28,122],"primarily":[29],"to":[30,73],"treat":[31],"symptoms":[32],"of":[33,56,128,131,148],"sexual":[34],"dysfunction":[35],"in":[36,43,80,100,108,123],"women":[39,109],"hot":[41],"flashes":[42],"Potential":[45],"benefits":[46],"include":[47,102,110],"improved":[48],"libido,":[49],"increased":[50,54],"bone":[51],"mass,":[52],"sense":[55],"well-being.":[57],"In":[58],"individuals":[59],"with":[60,82],"human":[61],"immunodeficiency":[62],"virus":[63],"infection":[64],"or":[65,96],"other":[66],"chronic":[67],"diseases,":[68],"has":[70],"been":[71,143],"shown":[72],"improve":[74],"mood":[75],"energy":[77],"levels,":[78],"patients":[81,158],"normal":[83],"levels.":[85],"can":[87],"be":[88],"administered":[89],"by":[90],"injection,":[91],"patch,":[92],"topical":[93],"gel,":[94],"pill,":[95],"implant.":[97],"Side":[98,106],"effects":[99,107,130],"polycythemia":[103],"acne.":[105],"acne,":[111],"hepatotoxicity,":[112],"virilization":[114],"usually":[116],"only":[117],"occur":[118],"when":[119],"supraphysiologic":[124],"doses.":[125],"Long-term":[126],"studies":[127],"the":[129],"on":[133],"prostate":[134],"cancer,":[135,137],"breast":[136],"heart":[139],"disease":[140],"have":[141],"completed.":[144],"Mammograms":[145],"monitoring":[147],"prostate-specific":[149],"antigen,":[150],"hematocrit,":[151],"lipid":[153],"levels":[154],"recommended":[156],"taking":[159],"testosterone.":[160]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}